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Specialty: Cytology
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Total 2613 results found since Jan 2013.
USP7 reduction leads to developmental failure of mouse early embryos
Exp Cell Res. 2023 Apr 18:113605. doi: 10.1016/j.yexcr.2023.113605. Online ahead of print.ABSTRACTAs a member of Ubiquitin-specific protease subfamily, ubiquitin specific protease 7 (USP7) has been reported to participate in a variety of cellular processes, including cell cycle, apoptosis, DNA damage response, and epigenetic modification. However, its function in preimplantation embryos is still obscure. To investigate the functions of USP7 during preimplantation embryo development, we used siRNA to degrade endogenous USP7 messenger RNA. We found that USP7 knockdown significantly decreased the development rate of mouse ear...
Source: Experimental Cell Research - April 18, 2023 Category: Cytology Authors: Xue Zhang Xue-Feng Xie Ang Li Wei Song Chao Li Fei Li Xiao-Zhen Li Xiao-Yan Fan Chang-Yin Zhou Guang Wang Qing-Yuan Sun Xiang-Hong Ou Source Type: research
IL-1 β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
In this study, we examined the activation of non-canonical nuclear factor Kappa B (NFκB) signalling in U2OS cells, a cellular metastatic bone cancer model. Whilst Lymphotoxin α1β2 (LTα1β2) stimulated the expected slow, delayed, sustained activation of serine 866/870 p100 phosphorylation and increased cellular expression of p52 NFκB, we found that canonical agonists, Interleukin-1β (IL-1β) and also Tumour necrosis factor-α (TNFα) generated a rapid transient increase in pp100, which was maximal by 15-30 min. This rapid phosphorylation was also observed in other cells types, such as DU145 and HCAECs suggesting the p...
Source: Cellular Signalling - April 18, 2023 Category: Cytology Authors: Kathryn McIntosh Yousif H Khalaf Rachel Craig Christopher West Ashley McCulloch Ajay Waghmare Christopher Lawson Edmond Y W Chan Simon Mackay Andrew Paul Robin Plevin Source Type: research
USP7 reduction leads to developmental failure of mouse early embryos
Exp Cell Res. 2023 Apr 18:113605. doi: 10.1016/j.yexcr.2023.113605. Online ahead of print.ABSTRACTAs a member of Ubiquitin-specific protease subfamily, ubiquitin specific protease 7 (USP7) has been reported to participate in a variety of cellular processes, including cell cycle, apoptosis, DNA damage response, and epigenetic modification. However, its function in preimplantation embryos is still obscure. To investigate the functions of USP7 during preimplantation embryo development, we used siRNA to degrade endogenous USP7 messenger RNA. We found that USP7 knockdown significantly decreased the development rate of mouse ear...
Source: Experimental Cell Research - April 18, 2023 Category: Cytology Authors: Xue Zhang Xue-Feng Xie Ang Li Wei Song Chao Li Fei Li Xiao-Zhen Li Xiao-Yan Fan Chang-Yin Zhou Guang Wang Qing-Yuan Sun Xiang-Hong Ou Source Type: research
Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis
In conclusion, our results suggest that URI is involved in the cisplatin-induced DNA damage response via the ATM/CHK2 pathway, and silencing URI can increase cisplatin-induced DNA damage and enhance drug sensitivity in gastric cancer cells.PMID:37034221 | PMC:PMC10077030
Source: Cell Research - April 10, 2023 Category: Cytology Authors: Huiqin Bian Yu Gu Chen Chen Jinnan Chen Fei Zhang Zhonghai Xu Qian Wang Rui Mi Xuan Wu Yaojuan Lu Qiping Zheng Junxia Gu Source Type: research
IRAK-M has effects in regulation of lung epithelial inflammation
CONCLUSION: Our findings suggested that IRAK-M has effect on lung epithelial inflammation with an influence on epithelial secretion of CXCL10 partly mediated through JNK and p38 MAPK pathways. IRAK-M modulation might indicate a new insight into asthma pathogenesis from disease origin.PMID:37029363 | DOI:10.1186/s12931-023-02406-5
Source: Cell Research - April 7, 2023 Category: Cytology Authors: Jia Li Zhoude Zheng Yi Liu Hongbing Zhang Youming Zhang Jinming Gao Source Type: research
Stratifin promotes the growth and proliferation of hepatocellular carcinoma
