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Specialty: Biotechnology
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Total 393 results found since Jan 2013.
Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air-liquid interface model
CONCLUSION: The ex vivo 3D tissue slice ALI culture model is a powerful system that allows the effective evaluation of biological nanoparticle efficacy and biocompatibility in an intact tissue environment. It is comparably inexpensive, time-saving, and follows the 3R principle, while allowing the identification of critical nanoparticle properties and optimal candidates for in vivo applications.PMID:36541426 | DOI:10.1002/biot.202200415
Source: Biotechnology Journal - December 21, 2022 Category: Biotechnology Authors: Michael Karimov Marlene Scherer Heike Franke Alexander Ewe Achim Aigner Source Type: research
Morphological changes of macrophages and their potential contribution to tendon healing
Colloids Surf B Biointerfaces. 2021 Oct 1;209(Pt 1):112145. doi: 10.1016/j.colsurfb.2021.112145. Online ahead of print.ABSTRACTPoor healing ability and adhesion formation greatly hinder the recovery of injured tendon function. Previously, our local sustained gene delivery system by using cyclooxygenases (COX-1 and COX-2)-engineered miRNA plasmid/nanoparticles loaded hydrogel significantly inhibited adhesion formation and promoted tendon healing. The present study aims to study morphological changes of the macrophages in the healing tendons after above treatment with the hydrogel. Firstly, we assessed the therapeutic effect...
Source: Colloids and Surfaces - October 12, 2021 Category: Biotechnology Authors: Qian Qian Yang Luzhong Zhang You Lang Zhou Jin Bo Tang Source Type: research
