Identification of key gene contributing to vitiligo by immune infiltration
CONCLUSION: The gene expression profile of vitiligo was realized by a bioinformatics method. The expressions of 8 hub genes and 22 immune cells were found, as the same as CRY2 and VRK1 have a special correlation with immune cells, which may be a significant cause of the pathogenesis of vitiligo. This provides a new idea for the diagnosis and treatment of vitiligo.PMID:35535201 | PMC:PMC9077110 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Hefang Xiao Yonghui Dong Likang Xiao Xiaming Liang Jia Zheng Source Type: research

Melanoma developing in a nevoid melanocytoma with myxoid changes: a case report
We present an atypical case of a melanoma progressing from a nevoid melanocytoma with myxoid changes. A 78-year-old female presented with a pigmented growth on her right thigh. Biopsy demonstrated a biphenotypic melanocytic proliferation composed of a nodule showing epithelioid melanocytes with enlarged nuclei, prominent nucleoli, lack of maturation, and abundant amphophilic cytoplasm with a rare mitotic figure. These findings were suggestive of melanoma along with a nevoid dermal component and myxoid stroma. FISH testing revealed a homozygous loss of 9p21 in the atypical component. SNP-microarray from the nevoid component...
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Andrew S Kao Kayla St Claire Lisa M Bedford Darius R Mehregan Aleodor A Andea David Kouba Source Type: research

Initial panel of immunocytochemical markers for identification of primary carcinoma site for effusions and peritoneal washings from women
CONCLUSION: An initial panel of markers including GATA-3, PAX-8, and TTF-1 allows, with high sensitivity and specificity, the identification or exclusion of frequent primary sites of carcinoma in effusions from women. Our results highlight the importance of using a panel of markers to avoid misidentification of the primary site of tumor.PMID:35535203 | PMC:PMC9077109 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Gustavo Henrique Soares Takano Rivad ávio Fernandes Amorim V ânia Moraes Ferreira Leonora Maciel de Souza Vianna Tercia Maria Mendes Lousa de Castro Marcos de Vasconcelos Carneiro Ísis de Araújo Oliveira Andrea Barretto Motoyama Fabiana Pirani Carneir Source Type: research

A pyroptosis-related prognosis model to predict survival in colorectal cancer patients
Int J Clin Exp Pathol. 2022 Apr 15;15(4):168-182. eCollection 2022.ABSTRACTPyroptosis is a recently-identified pathway of host cell death that is stimulated by a range of microbial infections. Emerging evidence indicates pyroptosis plays crucial roles in tumor growth, disease progression, and migration of different cancer cells. However, the clinical significance of pyroptosis in tumor behavior prognosis, as well as the underlying mechanism in different cancers remains elusive. Here, by evaluating the expression level of pyroptosis genes in colorectal cancer (CRC) patients from the TCGA cohort and GEO cohort (GSE39582), we...
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Meiyan Chen Jingyi Zhang Xiaoyan Lin Xiaosan Zhu Tao Xie Source Type: research

Cancer stem-like cells contribute to paclitaxel resistance in esophageal squamous cell carcinoma
CONCLUSIONS: Cancer stem cell (CSC)-like cells exist among paclitaxel-resistant cells in ESCC and may play a role in ESCC drug resistance.PMID:35535205 | PMC:PMC9077107 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Yanru Shen Lihui Yang Lei Li Source Type: research

Identification of key gene contributing to vitiligo by immune infiltration
CONCLUSION: The gene expression profile of vitiligo was realized by a bioinformatics method. The expressions of 8 hub genes and 22 immune cells were found, as the same as CRY2 and VRK1 have a special correlation with immune cells, which may be a significant cause of the pathogenesis of vitiligo. This provides a new idea for the diagnosis and treatment of vitiligo.PMID:35535201 | PMC:PMC9077110 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Hefang Xiao Yonghui Dong Likang Xiao Xiaming Liang Jia Zheng Source Type: research

Melanoma developing in a nevoid melanocytoma with myxoid changes: a case report
We present an atypical case of a melanoma progressing from a nevoid melanocytoma with myxoid changes. A 78-year-old female presented with a pigmented growth on her right thigh. Biopsy demonstrated a biphenotypic melanocytic proliferation composed of a nodule showing epithelioid melanocytes with enlarged nuclei, prominent nucleoli, lack of maturation, and abundant amphophilic cytoplasm with a rare mitotic figure. These findings were suggestive of melanoma along with a nevoid dermal component and myxoid stroma. FISH testing revealed a homozygous loss of 9p21 in the atypical component. SNP-microarray from the nevoid component...
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Andrew S Kao Kayla St Claire Lisa M Bedford Darius R Mehregan Aleodor A Andea David Kouba Source Type: research

