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Cancer: Ovarian Cancer

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Total 759 results found since Jan 2013.

DAP1 negatively regulates autophagy induced by cardamonin in SKOV3 cells.
This study aimed to investigate whether it is relevant for DAP1 in proliferation inhibition and autophagy induced by cardamonin in tumor cells. Using online bioinformatics tools, we found that DAP1 expression is closely related to the survival of patients with ovarian cancer. Our study showed that autophagy induced by cardamonin was associated with mTOR inhibition, and DAP1 was involved in this process. Silence of DAP1 decreased cell proliferation but enhanced antiproliferative effect of cardamonin in SKOV3 cells. The level of autophagy was elevated by DAP1 silencing in SKOV3 cells. Notably, cardamonin showed higher autoph...
Source: Cell Biology International - July 23, 2020 Category: Cytology Authors: Nie X, Chen H, Niu P, Zhu Y, Zhou J, Jiang L, Li D, Lin M, Chen Z, Shi D Tags: Cell Biol Int Source Type: research

Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells.
Abstract Nicotine is the major addictive component of cigarette smoke and although it is not considered carcinogenic, it can enhance or inhibit cancer cell proliferation depending on the type of cancer. Nicotine mediates its effects through nicotinic acetylcholine receptors (nAChRs), which are expressed in many different neuronal and non-neuronal cell types. We observed that the α4, α5, α7 subunits nAChRs were expressed in ovarian cancer (OC) cells. Nicotine inhibited the proliferation of SKOV3 and TOV112D OC cells, which have TP53 mutation and wild-type KRAS, but did not inhibit the proliferation of TOV21G or ...
Source: Experimental Cell Research - July 6, 2020 Category: Cytology Authors: Harmych SJ, Kumar J, Bouni ME, Chadee DN Tags: Exp Cell Res Source Type: research

GSE153440 NanoString gene expression data of OCI-C5x and OCI-P5x
Contributor : Reid ShawSeries Type : Expression profiling by arrayOrganism : Homo sapiensGene expression data of two ovarian carcinoma patient-derived cells was analyzed with respect to high-throughput functional siRNA screens and small-molecule screens.
Source: GEO: Gene Expression Omnibus - June 30, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Cancers, Vol. 12, Pages 1705: Potential of Tyrosine Kinase Receptor TIE-1 as Novel Therapeutic Target in High-PI3K-Expressing Ovarian Cancer
Nobuo Yaegashi Tyrosine kinase receptor TIE-1 plays a critical role in angiogenesis and blood-vessel stability. In recent years, increased TIE-1 expression has been observed in many types of cancers; however, the biological significance and underlying mechanisms remain unknown. Thus, in the present study, we investigated the tumor biological functions of TIE-1 in ovarian cancer. The treatment of SKOV3 ovarian-cancer cells with siRNA against TIE-1 decreased the expression of key molecules in the PI3K/Akt signaling pathway, such as p110α and phospho-Akt, suggesting that TIE-1 is related to the PI3K/Akt pat...
Source: Cancers - June 25, 2020 Category: Cancer & Oncology Authors: Xuewei Zhang Masumi Ishibashi Kazuyuki Kitatani Shogo Shigeta Hideki Tokunaga Masafumi Toyoshima Muneaki Shimada Nobuo Yaegashi Tags: Article Source Type: research

