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Cancer: Ovarian Cancer

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Total 759 results found since Jan 2013.

Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway
CONCLUSION: Knockdown of LIMD2 inhibits cell proliferation, migration, invasion and autophagy, and promotes the apoptosis through the ERK1/2 signaling pathway, suggesting that LIMD2-siRNA may be an effective molecule to prevent OC progression.PMID:37716918 | DOI:10.1007/s11033-023-08733-6
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Haiyang Hu Yanan Wang Yan Dong Lin Wang Yahui Chen Yan Zhou Lin Sun Source Type: research

Environmental-relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis
J Cell Mol Med. 2023 Aug 23. doi: 10.1111/jcmm.17920. Online ahead of print.ABSTRACTBisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. BPA has long been proposed to promote ovarian carcinogenesis, but the detrimental mechanistic target remains unclear. Cancer stem cells (CSCs) are considered as the trigger of tumour initiation and progression. Here, we show for the first time that nanomolar (environmentally relevant) concentration of BPA can markedly increase the formation and expansion of ovarian CSCs concomitant. This effect is observed in both oestrogen receptor (ER)-posit...
Source: Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Sophia S N Lam Zeyu Shi Carman K M Ip Chris K C Wong Alice S T Wong Source Type: research

GSE240039 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein ATAC
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of ...
Source: GEO: Gene Expression Omnibus - August 10, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE236275 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of PVRL4 are elev...
Source: GEO: Gene Expression Omnibus - July 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway
CONCLUSION: Taken together, our findings suggest that circ-PHC3 enhances OC progression through functioning as an miR-497-5p sponge to promote SOX9 expression, supporting its potential as a promising candidate target for OC therapy.PMID:37468993 | DOI:10.1186/s13048-023-01170-w
Source: Cell Research - July 19, 2023 Category: Cytology Authors: Hongxia Wang Suwei Lan Lingxiang Wang Jingyun Zhao Xinzhuan Jia Jie Xu Guangyu Sun Leilei Liu Shan Gong Na Wang Baoen Shan Fenghua Zhang Zhengmao Zhang Source Type: research

NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway.PMID:37392963 | DOI:10.1016/j.yexcr.2023.113693
Source: Cell Research - July 1, 2023 Category: Cytology Authors: Ze Wu Qiongqiong Jia Boqun Liu Lanlan Fang Peter C K Leung Jung-Chien Cheng Source Type: research

Anti-HPV16 oncoproteins siRNA therapy for cervical cancer using a novel transdermal peptide PKU12
In conclusion, the transdermal peptide PKU12 is potentially a good candidate for a siRNA delivery vehicle for the treatment of cervical cancer.PMID:37350944 | PMC:PMC10282752 | DOI:10.3389/fonc.2023.1175958
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Yan Deng Yi Song Quan Du Chi Chiu Wang Hu Li Yi Sui Yuying Zhang Tao Tang Source Type: research

MiR-5590-3p inhibits the proliferation and invasion of ovarian cancer cells through mediating the Wnt/ β-catenin signaling pathway by targeting TNIK
In conclusion, miR-5590-3p may function as a cancer suppressor gene in OC progression through the Wnt/β-catenin signaling by transcriptionally suppressing TNIK expression, which provides a potential therapeutic approach for ovarian cancer treatment.PMID:37318197 | DOI:10.14670/HH-18-636
Source: Histology and Histopathology - June 15, 2023 Category: Cytology Authors: Xiaoling Wu Youwen Zhong Hua Zhang Mu Li Source Type: research