CONCLUSIONS: Our results suggest that SFN may play an important role in HCC progression and may interact with CDC25B to promote malignant progression of HCC, providing a molecular target for future HCC therapy.PMID:36996719 | DOI:10.1016/j.tice.2023.102080
Source: Tissue and Cell - March 30, 2023 Category: Cytology Authors: Xinyu Zhao Enqin Wang Hongkun Xu Lihong Zhang Source Type: research
SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells
CONCLUSION: SOX10 has a role in the intrinsic immune suppressive mechanisms of melanoma through expression of PD-L1.PMID:36974807 | DOI:10.21873/anticanres.16296
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Kenta Sasaki Yoshihiko Hirohashi Kenji Murata Tomoyuki Minowa Munehide Nakatsugawa Aiko Murai Yuka Mizue Terufumi Kubo Takayuki Kanaseki Tomohide Tsukahara Sadahiro Iwabuchi Shinichi Hashimoto Hisashi Uhara Akemi Ishida-Yamamoto Toshihiko Torigoe Source Type: research
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6
J Lipid Res. 2023 Mar 21:100362. doi: 10.1016/j.jlr.2023.100362. Online ahead of print.ABSTRACTCholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and post-translational level. Whilst some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzymes via the ubiquitin-proteasome system. Of note, we previously identified four cholesterol synthesis enzymes as substrates for one E3 ubiquitin ligase, membrane-associated RING-CH-type finger 6 (MARCHF6). Whether MARCHF6 targets the cholesterol synthesis pathway at other points is unk...
Source: Cell Research - March 23, 2023 Category: Cytology Authors: Lydia Qian Nicola A Scott Isabelle M Capell-Hattam Eliza A Draper Nicole M Fenton Winnie Luu Laura J Sharpe Andrew J Brown Source Type: research
20-Hydroxyecdysone inhibits inflammation via SIRT6-mediated NF- κB signaling in endothelial cells
In conclusion, the present study demonstrates that 20E exerts its effect through SIRT6-mediated deacetylation of NF-κB p65 (K310) to inhibit CD40 expression in ECs, and 20E may have therapeutic potential for the treatment of cardiovascular diseases.PMID:36958525 | DOI:10.1016/j.bbamcr.2023.119460
Source: Cell Research - March 23, 2023 Category: Cytology Authors: Zhen Jin Bo Wang Lingxuan Ren Jianjun Yang Zihan Zheng Feng Yao Rongcheng Ding Jianjiang Wang Jianyu He Weirong Wang Guanjun Nan Rong Lin Source Type: research
ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis
CONCLUSIONS: Our results show that anchorage-independent survival and growth of cancer cells are supported by changes in genes and proteins that drive glucose metabolism towards an enhanced lactate production. Notably, this finding is valid for all lung and breast cancer cell lines we have analyzed in different nutrient environmental conditions. broader Validation of this mechanism in other cancer cells of different origin will be necessary to broaden the role of ALDOC and ENO2 to other tumor types. Future in vivo studies will be necessary to assess the role of ALDOC and ENO2 in cancer metastasis.PMID:36945054 | DOI:10.1186/s13046-023-02641-0
Source: Cell Research - March 22, 2023 Category: Cytology Authors: Claudia De Vitis Anna Martina Battaglia Matteo Pallocca Gianluca Santamaria Maria Chiara Mimmi Alessandro Sacco Francesca De Nicola Marco Gaspari Valentina Salvati Francesca Ascenzi Sara Bruschini Antonella Esposito Giulia Ricci Eleonora Sperandio Alice M Source Type: research
MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression
This study aimed to determine the function of miR146a in the chondrogenic differentiation of MSCs and the potential mechanisms involved. MiR146a expression increased during chondrogenesis. MiR146a knockout (KO) led to the increased chondrogenesis of MSCs compared to that in wild-type (WT) MSCs, whereas the overexpression of miR146a by mimics resulted in the decreased chondrogenesis of MSCs, as determined by the mRNA expression of collagen, type II, alpha 1 (COL2A1), aggrecan, cartilage oligomeric matrix protein (COMP), and matrix metallopeptidase 13 (MMP13). Furthermore, cartilage defects could be treated better when injec...
Source: Am J Physiol Cell Ph... - March 20, 2023 Category: Cytology Authors: Yuhang Liu Xudong Zhang Xiaodong Chen Bingjun Zhang Liming Dai Chenglong Wang Yang Li Xiaoling Zhang Source Type: research
