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Total 393 results found since Jan 2013.

Microarray Analysis of Immunity Against WSSV in Response to Injection of Non-specific Long dsRNA in Kuruma Shrimp, Marsupenaeus japonicus.
Abstract Injection of shrimp with non-specific double-stranded RNA (dsRNA) of diverse lengths, sequences, and base compositions is known to induce non-specific immunity and protect against lethal disease, although the mechanisms are unclear. Previous shrimp studies examined the effects of non-specific RNA on particular pathways, while their global effects have not been examined. To understand the global effects of non-specific RNA in shrimp, we injected kuruma shrimp (Marsupenaeus japonicus) with a dsRNA and a small interfering RNA (siRNA) that is not specific to any gene in the shrimp genome and then examined glo...
Source: Marine Biotechnology - May 8, 2015 Category: Biotechnology Authors: Maralit BA, Komatsu M, Hipolito SG, Hirono I, Kondo H Tags: Mar Biotechnol (NY) Source Type: research

Corrigendum: Taking charge of siRNA delivery
Nature Biotechnology 33, 563 (2015). doi:10.1038/nbt0515-563c Authors: Anastasia Khvorova, Maire F Osborn & Matthew R Hassler
Source: Nature Biotechnology - May 12, 2015 Category: Biotechnology Authors: Anastasia KhvorovaMaire F OsbornMatthew R Hassler Tags: Research Source Type: research

Histone H3 is digested by Granzyme A during compromised cell death in the Raji cells.
Abstract Granzyme A (GzmA) was identified as a cytotoxic T lymphocyte protease protein expressed at nucleus. A number of nuclear proteins are well known as GzmA substrates, and GzmA is related with caspase independent apoptosis. Histones H1, H2B, and H3 were identified as GzmA substrates through in vitro experiment with purified nucleosome. Here, we demonstrated that histone H3 was cleaved by GzmA in vivo during staurosporine-induced cell death. Moreover, histone H3 cleavage was blocked by the GzmA inhibitor nafamostat mesylate and by GzmA knockdown using siRNA. Taken together we verified that histone H3 is a real...
Source: Journal of Microbiology and Biotechnology - June 2, 2015 Category: Biotechnology Authors: Lee PY, Park BC, Chi SW, Bae KH, Kim S, Cho S, Kim JH, Park SG Tags: J Microbiol Biotechnol Source Type: research

ΔNp63α-responsive microRNAs modulate the expression of metabolic enzymes in squamous cell carcinoma cells.
Abstract MicroRNAs, whose transcription is regulated by members of the tumor protein p53 family, modulate the expression of numerous metabolic enzymes, significantly altering tumor cell response to chemotherapeutic treatments. The role for ΔNp63α-regulated microRNAs in regulation of cell cycle arrest, apoptosis and autophagy in squamous cell carcinoma (SCC) cells upon cisplatin exposure has been reported. The current study indicated that the selected microRNA targets differentially regulated by ΔNp63α in cisplatin-sensitive and cisplatin-resistant SCC cells could alter the expression of a few metabolic enzymes...
Source: Current Pharmaceutical Biotechnology - June 19, 2015 Category: Biotechnology Authors: Ratovitski EA Tags: Curr Pharm Biotechnol Source Type: research

Expression of dsRNA in recombinant Isaria fumosorosea strain targets the TLR7 gene in Bemisia tabaci
Conclusion: The expression of the dsRNA of whitefly TLR7 gene in recombinant I. fumosorosea strain successfully knocked down the host target gene by infecting the nymphs and enhanced the whiteflies mortality. The present study will give insight to new application of RNAi technology for more effective biocontrol of this pests.
Source: BMC Biotechnology - July 22, 2015 Category: Biotechnology Authors: Xiurun ChenLin LiQiongbo HuBowen ZhangWei WuFengliang JinJunxi Jiang Source Type: research

Polyelectrolyte complexes of hTERT siRNA and polyethyleneimine: Effect of degree of PEG grafting on biological and cellular activity
Artificial Cells, Nanomedicine, and Biotechnology, Ahead of Print.
Source: Artificial Cells, Blood Substitutes, and Biotechnology - August 1, 2015 Category: Biotechnology Tags: article Source Type: research

Comparison of different cationized proteins as biomaterials for nanoparticle-based ocular gene delivery.
Abstract Cationized polymers have been proposed as transfection agents for gene therapy. The present work aims to improve the understanding of the potential use of different cationized proteins (atelocollagen, albumin and gelatin) as nanoparticle components and to investigate the possibility of modulating the physicochemical properties of the resulting nanoparticle carriers by selecting specific protein characteristics in an attempt to improve current ocular gene-delivery approaches. The toxicity profiles, as well as internalization and transfection efficiency, of the developed nanoparticles can be modulated by mo...
Source: Colloids and Surfaces - August 12, 2015 Category: Biotechnology Authors: Zorzi GK, Párraga JE, Seijo B, Sanchez A Tags: Colloids Surf B Biointerfaces Source Type: research

