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Cancer: Ovarian Cancer
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Total 759 results found since Jan 2013.
Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation
J Pineal Res. 2021 Nov 26:e12781. doi: 10.1111/jpi.12781. Online ahead of print.ABSTRACTMelatonin, secreted by the pineal gland, regulates the circadian rhythms and also plays an oncostatic roles in cancer cells. Previously, we showed that melatonin induced the expression of Bim, a pro-apoptotic Bcl-2 protein, at both the transcriptional and post-translational levels. In the present study, we investigated the molecular mechanisms underlying the melatonin-mediated Bim upregulation through post-translational regulation. We found that ovarian tumor domain-containing protein 1 (OTUD1), a deubiquitinase belonging to the OTU pro...
Source: Cell Research - November 26, 2021 Category: Cytology Authors: Seon Min Woo Seung Un Seo Kyoung-Jin Min Taeg Kyu Kwon Source Type: research
Epiphycan Predicts Poor Outcomes and Promotes Metastasis in Ovarian Cancer
The small leucine-rich proteoglycan (SLRP) family is widely expressed in extracellular matrix and aggravates tumor progression. However, epiphycan (EPYC), as a member of the SLRPs family, its biological function in cancer has not been confirmed. Thus, we aimed to clarify the role of EPYC in progression of ovarian cancer (OC), and further analyze the molecular mechanisms implicated in tumorigenesis. Here, we analyzed the differential expression genes of GSE38734, including 4 matched primary OC and metastatic tissues. We obtained OC RNAseqs data from the Cancer Genome Atlas (TCGA) and analyzed the correlation between EPYC ex...
Source: Frontiers in Oncology - November 23, 2021 Category: Cancer & Oncology Source Type: research
Overexpression of miR-138-5p Sensitizes Taxol-Resistant Epithelial Ovarian Cancer Cells through Targeting Cyclin-Dependent Kinase 6
Conclusion: In summary, these findings suggest important molecular mechanisms for the miR-138-5p-mediated Taxol sensitivity of ovarian cancer via directly targeting CDK6, suggesting miR-138-5p is an effective therapeutic target for the noncoding RNA-based anti-chemoresistance treatment.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - November 10, 2021 Category: OBGYN Source Type: research
BAF57 Is a Potential Determinant of Colorectal Cancer Malignancy
CONCLUSION: BAF57 correlates with oncological malignancy and may be a novel therapeutic target in CRC.PMID:34732413 | DOI:10.21873/anticanres.15356
Source: Cell Research - November 4, 2021 Category: Cytology Authors: Hirofumi Suzumura Masashi Tsuruta Koji Okabayashi Kohei Shigeta Ryo Seishima Takashi Ishida Takehiro Shimada Yusuke Asada Kaoru Koishikawa Shingo Akimoto Osamu Itano Hirotoshi Hasegawa Yuko Kitagawa Source Type: research
miR-874-3p mitigates cisplatin resistance through modulating NF- κB/inhibitor of apoptosis protein signaling pathway in epithelial ovarian cancer cells
Mol Cell Biochem. 2021 Oct 30. doi: 10.1007/s11010-021-04271-6. Online ahead of print.ABSTRACTThe resistance to cisplatin, the most common platinum chemotherapy drug, may confine the efficacy of treatment in epithelial ovarian cancer patients. Aberrant expression of inhibitor of apoptosis proteins set the stage for resistance to cisplatin in EOC; besides, chemosensitivity in EOC can be chalked up to dysregulation of specific miRNAs. Herein, we investigated whether there is a potential correlation between miR-874-3p and the X-chromosome-linked inhibitor of apoptosis, a member of the IAP protein family in cisplatin-resistant...
Source: Molecular and Cellular Biochemistry - October 30, 2021 Category: Biochemistry Authors: Ying Wang Chenming Yan Junxia Qi Chunyan Liu Juan Yu Huabin Wang Source Type: research
lncRNA OR3A4 Promotes the Proliferation and Metastasis of Ovarian Cancer Through KLF6 Pathway
Conclusion: lncRNA OR3A4 promotes the proliferation and metastasis of ovarian cancer through the KLF6 pathway.
Source: Frontiers in Pharmacology - October 27, 2021 Category: Drugs & Pharmacology Source Type: research
Differential expression of estrogen receptor subtypes in ovarian high-grade serous carcinoma and clear cell carcinoma
CONCLUSIONS: High GPER-1 expression is an independent prognostic factor for PFS in HGSC patients, and GPER-1 may play a role in HGSC cell proliferation.PMID:34646075 | PMC:PMC8499597 | DOI:10.1002/rmb2.12402
Source: Reproductive Biology - October 14, 2021 Category: Reproduction Medicine Authors: Daiken Osaku Tetsuro Oishi Naoshi Kawamura Yuki Iida Hiroaki Komatsu Akiko Kudoh Jun Chikumi Shinya Sato Tasuku Harada Source Type: research
Actin Beta-Like 2 as a New Mediator of Proliferation and Migration in Epithelial Ovarian Cancer
In this study, we analyzed the prognostic and functional significance of ACTBL2 and its regulatory element Nuclear factor of activated T-cells 5 (NFAT5). The expression of ACTBL2 and NFAT5 was examined in tissue microarrays of 156 ovarian cancer patients by immunohistochemistry. Aiming to assess the molecular impact of ACTBL2 on cellular characteristics, functional assays were executed in vitro upon siRNA knockdown of ACTBL2 and NFAT5. ACTBL2 expression was identified as an independent negative prognostic factor for overall survival of EOC patients. EOC cell lines showed a significantly increased mRNA and protein level of ...
Source: Frontiers in Oncology - September 23, 2021 Category: Cancer & Oncology Source Type: research
Non-invasive evaluation of HABP1 expression with < sup > 99m < /sup > Tc-labeled small-interference RNA in ovarian cancer
CONCLUSIONS: We showed that 99mTc-HYNIC-siHABP1 is a feasible probe for the noninvasive visualization of HABP1 expression in ovarian cancer.PMID:34402389 | DOI:10.1080/09553002.2021.1969052
Source: International Journal of Radiation Biology - August 17, 2021 Category: Radiology Authors: Chunyu Duan Yue Gao Sha Luan Shibo Guo Xueliang Cao Peng Xu Peng Fu Changjiu Zhao Source Type: research
