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Specialty: Cytology
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Total 2613 results found since Jan 2013.
Combination of B7H6-siRNA and temozolomide synergistically reduces stemness and migration properties of glioblastoma cancer cells
This study aimed to understand the potential role and molecular mechanism of the combination therapy of B7H6-siRNA and temozolomide in glioblastoma cancer. U87 cells were treated with B7H6-siRNA and temozolomide, separately and in combination. Cell viability, stemness, cell migration, and apoptosis were measured. The results of this work presented the synergistic effect of B7H6-siRNA and temozolomide in inhibiting the cancerous features of the U87 cell line. Down-regulating B7H6-siRNA expression inhibited the cell viability of U87 glioblastoma cancer cells and increased their sensitivity to temozolomide. In addition, a not...
Source: Experimental Cell Research - May 29, 2023 Category: Cytology Authors: Nadia Allahyarzadeh Khiabani Mohammad Amin Doustvandi Fateme Mohammadnejad Elnaz Salmani Hassan Kohal Neda Boushehri Mahdi Jafarlou Behzad Baradaran Source Type: research
Serum Starvation Induces Matrix Metalloproteinase 9 Expression in Nasopharyngeal Carcinoma Cells Through the ERK-AP1 Pathway < em > In Vitro < /em >
CONCLUSION: Serum starvation could up-regulate MMP9 expression in NPC cells, contributing to NPC invasion. Therefore, serum starvation may promote malignancy of NPC cells but also support MMP9 as a potential therapeutic target to prevent NPC cell invasion and metastasis.PMID:37247927 | DOI:10.21873/anticanres.16425
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Yen-Ting Wu Chung-Chi Hsu Bu-Miin Huang Yun-Ching Chang Cheng-Han Lin Yu-Yan Lan Source Type: research
The CCL2-CCR2 Axis Contributes to Migration of Cabazitaxel-resistant Prostate Cancer Cells
CONCLUSION: The CCL2-CCR2 axis is a key contributor to resistance to the antimigration effect of cabazitaxel in prostate cancer cells. CCL2-CCR2 axis inhibition may be a potential therapeutic target against chemoresistant CRPC in combination with cabazitaxel.PMID:37247914 | DOI:10.21873/anticanres.16423
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Ariunbold Natsagdorj Kouji Izumi Kaoru Hiratsuka Renato Naito Suguru Kadomoto Hiroaki Iwamoto Hiroshi Yaegashi Kazuyoshi Shigehara Hiroki Nakata Atsushi Mizokami Source Type: research
The Expression and Role of NADPH Oxidase 2 in Colon Cancer
CONCLUSION: NOX2 expression level has a close association with the prognosis of colon cancer patients and physiological functions of colon cancer cells. NOX2 may be a useful prognostic biomarker for colon cancer patients.PMID:37247898 | DOI:10.21873/anticanres.16427
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Koichi Takiguchi Hiroki Shimizu Katsutoshi Shoda Kensuke Shiraishi Shinji Furuya Naohiro Hosomura Hidenori Akaike Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Kunio Mochizuki Tetsuo Kondo Daisuke Ichikawa Source Type: research
Combination of B7H6-siRNA and temozolomide synergistically reduces stemness and migration properties of glioblastoma cancer cells
This study aimed to understand the potential role and molecular mechanism of the combination therapy of B7H6-siRNA and temozolomide in glioblastoma cancer. U87 cells were treated with B7H6-siRNA and temozolomide, separately and in combination. Cell viability, stemness, cell migration, and apoptosis were measured. The results of this work presented the synergistic effect of B7H6-siRNA and temozolomide in inhibiting the cancerous features of the U87 cell line. Down-regulating B7H6-siRNA expression inhibited the cell viability of U87 glioblastoma cancer cells and increased their sensitivity to temozolomide. In addition, a not...
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Nadia Allahyarzadeh Khiabani Mohammad Amin Doustvandi Fateme Mohammadnejad Elnaz Salmani Hassan Kohal Neda Boushehri Mahdi Jafarlou Behzad Baradaran Source Type: research
The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation
AbstractOsteoblast differentiation is regulated by various transcription factors, signaling molecules, and posttranslational modifiers. The histone acetyltransferase Mof (Kat8) is involved in distinct physiological processes. However, the exact role of Mof in osteoblast differentiation and growth remains unknown. Herein, we demonstrated that Mof expression with histone H4K16 acetylation increased during osteoblast differentiation. Inhibition of Mof by siRNA knockdown or small molecule inhibitor, MG149 which is a potent histone acetyltransferase inhibitor, reduced the expression level and transactivation potential of osteog...
