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Specialty: Cytology
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Total 2613 results found since Jan 2013.
ETS-1/c-Met drives resistance to sorafenib in hepatocellular carcinoma
CONCLUSION: c-Met overexpression and activation is an essential mechanism of sorafenib resistance in HCC. Combination therapy of sorafenib plus c-Met inhibitor overcame the resistance of sorafenib-targeted therapy for HCC.PMID:36915773 | PMC:PMC10006745
Source: Cell Research - March 14, 2023 Category: Cytology Authors: Yongfang Ma Xueke Liu Xiaolong Tang Source Type: research
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes
J Cell Commun Signal. 2023 Mar 14. doi: 10.1007/s12079-023-00735-0. Online ahead of print.ABSTRACTSeveral reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we show that miR-98-5p, that is down-regulated in the circulation during diabetes, regulates hepatic gluconeogenesis and lipogenesis by targeting PPP1R15B. miR-98-5p overexpression significantly decreased the transcript and protein levels of PPP1R15B in hepatic HepG2 cells and increased p-eIF2α expression and these were prevented in the presence of its inhibitor. Two major hepatic h...
Source: Cell Research - March 14, 2023 Category: Cytology Authors: Rukshar Khan Amit Kumar Verma Malabika Datta Source Type: research
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration
This study validates a protective role of Krt8 during overloading-induced IDD and demonstrates that targeting overloading activation of PKNs could be a novel and effective approach to mechano stress-induced pathologies with a wider window of therapeutic opportunity.Abbreviations: AAV: adeno-associated virus; AF: anulus fibrosus; ANOVA: analysis of variance; ATG: autophagy related; BSA: bovine serum albumin; cDNA: complementary deoxyribonucleic acid; CEP: cartilaginous endplates; CHX: cycloheximide; cKO: conditional knockout; Cor: coronal plane; CT: computed tomography; Cy: coccygeal vertebra; D: aspartic acid; DEG: differe...
Source: Autophagy - March 10, 2023 Category: Cytology Authors: Di Wang Qiliang Shang Jianxin Mao Chu Gao Jie Wang Dong Wang Han Wang Haoruo Jia Pandi Peng Mu Du Zhuojing Luo Liu Yang Source Type: research
Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling
CONCLUSIONS: This research indicated that targeting LCN2 could be a promising strategy for the treatment of OSCC.PMID:36899380 | DOI:10.1186/s13046-023-02618-z
Source: Cell Research - March 10, 2023 Category: Cytology Authors: Zixian Huang Xi Rui Chen Yi Yongju Chen Rui Chen Yancan Liang Yan Wang Weicheng Yao Xiaoding Xu Zhiquan Huang Source Type: research
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration
This study validates a protective role of Krt8 during overloading-induced IDD and demonstrates that targeting overloading activation of PKNs could be a novel and effective approach to mechano stress-induced pathologies with a wider window of therapeutic opportunity.Abbreviations: AAV: adeno-associated virus; AF: anulus fibrosus; ANOVA: analysis of variance; ATG: autophagy related; BSA: bovine serum albumin; cDNA: complementary deoxyribonucleic acid; CEP: cartilaginous endplates; CHX: cycloheximide; cKO: conditional knockout; Cor: coronal plane; CT: computed tomography; Cy: coccygeal vertebra; D: aspartic acid; DEG: differe...
Source: Autophagy - March 10, 2023 Category: Cytology Authors: Di Wang Qiliang Shang Jianxin Mao Chu Gao Jie Wang Dong Wang Han Wang Haoruo Jia Pandi Peng Mu Du Zhuojing Luo Liu Yang Source Type: research
FOXA2 and STAT5A regulate oncogenic activity of KIF5B-RET fusion
Am J Cancer Res. 2023 Feb 15;13(2):638-653. eCollection 2023.ABSTRACTKIF5B-RET gene rearrangement occurs in ~1% of lung adenocarcinomas. Recently, targeted agents that inhibit RET phosphorylation have been evaluated in several clinical studies; however, little is known about the role of this gene fusion in driving lung cancer. Immunohistochemistry was used to evaluate the expression of the FOXA2 protein in tumor tissues of patients with lung adenocarcinoma. KIF5B-RET fusion cells proliferated in a cohesive form and grew tightly packed with variable-sized colonies. The expression of RET and its downstream signaling molecule...
