ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1

Autophagy. 2023 Jul 11:1-16. doi: 10.1080/15548627.2023.2233846. Online ahead of print.ABSTRACTBaf A1: bafilomycin A1; GABARAP: GABA type A receptor-associated protein; GFP: green fluorescent protein; IFN: interferon; IKBKE/IKKi: inhibitor of nuclear factor kappa B kinase subunit epsilon; IRF3: interferon regulatory factor 3; ISG: interferon-stimulated gene; ISRE: IFN-stimulated response element; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAVS: mitochondrial antiviral signaling protein; MOI: multiplicity of infection; PAMPs: pathogen-associated molecule patterns; RIGI/DDX58: RNA sensor RIG-I; SeV: Sendai virus; siRNA: small interfering RNA; TBK1: TANK binding kinase 1; WT: wild-type; VSV: vesicular stomatitis virus.PMID:37434364 | DOI:10.1080/15548627.2023.2233846

Source: Autophagy - July 12, 2023 Category: Cytology Authors: Weihong Xie Chenqiu Zhang Zheyu Wang Hui Chen Tonghui Gu Tao Zhou Yaoxing Wu Fan Xia Min Li Jun Wang Renjie Jiao Jun Cui Shouheng Jin Source Type: research