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Cancer: Ovarian Cancer

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Total 759 results found since Jan 2013.

Cancers, Vol. 13, Pages 3174: Establishment of a Novel In Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis
Tohru Kiyono Satoru Kyo Endometriosis-harboring cancer-associated somatic mutations of PIK3CA and KRAS provides new opportunities for studying the multistep processes responsible for the functional and molecular changes in this disease. We aimed to establish a novel in vitro endometriosis model to clarify the functional behavior and molecular pathogenesis of this disorder. Immortalized HMOsisEC10 human ovarian endometriotic epithelial cell line was used in which KRAS and PIK3CA mutations were introduced. Migration, invasion, proliferation, and microarray analyses were performed using KRAS and PIK3CA mutant cell lines...
Source: Cancers - June 25, 2021 Category: Cancer & Oncology Authors: Mohammad Mahmud Hossain Kentaro Nakayama Kamrunnahar Shanta Sultana Razia Masako Ishikawa Tomoka Ishibashi Hitomi Yamashita Seiya Sato Kouji Iida Kosuke Kanno Noriyoshi Ishikawa Tohru Kiyono Satoru Kyo Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2745: CC Chemokine Ligand 7 Derived from Cancer-Stimulated Macrophages Promotes Ovarian Cancer Cell Invasion
We examined the effect of these macrophages on human ovarian cancer cell invasion and found that conditioned medium of macrophages stimulated by ovarian cancer cells (OC-MQs) significantly increased cell invasion. CC chemokine ligand 7 (CCL7) expression and production were significantly higher in OC-MQs than in the control macrophages. Peritoneal macrophages from patients with ovarian cancer showed higher CCL7 expression levels than those from healthy controls. Inhibition of CCL7 using siRNA and neutralizing antibodies reduced the OC-MQ-CM-induced ovarian cancer cell invasion. CC chemokine receptor 3 (CCR3) was highly expr...
Source: Cancers - June 1, 2021 Category: Cancer & Oncology Authors: Miran Jeong Yi-Yue Wang Ju-Yeon Choi Myong-Cheol Lim Jung-Hye Choi Tags: Article Source Type: research

hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin
Publication date: 15 July 2021Source: Life Sciences, Volume 277Author(s): Somayyeh Ghareghomi, Shahin Ahmadian, Nosratollah Zarghami, Salar Hemmati
Source: Life Sciences - May 17, 2021 Category: Biology Source Type: research

Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer
Lipid nanoparticles encapsulating small interfering ribonucleic acids are developed that block two essential pathways for cancer cell survival. Targeting of metastasized ovarian cancer cells is further enhanced by coating nanoparticles with hyaluronan. Robust gene silencing in key tissues involved in ovarian cancer pathophysiology in an advanced ovarian cancer mouse model is demonstrated and improved median and overall survival observed. AbstractOvarian cancer is an aggressive tumor owing to its ability to metastasize from stage II onward. Herein, lipid nanoparticles (LNPs) that encapsulate combination of small interfering...
Source: Small - May 12, 2021 Category: Nanotechnology Authors: Manu Smriti Singh, Srinivas Ramishetti, Dalit Landesman ‐Milo, Meir Goldsmith, Sushmita Chatterjee, Ramesh Palakuri, Dan Peer Tags: Research Article Source Type: research

The Exocrine Differentiation and Proliferation Factor (EXDPF) Gene Promotes Ovarian Cancer Tumorigenesis by Up-Regulating DNA Replication Pathway
In conclusion, this study demonstrated that EXDPF could be a potential therapeutic target as a pro-oncogene of ovarian cancer.
Source: Frontiers in Oncology - May 10, 2021 Category: Cancer & Oncology Source Type: research

Biocompatible AIEgen/p-glycoprotein siRNA@reduction-sensitive paclitaxel polymeric prodrug nanoparticles for overcoming chemotherapy resistance in ovarian cancer
Conclusion: Our findings demonstrated the Py-TPE/siRNA@PMP as a promising agent for the highly efficient treatment of PTX-resistant cells and overcoming the shortage of chemotherapy in ovarian cancer.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jun Wu, Quan Wang, Xiaoqi Dong, Min Xu, Juliang Yang, Xiaoqing Yi, Biao Chen, Xiyuan Dong, Ying Wang, Xiaoding Lou, Fan Xia, Shixuan Wang, Jun Dai Tags: Research Paper Source Type: research

Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells
ConclusionThis study is the first to reveal that ZEB1-AS1 plays a pivotal role in cancer chemoresistance.
Source: Archives of Gynecology and Obstetrics - April 18, 2021 Category: OBGYN Source Type: research

Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer
Lipid nanoparticles encapsulating small interfering ribonucleic acids are developed that block two essential pathways for cancer cell survival. Targeting of metastasized ovarian cancer cells is further enhanced by coating nanoparticles with hyaluronan. Robust gene silencing in key tissues involved in ovarian cancer pathophysiology in an advanced ovarian cancer mouse model is demonstrated and improved median and overall survival observed. AbstractOvarian cancer is an aggressive tumor owing to its ability to metastasize from stage II onward. Herein, lipid nanoparticles (LNPs) that encapsulate combination of small interfering...
Source: Small - April 7, 2021 Category: Nanotechnology Authors: Manu Smriti Singh, Srinivas Ramishetti, Dalit Landesman ‐Milo, Meir Goldsmith, Sushmita Chatterjee, Ramesh Palakuri, Dan Peer Tags: Research Article Source Type: research

ClC-3 promotes paclitaxel resistance via modulating tubulins polymerization in ovarian cancer cells
Biomed Pharmacother. 2021 Mar 22;138:111407. doi: 10.1016/j.biopha.2021.111407. Online ahead of print.ABSTRACTEpithelial ovarian cancers (EOC) present as malignant tumors with high mortality in the female reproductive system diseases. Acquired resistance to paclitaxel (PTX), one of the first-line treatment of EOC, remains a therapeutic challenge. ClC-3, a member of the voltage-gated Cl- channels, plays an essential role in a variety of cellular activities, including chemotherapeutic resistance. Here, we demonstrated that the protein expression and channel function of ClC-3 was upregulated in PTX resistance A2780/PTX cells ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 25, 2021 Category: Drugs & Pharmacology Authors: Jiezhu Feng Zihan Peng Lvfen Gao Xiurou Yang Zele Sun Xiuying Hou Enze Li Linyan Zhu Haifeng Yang Source Type: research

Cancers, Vol. 13, Pages 1469: The Epithelial –Mesenchymal Transcription Factor SNAI1 Represses Transcription of the Tumor Suppressor miRNA let-7 in Cancer
In conclusion, the SNAI1/let-7 axis is an important component of stemness pathways in cancer cells, and this study provides a rationale for future work examining this axis as a potential target for cancer stem cell-specific therapies.
Source: Cancers - March 23, 2021 Category: Cancer & Oncology Authors: Hanmin Wang Evgeny Chirshev Nozomi Hojo Tise Suzuki Antonella Bertucci Michael Pierce Christopher Perry Ruining Wang Jeffrey Zink Carlotta A. Glackin Yevgeniya J. Ioffe Juli J. Unternaehrer Tags: Article Source Type: research

Corrigendum Silencing of type I γ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion
Oncol Rep. 2021 Apr;45(4):1. doi: 10.3892/or.2021.7982. Epub 2021 Feb 18.ABSTRACTSubsequently to the publication of the above paper, the authors have drawn to our attention that the middle panel in Fig. 3B, representing the migration of PIPKIγ‑depleted cells (PIPKIγ‑1), was inadvertently mixed up with the left panel of control cells (siRNA Ctrl). The results presented in Fig. 3D, however, were quantified based on the original images from three independent experiments, each containing five randomly picked micro-scopic fields. The authors were able to re‑examine the original data files and retrieve the correct data p...
Source: Oncology Reports - March 3, 2021 Category: Cancer & Oncology Authors: Siyu Cao Chunhua Chen Junli Xue Yan Huang Xiaofeng Yang Kun Ling Source Type: research