Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.
This study was done to screen differentially expressed circular RNAs (circRNAs) in human monocytes from patients with AF and healthy controls using microarray, and preliminarily explore the role of circRNAs in the development of AF. The expression of circRNAs in peripheral blood monocytes of 4 AF patients and 4 healthy donors was detected by chip technology and validated by qRT-PCR. Differentially expressed genes were screened out. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify the function of differentially expressed genes and related pathways. Potential connectio...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Ruan ZB, Wang F, Bao TT, Yu QP, Chen GC, Zhu L Tags: Int J Clin Exp Pathol Source Type: research

Knockdown of long non-coding RNA TTTY15 protects cardiomyocytes from hypoxia-induced injury by regulating let-7b/MAPK6 axis.
In conclusion, knockdown of TTTY15 suppressed hypoxia-induced cardiomyocyte injury through the let-7b/MAPK6 axis. PMID: 32922590 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Xie X, Ji Q, Han X, Zhang L, Li J Tags: Int J Clin Exp Pathol Source Type: research

Apoptosis and fibrosis of vascular smooth muscle cells in aortic dissection: an immunohistochemical study.
Abstract Aortic dissection (AD) is a fatal disease characterized by a ruptured intima that leads to the complete rupture of the aorta. The aim of this study is to examine the immunohistochemical expression of inflammation/fibrosis-associated chemical mediators in AD patients. Surgical specimens of aortic tissues were obtained from 37 patients who underwent an open thoracic aortic repair. AD was detected with histological staining. Local congestion and hemorrhage as well as chronic inflammatory cells infiltrations were observed at the dissection. Moreover, extensive disarrangement and disruption of elastic fibers w...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Lee JH, Kim J, Lee SJ, Kim YA, Maeng YI, Park KK Tags: Int J Clin Exp Pathol Source Type: research

Effect of diode laser biostimulation compared to Teriparatide on induced osteoporosis in rats: an animal study from Egypt.
Abstract Our aim in this study was to evaluate the effect of low-level laser therapy (LLLT) by means of diode laser bio-stimulation compared to Teriparatide in induced osteoporosis in rats. A total of 45 adult female Egyptian albino rats were used. Rats were divided into five groups: normal control, osteoporotic control, Teriparatide (TPTD) group (T), laser group (L), and laser and teriparatide (T+L) combination group. Osteoporosis was induced by performing double ovariectomy in rats. Lower jaws and left femurs were dissected. The specimens were tested using a Computed tomography unit, scanning EM (SEM) equipped w...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Hamza S, Fathy S, El-Azab S Tags: Int J Clin Exp Pathol Source Type: research

Resolvin D2 prevents inflammation and oxidative stress in the retina of streptozocin-induced diabetic mice.
In conclusion, RvD2 might be used as a retinal protective factor for diabetes mellitus by reducing inflammation and oxidative stress. PMID: 32922593 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Chen JP, Xu HY, Liao L, Zhang Z Tags: Int J Clin Exp Pathol Source Type: research

α-Syn oligomers incubated with Parkinson's disease plasma promote neuron damage.
α-Syn oligomers incubated with Parkinson's disease plasma promote neuron damage. Int J Clin Exp Pathol. 2020;13(8):1995-2008 Authors: Yang W, Li X, Yin N Abstract Alpha-Synuclein (α-Syn) aggregates represent the major component of Lewy bodies (LBs), a pathologic hallmark of Parkinson's disease (PD). Current reports have assessed the toxicity of oligomeric α-Syn (o-α-Syn) mostly in vitro after the incubation with PBS, which leaves o-α-Syn non-phosphorylated and does not reflect actual physiologic conditions in PD patients. The present study aimed to assess the pathogenic r...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Yang W, Li X, Yin N Tags: Int J Clin Exp Pathol Source Type: research

IFN γ and TNFα synergistically promote galectin 9 secretion by human osteosarcoma cells MG-63 to prevent T cell killing.
CONCLUSION: We found that Galectin-9 is induced by IFNγ and TNFα stimuli in osteosarcoma cells. Furthermore, Tim-3/Galectin-9 pathway contributes to the inducible immunomodulatory functions of osteosarcoma cells, which may provide a new clue to novel strategies for the osteosarcoma therapy. PMID: 32922595 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Liu Y, Luo J, Li Y, Cao J, Wang X Tags: Int J Clin Exp Pathol Source Type: research

