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Specialty: Cytology
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Total 2613 results found since Jan 2013.
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway
Exp Cell Res. 2023 Mar 7;425(2):113542. doi: 10.1016/j.yexcr.2023.113542. Online ahead of print.ABSTRACTEndothelial cell senescence is involved in endothelial dysfunction and aging-related vascular diseases. The D1-like dopamine receptor (DR1), a number of G-protein-coupled receptors, is currently under consideration as a potential therapeutic target for the prevention of atherosclerosis. However, the role of DR1 in regulating ox-LDL-stimulated endothelial cell senescence remains unknown. Here, we found that the elevated Prx hyperoxidation and reactive oxygen species (ROS) levels in ox-LDL-treated Human umbilical vein endo...
Source: Experimental Cell Research - March 9, 2023 Category: Cytology Authors: Yiming Zhao Yuxia Li Hongxia Li Sa Shi Source Type: research
NLRP3 Disturbs Treg/Th17 Cell Balance to Aggravate Apical Periodontitis
J Dent Res. 2023 Mar 8:220345231151692. doi: 10.1177/00220345231151692. Online ahead of print.ABSTRACTApical periodontitis is an inflammatory condition that is considered an immunological reaction of the periapical tissue to invading bacteria and their pathogenic components. Recent research has revealed that NLR family pyrin domain containing 3 (NLRP3) is crucial to the pathogenesis of apical periodontitis and serves as a link between innate and adaptive immunity. The balance between regulatory T-cell (Treg) and T helper cell 17 (Th17 cell) determines the direction of the inflammatory response. Therefore, this study aimed ...
Source: Cell Research - March 8, 2023 Category: Cytology Authors: S Leng W Xu L Wu L Liu J Du F Yang D Huang L Zhang Source Type: research
Inflammatory Cytokine Interleukin-6 (IL-6) Promotes the Proangiogenic Ability of Adipose Stem Cells from Obese Subjects < em > via < /em > the IL-6 Signaling Pathway
CONCLUSION: The finding suggests that inflammatory cytokine interleukin-6 (IL-6) promotes the proangiogenic ability of obADSCs via the IL-6 signaling pathway.PMID:36883256 | DOI:10.2174/1574888X17666220429103935
Source: Cell Research - March 8, 2023 Category: Cytology Authors: Yuanyuan Zhang Pengju Lv Yalong Li Yonghui Zhang Chaofei Cheng Hongbo Hao Han Yue Source Type: research
Regulation of Hippo/YAP signaling pathway ameliorates cochlear hair cell injury by regulating ferroptosis
In conclusion, YAP1 ameliorated cochlear hair cell injury by upregulating FTL and TFRC to suppress ferroptosis.PMID:36889225 | DOI:10.1016/j.tice.2023.102051
Source: Tissue and Cell - March 8, 2023 Category: Cytology Authors: Xiaorong Niu Peng Han Junsong Liu Zichen Chen Xiaoyan Ma Ting Zhang Baiya Li Xudong Ma Source Type: research
Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin
We examined the role of DMT1 inhibition or salinomycin in promoting ferroptosis by lysosomal iron targeting in HNC cells. RNA interference was performed by transfection of siRNA targeting DMT1 or scrambled control siRNA in HNC cell lines. Cell death and viability, lipid peroxidation, iron contents, and molecular expression were compared between the DMT1 silencing or salinomycin group and the control. DMT1 silencing markedly accelerated cell death induced by the ferroptosis inducers. DMT1 silencing marked increases in the labile iron pool, intracellular ferrous and total iron contents, and lipid peroxidation. DMT1 silencing...
Source: Human Cell - March 8, 2023 Category: Cytology Source Type: research
N protein of PEDV plays chess game with host proteins by selective autophagy
In this study, we have found a novel host restriction factor, HNRNPA1, that could inhibit PEDV replication by degrading viral nucleocapsid (N) protein. The restriction factor activates the HNRNPA1-MARCHF8/MARCH8-CALCOCO2/NDP52-autophagosome pathway with the help of transcription factor EGR1 targeting the HNRNPA1 promoter. HNRNPA1 could also promote the expression of IFN to facilitate the host antiviral defense response for antagonizing PEDV infection through RIGI protein interaction. During viral replication, we found that PEDV can, in contrast, degrade the host antiviral proteins HNRNPA1 and others (FUBP3, HNRNPK, PTBP1, ...
