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Cancer: Ovarian Cancer
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Total 759 results found since Jan 2013.
Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells
In conclusion, enhancement of ferritinophagy is an important step involved in the mechanism of Artesunate-induced ferroptosis, and ferritin heavy chain levels may contribute to the regulation of sensitivity in Artesunate-induced ferroptosis in ovarian serous carcinoma cells.PMID:35903602 | PMC:PMC9309081 | DOI:10.3164/jcbn.21-82
Source: Journal of Clinical Biochemistry and Nutrition - July 29, 2022 Category: Nutrition Authors: Tiger Koike Motoki Takenaka Noriko Suzuki Yoko Ueda Minako Mori Tasuku Hirayama Hideko Nagasawa Ken-Ichirou Morishige Source Type: research
GSE185932 Gene expression changes associated with reducing Sox2 expression in ovarian cancer cell line PA1 under anchorage independence
The objective of this study is to examine the effect of changing Sox2 expression under the conditions of anchorage independent growth that is known to drive the expression of survival genes. We compared genome wide gene expression profiles of the ovarian tumor cell line PA1 upon transient knockdown of Sox2 expression using siRNA and compared to negative silencer control siRNA cells. Cells grown in biological triplicates were transfected under steady state 2D growth conditions and then transferred to poly-hema coated plates to prevent attachment. After 72 hrs, RNA was collected from siSox2 and sicontrol cells followed by ve...
Source: GEO: Gene Expression Omnibus - July 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Molecules, Vol. 27, Pages 4350: Melatonin Reverses the Warburg-Type Metabolism and Reduces Mitochondrial Membrane Potential of Ovarian Cancer Cells Independent of MT1 Receptor Activation
ustavo de Almeida Chuffa
Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown various antitumor properties. Herein, we investigated the influence of melatonin therapy on energy metabolism and mitochondrial integrity in SKOV-3 cells and tested whether its effects depended on MT1 receptor activation. SKOV-3 cells were exposed to different melatonin concentrations, and experimental groups were divided as to the presence of MT1 receptors (melatonin groups) or receptor absence by RNAi silencing (siRNA MT1+melatonin). Intracellular melatonin levels increased after treatment with melatonin in...
Source: Molecules - July 7, 2022 Category: Chemistry Authors: Maira Smaniotto Cucielo Roberta Carvalho Ces ário Henrique Spaulonci Silveira Let ícia Barbosa Gaiotte S érgio Alexandre Alcantara dos Santos Debora Aparecida Pires de Campos Zuccari F ábio Rodrigues Ferreira Seiva Russel J. Reiter Luiz Gustavo de Alm Tags: Article Source Type: research
The EMT-activator ZEB1 is unrelated to platinum drug resistance in ovarian cancer but is predictive of survival
AbstractThe IGROVCDDP cisplatin-resistant ovarian cancer cell line is an unusual model, as it is also cross-resistant to paclitaxel. IGROVCDDP, therefore, models the resistance phenotype of serous ovarian cancer patients who have failed frontline platinum/taxane chemotherapy. IGROVCDDP has also undergone epithelial-mesenchymal transition (EMT). We aim to determine if alterations in EMT-related genes are related to or independent from the drug-resistance phenotypes. EMT gene and protein markers, invasion, motility and morphology were investigated in IGROVCDDP and its parent drug-sensitive cell line IGROV-1.ZEB1 was investig...
Source: Human Cell - July 6, 2022 Category: Cytology Source Type: research
Effects of MCU mediated Ca2+ homeostasis on ovarian cancer cell SKOV3 proliferation, migration and transforming
CONCLUSIONS: Down-regulation of MCU inhibited SKOV3 cell proliferation, migration, and transforming via disturbing Ca2+ homeostasis and decreasing ROS production. MICU1and phosphorylation of Akt was associated with MCU -mediated ovarian cancer malignancy.PMID:35718978 | DOI:10.2174/1566524022666220617143754
Source: Current Molecular Medicine - June 20, 2022 Category: Molecular Biology Authors: Guanqun Wang Lantao Zhao Man Jiang Tian Tian Yingying Mei Guangming Fu Na Zhou Source Type: research
USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway
In conclusion, USP18 promoted the proliferation and migration of ovarian cancer cells by activating AKT/mTOR signaling.PMID:35696596 | DOI:10.18388/abp.2020_5871
Source: Acta Biochim Pol - June 13, 2022 Category: Biochemistry Authors: Meiqin Liu Shile Gao Xingjun Xu Lijie Zhang Bin Xu Donghui Lu Source Type: research
The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 Promotes Ovarian Cancer Pathogenesis
Int J Mol Sci. 2022 May 21;23(10):5793. doi: 10.3390/ijms23105793.ABSTRACTSyndecans are transmembrane heparan sulfate proteoglycans that integrate signaling at the cell surface. By interacting with cytokines, signaling receptors, proteases, and extracellular matrix proteins, syndecans regulate cell proliferation, metastasis, angiogenesis, and inflammation. We analyzed public gene expression datasets to evaluate the dysregulation and potential prognostic impact of Syndecan-3 in ovarian cancer. Moreover, we performed functional in vitro analysis in syndecan-3-siRNA-treated SKOV3 and CAOV3 ovarian cancer cells. In silico anal...
Source: Cancer Control - May 28, 2022 Category: Cancer & Oncology Authors: Lara Hillemeyer Nancy Adriana Espinoza-Sanchez Burkhard Greve Nourhan Hassan Anca Chelariu-Raicu Ludwig Kiesel Martin G ötte Source Type: research
