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Cancer: Ovarian Cancer
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Total 759 results found since Jan 2013.
Long non-coding RNA PVT1 promotes the proliferation, migration and EMT process of ovarian cancer cells by regulating CTGF
In conclusion, lncRNA PVT1 promotes the proliferation, migration, invasiveness and EMT process of ovarian cancer cells, and CTGF contributes to the effect of lncRNA PVT1.PMID:36688109 | PMC:PMC9843302 | DOI:10.3892/ol.2022.13657
Source: Oncology Letters - January 23, 2023 Category: Cancer & Oncology Authors: Lingling Dong Huan Wang Yun Gao Shuai Wang Weibo Wang Source Type: research
NUF2 promotes tumorigenesis by interacting with HNRNPA2B1 via PI3K/AKT/mTOR pathway in ovarian cancer
CONCLUSION: NUF2 could serve as a prognostic biomarker, and regulated the carcinogenesis and progression of OC. Moreover, NUF2 may interact with HNRNPA2B1 by activating the PI3K/AKT/mTOR signaling pathway to promote the development of OC cells. Our present study supported the key role of NUF2 in OC and suggested its potential as a novel therapeutic target.PMID:36670423 | DOI:10.1186/s13048-023-01101-9
Source: Cell Research - January 20, 2023 Category: Cytology Authors: Meng Ren Hongyu Zhao Yan Gao Qi Chen Xiaoting Zhao Wentao Yue Source Type: research
ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models
WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear. Here, through a cell cycle machinery–related gene RNAi screen, we found that targeting outer dense fiber of sperm tails 2–like (ODF2L) was a synthetic lethal partner with WEE1 kinase inhibition in EOC cells. Knockdown of ODF2L robustly sensitized cells to treatment with the WEE1 inhibitor AZD1775 in EOC cell lines in vitro as well as in xenografts in vivo. Mechanistically, the increased sensitivity to WEE1 inhibition upon ODF2L loss was accompanied by accumulated...
Source: Journal of Clinical Investigation - January 18, 2023 Category: Biomedical Science Authors: Jie Li, Jingyi Lu, Manman Xu, Shiyu Yang, Tiantian Yu, Cuimiao Zheng, Xi Huang, Yuwen Pan, Yangyang Chen, Junming Long, Chunyu Zhang, Hua Huang, Qingyuan Dai, Bo Li, Wei Wang, Shuzhong Yao, Chaoyun Pan Source Type: research
Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer
CONCLUSIONS: Our results suggest that the inhibition of TIMP-2 by siRNA and CRISPR/Cas-9 modulate the expression of MMP-2 and MMP-14 and reprogram ovarian cancer cells to facilitate proliferation and invasion. Distinct disparities in in vitro chemosensitivity and growth in 3D culture, and differences in tumour burden and invasion to proximal organs in a mouse model imply that selective suppression of TIMP-2 expression by siRNA or CRISPR/Cas-9 alters important aspects of metastasis and chemosensitivity in ovarian cancer.PMID:36585738 | DOI:10.1186/s12935-022-02838-x
Source: Cancer Control - December 30, 2022 Category: Cancer & Oncology Authors: Ruth M Escalona Simon Chu Elif Kadife Jason K Kelly George Kannourakis Jock K Findlay Nuzhat Ahmed Source Type: research
High expression of RARG accelerates ovarian cancer progression by regulating cell proliferation
ConclusionsHigh expression of RARG could promote OC cell proliferation and was an independent predictor of poor prognosis. RARG might work as a potential molecular target and biomarker for individualized diagnosis and treatment in OC patients.
Source: Frontiers in Oncology - November 29, 2022 Category: Cancer & Oncology Source Type: research
Systematic Pan-Cancer Analysis and Experimental Verification Identify FOXA1 as an Immunological and Prognostic Biomarker in Epithelial Ovarian Cancer
CONCLUSIONS: Our results predict and validate the function of FOXA1 in promoting EMT and the progression of disease in EOC. Targeting FOXA1 may improve the sensitivity of EOC treatment.PMID:36393971 | PMC:PMC9646314 | DOI:10.1155/2022/9328972
Source: Disease Markers - November 17, 2022 Category: Laboratory Medicine Authors: Kai Wang Chenan Guan Junhui Yu Xing Chen Xianwen Shang Shuangshuang Mei Xingjun Feng Lingzhi Zheng Source Type: research
The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer
ConclusionIn conclusion, our study shows that the hyaluronic acid system has a relevant influence on the survival of ovarian cancer patients and could therefore be considered as a possible prognostic factor.
Source: Journal of Cancer Research and Clinical Oncology - October 21, 2022 Category: Cancer & Oncology Source Type: research
ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways
CONCLUSION: These results indicated that ZNF574 may function as an oncogene in ovarian cancer through regulation of the AKT and AMPK signaling pathways. Furthermore, ZNF574 may be a prognostic indicator and therapeutic target for ovarian cancer.PMID:36197766
Source: Annals of Clinical and Laboratory Science - October 5, 2022 Category: Laboratory Medicine Authors: Jingjing Zhang Xiaoli Wu Li Huang Source Type: research
