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Cancer: Ovarian Cancer

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Cancers, Vol. 14, Pages 1877: The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers
s Borhane Annabi Sortilin (SORT1) receptor-mediated endocytosis functions were exploited for this new approach for effective and safe treatments of gynecological cancers. Here, high expression of SORT1 was found in >75% of the clinically annotated ovarian and endometrial tumors analyzed by immunohistochemistry. Therefore, the anticancer properties of the peptide-drug conjugate TH1902, a peptide that targets SORT1 and which is linked to docetaxel molecules, were investigated both in vitro using ovarian and endometrial cancer cell cultures and in vivo using xenograft models. In vitro, TH1902 inhibited cell p...
Source: Cancers - April 8, 2022 Category: Cancer & Oncology Authors: Jean-Christophe Currie Michel Demeule Cyndia Charfi Alain Zgheib Alain Larocque Bogdan Alexandru Danalache Amira Ouanouki Richard B éliveau Christian Marsolais Borhane Annabi Tags: Article Source Type: research

< em > Chelidonium majus < /em > Induces Apoptosis of Human Ovarian Cancer Cells Via ATF3-Mediated Regulation of Foxo3a by Tip60
This study demonstrated that Chelidonium majus upregulated the expression of ATF3 and Tip60 and promoted Foxo3a nuclear translocation, ultimately increasing the level of Bcl-2-associated X protein (Bax) protein. ATF3 overexpression stimulated Tip60 expression, while ATF3 inhibition by siRNA repressed Tip60 expression. Furthermore, siRNA-mediated Tip60 inhibition significantly promoted Foxo3a phosphorylation, leading to blockade of Foxo3a translocation into the nucleus. Thus, we were able to deduce that ATF3 mediates the regulation of Foxo3a by Tip60. Moreover, siRNA-mediated Foxo3a inhibition suppressed the expression of B...
Source: Journal of Microbiology and Biotechnology - March 14, 2022 Category: Biotechnology Authors: Lei Shen Soon Lee Jong Cheon Joo Eunmi Hong Zhen Yang Cui Eunbi Jo Soo Jung Park Hyun-Jin Jang Source Type: research

Cancers, Vol. 14, Pages 1120: Estrogen Receptor-beta2 (ER & beta;2) & ndash;Mutant p53 & ndash;FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC)
Cancers, Vol. 14, Pages 1120: Estrogen Receptor-beta2 (ER&beta;2)&ndash;Mutant p53&ndash;FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC) Cancers doi: 10.3390/cancers14051120 Authors: Chetan C. Oturkar Nishant Gandhi Pramod Rao Kevin H. Eng Austin Miller Prashant K. Singh Emese Zsiros Kunle O. Odunsi Gokul M. Das High grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of epithelial ovarian cancer. Prevalence (~96%) of mutant p53 is a hallmark of HGSOC. Estrogen receptor-beta (ER&am...
Source: Cancers - February 22, 2022 Category: Cancer & Oncology Authors: Chetan C. Oturkar Nishant Gandhi Pramod Rao Kevin H. Eng Austin Miller Prashant K. Singh Emese Zsiros Kunle O. Odunsi Gokul M. Das Tags: Article Source Type: research