Effect of siRNA-induced Atg7 gene silencing on the sensitivity of ovarian cancer SKOV3 cells to cisplatin.
Authors: Zhang X, Wang LL, Wang B, Liu HL, Zhang J, Li YH, Wang LH Abstract Ovarian cancer is one of the most common types of gynecological malignant tumors. A proclivity for, or the development of chemoresistance severely affects treatment efficacy for ovarian cancer. Herein we found that as concentrations of cisplatin (DDP) used in SKOV3 cells increased, expression of intracellular reactive oxygen species (ROS) increased as did amounts of proteins of Beclin-1 and Autophagy-Related Gene 7 (Atg7) whereas in contrast, expression of P62 protein decreased gradually. Expression of Atg7 protein in SKOV3 cells in the siR...
Source: American Journal of Translational Research - June 10, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells.
Authors: Santana-Rivera Y, Rabelo-Fernández RJ, Quiñones-Díaz BI, Grafals-Ruíz N, Santiago-Sánchez G, Lozada-Delgado EL, Echevarría-Vargas IM, Apiz J, Soto D, Rosado A, Meléndez L, Valiyeva F, Vivas-Mejía PE Abstract Despite good responses to first-line treatment with platinum-based combination chemotherapy, most ovarian cancer patients will relapse and eventually develop a platinum-resistant disease with a poor overall prognosis. The molecular events leading to the cisplatin resistance of ovarian cancer cells are not fully understood. Here, we performed a proteomic analysis to identify protein candidates d...
Source: American Journal of Translational Research - May 2, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Cancers, Vol. 12, Pages 880: Downstream Effectors of ILK in Cisplatin-Resistant Ovarian Cancer
ivas-Mejía Despite good responses to first-line treatment with platinum-based combination chemotherapy, most ovarian cancer patients will relapse and eventually develop platinum-resistant disease with poor prognosis. Although reports suggest that integrin-linked kinase (ILK) is a potential target for ovarian cancer treatment, identification of ILK downstream effectors has not been fully explored. The purpose of this study was to investigate the molecular and biological effects of targeting ILK in cisplatin-resistant ovarian cancer. Western blot analysis showed that phosphorylation levels of ILK were higher in cisplati...
Source: Cancers - April 3, 2020 Category: Cancer & Oncology Authors: Jeyshka M. Reyes-Gonz ález Blanca I. Qui ñones-Díaz Yasmarie Santana Perla M. B áez-Vega Daniel Soto Fatima Valiyeva Mar ía J. Marcos-Martínez Ricardo J. Fern ández-de Fernández-de Thomas Pablo E. Vivas-Mej ía Tags: Article Source Type: research

RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells.
In this study we investigated what role RIP1 plays in human ovarian cancer cells. We showed that knockout (KO) of RIP1 substantially suppressed cell proliferation, accompanied by the G2/M checkpoint arrest in two human ovarian cancer cell lines SKOV3 and A2780. On the other hand, RIP1 KO remarkably attenuated cisplatin-induced cytotoxicity, which was associated with reduction of the apoptosis markers PARP cleavage and the necroptosis marker phospho-MLKL. We found that RIP1 KO suppressed cisplatin-induced ROS accumulation in both SKOV3 and A2780 cells. ROS scavenger BHA, apoptosis inhibitor Z-VAD or necroptosis inhibitor NS...
Source: Acta Pharmacologica Sinica - April 1, 2020 Category: Drugs & Pharmacology Authors: Zheng XL, Yang JJ, Wang YY, Li Q, Song YP, Su M, Li JK, Zhang L, Li ZP, Zhou B, Lin Y Tags: Acta Pharmacol Sin Source Type: research

Cancers, Vol. 12, Pages 672: Identification of PLK1 as a New Therapeutic Target in Mucinous Ovarian Carcinoma
li Damia Mucinous epithelial ovarian cancer (mEOC) is a rare subset of epithelial ovarian cancer. When diagnosed at a late stage, its prognosis is very poor, as it is quite chemo-resistant. To find new therapeutic options for mEOC, we performed high-throughput screening using a siRNA library directed against human protein kinases in a mEOC cell line, and polo-like kinase1 (PLK1) was identified as the kinase whose downregulation interfered with cell proliferation. Both PLK1 siRNA and two specific PLK1 inhibitors (onvansertib and volasertib) were able to inhibit cell growth, induce apoptosis and block cells in the G2/...
Source: Cancers - March 12, 2020 Category: Cancer & Oncology Authors: Affatato Carrassa Chil à Lupi Restelli Damia Tags: Article Source Type: research

