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Cancer: Ovarian Cancer

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Total 759 results found since Jan 2013.

Corrigendum Silencing of type I γ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion
Oncol Rep. 2021 Apr;45(4):1. doi: 10.3892/or.2021.7982. Epub 2021 Feb 18.ABSTRACTSubsequently to the publication of the above paper, the authors have drawn to our attention that the middle panel in Fig. 3B, representing the migration of PIPKIγ‑depleted cells (PIPKIγ‑1), was inadvertently mixed up with the left panel of control cells (siRNA Ctrl). The results presented in Fig. 3D, however, were quantified based on the original images from three independent experiments, each containing five randomly picked micro-scopic fields. The authors were able to re‑examine the original data files and retrieve the correct data p...
Source: Oncology Reports - March 3, 2021 Category: Cancer & Oncology Authors: Siyu Cao Chunhua Chen Junli Xue Yan Huang Xiaofeng Yang Kun Ling Source Type: research

Low expression of FXYD5 reverses the cisplatin resistance of epithelial ovarian cancer cells.
CONCLUSION: FXYD5 downregulation may reduce the invasion, migration and EMT formation of EOC cells to increase their sensitivity to cisplatin chemotherapy by inhibiting cell proliferation and promoting cell apoptosis. PMID: 33570156 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - February 13, 2021 Category: Cytology Tags: Histol Histopathol Source Type: research

PRMT1 expression predicts sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma.
In conclusion, PRMT1 expression could predict sensitivity to platinum-based chemotherapy in patients with ovarian serous carcinoma. PMID: 33552280 [PubMed]
Source: Oncology Letters - February 9, 2021 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer.
Abstract Ovarian cancer (OC) is the deadliest gynecological cancer and is currently incurable with standard treatment regimens. Early invasion, intraperitoneal metastasis, and an aggressive course are the hallmarks of OC. The major reason for poor prognosis is a lack of molecular targets and highly effective targeted therapies. Therefore, identification of novel molecular targets and therapeutic strategies is urgently needed to improve OC survival. Herein we report that eukaryotic elongation factor-2 kinase (EF2K) is highly upregulated in primary and drug-resistant OC cells and its expresssion associated with prog...
Source: Cellular Signalling - February 1, 2021 Category: Cytology Authors: Erdogan MA, Ashour A, Yuca E, Gorgulu K, Ozpolat B Tags: Cell Signal Source Type: research