Source: Cell Research - March 10, 2023 Category: Cytology Authors: Mi-Ran Lee Jung-Young Shin Min-Young Kim Jeong-Oh Kim Chan Kwon Jung Jinhyoung Kang Source Type: research
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration
This study validates a protective role of Krt8 during overloading-induced IDD and demonstrates that targeting overloading activation of PKNs could be a novel and effective approach to mechano stress-induced pathologies with a wider window of therapeutic opportunity.Abbreviations: AAV: adeno-associated virus; AF: anulus fibrosus; ANOVA: analysis of variance; ATG: autophagy related; BSA: bovine serum albumin; cDNA: complementary deoxyribonucleic acid; CEP: cartilaginous endplates; CHX: cycloheximide; cKO: conditional knockout; Cor: coronal plane; CT: computed tomography; Cy: coccygeal vertebra; D: aspartic acid; DEG: differe...
Source: Autophagy - March 10, 2023 Category: Cytology Authors: Di Wang Qiliang Shang Jianxin Mao Chu Gao Jie Wang Dong Wang Han Wang Haoruo Jia Pandi Peng Mu Du Zhuojing Luo Liu Yang Source Type: research
Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
AbstractEukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is highly expressed in many cancers and affects their occurrence and development. However, the effect of EIF4G1 on the prognosis, biological function and the relevant mechanism in lung squamous cell carcinoma (LSCC) is unclear. Through clinical cases, Cox ’s proportional hazard model and Kaplan–Meier plotter survival analysis, we find the expression levels of EIF4G1 are dependent on age and clinical stage, high expression of EIF4G1 could be used to predict the overall survival of LSCC patients. LSCC cell line NCI-H1703, NCI-H226 and SK-MES-1infec ted w...
Source: Human Cell - March 10, 2023 Category: Cytology Source Type: research
STAMP2 alleviates microglial neurotoxicity by inhibiting LPS-induced NF- κB activation
ConclusionThese findings revealed that STAMP2 is involved in regulating the LPS-NF-kB signal pathway to modulate inflammatory processes in microglia cells, which could represent a possible therapeutic therapy for neurodegenerative disorders.Graphical abstract
Source: Molecular and Cellular Toxicology - March 10, 2023 Category: Cytology Source Type: research
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway
Exp Cell Res. 2023 Mar 7:113542. doi: 10.1016/j.yexcr.2023.113542. Online ahead of print.ABSTRACTEndothelial cell senescence is involved in endothelial dysfunction and aging-related vascular diseases. The D1-like dopamine receptor (DR1), a number of G-protein-coupled receptors, is currently under consideration as a potential therapeutic target for the prevention of atherosclerosis. However, the role of DR1 in regulating ox-LDL-stimulated endothelial cell senescence remains unknown. Here, we found that the elevated Prx hyperoxidation and reactive oxygen species (ROS) levels in ox-LDL-treated Human umbilical vein endothelial...
Source: Experimental Cell Research - March 9, 2023 Category: Cytology Authors: Yiming Zhao Yuxia Li Hongxia Li Sa Shi Source Type: research
Photothermal Nanomaterial-Mediated Photoporation
Acc Chem Res. 2023 Mar 9. doi: 10.1021/acs.accounts.2c00770. Online ahead of print.ABSTRACTConspectusDelivering biological effector molecules in cultured cells is of fundamental importance to any study or application in which the modulation of gene expression is required. Examples range from generating engineered cell lines for studying gene function to the engineering of cells for cell-based therapies such as CAR-T cells and gene-corrected stem cells for regenerative medicine. It remains a great challenge, however, to deliver biological effector molecules across the cell membrane with minimal adverse effects on cell viabi...
Source: Cell Research - March 9, 2023 Category: Cytology Authors: Ranhua Xiong F élix Sauvage Juan C Fraire Chaobo Huang Stefaan C De Smedt Kevin Braeckmans Source Type: research
