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Specialty: Cytology
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Total 2613 results found since Jan 2013.
NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway.PMID:37392963 | DOI:10.1016/j.yexcr.2023.113693
Source: Cell Research - July 1, 2023 Category: Cytology Authors: Ze Wu Qiongqiong Jia Boqun Liu Lanlan Fang Peter C K Leung Jung-Chien Cheng Source Type: research
Contribution of TRPC channels in human and experimental pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00011.2023. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA) obstruction leading to right ventricular hypertrophy and failure. Exacerbated store-operated Ca2+ entry (SOCE) contributes to PAH pathogenesis, mediating human PA smooth muscle cells (hPASMCs) abnormalities. The transient receptor potential canonical channels (TRPC family) are Ca2+-permeable channels contributing to SOCE in different cell types, including PASMCs. However, the properties, signaling pathways, and contribution t...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Bastien Masson Ana ïs Saint-Martin Willer Mary Dutheil Lucille Penalva H élène Le Ribeuz Kristelle El Jekmek Yann Ruchon Sylvia Cohen-Kaminsky Jessica Sabourin Marc Humbert Olaf Mercier David Montani V éronique Capuano Fabrice Antigny Source Type: research
HSP90-Dependent Upregulation of EZH2 Promotes Hypoxia/Reoxygenation-Induced Pyroptosis by Inhibiting miR-22 in Endothelial Cells
CONCLUSION: H/R induces pyroptosis via the HSP90/EZH2/miR-22/NLRP3 signaling axis in endothelial cells.PMID:37360624 | PMC:PMC10289174 | DOI:10.2147/JIR.S403531
Source: Cell Research - June 26, 2023 Category: Cytology Authors: Paihe Deng Huimin Hu Source Type: research
FOXK2 regulates PFKFB3 in promoting glycolysis and tumorigenesis in multiple myeloma
Leuk Res. 2023 Jun 17;132:107343. doi: 10.1016/j.leukres.2023.107343. Online ahead of print.ABSTRACTForkhead box K2 (FOXK2) is a transcription factor involved in regulating the pathophysiological processes in many types of cancers. Functioning as either an oncogene or tumor suppressor, FOXK2 is involved in cell proliferation, metastasis, DNA damage, metabolism, and autophagy. However, the functions of FOXK2 in multiple myeloma (MM) are still unexplored. Here we show that FOXK2 silencing by small interfering RNA (siRNA) prevented the expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) via dephosphor...
Source: Cell Research - June 25, 2023 Category: Cytology Authors: Xinling Liu Na Tang Yong Liu Jieting Fu Yao Zhao Haihua Wang Haiying Wang Zhenbo Hu Source Type: research
RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling
CONCLUSION: RHAMM expression-loss blunts STING-IFN signaling, which offers growth advantages under specific microenvironmental conditions of lung tissue. These results provide mechanistic insight into factors controlling clonal survival/expansion of metastatic colonies and has translational potential for RHAMM expression as a marker of sensitivity to interferon therapy.PMID:37349798 | DOI:10.1186/s13058-023-01652-1
Source: Cell Research - June 22, 2023 Category: Cytology Authors: Cornelia Tolg Maja Milojevic Freda W Qi Hailie A Pavanel M Elizabeth O Locke Jenny Ma Mathew Price Andrew C Nelson James B McCarthy Kathleen A Hill Eva A Turley Source Type: research
SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF- β1
Cell Signal. 2023 Jun 19;109:110778. doi: 10.1016/j.cellsig.2023.110778. Online ahead of print.ABSTRACTCardiac fibroblasts (CFs) activation is a common response to most pathological conditions affecting the heart, characterized by increased cellular secretory capacity and increased expression of fibrotic markers, such as collagen I and smooth muscle actin type alpha (α-SMA). Fibrotic activation of CFs induces the increase in tissue protein content, with the consequent tissue stiffness, diastolic dysfunction, and heart failure. Therefore, the search for new mechanisms of CFs activation is important to find novel treatments...
Source: Cellular Signalling - June 21, 2023 Category: Cytology Authors: Fabiola Gonz ález-Herrera Mabel Catal án Renatto Anfossi Juan Diego Maya Zully Pedrozo Guillermo D íaz-Araya Ra úl Vivar Source Type: research
Activation of the mTOR pathway promotes neurite growth through upregulation of CD44 expression
CONCLUSION: Activation of the mTOR pathway promoted neurite growth through upregulation of CD44 expression, thus promoting neuronal regeneration.PMID:37340717 | DOI:10.1177/03000605231178510
Source: Cell Research - June 21, 2023 Category: Cytology Authors: Jiwei Zhang Wenjuan Gan Ru Peng Lei Lu Weiqing Lu Jiamei Liu Source Type: research
The regulatory role and mechanism of lncTUG1 on cartilage apoptosis and inflammation in osteoarthritis
CONCLUSIONS: In conclusion, our study clarifies the role of the ceRNA regulatory network of TUG1/miR-144-3p/DUSP1/P38 MAPK in OA cartilage injury and provides an experimental and theoretical basis for genetic engineering tools to promote articular cartilage repair.PMID:37340458 | DOI:10.1186/s13075-023-03087-7
Source: Cell Research - June 20, 2023 Category: Cytology Authors: Nan-Nan Liu Yan-Ping Huang Yu-Bao Shao Xue-Fei Fan He-Yan Sun Tao-Rong Wang Tao Yao Xiao-Yu Chen Source Type: research
