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Cancer: Brain Cancers

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Total 538 results found since Jan 2013.

Targeting Protein Kinase CK2 Suppresses Pro-survival Signaling Pathways and Growth of Glioblastoma.
CONCLUSIONS: CK2 inhibitors may be considered for treatment of patients with GBM. PMID: 24036851 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - September 13, 2013 Category: Cancer & Oncology Authors: Zheng Y, McFarland BC, Drygin D, Yu H, Bellis SL, Kim H, Bredel M, Benveniste EN Tags: Clin Cancer Res Source Type: research

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells
Conclusion: The results of this study supported YB-1 based virotherapy as an attractive therapeutic strategy for GBM treatment which will be exploited further in multimodal treatment concepts.
Source: Journal of Translational Medicine - September 18, 2013 Category: Research Authors: Klaus MantwillUlrike NaumannJanina SeznecVroni GirbingerHermann LagePawel SurowiakDagmar BeierMichel MittelbronnJürgen SchlegelPer Holm Source Type: research

Wnt signaling in triple negative breast cancer is associated with metastasis
Conclusion: These data implicate transcriptional Wnt signaling as a hallmark of TNBC disease associated with specific metastatic pathways.
Source: BMC Cancer - November 10, 2013 Category: Cancer & Oncology Authors: Nandini DeyBenjamin BarwickCarlos MorenoMaja Ordanic-KodaniZhengjia ChenGabriella Oprea-IliesWeining TangCharles CatzavelosKimberly KerstannGeorge SledgeMark AbramovitzMark BouzykPradip DeBrian Leyland-Jones Source Type: research

Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine-phosphorylation of coronin-1C.
In this study, we demonstrated that silencing of Nox4 expression by Nox4-targeted siRNA suppressed cell growth and motility of glioblastoma U87 cells, indicating the involvement of Nox4. Furthermore, Nox4-derived ROS oxidized and inactivated protein tyrosine phosphatase (PTP):1B: PTP1B in its active form downregulates cell proliferation and migration. By affinity purification with the substrate-trapping mutant of PTP1B, tyrosine-phosphorylated coronin-1C was identified as a substrate of PTP1B. Its tyrosine phosphorylation level was suppressed by Nox4 inhibition, suggesting that tyrosine-phosphorylation of coronin-1C is reg...
Source: Free Radical Biology and Medicine - November 13, 2013 Category: Biology Authors: Mondol AS, Tonks NK, Kamata T Tags: Free Radic Biol Med Source Type: research

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
CONCLUSIONS: These data are the first to link PID1 to cancer and suggest that PID1 may have a tumor inhibitory function in these pediatric and adult brain tumors. PMID: 24300787 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - December 3, 2013 Category: Cancer & Oncology Authors: Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson TB, Schur M, Gilles FH, Ji L, Malvar J, Shackleford GM, Margol A, Krieger MD, Judkins AR, Jones DT, Pfister SM, Kool M, Sposto R, Asgharzadeh S Tags: Clin Cancer Res Source Type: research

Expression of far upstream element (FUSE) binding protein 1 in human glioma is correlated with c‐Myc and cell proliferation
Abstract Glioma is one of the most common type of primary intracranial tumor. Although great advances have been achieved in treatment of glioma, the underlying molecular mechanisms remain largely unknown. Previous studies demonstrated that FBP1 is a transcriptional regulator of c‐Myc and acts as an important prognostic indicator in many cancers. Our study aimed to assess the expression and function of FBP1 in human glioma. Immunohistochemical and Western blot analysis were performed in human glioma and normal brain tissues. High FBP1 expression (located in cell nuclei) was observed in 70 samples and its level was correla...
Source: Molecular Carcinogenesis - December 17, 2013 Category: Molecular Biology Authors: Zongmei Ding, Xiancheng Liu, Yonghua Liu, Jianguo Zhang, Xianting Huang, Xiaojing Yang, Li Yao, Gang Cui, Donglin Wang Tags: Research Article Source Type: research

FOXC2 Often Overexpressed in Glioblastoma Enhances Proliferation and Invasion in Glioblastoma Cells.
This study found that FOXC2 was overexpressed in GBM cell lines and GBM tissues. The proliferation and invasive potential of GBM cells were significantly increased by ectopic expression of FOXC2 but significantly decreased by RNA interference targeting FOXC2. EGFR expression was modulated by FOXC2 both in mRNA and protein levels. EGFR inhibition by siRNA reversed the FOXC2-induced proliferation and invasion. These findings suggested that FOXC2 expressed in GBM has a function in GBM cell proliferation and invasion and may be partly associated with the EGFR overexpression. PMID: 24406047 [PubMed - in process]
Source: Oncology Research - January 15, 2014 Category: Cancer & Oncology Authors: Li W, Fu X, Liu R, Wu C, Bai J, Xu Y, Zhao Y, Xu Y Tags: Oncol Res Source Type: research

iNOS Drives mTOR Pathway Activation by Nitrosylation of TSC2
Melanoma is one of the cancers of fastest-rising incidence in the world. Inducible nitric oxide synthase (iNOS) is overexpressed in melanoma and other cancers, and previous data suggest that iNOS and nitric oxide (NO) drive survival and proliferation of human melanoma cells. However, specific mechanisms through which this occurs are poorly defined. One candidate is the PI3K–AKT–mTOR pathway, which plays a major role in proliferation, angiogenesis, and metastasis of melanoma and other cancers. We used the chick embryo chorioallantoic membrane (CAM) assay to test the hypothesis that melanoma growth is regulated by iNOS-d...
Source: Cancer Research - February 16, 2014 Category: Cancer & Oncology Authors: Lopez-Rivera, E., Jayaraman, P., Parikh, F., Davies, M. A., Ekmekcioglu, S., Izadmehr, S., Milton, D. R., Chipuk, J. E., Grimm, E. A., Estrada, Y., Aguirre-Ghiso, J., Sikora, A. G. Tags: Molecular and Cellular Pathobiology Source Type: research