Membrane display and functional analysis of juxtacrine ligand-receptor signaling.
Abstract We developed a strategy for identifying modulators of juxtacrine signaling, triggered by a cell-surface ligand displayed on synthetic lipid bilayers, via cognate receptors on apposed cells. Using readouts for receptor lateral transport and intracellular signaling, we screened a small interfering RNA (siRNA) library and identified specific receptor tyrosine kinases (RTKs) that directly or indirectly modulate apoptosis signaling by a model death ligand through its cognate death receptors. This approach may be broadly useful for studying juxtacrine cell-cell signaling systems. PMID: 26458551 [PubMed - in process]
Source: BioTechniques - October 17, 2015 Category: Biotechnology Authors: Nair PM, Ngu H, Torres E, Marsters S, Lawrence DA, Stephan JP, Komuves L, Ashkenazi A Tags: Biotechniques Source Type: research

Nucleic-Acid Delivery Using Lipid Nanocapsules.
In conclusion, LNCs are very good candidates to deliver nucleic acids to cells in the course of anti-cancer therapies. PMID: 27033510 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - March 31, 2016 Category: Biotechnology Authors: Lagarce F, Passirani C Tags: Curr Pharm Biotechnol Source Type: research

Fluorescent peptide biosensor for monitoring CDK4/cyclin D kinase activity in melanoma cell extracts, mouse xenografts and skin biopsies
Publication date: 15 November 2016 Source:Biosensors and Bioelectronics, Volume 85 Author(s): Camille Prével, Morgan Pellerano, Juan A. González-Vera, Pauline Henri, Laurent Meunier, Julien Vollaire, Véronique Josserand, May C. Morris Melanoma constitutes the most aggressive form of skin cancer, which further metastasizes into a deadly form of cancer. The p16INK4a-Cyclin D-CDK4/6-pRb pathway is dysregulated in 90% of melanomas. CDK4/Cyclin D kinase hyperactivation, associated with mutation of CDK4, amplification of Cyclin D or loss of p16INK4a leads to increased risk of developing melanoma. This kinase therefo...
Source: Biosensors and Bioelectronics - May 17, 2016 Category: Biotechnology Source Type: research

Sucrose ester based cationic liposomes as effective non-viral gene vectors for gene delivery.
Abstract As sucrose esters (SEs) are natural and biodegradable excipients with excellent drug dissolution and drug absorption/permeation in controlled release systems, we firstly incorporated SE into liposomes for gene delivery in this article. A peptide-based lipid (CDO14), Gemini-based quaternary ammonium-based lipid (CTA14), and mono-head quaternary ammonium lipid (CPA14), and SE as helper lipid, were prepared into liposomes which could enhance the interactions between liposomes and pDNA. Most importantly, the liposomes with helper lipid SE showed higher transfection and lower cytotoxicity than those without SE...
Source: Colloids and Surfaces - May 11, 2016 Category: Biotechnology Authors: Zhao Y, Zhu J, Zhou H, Guo X, Tian T, Cui S, Zhen Y, Zhang S, Xu Y Tags: Colloids Surf B Biointerfaces Source Type: research

TP53INP1 3'-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity.
CONCLUSIONS: TP53INP1 3'-UTR could inhibit the EMT, thus hindering the migration and invasion of glioma via acting as a ceRNA for E-cadherin. PMID: 27341836 [PubMed - as supplied by publisher]
Source: Biotechnology Letters - June 23, 2016 Category: Biotechnology Authors: Wang Y, Lin G Tags: Biotechnol Lett Source Type: research

Effects of chitosan nanoparticle-mediated BRAF siRNA interference on invasion and metastasis of gastric cancer cells
Volume 44, Issue 5, August 2016, pages 1232-123510.3109/21691401.2015.1019666Jian Huo
Source: Artificial Cells, Blood Substitutes, and Biotechnology - March 20, 2015 Category: Biotechnology Authors: Jian Huo Source Type: research

Preparation and evaluation of a non-viral gene vector for SiRNA: Multifunctional envelope-type nano device
Volume 44, Issue 5, August 2016, pages 1259-126510.3109/21691401.2015.1024840Ying Zhang
Source: Artificial Cells, Blood Substitutes, and Biotechnology - March 26, 2015 Category: Biotechnology Authors: Ying ZhangHaitian WeiLisa XuGuowen YanChao MaMiao YuChen WeiYong Sun Source Type: research

SiRNA-mediated silencing of Snail-1 induces apoptosis and alters micro RNA expression in human urinary bladder cancer cell line
10.1080/21691401.2016.1198361Seyed Mohammad Hossein Musavi Shenas
Source: Artificial Cells, Blood Substitutes, and Biotechnology - June 19, 2016 Category: Biotechnology Authors: Seyed Mohammad Hossein Musavi ShenasBehzad MansooriAli MohammadiShima SalehiBehzad KaffashBehnaz TalebiZohreh BabalooDariush ShanehbandiBehzad Baradaran Source Type: research