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Cancer: Brain Cancers

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Total 538 results found since Jan 2013.

COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion
CONCLUSIONS: COL1A2 plays an important role in driving GBM progression. COL1A2 inhibition attenuated GBM proliferation by promoting cell cycle arrest, indicating that COL1A2 could be a promising therapeutic target for GBM treatment.PMID:35932265 | DOI:10.3171/2022.6.JNS22319
Source: Journal of Neurosurgery - August 6, 2022 Category: Neurosurgery Authors: Yi Wang Maki Sakaguchi Hemragul Sabit Sho Tamai Toshiya Ichinose Shingo Tanaka Masashi Kinoshita Yasuo Uchida Sumio Ohtsuki Mitsutoshi Nakada Source Type: research

TfR Aptamer Enhanced Blood ‐Brain Barrier Penetration of Biomimetic Nanocomplexes for Intracellular Transglutaminase 2 Imaging and Silencing in Glioma
Biomimetic nanocomplex (TMPsM) nanopartcles with dual blood-brain barrier (BBB)  targeting capability are prepared for simultaneous accurate diagnosis and effective treatment of glioma through single intracellular transglutaminase 2-triggered self-assembly aggregation-induced emission imaging and RNAi therapy. The dual BBB targeting biomimetic outer shells endow it with enhanc ed BBB penetration, prolonged blood circulation, and ensure the delivery of inner cores into brain tumor sites for theranostic agents release. AbstractEngineering a versatile nanocomplex integrating effective penetration of the blood-brain barrier (...
Source: Small - October 6, 2022 Category: Nanotechnology Authors: Juan Su, Zhipeng Yao, Zixuan Chen, Sisi Zhou, Zhi Wang, Hongping Xia, Songqin Liu, Yafeng Wu Tags: Research Article Source Type: research

Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation
Mol Cells. 2022 Dec 31;45(12):950-962. doi: 10.14348/molcells.2022.0045. Epub 2022 Dec 12.ABSTRACTAging is a major risk factor for common neurodegenerative diseases. Although multiple molecular, cellular, structural, and functional changes occur in the brain during aging, the involvement of caveolin-2 (Cav-2) in brain ageing remains unknown. We investigated Cav-2 expression in brains of aged mice and its effects on endothelial cells. The human umbilical vein endothelial cells (HUVECs) showed decreased THP-1 adhesion and infiltration when treated with Cav-2 siRNA compared to control siRNA. In contrast, Cav-2 overexpression ...
Source: Cancer Control - December 26, 2022 Category: Cancer & Oncology Authors: Hyunju Park Jung A Shin Jiwoo Lim Seulgi Lee Jung-Hyuck Ahn Jihee Lee Kang Youn-Hee Choi Source Type: research

Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
In this study, we found that inhibition of T-type Ca(2+) channels in GBM cells significantly reduced their survival and resistance to therapy. Moreover, either T-type selective antagonists, such as mibefradil, or siRNA-mediated knockdown of the T-type channel alpha subunits not only reduced cell viability and clonogenic potential, but also induced apoptosis. In response to channel blockade or ablation, we observed reduced phosphorylation of Akt and Rictor, suggesting inhibition of the mTORC2/Akt pathway. This was followed by reduction in phosphorylation of anti-apoptotic Bad and caspases activation. The apoptotic response ...
Source: Biochemical Pharmacology - December 31, 2012 Category: Drugs & Pharmacology Authors: Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J Tags: Biochem Pharmacol Source Type: research

FoxM1 and Stress Response Cell Biology
In this study we found that FoxM1 was up-regulated by heat shock factor 1 (HSF1) under heat shock stress condition in multiple cell lines. Knockdown of HSF1 with HSF1 siRNA or inhibition of HSF1 with a HSF1 inhibitor abrogated heat shock-induced expression of FoxM1. Genetic deletion of HSF1 in mouse embryo fibroblast cells also abolished heat shock stress-induced FoxM1 expression. Moreover, we showed that HSF1 directly bound to FoxM1 promoter and increased FoxM1 promoter activity. Furthermore, we demonstrated that FoxM1 was required for the G2-M phase progression through regulating Cdc2, Cdc20, and Cdc25B under a mild heat...
Source: Journal of Biological Chemistry - January 18, 2013 Category: Chemistry Authors: Dai, B., Gong, A., Jing, Z., Aldape, K. D., Kang, S.-H., Sawaya, R., Huang, S. Tags: Gene Regulation Source Type: research

Gene silencing of the BDNF/TrkB axis in multiple myeloma blocks bone destruction and tumor burden in vitro and in vivo
Abstract Osteolytic bone diseases are a prominent feature of multiple myeloma (MM), resulting from aberrant osteoclastic bone resorption that is uncoupled from osteoblastic bone formation. Myeloma stimulates osteoclastogenesis, which is largely dependent on an increase in receptor activator of NF‐κB ligand (RANKL) and a decrease in osteoprotegerin (OPG) within the bone marrow milieu. Recently, brain derived neurotrophic factor (BDNF) was identified as a MM‐derived factor that correlates with increased RANKL levels and contributes to osteolytic bone destruction in myeloma patients. Because tyrosine receptor kinase B (T...
Source: International Journal of Cancer - February 19, 2013 Category: Cancer & Oncology Authors: Li‐Sha Ai, Chun‐Yan Sun, Ya‐Dan Wang, Lu Zhang, Zhang‐Bo Chu, You Qin, Fei Gao, Han Yan, Tao Guo, Lei Chen, Di Yang, Yu Hu Tags: Cancer Cell Biology Source Type: research

Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme
Conclusions: Our results suggest that development of inhibitors which interfere with CD44-moesin interactions may open a new avenue in the future to mitigate cellular migration in gliomas.
Source: Molecular Cancer - July 15, 2013 Category: Cancer & Oncology Authors: Leroi DeSouzaAjay MattaZia KarimJoydeep MukherjeeX WangOlga KrakovskaGelareh ZadehAbhijit GuhaKW Siu Source Type: research

SGEF Promotes Fn14-induced GB Invasion Cell Biology
Glioblastoma (GB) is the highest grade of primary adult brain tumors, characterized by a poorly defined and highly invasive cell population. Importantly, these invading cells are attributed with having a decreased sensitivity to radiation and chemotherapy. TNF-like weak inducer of apoptosis (TWEAK)-Fn14 ligand-receptor signaling is one mechanism in GB that promotes cell invasiveness and survival and is dependent upon the activity of multiple Rho GTPases, including Rac1. Here we report that Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF), a RhoG-specific guanine nucleotide exchange factor, is over...
Source: Journal of Biological Chemistry - July 26, 2013 Category: Chemistry Authors: Fortin Ensign, S. P., Mathews, I. T., Eschbacher, J. M., Loftus, J. C., Symons, M. H., Tran, N. L. Tags: Cell Biology Source Type: research

Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation
This study suggests that PLK1 is an important therapeutic target for GBM and can enhance radiosensitivity in GBM.
Source: European Journal of Cancer - June 19, 2013 Category: Cancer & Oncology Authors: Anita T. Tandle, Tamalee Kramp, Whoon J. Kil, Aditya Halthore, Kristen Gehlhaus, Uma Shankavaram, Philip J. Tofilon, Natasha J. Caplen, Kevin Camphausen Tags: Neuro-oncology Source Type: research