Overcoming resistance to sonic hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma

ConclusionsRSK inhibitors are promising because they target RSK which is correlated with SHH patients as well as cause high levels of apoptosis to only MB cells. Importantly, BI‐D1870 crosses the BBB, acting as a scaffold for development of more long‐lived RSK inhibitors. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.

Source: Pediatric Blood and Cancer - August 12, 2013 Category: Cancer & Oncology Authors: Mary Rose Pambid, Rachel Berns, Hans H. Adomat, Kaiji Hu, Joanna Triscott, Norbert Maurer, Natalia Zisman, Vijay Ramaswamy, Cynthia E. Hawkins, Michael D. Taylor, Christopher Dunham, Emma Guns, Sandra E. Dunn Tags: Research Article Source Type: research