Filtered By:
Cancer: Brain Cancers

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 538 results found since Jan 2013.

CDK-associated Cullin 1 promotes Cell Proliferation and inhibits Cell Apoptosis in Human Glioblastoma
CONCLUSION: CACUL1 can promote cell proliferation and suppress apoptosis of glioma cells and might serve as a potential oncogene for gliomas.PMID:34080964 | DOI:10.2174/1568009621666210602164225
Source: Current Cancer Drug Targets - June 3, 2021 Category: Cancer & Oncology Authors: Xiaohua Zhang Tianying Zhang Xiaojuan Han Zhongying Qiu Jianghong Cheng Xingchun Gao Xingchun Gou Source Type: research

TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer
CONCLUSION: TrkB/BDNF signaling may be a new therapeutic target for PDAC. Therapies targeting TrkB/BDNF signaling may be a conclusive cancer therapy for refractory solid cancer.PMID:34281873 | DOI:10.21873/anticanres.15205
Source: Cell Research - July 20, 2021 Category: Cytology Authors: Yasuhiro Oyama Shinjiro Nagao Lin Na Kosuke Yanai Masayo Umebayashi Katsuya Nakamura Shuntaro Nagai Akiko Fujimura Akio Yamasaki Kazunori Nakayama Takashi Morisaki Hideya Onishi Source Type: research

The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma
CONCLUSIONS: Our results show for the first time that the expression of the TAC1R gene (NK-1R) is essential for the viability of GAMG and U-87 MG glioma cells. On the contrary, the TAC1R gene is not essential for the viability of normal cells, confirming that NK-1R could be a promising and specific therapeutic target for the treatment of glioma.PMID:35434136 | PMC:PMC9006081 | DOI:10.1155/2022/6291504
Source: Biomed Res - April 18, 2022 Category: Research Authors: Mario F Mu ñoz Sandro Arg üelles Marisa Rosso Rafael Medina Rafael Cove ñas Antonio Ayala Miguel Mu ñoz Source Type: research

The role of drebrin in glioma migration and invasion.
Abstract Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite current advances in therapy consisting of surgery followed by chemotherapy and radiation, the overall survival rate still remains poor. Therapeutic failures are partly attributable to the highly infiltrative nature of tumor adjacent to normal brain parenchyma. Recently, evidence is mounting to suggest that actin cytoskeleton dynamics are critical components of the cell invasion process. Drebrin is an actin-binding protein involved in the regulation of actin filament organization, and plays a significant role in cell motility; how...
Source: Experimental Cell Research - November 29, 2012 Category: Cytology Authors: Terakawa Y, Agnihotri S, Golbourn B, Nadi M, Sabha N, Smith CA, Croul SE, Rutka JT Tags: Exp Cell Res Source Type: research

Gab2 expression in glioma and its implications for tumor invasion.
Conclusion. Gab2 may be a useful prognostic marker for gliomas and a novel therapeutic target for glioma invasion intervention. PMID: 23231021 [PubMed - as supplied by publisher]
Source: Acta Oncologica - December 11, 2012 Category: Cancer & Oncology Authors: Shi L, Sun X, Zhang J, Zhao C, Li H, Liu Z, Fang C, Wang X, Zhao C, Zhang X, Zhou F, Lu S, Luo R, Zhang B Tags: Acta Oncol Source Type: research

TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma
In conclusion, BDNF/TrkB signal is involved in malignant progression of invasiveness and tumorigenicity for LCNEC, and may be a potential target for LCNEC without standard therapy.
Source: Lung Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Seiichi Odate, Katsuya Nakamura, Hideya Onishi, Masayuki Kojima, Akihiko Uchiyama, Kenji Nakano, Masato Kato, Masao Tanaka, Mitsuo Katano Tags: Carcinogenesis and molecular biology Source Type: research

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia
Conclusion: Activated microglia TLR4 expression mediated neuroinflammation via a NF-kappaB signaling pathway in response to hypoxia. Hence, microglia TLR4 presents as a potential therapeutic target for neonatal hypoxia brain injuries.
Source: Journal of Neuroinflammation - February 6, 2013 Category: Neurology Authors: Linli YaoEnci Mary KanJia LuAijun HaoS Thameem DheenCharanjit KaurEng-Ang Ling Source Type: research

Overcoming resistance to sonic hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma
ConclusionsRSK inhibitors are promising because they target RSK which is correlated with SHH patients as well as cause high levels of apoptosis to only MB cells. Importantly, BI‐D1870 crosses the BBB, acting as a scaffold for development of more long‐lived RSK inhibitors. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - August 12, 2013 Category: Cancer & Oncology Authors: Mary Rose Pambid, Rachel Berns, Hans H. Adomat, Kaiji Hu, Joanna Triscott, Norbert Maurer, Natalia Zisman, Vijay Ramaswamy, Cynthia E. Hawkins, Michael D. Taylor, Christopher Dunham, Emma Guns, Sandra E. Dunn Tags: Research Article Source Type: research

MELK Decreases Replication Stress Cell Biology
Maternal embryonic leucine zipper kinase (MELK) belongs to the subfamily of AMP-activated Ser/Thr protein kinases. The expression of MELK is very high in glioblastoma-type brain tumors, but it is not clear how this contributes to tumor growth. Here we show that the siRNA-mediated loss of MELK in U87 MG glioblastoma cells causes a G1/S phase cell cycle arrest accompanied by cell death or a senescence-like phenotype that can be rescued by the expression of siRNA-resistant MELK. This cell cycle arrest is mediated by an increased expression of p21WAF1/CIP1, an inhibitor of cyclin-dependent kinases, and is associated with the h...
Source: Journal of Biological Chemistry - August 16, 2013 Category: Chemistry Authors: Kig, C., Beullens, M., Beke, L., Van Eynde, A., Linders, J. T., Brehmer, D., Bollen, M. Tags: Signal Transduction Source Type: research