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Specialty: Cytology
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Total 2613 results found since Jan 2013.
Correlation of 3'-Phosphoadenosine-5'-Phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous carcinoma
CONCLUSIONS: PAPSS1 may be an ESCC suppressor gene, and its specific molecular mechanism in ESCC needs to be further studied.PMID:36734141 | DOI:10.14670/HH-18-590
Source: Histology and Histopathology - February 3, 2023 Category: Cytology Authors: Xuyou Zhu Peipei Zhu Xue Chen Long Zhang Caixia Wu Haoyang Zhang Xiaoying Shen Yao Qi Mingmin Chen Shunli Wang Xianghua Yi Source Type: research
A20 functions as a negative regulator of the lipopolysaccharide-induced inflammation in corneal epithelial cells
Exp Eye Res. 2023 Jan 27:109392. doi: 10.1016/j.exer.2023.109392. Online ahead of print.ABSTRACTA20, also called TNFAIP3, is a crucial regulator of inflammation in various diseases but has not evidenced its function in the cornea. We aimed to evaluate the existence and the functions of A20 in human corneal epithelial (HCE-T) cells. After being treated with lipopolysaccharide (LPS) in different concentrations or at separate times, cells were collected to analyze A20 expressions. We then constructed the A20 knockdown system by siRNA and the A20 overexpressing system by lentivirus transduction. Systems were further exposed to...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Yubin Yu Kunke Li Ran Xue Sihao Liu Xiuping Liu Kaili Wu Source Type: research
Cytoskeletal orchestration of glucose uptake in Sertoli cell to support efferocytosis of apoptotic germ cells
In this study, we identified a cross-regulation between glucose metabolism and efferocytosis in SCs. Pharmacological or genetic inhibition of glucose uptake or glycolysis compromises efferocytosis activity. We further found that βII-spectrin is a hitherto unappreciated regulator of glucose metabolism and cytoskeletal architecture. βII-spectrin deficiency impairs glucose uptake and lactate production in SCs. Moreover, a defective assembly of cytoskeleton and a loss of blood-testis barrier integrity are also featured by SCs deficient in βII-spectrin. The disruption in glucose metabolism and cytoskeletal organization syner...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Di Wu Nuruliarizki Shinta Pandupuspitasari Kejia Zhang Yuan Tang Faheem Ahmed Khan Haitao Li Chunjie Huang Fei Sun Source Type: research
Downregulation of Sonic hedgehog signaling induces G2-arrest in genital warts
CONCLUSIONS: The downregulation of the SHh signaling promotes HPV replication and the formation of warts by inducing G2/M arrest in the keratinocytes of CA.PMID:36704875 | DOI:10.1111/srt.13265
Source: Cell Research - January 27, 2023 Category: Cytology Authors: Xiangxi Du Shan Li Kun Yang Yuchun Cao Source Type: research
MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
CONCLUSION: Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for non-small cell lung cancer therapy.PMID:36701842 | DOI:10.4143/crt.2022.1042
Source: Cell Research - January 26, 2023 Category: Cytology Authors: Yang Yang Rongfang Qiu Qiaoyou Weng Ziwei Xu Jingjing Song Siyu Zhao Miaomiao Meng Dengke Zhang Chunli Kong Hailin Wang Min Xu Zhongwei Zhao Jiansong Ji Source Type: research
