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Specialty: Cytology
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Total 2613 results found since Jan 2013.
ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research
Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway
CONCLUSION: Our findings revealed that ZWZ-3 could downregulate BIRC5 and inhibit melanoma proliferation and metastasis through the β-catenin/HIF-1α/VEGF/MMPs pathway. Therefore, BIRC5 represents a promising therapeutic target for the treatment of melanoma.PMID:37728702 | DOI:10.1007/s00432-023-05425-3
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qingqing He Yijing He Changqiang Li Jianv Wang Tong Xia Xia Xiong Jixiang Xu Li Liu Source Type: research
Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus
CONCLUSION: Our findings reveal a mechanism which underlies the contribution of the fSNP rs8085824 on the SMD7 locus to CRC susceptibility.PMID:37721570 | DOI:10.1007/s00432-023-05402-w
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Zhao Liu Yihan Zhao Hongli Song Huaxue Miao Yingying Wang Chuntian Tu Tianyun Fu Juliang Qin Bing Du Min Qian Hua Ren Source Type: research
Autocrine motility factor receptor promotes the malignancy of glioblastoma by regulating cell migration and invasion
CONCLUSION: This study suggests that AMFR could be used as a therapeutic strategy for the clinical treatment of glioblastoma.PMID:37703903 | DOI:10.1080/01616412.2023.2257463
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Yao Zhang Xiuping Wang Guanghui Chen Yajing Lu Qiang Chen Source Type: research
Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia
Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04022-7. Online ahead of print.ABSTRACTActivation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic pathology in AD brain, is known to be produced by neurons and to activate glial cells. Clearance of Aβ from the brain via active transport system is important to prevent the accumulation and aggregation. Low density lipoprotein receptor-related protein 2 (LRP2/megalin) is an Aβ transporter. However, expression ...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Katsura Takano-Kawabe Kazuyuki Matoba Yoichi Nakamura Mitsuaki Moriyama Source Type: research
ATRX loss suppresses the type I interferon response in sarcoma cells through chromatin remodeling
Am J Cancer Res. 2023 Aug 15;13(8):3547-3558. eCollection 2023.ABSTRACTSarcomas constitute a heterogeneous group of mesenchymal cancers and are particularly common in children and adolescents, leading to significant lethality. Therefore, it is necessary to understand the underlying mechanisms by which genetic alterations promote sarcoma progression. Here, we demonstrate that loss-of-function of ATRX, a member of the SWI/SNF DNA-remodeling family, represses the interferon (IFN)-β response by inducing chromatin remodeling in sarcoma cells. We show that ATRX mutations are associated with worse prognosis and attenuate IFN-α/...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Xinrui Wang Zige Jin Shanshan Tang Xiyu Huang Shanshan Wang Xiaohe Ren Mafei Xu Source Type: research
FOXO1 regulates NLRP3 inflammasome proteins in LPS-induced cardiotoxicity
CONCLUSION: FOXO1 overexpression attenuated apoptosis, ROS generation, and inflammation, whereas FOXO1 inhibition aggravated LPS-induced cardiomyocyte injury via the NLRP3 inflammasome signaling pathway.PMID:37692952 | PMC:PMC10492091
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Hui Zhao Lingcun Qin Ruyi Wang Dejie Qu Suting Li Source Type: research
RACK1 mediates NLRP3 inflammasome activation during Pasteurella multocida infection
This study shows that RACK1 expression was downregulated by PmCQ2 infection in primary mouse peritoneal macrophages and mouse tissues, and overexpression of RACK1 prevented PmCQ2-induced cell death and reduced the numbers of adherent and invasive PmCQ2, indicating a modulatory role of RACK1 in the cell death that is induced by P. multocida infection. Next, RACK1 knockdown by siRNA significantly attenuated PmCQ2-induced NLRP3 inflammasome activation, which was accompanied by a reduction in the protein expression of interleukin (IL)-1β, pro-IL-1β, caspase-1 and NLRP3 as well as the formation of ASC specks, while RACK1 over...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Jinrong Ran Hang Yin Yating Xu Yu Wang Gang Li Xingping Wu Lianci Peng Yuanyi Peng Rendong Fang Source Type: research
Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research
Silencing of novel TtVtg6-like induced ovarian cell apoptosis in ancient chelicerate Tachypleus tridentatus
In this study, we have successfully elucidated the complete transcript sequence of TtVtg6-like from an ancient chelicerate Tachypleus tridentatus. The TtVtg6-like transcript encompassed a length of 4887 bp and encoded 1629 amino acids residues. Notably, TtVtg6-like was found to contain 25 exons. Furthermore, the molecular weight and isoelectric point of TtVtg6-like were determined to be 191.6 KDa and 6.73, respectively. Subsequent mRNA expression analysis demonstrated the specific expression of TtVtg6-like in ovary and yellow connective tissue. In addition, TtVtg6-like was located and distributed in both ovary and yellow c...
Source: Cell Research - September 6, 2023 Category: Cytology Authors: Kianann Tan Khor Waiho Karsoon Tan Ying Qiao Leong-Seng Lim Xin Yang Yulong Wen Peng Xu Ya Peng Xiaowan Ma Kit Yue Kwan Source Type: research
MARCH8 downregulation modulates profibrotic responses including myofibroblast differentiation
In this study, we demonstrated decreased MARCH8 expression in IPF patients compared to non-PF controls and in bleomycin induced PF. TGF-β dose and time dependently decreased MARCH8 expression in normal and IPF human lung fibroblast (HLFs), along with induction of FMT markers α-SMA, collagen type I (Col-1), and fibronectin (FN). Interestingly, overexpression of MARCH8 significantly suppressed TGF-β-induced expression of α-SMA, Col-1, and FN. By contrast, knockdown of MARCH8 using siRNA upregulated basal expression of α-SMA/Col-1/FN. Moreover, MARCH8 knockdown enhanced TGF-β-induced FMT marker expression. These data cl...
Source: Am J Physiol Cell Ph... - September 4, 2023 Category: Cytology Authors: Xia Guo Oluwaseun Adeyanju Ayobami Matthew Olajuyin Venkatakirankumar Mandlem Christudas Sunil Joy Adewumi Steven Huang Torry A Tucker Steven Idell Guoqing Qian Source Type: research