Source: Cell and Tissue Research - May 29, 2023 Category: Cytology Source Type: research
UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks
Biochem Biophys Res Commun. 2023 May 18;668:42-48. doi: 10.1016/j.bbrc.2023.05.068. Online ahead of print.ABSTRACTCamptothecin (CPT) exhibits strong cytotoxicity by inducing DNA double-strand breaks (DSBs) through DNA replication. Unlike radiation-induced DSBs, which have two DNA ends, CPT-induced DSBs are considered to have only one DNA end. However, the differences in cellular responses to one-ended and two-ended DSBs are not well understood. Our previous study showed that proteasome inhibitor treatment suppressed CPT-induced activation of DNA-PK, a factor required for non-homologous end-joining in DSB repair, suggesting...
Source: Cell Research - May 27, 2023 Category: Cytology Authors: Ryo Sakasai Tadashi Matsui Yumi Sunatani Kuniyoshi Iwabuchi Source Type: research
ERK/PKM2 Is Mediated in the Warburg Effect and Cell Proliferation in Arsenic-Induced Human L-02 Hepatocytes
This study aimed to investigate the potential role of pyruvate kinase M2 (PKM2) and extracellular regulated protein kinase (ERK) in arsenic-induced cell proliferation. L-02 cells were treated with 0.2 and 0.4 μmol/L As3+, glycolysis inhibitor (2-deoxy-D-glucose,2-DG), ERK inhibitor [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene, U0126] or transfected with PKM2 plasmid. Cell viability, proliferation, lactate acid production, and glucose intake capacity were determined by CCK-8 assay, EdU assay, lactic acid kit and 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]-D-glucose (2-NBDG) uptake kit, respectivel...
Source: Cell Research - May 26, 2023 Category: Cytology Authors: Fanshuo Yin Xin Zhang Zaihong Zhang Meichen Zhang Yunyi Yin Yanmei Yang Yanhui Gao Source Type: research
Notch1 is a marker for < em > in situ < /em > resting osteocytes in a 3-dimensional gel culture model
CONCLUSIONS: We established "resting state" osteocytes using an in vitro 3D model. Notch1 can be a useful marker to help differentiate the functional states of osteocytes (activated vs. resting state).PMID:37227119 | DOI:10.1080/03008207.2023.2217271
Source: Cell Research - May 25, 2023 Category: Cytology Authors: Ying-Hui Zhou Jia-Yu Zhu Yue Guo Hao-Neng Tang Fang Wang Junaid Iqbal Hui-Xuan Wu Nan Hu Fen Xiao Ting Wang Long Li Hou-De Zhou Source Type: research
Neuroprotective effects of the PPAR β/δ antagonist GSK0660 in in vitro and in vivo Parkinson's disease models
CONCLUSIONS: In summary, PPARβ/δ antagonist displayed neuroprotective activities against 6-hydroxydopamine detrimental effects both in vitro and in vivo models of Parkinson's disease, suggesting that it may represent a novel therapeutic approach for this disorder.PMID:37226204 | DOI:10.1186/s40659-023-00438-1
Source: Cell Research - May 24, 2023 Category: Cytology Authors: Andrea Antonosante Vanessa Castelli Martina Sette Margherita Alfonsetti Mariano Catanesi Elisabetta Benedetti Matteo Ardini Annamaria Cimini Michele d'Angelo Source Type: research
Inhibition of ubiquitin specific peptidase 8 is effective against 5-fluorouracil resistance in colon cancer via suppressing EGFR and EGFR-mediated signaling pathways
CONCLUSIONS: Our work is the first to reveal the essential role of USP8 in colon cancer via EGFR oncogenic signalling pathways. Our findings provide a proof-of-concept that USP8 inhibitors are promising candidates to overcome 5-FU resistance in colon cancer.PMID:37222451 | DOI:10.14670/HH-18-629
Source: Histology and Histopathology - May 24, 2023 Category: Cytology Authors: Changlei Xi Zhilin Gong Hui Ye Longlei Cao Jie Yu Source Type: research
HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition
This study explored the role of methyltransferase components in HPV-related cervical cancer and the mechanism. The levels of methyltransferase components and autophagy, ubiquitylation of RBM15 protein and the co-localization of lysosomal markers LAMP2A and RBM15 were measured. CCK-8 assay, flow cytometry, clone formation experiment and immunofluorescence assay were conducted to measure cell proliferation. The mouse tumor model was developed to study the cell growth in vivo. The binding of RBM15 to c-myc mRNA and m6A modifcation of c-myc mRNA were analyzed. The expressions of METTL3, RBM15 and WTAP were higher in HPV-positi...
Source: Cell Biology International - May 16, 2023 Category: Cytology Authors: Gang Nie Bo Tang Mingfen Lv Danyang Li Tian Li Rongying Ou Yunsheng Xu Juan Wen Source Type: research