CXCL12-induced upregulation of FOXM1 expression promotes human glioblastoma cell invasion.
In this study, we demonstrate that CXCL12 increases the production of FOXM1 by binding to CXCR4 in GBM cell lines. Furthermore, pretreatment with an inhibitor of the PI3K/AKT pathway abrogated the CXCL12-induced expression of FOXM1. In addition, there was a positive correlation between CXCL12/CXCR4 expression and FOXM1 expression in human malignant glioma tissues. Finally, a functional assay revealed that CXCL12 does not stimulate GBM cell invasion when FOXM1 expressionis silenced using a small interfering RNA (siRNA). Collectively, these findings suggest that CXCL12 promotes GBM cell invasion in part byincreasing the expr...
Source: Biochemical and Biophysical Research communications - February 19, 2014 Category: Biochemistry Authors: Wang S, Zhang S, Li J, Xu X, Weng Y, Zheng M, Ouyang L, Li F Tags: Biochem Biophys Res Commun Source Type: research

Increased paired box transcription factor 8 has a survival function in Glioma
Conclusions: PAX8 is increased in the majority of glioblastomas and promoted cell survival. Because PAX8 is absent in normal brain tissue, it may be a promising therapeutic target pathway for treating aggressive gliomas.
Source: BMC Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Noelyn HungYu-Jen ChenAhmad TahaMagnus OlivecronaRonald BoetAnna WilesTracy WarrAlisha ShawRamona EiholzerBruce BaguleyMichael EcclesAntony BraithwaiteMartin MacFarlaneJanice RoydsTania Slatter Source Type: research

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
Conclusions: Taken together, these findings highlight mitotic kinases and, in particular, WEE1 as a rational therapeutic target for medulloblastoma.
Source: Molecular Cancer - March 24, 2014 Category: Cancer & Oncology Authors: Peter HarrisSujatha VenkataramanIrina AlimovaDiane BirksIlango BalakrishnanBrian CristianoAndrew DonsonAdrian DubucMichael TaylorNicholas ForemanPhilip ReiganRajeev Vibhakar Source Type: research

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy.
In this study, the effects of miRNA-30a on ischemic injury in N2A cells and cultured cortical neurons after oxygen glucose deprivation (OGD), and mouse brain with MCAO-induced ischemic stroke were evaluated. The results showed that miRNA-30a expression levels were up regulated in the brain of mice after 6 h MCAO without reperfusion, but significantly down regulated in the peri-infarct region of mice with 1 h MCAO/24 h reperfusion and in N2A cells after 1 h OGD/6-48 h reoxygenation. Both the conversion ratio of microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I and Beclin 1 protein level increased in N2A cel...
Source: Neurochemical Research - April 26, 2014 Category: Neuroscience Authors: Wang P, Liang J, Li Y, Li J, Yang X, Zhang X, Han S, Li S, Li J Tags: Neurochem Res Source Type: research

MiR-224 expression increases radiation sensitivity of glioblastoma cells.
Abstract Glioblastoma (GBM) is the most common and highly aggressive primary malignant brain tumor. The intrinsic resistance of this brain tumor limits the efficacy of administered treatment like radiation therapy. In the present study, effect of miR-224 on growth characteristics of established GBM cell lines was analyzed. MiR-224 expression in the cell lines as well as primary GBM tumor tissues was found to be low. Exogenous transient expression of miR-224 using either synthetic mimics or stable inducible expression using doxycycline inducible lentiviral vector carrying miR-224 gene, was found to bring about 30-5...
Source: Biochemical and Biophysical Research communications - April 29, 2014 Category: Biochemistry Authors: Upraity S, Shaikh S, Padul V, Shirsat NV Tags: Biochem Biophys Res Commun Source Type: research

Activation of STAT5 contributes to proliferation in U87 human glioblastoma multiforme cells.
Abstract Rapid increases in the tyrosine phosphorylation of signal transducers and activators of transcription 5 (STAT5) proteins have been extensively documented in cells stimulated with cytokines and growth factors. However, the mechanisms by which STAT5 translocates to the nucleus and regulates proliferation in human glioblastoma multiforme cells have not been studied in detail. To the best of our knowledge, the present study demonstrated for first time that stimulation of a glioblastoma multiforme (GBM) cell line (U87-MG) with hepatocyte growth factor (HGF) resulted in the phosphorylation of STAT5 at Tyr-694/6...
Source: Molecular Medicine - May 17, 2014 Category: Molecular Biology Authors: Feng C, Cao S Tags: Mol Med Rep Source Type: research

Up-Regulation of Podoplanin Involves in Neuronal Apoptosis in LPS-Induced Neuroinflammation.
In this study, we performed a neuroinflammatory model by lipopolysaccharide (LPS) lateral ventral injection in adult rats and detected increased expression of PDPN in the brain cortex. Immunofluorescence indicated that PDPN was located in the neurons, but not astrocytes. Moreover, there was a concomitant up-regulation of active caspase-3, cyclin D1, and CDK4 in vivo and vitro studies. In addition, the expression of these three proteins in cortical primary neurons was decreased after knocking down PDPN by siRNA. Collectively, all these results suggested that the up-regulation of PDPN might be involved in neuronal apoptosis ...
Source: Cellular and Molecular Neurobiology - May 13, 2014 Category: Cytology Authors: Song Y, Shen J, Lin Y, Shen J, Wu X, Yan Y, Zhou L, Zhang H, Zhou Y, Cao M, Liu Y Tags: Cell Mol Neurobiol Source Type: research