Initial panel of immunocytochemical markers for identification of primary carcinoma site for effusions and peritoneal washings from women
CONCLUSION: An initial panel of markers including GATA-3, PAX-8, and TTF-1 allows, with high sensitivity and specificity, the identification or exclusion of frequent primary sites of carcinoma in effusions from women. Our results highlight the importance of using a panel of markers to avoid misidentification of the primary site of tumor.PMID:35535203 | PMC:PMC9077109 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Gustavo Henrique Soares Takano Rivad ávio Fernandes Amorim V ânia Moraes Ferreira Leonora Maciel de Souza Vianna Tercia Maria Mendes Lousa de Castro Marcos de Vasconcelos Carneiro Ísis de Araújo Oliveira Andrea Barretto Motoyama Fabiana Pirani Carneir Source Type: research

A pyroptosis-related prognosis model to predict survival in colorectal cancer patients
Int J Clin Exp Pathol. 2022 Apr 15;15(4):168-182. eCollection 2022.ABSTRACTPyroptosis is a recently-identified pathway of host cell death that is stimulated by a range of microbial infections. Emerging evidence indicates pyroptosis plays crucial roles in tumor growth, disease progression, and migration of different cancer cells. However, the clinical significance of pyroptosis in tumor behavior prognosis, as well as the underlying mechanism in different cancers remains elusive. Here, by evaluating the expression level of pyroptosis genes in colorectal cancer (CRC) patients from the TCGA cohort and GEO cohort (GSE39582), we...
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Meiyan Chen Jingyi Zhang Xiaoyan Lin Xiaosan Zhu Tao Xie Source Type: research

Cancer stem-like cells contribute to paclitaxel resistance in esophageal squamous cell carcinoma
CONCLUSIONS: Cancer stem cell (CSC)-like cells exist among paclitaxel-resistant cells in ESCC and may play a role in ESCC drug resistance.PMID:35535205 | PMC:PMC9077107 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Yanru Shen Lihui Yang Lei Li Source Type: research

Identification of key gene contributing to vitiligo by immune infiltration
CONCLUSION: The gene expression profile of vitiligo was realized by a bioinformatics method. The expressions of 8 hub genes and 22 immune cells were found, as the same as CRY2 and VRK1 have a special correlation with immune cells, which may be a significant cause of the pathogenesis of vitiligo. This provides a new idea for the diagnosis and treatment of vitiligo.PMID:35535201 | PMC:PMC9077110 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Hefang Xiao Yonghui Dong Likang Xiao Xiaming Liang Jia Zheng Source Type: research

Melanoma developing in a nevoid melanocytoma with myxoid changes: a case report
We present an atypical case of a melanoma progressing from a nevoid melanocytoma with myxoid changes. A 78-year-old female presented with a pigmented growth on her right thigh. Biopsy demonstrated a biphenotypic melanocytic proliferation composed of a nodule showing epithelioid melanocytes with enlarged nuclei, prominent nucleoli, lack of maturation, and abundant amphophilic cytoplasm with a rare mitotic figure. These findings were suggestive of melanoma along with a nevoid dermal component and myxoid stroma. FISH testing revealed a homozygous loss of 9p21 in the atypical component. SNP-microarray from the nevoid component...
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Andrew S Kao Kayla St Claire Lisa M Bedford Darius R Mehregan Aleodor A Andea David Kouba Source Type: research

Initial panel of immunocytochemical markers for identification of primary carcinoma site for effusions and peritoneal washings from women
CONCLUSION: An initial panel of markers including GATA-3, PAX-8, and TTF-1 allows, with high sensitivity and specificity, the identification or exclusion of frequent primary sites of carcinoma in effusions from women. Our results highlight the importance of using a panel of markers to avoid misidentification of the primary site of tumor.PMID:35535203 | PMC:PMC9077109 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Gustavo Henrique Soares Takano Rivad ávio Fernandes Amorim V ânia Moraes Ferreira Leonora Maciel de Souza Vianna Tercia Maria Mendes Lousa de Castro Marcos de Vasconcelos Carneiro Ísis de Araújo Oliveira Andrea Barretto Motoyama Fabiana Pirani Carneir Source Type: research

A pyroptosis-related prognosis model to predict survival in colorectal cancer patients
Int J Clin Exp Pathol. 2022 Apr 15;15(4):168-182. eCollection 2022.ABSTRACTPyroptosis is a recently-identified pathway of host cell death that is stimulated by a range of microbial infections. Emerging evidence indicates pyroptosis plays crucial roles in tumor growth, disease progression, and migration of different cancer cells. However, the clinical significance of pyroptosis in tumor behavior prognosis, as well as the underlying mechanism in different cancers remains elusive. Here, by evaluating the expression level of pyroptosis genes in colorectal cancer (CRC) patients from the TCGA cohort and GEO cohort (GSE39582), we...
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Meiyan Chen Jingyi Zhang Xiaoyan Lin Xiaosan Zhu Tao Xie Source Type: research

Cancer stem-like cells contribute to paclitaxel resistance in esophageal squamous cell carcinoma
CONCLUSIONS: Cancer stem cell (CSC)-like cells exist among paclitaxel-resistant cells in ESCC and may play a role in ESCC drug resistance.PMID:35535205 | PMC:PMC9077107 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 10, 2022 Category: Pathology Authors: Yanru Shen Lihui Yang Lei Li Source Type: research