Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression

CONCLUSIONS: Our study identifies important gene regulatory functions for YAP/TAZ-TEAD-TP63 in the early stages of lung cancer development, which notably includes immune-suppressive roles, and suggest that an assessment of the activity of this transcriptional complex may offer a means to identify immune evasive bronchial PMLs and serve as a potential therapeutic target.PMID:37150829 | DOI:10.1186/s13046-023-02674-5

Source: Cell Research - May 7, 2023 Category: Cytology Authors: Boting Ning Andrew M Tilston-Lunel Justice Simonetti Julia Hicks-Berthet Adeline Matschulat Roxana Pfefferkorn Avrum Spira Matthew Edwards Sarah Mazzilli Marc E Lenburg Jennifer E Beane Xaralabos Varelas Source Type: research