MicroRNA-31 regulates TNF- α and IL-17A co-induced-endothelial cell apoptosis by repressing E2F6

In conclusion, TNF-α and IL-17A generated in the aortic vascular tissue and serum from Ang II-induced hypertensive mice could trigger VECs apoptosis by the miR-31/E2F6 axis. To sum up, our study suggests that the key factor between cytokine co-stimulation effect and VEC apoptosis was miR-31/E2F6 axis, which was mainly regulated by NF-қB signaling pathway. This gives us a new sight to treat hypertension-associated VR.PMID:37178508 | DOI:10.1016/j.bbrc.2023.05.012

Source: Cell Research - May 13, 2023 Category: Cytology Authors: Zilong Fang Xinran Tong Guangzheng Shi Wendong Chen Qun Li Source Type: research