Cancers, Vol. 12, Pages 605: Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway
This study aimed to evaluate the anti-cancer effects of ginsenoside Rp1, actinomycin D (ActD), and their co-administration in drug-resistant cells and murine xenograft model of colon cancer, and explore the underlying mechanisms. ActD increased expression and activity of SIRT1 in drug-resistant LS513 colon cancer, OVCAR8-DXR ovarian cancer, and A549-DXR lung cancer cells, but not in ActD-sensitive SW620 colon cancer cells. Inhibition of SIRT1, either pharmacologically, with EX527 or through siRNA, stimulated p53 acetylation and apoptosis in LS513 cells when treated with ActD. ActD also increased AKT activation in drug-resi...
Source: Cancers - March 4, 2020 Category: Cancer & Oncology Authors: Yun Lee Lee Shim Kim Tags: Article Source Type: research

Cancers, Vol. 12, Pages 500: Protein Tyrosine Phosphatase-1B Inhibition Disrupts IL13R α2-Promoted Invasion and Metastasis in Cancer Cells
Conclusions: We have uncovered that IL13 signaling through IL13Rα2 requires PTP1B activity and therefore, PTP1B inhibition represents a promising therapeutic strategy in multiple types of cancer, including glioblastoma.
Source: Cancers - February 20, 2020 Category: Cancer & Oncology Authors: Bartolom é Mart ín-Regalado Ja én Zannikou Zhang de los R íos Balyasnikova Casal Tags: Article Source Type: research

Clinical significance of RAD51C and its contribution to ovarian carcinogenesis.
CONCLUSIONS: Our results supported that RAD51C contributes to the progression of ovarian carcinoma, suggesting its promising application as an independent prognostic marker for diagnosis and treatment. PMID: 32055267 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Lu XL, Liu SS, Xiong ZF, Wang F, Li XY, Deng H Tags: Int J Clin Exp Pathol Source Type: research

Non‐coding RNA LOXL1-AS1 exhibits oncogenic activity in ovarian cancer via regulation of miR‐18b‐5p/VMA21 axis
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Fang Xue, Yan Hua Xu, Cheng Cheng Shen, Zhen Li Qin, Hai Bin ZhouAbstractLong non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene in multiple tumor types. In the current study, we illuminated the precise roles of LOXL1-AS1 in the development of ovarian cancer. LOXL1-AS1 is significantly overexpressed in ovarian carcinoma tissue compared with adjacent non‐cancerous sample. The luciferase reporter gene assay reveals the...
Source: Biomedicine and Pharmacotherapy - February 12, 2020 Category: Drugs & Pharmacology Source Type: research

Non-coding RNA LOXL1-AS1 exhibits oncogenic activity in ovarian cancer via regulation of miR-18b-5p/VMA21 axis.
Abstract Long non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene in multiple tumor types. In the current study, we illuminated the precise roles of LOXL1-AS1 in the development of ovarian cancer. LOXL1-AS1 is significantly overexpressed in ovarian carcinoma tissue compared with adjacent non-cancerous sample. The luciferase reporter gene assay reveals the relationship between LOXL1-AS1 and miR-18b-5p, miR-18b-5p and its target gene, Vacuolar ATPase Assembly Factor VMA21 (VMA21). Transfection of ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 9, 2020 Category: Drugs & Pharmacology Authors: Xue F, Xu YH, Shen CC, Qin ZL, Zhou HB Tags: Biomed Pharmacother Source Type: research

Overexpression of IGF2BP3 as a Potential Oncogene in Ovarian Clear Cell Carcinoma
In conclusion, our study shows that IGF2BP3 expression is a promising biomarker for prognostication of women diagnosed with OCCC with multiple effects on key cell functions, supporting its role as an important cellular regulator with potential oncogenic activity, and as a potential target for future intervention strategies.
Source: Frontiers in Oncology - January 29, 2020 Category: Cancer & Oncology Source Type: research