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Specialty: Cytology
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Total 2613 results found since Jan 2013.
LncRNA AGPG confers endocrine resistance in breast cancer by promoting E2F1 activity
Cancer Res. 2023 Jul 18:CAN-23-0015. doi: 10.1158/0008-5472.CAN-23-0015. Online ahead of print.ABSTRACTResistance to endocrine therapy represents a major concern for patients with estrogen receptor α positive (ERα+) breast cancer. Endocrine therapy resistance is commonly mediated by activated E2F signaling. A better understanding of the mechanisms governing E2F1 activity in resistant cells could reveal strategies for overcoming resistance. Here, we identified the long non-coding RNA (lncRNA) actin gamma 1 pseudogene 25 (AGPG) as a regulator of E2F1 activity in endocrine resistant breast cancer. Expression of EGPG was inc...
Source: Cell Research - July 18, 2023 Category: Cytology Authors: Shiyi Yu Ying Wang Xue Gong Zhehao Fan Zheng Wang Zhengyan Liang Rui Wu Binjie Cao Ning Wang Caili Bi Dan Lv Haibo Sun Source Type: research
Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells
In this study, we hypothesized that semaphorin 7a (Sema7a) was involved in the increased inflammatory mediators and permeability changes in retinal endothelial cells (REC) grown in high glucose. For these studies, we used diabetic mouse samples and REC to investigate our hypothesis. Primary retinal endothelial cells were grown in normal (5 mM) or high glucose (25 mM glucose) for measurements. In a subset of cells grown in high glucose, cells were transfected with Sema7a siRNA or scrambled siRNA. We measured levels of key inflammatory mediators and zonula occludens-1 (ZO-1) and occludin levels by Western blot. Data suggest ...
Source: Cell Research - July 15, 2023 Category: Cytology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
Role of APE1/Ref-1 in hydrogen peroxide-induced apoptosis in human renal HK-2 cells
CONCLUSION: The inhibition of APE1/Ref-1 with siRNA attenuated H2O2-induced apoptosis through the modulation of mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 and the nuclear activation of NF-κB and proapoptotic factors.PMID:37448293 | DOI:10.23876/j.krcp.22.171
Source: Cell Research - July 14, 2023 Category: Cytology Authors: Ha Yeon Kim Jung Sun Park Byeong Hwa Jeon Hong Sang Choi Chang Seong Kim Seong Kwon Ma Soo Wan Kim Eun Hui Bae Source Type: research
AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation
In conclusion, AMPK activation is an obvious inducer of ADAM10 shedding activity. Our findings suggest that AMPK boosts ADAM10 shedding activity in HAECs by promoting Rab14-dependent ADAM10 cell surface translocation.PMID:37451218 | DOI:10.1016/j.bbrc.2023.07.010
Source: Cell Research - July 14, 2023 Category: Cytology Authors: Chung Hee Baek Hyosang Kim Soo Young Moon Won Seok Yang Source Type: research
The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells
Exp Cell Res. 2023 Jul 11:113722. doi: 10.1016/j.yexcr.2023.113722. Online ahead of print.ABSTRACTOsimertinib is a third-generation epidermal growth factor receptor (EGFR)1 tyrosine kinase inhibitor (TKI) approved for the treatment of EGFR-positive patients exhibiting a T790 M resistance mutation after treatment with an earlier generation of EGFR TKIs. However, resistance to osimertinib inevitably develops despite its efficacy, and the resistance mechanisms are complex and not fully understood. We established cell lines with acquired resistance to osimertinib from gefitinib- or erlotinib-resistant NSCLC cells using a dose-...
Source: Experimental Cell Research - July 13, 2023 Category: Cytology Authors: Tae-Gul Lee Hye-Min Kang Seo Yun Kim Hye-Ryoun Kim Cheol Hyeon Kim Source Type: research
Human β-defensins are correlated with the immune infiltration and regulated by vitamin D < sub > 3 < /sub > in periodontitis
CONCLUSION: HBDs are correlated with immune infiltration in periodontitis. Vitamin D3 inhibits the expression of HBDs and chemokines induced by TNF-α/Pg-LPS, possibly through NF-κB pathway, in human gingival fibroblasts.PMID:37439265 | DOI:10.1111/jre.13159
Source: Cell Research - July 13, 2023 Category: Cytology Authors: Churen Zhang Ye Han Lili Miao Zhaoguo Yue Min Xu Kaining Liu Jianxia Hou Source Type: research
ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1
Autophagy. 2023 Jul 11:1-16. doi: 10.1080/15548627.2023.2233846. Online ahead of print.ABSTRACTBaf A1: bafilomycin A1; GABARAP: GABA type A receptor-associated protein; GFP: green fluorescent protein; IFN: interferon; IKBKE/IKKi: inhibitor of nuclear factor kappa B kinase subunit epsilon; IRF3: interferon regulatory factor 3; ISG: interferon-stimulated gene; ISRE: IFN-stimulated response element; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAVS: mitochondrial antiviral signaling protein; MOI: multiplicity of infection; PAMPs: pathogen-associated molecule patterns; RIGI/DDX58: RNA sensor RIG-I; SeV: Sendai ...
Source: Autophagy - July 12, 2023 Category: Cytology Authors: Weihong Xie Chenqiu Zhang Zheyu Wang Hui Chen Tonghui Gu Tao Zhou Yaoxing Wu Fan Xia Min Li Jun Wang Renjie Jiao Jun Cui Shouheng Jin Source Type: research
Exploring the correlation of glycolysis-related chondroitin polymerizing factor ( < em > CHPF < /em > ) with clinical characteristics, immune infiltration, and cuproptosis in bladder cancer
Am J Cancer Res. 2023 Jun 15;13(6):2213-2233. eCollection 2023.ABSTRACTBladder cancer (BLCA) is a common malignant neoplasm of the urinary system. Glycolysis is an essential metabolic pathway regulated by various genes with implications for tumor progression and immune escape. Scoring the glycolysis for each sample in the TCGA-BLCA dataset was done using the ssGSEA algorithm for quantification. The results showed that the score in BLCA tissues was markedly greater than those in adjacent tissues. Additionally, the score was found to be correlated with metastasis and high pathological stage. Functional enrichment analyses of...
Source: Cell Research - July 10, 2023 Category: Cytology Authors: Quliang Zhong Kehua Jiang Facai Zhang Yuan Tian Jiang Gu Tao Li Xulong Chen Jianjun Yang Fa Sun Source Type: research
Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner
Eur J Cell Biol. 2023 Jul 6;102(3):151339. doi: 10.1016/j.ejcb.2023.151339. Online ahead of print.ABSTRACTDespite their significance in receptor-mediated internalization and continued signal transduction in cells, early/sorting endosomes (EE/SE) remain incompletely characterized, with many outstanding questions that surround the dynamics of their size and number. While several studies have reported increases in EE/SE size and number resulting from endocytic events, few studies have addressed such dynamics in a methodological and quantitative manner. Herein we apply quantitative fluorescence microscopy to measure the size a...
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Naava Naslavsky Steve Caplan Source Type: research
