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Total 393 results found since Jan 2013.

Morphological changes of macrophages and their potential contribution to tendon healing
Colloids Surf B Biointerfaces. 2021 Oct 1;209(Pt 1):112145. doi: 10.1016/j.colsurfb.2021.112145. Online ahead of print.ABSTRACTPoor healing ability and adhesion formation greatly hinder the recovery of injured tendon function. Previously, our local sustained gene delivery system by using cyclooxygenases (COX-1 and COX-2)-engineered miRNA plasmid/nanoparticles loaded hydrogel significantly inhibited adhesion formation and promoted tendon healing. The present study aims to study morphological changes of the macrophages in the healing tendons after above treatment with the hydrogel. Firstly, we assessed the therapeutic effect...
Source: Colloids and Surfaces - October 12, 2021 Category: Biotechnology Authors: Qian Qian Yang Luzhong Zhang You Lang Zhou Jin Bo Tang Source Type: research

Multiple suppressing small interfering rna for cancer treatment - application to triple-negative breast cancer
This article is protected by copyright. All rights reserved.PMID:37478121 | DOI:10.1002/biot.202300060
Source: Biotechnology Journal - July 21, 2023 Category: Biotechnology Authors: Jaewook Lee Jang Hyuk Bang Yeong Chae Ryu Byeong Hee Hwang Source Type: research

Ideal and Reality: Barricade in the Delivery of Small Interfering RNA for Cancer Therapy.
In conclusion, the siRNA-based gene silencing drug will gain an important position for treating human diseases if we can solve the gap between ideal and reality. PMID: 26511977 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - October 29, 2015 Category: Biotechnology Authors: Wu D, Han H, Xing Z, Zhang J, Li L, Shi W, Li Q Tags: Curr Pharm Biotechnol Source Type: research

A fast and efficient protocol for small RNA extraction in Japanese plum and other Prunus species
Conclusion We propose this protocol as a reliable and reproducible small RNA isolation procedure for P. salicina and other Prunus species.
Source: Electronic Journal of Biotechnology - October 17, 2017 Category: Biotechnology Source Type: research

Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo.
Abstract Pancreatic cancer remains a major unsolved health problem lacking a potent therapeutic option. Our previous studies showed that the ribosomal protein L39 (RPL39) gene was up-regulated after long-term silencing of oncogenic KRAS in pancreatic cancer PANC-1 cells, which indicated that RPL39 may be important for pancreatic cancer development and survival. In the current study, small interfering RNA (siRNA) targeting of the RPL39 gene was performed to determine the effects of the RPL39 gene on growth of pancreatic cancer PANC-1 and BxPC-3 cells in vitro and in vivo. Results from in vitro experiments showed th...
Source: Biotechnology Journal - May 1, 2014 Category: Biotechnology Authors: Li CO, Chen D, Luo M, Ge M, Zhu J Tags: Biotechnol J Source Type: research

Nano Carriers That Enable Co-Delivery of Chemotherapy and RNAi Agents for Treatment of Drug-Resistant Cancers.
Abstract Tumor cells exhibit drug resistant phenotypes that decrease the efficacy of chemotherapeutic treatments. The drug resistance has a genetic basis that is caused by an abnormal gene expression. There are several types of drug resistance: efflux pumps reducing the cellular concentration of the drug, alterations in membrane lipids that reduce cellular uptake, increased or altered drug targets, metabolic alteration of the drug, inhibition of apoptosis, repair of the damaged DNA, and alteration of the cell cycle checkpoints (Gottesman et al. , 2002, Holohan et al. , 2013). siRNA is used to silence the drug resi...
Source: Biotechnology Advances - June 9, 2014 Category: Biotechnology Authors: Tsouris V, Joo MK, Kim SH, Kwon IC, Won YY Tags: Biotechnol Adv Source Type: research

Down-regulation of STAT3 expression using vector-based RNA interference promotes apoptosis in Hepatocarcinoma cells.
In this study, we followed a DNA vector-based RNAi approach to silence the signal transducer and activator of transcription 3 (STAT3) expression in Bel-7402 cells, to explore how the Janus kinase (JAK)/STAT3 signaling pathway influences the apoptosis of hepatocarcinoma cells. According to GenBank's STAT3 cDNA, the plasmid pGCsi.U6/neoRFP STAT3, which was designed for expression of STAT3 small interfering RNA (siRNA), was constructed and synthesized, and then transfected into Bel-7402 cells using Lipofectamine 2000. Cells with or without siRNA transfection were treated in wells. The apoptotic rate was detected by flow cytom...
Source: Artificial Cells, Nanomedicine and Biotechnology - December 12, 2015 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1
CONCLUSIONS: We found that BMSCs can induce Treg differentiation by inhibiting the Akt/mTOR pathway via PD-L1; this significantly improved symptoms and pathology in our ulcerative colitis rat models.PMID:36261682 | DOI:10.1007/s10529-022-03307-1
Source: Biotechnology Letters - October 19, 2022 Category: Biotechnology Authors: Fei Gao Dandan Cui Dongmei Zuo Zhexing Shou Jia Yang Ting Yu Yujin Liu Si Chu Feng Zhu Chunzhu Wei Source Type: research

RNA interference technology with emphasis on delivery vehicles-prospects and limitations.
CONCLUSION: With the current challenges, there is a need for collaborative work allowing for the successful development of nanoparticle/siRNA complexes as health-promoting biotherapeutics. PMID: 26140615 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - December 12, 2015 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression.
CONCLUSIONS: BACH1 is overexpressed in prostate cancer. Because this promotes invasion and migration, it may facilitate metastasis of prostate cancer. Thus, BACH1 is a potential therapeutic target for metastatic prostate cancer. BACH1 silencing therapy can be considered as a novel and effective adjuvant in prostate cancer targeted therapies. PMID: 28889753 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - September 12, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Enhancement of chemosensitivity by simultaneously silencing of Mcl-1 and Survivin genes using small interfering RNA in human myelomonocytic leukaemia.
Authors: Jafarlou M, Shanehbandi D, Dehghan P, Mansoori B, Othman F, Baradaran B Abstract Acute myeloid leukaemia (AML) is a genetically heterogeneous, severe and rapidly progressing disease triggered by blocking granulocyte or monocyte differentiation and maturation. Overexpression of myeloid cell leukaemia-1 (Mcl-1) and Survivin is associated with drug resistance, tumour progression and inhibition of apoptotic mechanisms in leukaemia and several cancers. In the present study, we examined the combined effect of etoposide and dual siRNA-mediated silencing of Mcl-1 and Survivin on U-937 AML cells. The AML cells were...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 10, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research