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Specialty: Cytology
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Total 2613 results found since Jan 2013.
MiR-767-3p promotes the progression of hepatocellular carcinoma via targeting CASP-3/-9
CONCLUSION: MiR-767-3p promoted proliferation and prevented apoptosis in human hepatocellular carcinoma (HCC) through inhibiting the caspase-3/caspase-9 pathway.PMID:37193190 | PMC:PMC10182511
Source: Cell Research - May 16, 2023 Category: Cytology Authors: Maolin Wu Jing Deng Dejiao Yao Shijie Li Source Type: research
HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition
This study explored the role of methyltransferase components in HPV-related cervical cancer and the mechanism. The levels of methyltransferase components and autophagy, ubiquitylation of RBM15 protein and the co-localization of lysosomal markers LAMP2A and RBM15 were measured. CCK-8 assay, flow cytometry, clone formation experiment and immunofluorescence assay were conducted to measure cell proliferation. The mouse tumor model was developed to study the cell growth in vivo. The binding of RBM15 to c-myc mRNA and m6A modifcation of c-myc mRNA were analyzed. The expressions of METTL3, RBM15 and WTAP were higher in HPV-positi...
Source: Cell Biology International - May 16, 2023 Category: Cytology Authors: Gang Nie Bo Tang Mingfen Lv Danyang Li Tian Li Rongying Ou Yunsheng Xu Juan Wen Source Type: research
MicroRNA-31 regulates TNF- α and IL-17A co-induced-endothelial cell apoptosis by repressing E2F6
In conclusion, TNF-α and IL-17A generated in the aortic vascular tissue and serum from Ang II-induced hypertensive mice could trigger VECs apoptosis by the miR-31/E2F6 axis. To sum up, our study suggests that the key factor between cytokine co-stimulation effect and VEC apoptosis was miR-31/E2F6 axis, which was mainly regulated by NF-қB signaling pathway. This gives us a new sight to treat hypertension-associated VR.PMID:37178508 | DOI:10.1016/j.bbrc.2023.05.012
Source: Cell Research - May 13, 2023 Category: Cytology Authors: Zilong Fang Xinran Tong Guangzheng Shi Wendong Chen Qun Li Source Type: research
Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
CONCLUSIONS: Our study identifies important gene regulatory functions for YAP/TAZ-TEAD-TP63 in the early stages of lung cancer development, which notably includes immune-suppressive roles, and suggest that an assessment of the activity of this transcriptional complex may offer a means to identify immune evasive bronchial PMLs and serve as a potential therapeutic target.PMID:37150829 | DOI:10.1186/s13046-023-02674-5
Source: Cell Research - May 7, 2023 Category: Cytology Authors: Boting Ning Andrew M Tilston-Lunel Justice Simonetti Julia Hicks-Berthet Adeline Matschulat Roxana Pfefferkorn Avrum Spira Matthew Edwards Sarah Mazzilli Marc E Lenburg Jennifer E Beane Xaralabos Varelas Source Type: research
Multidrug resistance protein 1 silencing in osteosarcoma and chondrosarcoma cell lines
CONCLUSION: Lipofectamine 2000 was the least toxic transfection reagent in osteo- and chondrosarcoma. Successful siRNA-induced MDR1 mRNA silencing of over 80% was achieved.PMID:37148005 | DOI:10.4103/jcrt.JCRT_565_19
Source: Cell Research - May 6, 2023 Category: Cytology Authors: Sarah S Freund Michael M Bendtsen Akmal Safwat Peter H Joergensen Source Type: research
miR-92a-1-5p enriched prostate cancer extracellular vesicles regulate osteoclast function via MAPK1 and FoxO1
CONCLUSION: These experiments suggest that miR-92a-1-5p enriched EVs regulate osteoclast function via reduction of MAPK1 and FoxO1.PMID:37131239 | DOI:10.1186/s13046-023-02685-2
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Lijuan Yu Bingdong Sui Xin Zhang Jiayun Liu Xiaoke Hao Lei Zheng Source Type: research
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1
Phytother Res. 2023 May 1. doi: 10.1002/ptr.7831. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and development of DCM. Additionally, the upregulation/activation of silent information regulation 2 homolog-1 (SIRT1) has been shown to protect against DCM. Tanshinone II A (Tan IIA), the main active component of Salviae miltiorrhizae radix et rhizome (a valuable Chinese medicine), has protective effe...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Shun Wu Dingchun Lu Babu Gajendran Qilan Hu Jian Zhang Shengquan Wang Minzhen Han Yini Xu Xiangchun Shen Source Type: research
The Exocyst Complex is Required for the Trafficking and Delivery of KCa3.1 to the Basolateral Membrane of Polarized Epithelia
Am J Physiol Cell Physiol. 2023 May 1. doi: 10.1152/ajpcell.00374.2022. Online ahead of print.ABSTRACTControl of the movement of ions and water across epithelia is essential for homeostasis. Changing the number or activity of ion channels at the plasma membrane is a significant regulator of epithelial transport. In polarized epithelia, the intermediate-conductance calcium-activated potassium channel, KCa3.1 is delivered to the basolateral membrane where it generates and maintains the electrochemical gradients required for epithelial transport. The mechanisms that control the delivery of KCa3.1 to the basolateral membrane a...
Source: American Journal of Physiology. Cell Physiology - May 1, 2023 Category: Cytology Authors: Matthew J E Logue Rachel E Farquhar Yoakim Eckhoff-Bj örngard Tanya T Cheung Daniel C Devor Fiona J McDonald Kirk L Hamilton Source Type: research
