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Cancer: Ovarian Cancer
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Total 759 results found since Jan 2013.
ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways
CONCLUSION: These results indicated that ZNF574 may function as an oncogene in ovarian cancer through regulation of the AKT and AMPK signaling pathways. Furthermore, ZNF574 may be a prognostic indicator and therapeutic target for ovarian cancer.PMID:36197766
Source: Annals of Clinical and Laboratory Science - October 5, 2022 Category: Laboratory Medicine Authors: Jingjing Zhang Xiaoli Wu Li Huang Source Type: research
NANOG regulates epithelial-mesenchymal transition via AMPK/mTOR signalling pathway in ovarian cancer SKOV-3 and A2780 cells
J Cell Mol Med. 2022 Sep 16. doi: 10.1111/jcmm.17557. Online ahead of print.ABSTRACTNANOG engages with tumour initiation and metastasis by regulating the epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer (EOC). However, its role in association with pAMPKα, and its clinical significance in EOC have not been elucidated even though AMPK is known to degrade NANOG in various human cancers. Hence, we investigated the role of pAMPKα and its association with NANOG as potential prognostic biomarkers in EOC. Both NANOG and pAMPKα expression were significantly overexpressed in EOCs comparing nonadjacent normal e...
Source: J Cell Mol Med - September 17, 2022 Category: Molecular Biology Authors: Hee Yun Gwan Hee Han Julie Kim Joon-Yong Chung Jae-Hoon Kim Hanbyoul Cho Source Type: research
Functions of Membrane Progesterone Receptors (mPRs, PAQRs) in Nonreproductive Tissues
Endocrinology. 2022 Aug 30:bqac147. doi: 10.1210/endocr/bqac147. Online ahead of print.ABSTRACTGender differences in a wide variety of physiological parameters have implicated the ovarian hormones, estrogens and progesterone, in the regulation of numerous nonreproductive tissue functions. Rapid, nongenomic (nonclassical) progesterone actions mediated by membrane progesterone receptors (mPRs), which belong to the progestin and AdipoQ receptor (PAQR) family, have been extensively investigated in reproductive and nonreproductive tissues since their discovery in fish ovaries 20 years ago. The five mPR subtypes (α, β, γ, δ,...
Source: Endocrinology - August 30, 2022 Category: Endocrinology Authors: Peter Thomas Yefei Pang Maria Andrea Camilletti Luca F Castelnovo Source Type: research
Polymeric nanoparticles-siRNA as an emerging nano-polyplexes against ovarian cancer
Colloids Surf B Biointerfaces. 2022 Aug 9;218:112766. doi: 10.1016/j.colsurfb.2022.112766. Online ahead of print.ABSTRACTOvarian cancer (OC) is considered fifth-deadliest cancer globally responsible for high mortality in women. As the conventional therapeutic and diagnostic approaches are ineffective in increasing the survival rates of advanced staged patients by more than 5 years, OC has resulted in high morbidity and mortality rates over the last two decades. As a result, there is a dire need for innovative treatment approaches to address the issues. RNAi and nanotechnology can be considered the most appropriate strategi...
Source: Colloids and Surfaces - August 22, 2022 Category: Biotechnology Authors: Urushi Rehman Neha Parveen Afsana Sheikh Mohammed A S Abourehab Amirhossein Sahebkar Prashant Kesharwani Source Type: research
