Filtered By:
Specialty: Cytology
This page shows you your search results in order of date. This is page number 3.
Order by Relevance | Date
Total 2613 results found since Jan 2013.
Long non-coding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-Myocardin axis
Am J Physiol Cell Physiol. 2023 Aug 29. doi: 10.1152/ajpcell.00275.2023. Online ahead of print.ABSTRACTAbdominal Aortic Aneurysms (AAAs) are asymptomatic vascular diseases that have life-threatening outcomes. Smooth-muscle cell (SMC) dysfunction plays an important role in AAA development. The contribution of non-coding genome, specifically the role of long non-coding RNAs (lncRNAs) in SMC dysfunction is relatively unexplored. we investigated the role of lncRNA TUG1 in SMC dysfunction. To identify potential lncRNAs relevant to SMC functionality, lncRNA profiling was performed in angiotensin-II treated SMCs. AAA was induced ...
Source: Am J Physiol Cell Ph... - August 29, 2023 Category: Cytology Authors: Ravi Abishek Bharadhwaj Regalla Kumarswamy Source Type: research
Lnc-Malat1 promotes slow myofiber-type transformation through sponging miR-129-5p in C2C12 myotubes
In this study, knockdown of lnc-Malat1 by siRNA significantly inhibited the expression of myoblast marker genes (MyHC, MyoD, and MyoG) and slow muscle fiber marker genes (MyHC I), together with repressed expression of mitochondria-related genes COX5A, ACADM, CPTA1, FABP3, and NDUFA1. Overexpression of lnc-Malat1 exerted an opposite effect, promoting myoblast differentiation and slow muscle fiber formation. Dual luciferase reporter assay revealed a direct interaction between lnc-Malat1 and miR-129-5p, and overexpression of lnc-Malat1 significantly inhibited miR-129-5p expression, thereby elevating the expression of Mef2a, m...
Source: Cell Research - August 27, 2023 Category: Cytology Authors: Yongqi Yue Yuhe Wang Chenglong Wen Yingying Meng Ying Peng Xiao Li Source Type: research
Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis
CONCLUSION: Our findings demonstrated that MSI2 could bind with Fbxo6 to induce Rnaset2 ubiquitination and the activation of chemokine signaling pathway during VSMC phenotypic switch in AS.PMID:37633478 | DOI:10.1016/j.cellsig.2023.110869
Source: Cellular Signalling - August 26, 2023 Category: Cytology Authors: Tao Zhang Shusheng Wu Rongwei Xu Shuguang Zhang Minghai Wang Jie Li Source Type: research
New and future therapies: Changes in the therapeutic armamentarium for SLE
Best Pract Res Clin Rheumatol. 2023 Aug 24:101865. doi: 10.1016/j.berh.2023.101865. Online ahead of print.ABSTRACTFollowing better understanding of molecular pathways involved in the pathogenesis of Systemic lupus erythematosus (SLE), pharmaceutical companies have been investigating new targeted drugs for SLE. The purpose of this scoping review is to provide an updated view of the most promising targeted therapies currently in clinical development or recently approved for SLE treatment as well as of the most promising potential future therapeutic strategies in SLE. In the past several years, two new drugs have been develop...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anca Askanase Leila Khalili Wei Tang Philippe Mertz Marc Scherlinger Eden Sebbag Fran çois Chasset Renaud Felten Laurent Arnaud Source Type: research
Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis
CONCLUSION: Our findings demonstrated that MSI2 could bind with Fbxo6 to induce Rnaset2 ubiquitination and the activation of chemokine signaling pathway during VSMC phenotypic switch in AS.PMID:37633478 | DOI:10.1016/j.cellsig.2023.110869
Source: Cellular Signalling - August 26, 2023 Category: Cytology Authors: Tao Zhang Shusheng Wu Rongwei Xu Shuguang Zhang Minghai Wang Jie Li Source Type: research
Chinese Giant Salamander Bcl-w:An Inhibitory Role in Iridovirus-Induced Mitochondrial Apoptosis and Virus Replication
In this study, we characterized for the first time an amphibian Bcl-w from Chinese giant salamander Andrias davidianus (AdBcl-w), and its function and regulatory mechanism during GSIV infection were investigated. AdBcl-w possesses the conserved structural features of Bcl-w and shares 35% - 54% sequence identities with other Bcl-w. mRNA expression of AdBcl-w was most abundant in liver and muscle. The AdBcl-w mRNA expression was regulated during GSIV infection. Western blotting assays revealed that the level of Bcl-w protein was downregulated markedly as the infection progresses. Confocal microscopy showed that overexpressed...
Source: Cell Research - August 19, 2023 Category: Cytology Authors: Yiqun Li Mingyang Xue Yanlin Dai Yixing Xie Ying Wei Cheng Wang Mingzhu Tian Yuding Fan Nan Jiang Chen Xu Wenzhi Liu Yan Meng Yong Zhou Source Type: research
