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Specialty: Cytology
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Total 2613 results found since Jan 2013.
Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner
Eur J Cell Biol. 2023 Jul 6;102(3):151339. doi: 10.1016/j.ejcb.2023.151339. Online ahead of print.ABSTRACTDespite their significance in receptor-mediated internalization and continued signal transduction in cells, early/sorting endosomes (EE/SE) remain incompletely characterized, with many outstanding questions that surround the dynamics of their size and number. While several studies have reported increases in EE/SE size and number resulting from endocytic events, few studies have addressed such dynamics in a methodological and quantitative manner. Herein we apply quantitative fluorescence microscopy to measure the size a...
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Naava Naslavsky Steve Caplan Source Type: research
The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
Autophagy. 2023 Jul 7:1-19. doi: 10.1080/15548627.2023.2229656. Online ahead of print.ABSTRACTApoptosis is a tightly controlled cell death program executed by proteases, the so-called caspases. It plays an important role in tissue homeostasis and is often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes microtubule plus end-directed transport of autophagic and endosomal vesicles as a molecular interaction partner of activated CASP8 (caspase 8). The absence of FYCO1 sensitized cells to basal and TNFSF10/TRAIL-induced apoptosis by receptor accumulation and stabilization of the Death Inducing Signali...
Source: Autophagy - July 7, 2023 Category: Cytology Authors: Valeria Coppola Ilaria Marino Uwe Warnken Mario Falchi Luca Pasquini Mauro Biffoni Ruggero De Maria Tobias Longin Haas Source Type: research
Butyrate Improves Porcine Endometrial Epithelial Cell Receptivity via Enhancing Acetylation of Histone H3K9
CONCLUSION: The findings reveal that butyrate improves endometrial epithelial cell receptivity by enhancing the acetylation of histone H3K9, which shows nutritional regulation and therapeutic potential for poor uterine receptivity and difficulty in embryo implantation.PMID:37417211 | DOI:10.1002/mnfr.202200703
Source: Cell Research - July 7, 2023 Category: Cytology Authors: Qianhong Ye Haoyu Li Baoyang Xu Ziyi He Xianghua Yan Source Type: research
LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral
CONCLUSIONS: LAMC2 interacts with autophagy to regulate OSCC metastasis, invasion, and proliferation via the PI3K/AKT/mTOR pathway. LAMC2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration, invasion, and proliferation.PMID:37415741 | PMC:PMC10319602 | DOI:10.32604/or.2023.029064
Source: Cell Research - July 7, 2023 Category: Cytology Authors: Fayu Shan Lanlan Liang Chong Feng Hongbao Xu Zirou Wang Weili Liu Lingling Pu Zhaoli Chen Gang Chen Xinxing Wang Source Type: research
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts
In this study, we visualized and assessed the level of mitophagy in H9c2 cardiomyoblasts at basal conditions and after OXPHOS induction by galactose adaptation. We used cells with a stable expression of a pH-sensitive fluorescent mitochondrial reporter and applied state-of-the-art imaging techniques and image analysis. Our data showed a significant increase in acidic mitochondria after galactose adaptation. Using a machine-learning approach we also demonstrated increased mitochondrial fragmentation by OXPHOS induction. Furthermore, super-resolution microscopy of live cells enabled capturing of mitochondrial fragments withi...
Source: Autophagy - July 5, 2023 Category: Cytology Authors: Gustav Godtliebsen Kenneth Bowitz Larsen Zambarlal Bhujabal Ida S Opstad Mireia Nager Abhinanda R Punnakkal Trine B Kalstad Randi Olsen Trine Lund Dilip K Prasad Krishna Agarwal Truls Myrmel Asa Birna Birgisdottir Source Type: research
Puerarin Attenuates High-Glucose and High-Lipid-Induced Inflammatory Injury in H9c2 Cardiomyocytes via CAV3 Protein Upregulation
CONCLUSION: Puerarin upregulated CAV3 protein expression in H9c2 cardiomyocytes and inhibited the NF-κB and p38MAPK pathways, thereby reducing HGHL-induced inflammation and may related to the apoptosis and hypertrophy of cardiomyocytes.PMID:37404717 | PMC:PMC10317540 | DOI:10.2147/JIR.S408681
Source: Cell Research - July 5, 2023 Category: Cytology Authors: YiFu Tian CaiXia Zhou XiaoYang Bu Qian Lv Qin Huang Source Type: research
Characterization of RACK1-depleted mammalian cells by a palette of microscopy approaches reveals defects in cell cycle progression and polarity establishment
Exp Cell Res. 2023 Jun 30:113695. doi: 10.1016/j.yexcr.2023.113695. Online ahead of print.ABSTRACTThe Receptor for Activated C Kinase 1 (RACK1) is an evolutionarily conserved scaffold protein involved in the regulation of numerous cellular processes. Here, we used CRISPR/Cas9 and siRNA to reduce the expression of RACK1 in Madin-Darby Canine Kidney (MDCK) epithelial cells and Rat2 fibroblasts, respectively. RACK1-depleted cells were examined using coherence-controlled holographic microscopy, immunofluorescence, and electron microscopy. RACK1 depletion resulted in decreased cell proliferation, increased cell area and perimet...
Source: Cell Research - July 2, 2023 Category: Cytology Authors: Vera Chvalova Vignesh Venkadasubramanian Zuzana Klimova Jana Vojtova Oldrich Benada Ondrej Vanatko Tomas Vomastek Tomas Grousl Source Type: research
NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway.PMID:37392963 | DOI:10.1016/j.yexcr.2023.113693
Source: Experimental Cell Research - July 1, 2023 Category: Cytology Authors: Ze Wu Qiongqiong Jia Boqun Liu Lanlan Fang Peter C K Leung Jung-Chien Cheng Source Type: research
