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Total 393 results found since Jan 2013.

Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression
This study tested the hypothesis that, through modulation of angiogenic signalling pathways, corin is a critical regulator of osteogenic differentiation and endochondral ossification. In vitro, corin expression in hASC was suppressed via siRNA knockdown and vascular en dothelial growth factor A (VEGF‐A) expression was quantified via reverse transcription polymerase chain reaction. In vivo, a murine corin knockout model (female, 10 weeks) was used to determine the effect of corin deficiency on long bone development. Wild‐type and corin knockout long bones were compared via haematoxylin and eosin staining to assess tiss...
Source: Journal of Tissue Engineering and Regenerative Medicine - November 22, 2018 Category: Biotechnology Authors: Rachel C. Nordberg, Hao Wang, Qingyu Wu, Elizabeth G. Loboa Tags: RESEARCH ARTICLE Source Type: research

Cyclic peptide-based nanostructures as efficient siRNA carriers
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Source: Artificial Cells, Blood Substitutes, and Biotechnology - October 12, 2018 Category: Biotechnology Authors: Bijayananda Panigrahi Rohit Kumar Singh Sourav Mishra Dindyal Mandal Source Type: research

Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway.
In this study, we found that addition of HGF to sorafenib-treated HCC cells activated MET and re-stimulated the downstream AKT and ERK1/2 pathways. Thereby, restored sorafenib-treated HCC cells proliferation, migration and invasion ability, and rescued cells from apoptosis. In addition, we found that HGF treatment of HCC cells induced early growth response protein (EGR1) expression, which is involved in sorafenib resistance. Importantly, the HGF rescued effect in sorafenib-treated HCC cells could be abrogated by inhibiting MET activation with PHA-665752 or by downregulating EGR1 expression with small interfering RNA (siRNA...
Source: Artificial Cells, Nanomedicine and Biotechnology - January 23, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challenges.
Abstract The recent progress in genetic engineering has brought multiple benefits to the food and agricultural industry by enhancing essential characteristics of agronomic traits. Powerful tools in the field of genome editing, such as siRNA-mediated RNA interference for targeted suppression of gene expression and transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs) for DNA repair have been widely used for commercial purposes. However, in the last few years, the discovery of the CRISPR-Cas9 system has revolutionized genome editing and has attracted attention as a powerful tool f...
Source: Biotechnology Advances - February 16, 2019 Category: Biotechnology Authors: Eş I, Gavahian M, Marti-Quijal FJ, Lorenzo JM, Khaneghah AM, Tsatsanis C, Kampranis SC, Barba FJ Tags: Biotechnol Adv Source Type: research

Expression analysis of proteasome maturation protein (POMP) gene in Liaoning Cashmere goat.
Abstract Liaoning Cashmere goat is a precious genetic resource of China. To explore the relationship between POMP and cashmere growth, we analyzed the expression of POMP. POMP encodes a hudrophilic protein which is most closely related to bos. RT-PCR showed that POMP was expressed in skin, heart, liver, spleen, lung, and kidney tissues. Real-time PCR showed that the expression of POMP was more active in the secondary hair follicles than the primary hair follicles in anagen. In situ hybridization showed that POMP was obviously expressed in the Inner Root Sheath (IRS) but no expression in Outer Root. The treatment o...
Source: Animal Biotechnology - April 6, 2019 Category: Biotechnology Authors: Piao J, Xu CL, Piao JA, Cao M, Huang N, Jin M Tags: Anim Biotechnol Source Type: research

Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma
Volume 47, Issue 1, December 2019, Page 1374-1383 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 11, 2019 Category: Biotechnology Authors: Yao Yao Tianqi Wang Yongjun Liu Na Zhang Source Type: research

Cancer cell membrane cloaking nanoparticles for targeted co-delivery of doxorubicin and PD-L1 siRNA
Volume 47, Issue 1, December 2019, Page 1635-1641 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 26, 2019 Category: Biotechnology Authors: Mushi Chen Ming Chen Jiantai He Source Type: research

Study of As2O3 regulating proliferation and apoptosis of Tca8113 cells by inhibiting the expression of Id-1.
CONCLUSION: As2O3 could regulate the proliferation and apoptosis of Tca8113 cells by inhibiting the expression of Id-1. PMID: 31079498 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - May 15, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Effects of Srxn1 on growth and Notch signalling of astrocyte induced by hydrogen peroxide.
CONCLUSION: Srxn1 may protect astrocytes from oxidative stress injury induced by H2O2 by activation of Notch signalling pathway. PMID: 31079497 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - May 15, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Cyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/ β-catenin signalling.
Conclusions: Cyclin D1 regulated chondrocyte proliferation and apoptosis through Wnt3/β-catenin instead of Wnt10a/β-catenin signalling pathway. PMID: 31155960 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 4, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Pretreatment of ghrelin protects H9c2 cells against hypoxia/reoxygenation-induced cell death via PI3K/AKT and AMPK pathways.
In conclusion, this study demonstrated that ghrelin pretreatment protected H9c2 cells against H/R-induced cell damage, possibly via PI3K/AKT and AMPK pathways. PMID: 31159591 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 6, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Molecular characterization, expression analysis of Chemerin gene and its potential role in intramuscular adipocyte differentiation of goat.
Abstract Chemerin is a cytokine secreted by adipose cells and plays an important regulatory role in adipocyte differentiation and lipid metabolism. However, the function of Chemerin on intramuscular fat (IMF) deposition is still unknown in goat. Here, we cloned the cDNA of goat Chemerin gene using quantitative real-time PCR (qRT-PCR) technique and further clarified the expression pattern of Chemerin in various tissues of goat. The siRNA against Chemerin were synthesized to explore the potential role in intramuscular preadipocyte differentiation of goat. Our results showed that the full-length open reading frame (O...
Source: Animal Biotechnology - June 12, 2019 Category: Biotechnology Authors: Ma J, Liao H, Lin Y, Huang K, Zhu J, Wang Y Tags: Anim Biotechnol Source Type: research

FAK mediates BMP9-induced osteogenic differentiation via Wnt and MAPK signaling pathway in synovial mesenchymal stem cells.
Conclusion: FAK plays a pivotal role in promoting BMP9-induced osteogenesis of SMSCs, which is probably via activating Wnt and MAPK pathway. PMID: 31240956 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 27, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

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