Source: Autophagy - March 2, 2023 Category: Cytology Authors: Xueying Zhai Ning Kong Yu Zhang Yiyi Song Wenzhen Qin Xinyu Yang Chenqian Ye Manqing Ye Wu Tong Changlong Liu Hao Zheng Hai Yu Wen Zhang Xia Yang Gaiping Zhang Guangzhi Tong Tongling Shan Source Type: research
Suppression of small nucleolar RNA host gene 8 (SNHG8) inhibits the progression of colorectal cancer cells
In this study, we explored the role of SNHG8 in CRC cell lines by performing a series of functional experiments. Similar to the data reported in the Encyclopedia of RNA Interactome, our RT-qPCR results showed that SNHG8 expression was significantly upregulated in CRC cell lines (DLD-1, HT-29, HCT-116, and SW480) compared to the normal colon cell line (CCD-112CoN). We performed dicer-substrate siRNA transfection to knockdown the expression of SNHG8 in HCT-116 and SW480 cell lines which were expressing high levels of SNHG8. SNHG8 knockdown significantly reduced CRC cell growth and proliferation by inducing autophagy and apop...
Source: Cell Research - March 2, 2023 Category: Cytology Authors: Md Zahirul Islam Khan Helen Ka Wai Law Source Type: research
Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension
Pulm Pharmacol Ther. 2023 Feb 24:102200. doi: 10.1016/j.pupt.2023.102200. Online ahead of print.ABSTRACTEndothelial dysfunction is critical in the pulmonary vasculature during pulmonary hypertension (PH). Moreover, in PH, increased inflammation and oxidative/nitrosative stress cause DNA damage, activating poly (ADP-ribose) polymerase-1 (PARP-1). Meloche et al. (2014) and our previous research have shown that inhibiting PARP-1 is protective in PH and associated RV hypertrophy. However, the role of PARP-1 in pulmonary arterial endothelial dysfunction has not been explored completely. Therefore, the current study aims to inve...
Source: Cell Research - February 26, 2023 Category: Cytology Authors: Mohammad Shafiq Zahid Rasool Lone Adam Olaitan Abdulkareem Gurpreet Kaur Sai Navya Himalaya Singh Kumaravelu Jagavelu Kashif Hanif Source Type: research
Mfsd2a attenuated hypoxic-ischemic brain damage via protection of the blood-brain barrier in mfat-1 transgenic mice
This study aims to investigate the mechanisms of the protective effect against hypoxic-ischemic brain damage (HIBD) of mfat-1 transgenic mice. mfat-1 mice not only demonstrated a significant amelioration of neurological dysfunction and neuronal damage but also partly maintained the physiological permeability of the BBB after HIBD. We initially showed this was associated with elevated major facilitator superfamily domain-containing 2a (Mfsd2a) expression on the BBB, resulting from more lysophosphatidylcholine (LPC)-DHA entering the brain. Wild-type (WT) mice showed a similar Mfsd2a expression trend after long-term feeding w...
Source: Cellular and Molecular Life Sciences : CMLS - February 23, 2023 Category: Cytology Authors: Xiaoxue Li Yumeng Zhang Jianghao Chang Chenglin Zhang Lin Li Yifan Dai Haiyuan Yang Ying Wang Source Type: research
The Comprehensive Role of High Mobility Group Box 1 (HMGB1) Protein in Different Tumors: A Pan-Cancer Analysis
CONCLUSIONS: HMGB1 was differentially expressed in most tumors and normal tissues, and was closely related to the clinical stage, prognosis, immune infiltration, tumor microenvironment, and drug resistance of tumors. Therefore, HMGB1 may serve as a novel biomarker for predicting tumor prognosis, efficacy of immune checkpoint inhibitors, and a potential target for anti-tumor therapy.PMID:36820147 | PMC:PMC9938709 | DOI:10.2147/JIR.S386898
Source: Cell Research - February 23, 2023 Category: Cytology Authors: Hui Guan Ming Zhong Kongyang Ma Chun Tang Xiaohua Wang Muzi Ouyang Rencai Qin Jiasi Chen Enyi Zhu Ting Zhu Yongping Lu Yu Liu Chengzi Tian Zhihua Zheng Source Type: research