DLEU2 participates in lymphovascular invasion and inhibits cervical cancer cell proliferation, migration, and invasion.
CONCLUSION: DLEU2 is involved in the pathology of cervical cancer, and it may be a target for clinical therapy. PMID: 32922596 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Zhang H, Wang X, Zhang Q, Ma Y, Wang Z Tags: Int J Clin Exp Pathol Source Type: research

Retaining antigenicity and DNA in the melanin bleaching of melanin-containing tissues.
In conclusion, bleaching by increasing the concentration is a simple method, and it satisfies the requirements of clinical pathology and molecular pathology for the diagnosis and differential diagnosis of melanin-containing tissues. PMID: 32922597 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Hu L, Gao Y, Ren C, Chen Y, Cai S, Xie B, Zhang S, Wang X Tags: Int J Clin Exp Pathol Source Type: research

Use of segmental colorectal lavage cytology during surveillance colonoscopy for detecting dysplastic and cancer cells in patients with ulcerative colitis.
CONCLUSIONS: Segmental CRLC is a less-invasive and effective method in detecting dysplastic and cancer cells in UC patients during surveillance colonoscopy. It could be used as a complementary method for colonoscopy-directed biopsy. PMID: 32922598 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Torii Y, Sano D, Ikeuchi H, Hida N, Hirota S Tags: Int J Clin Exp Pathol Source Type: research

Protective effects of ferroptosis inhibition on high fat diet-induced liver and renal injury in mice.
Abstract As a complex and highly prevalent global public health problem, obesity is associated with multiple diseases, including liver and renal injury. As an iron-dependent form of cell death, ferroptosis is different from apoptosis and necrosis, which has been reported to participate in pathologic processes of many diseases. However, whether ferroptosis is involved in obesity-induced liver and renal injury remains unclear. Male C57BL/6 mice were fed with high-fat diet (HFD) or control diet for 16 weeks and treated with 5 mg/kg or 10 mg/kg ferroptosis inhibitor, ferrostatin-1 (Fer-1), for the last 8 weeks with re...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Luo Y, Chen H, Liu H, Jia W, Yan J, Ding W, Zhang Y, Xiao Z, Zhu Z Tags: Int J Clin Exp Pathol Source Type: research

The clinicopathological features of parotid lymphoma.
This study aimed to retrospectively evaluate the clinicopathological characteristics of patients diagnosed with non-Hodgkin lymphoma of the parotid gland. This study included 31 patients diagnosed with lymphoma of the parotid gland. Data on the pathological subtypes, the WHO classifications of the hematopoietic and lymphoid tissues, and the Ann Arbor staging, treatment modalities, and survival times were collected and analyzed. Among the 31 patients, there were 18 cases of extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT), 7 cases of diffuse large B-cell lymphoma (DLBCL), and 6 cases ...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Wang J, Li R, Wang Q, Chen Y, Gao T, Han R, Li N, Zhang K Tags: Int J Clin Exp Pathol Source Type: research

Correlations of SDF-1 and CXCR4 levels with caspase-3 expression in the retina of rats after optic nerve injury.
This study explores the correlations of stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) levels with caspase-3 expression in the retina of rats after optic nerve injury. MATERIALS AND METHODS: A total of 24 adult healthy specific pathogen-free Sprague-Dawley rats were selected and randomly divided into an optic nerve injury group (n=16) and an optic nerve sham-injury group (n=8). The optic nerve injury group was further sub-divided into a 3 d group (n=8) and a 7 d group (n=8) after their injuries. In the optic nerve injury group, the left eye of each rat was removed and prepared for the optic...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Zhang X, Liao Y, Ye T Tags: Int J Clin Exp Pathol Source Type: research

Relationship between M235T and T174M polymorphisms in angiotensin gene and atrial fibrillation in Uyghur and Han populations of Xinjiang, China.
Abstract OBJECTIVE: To elucidate the association between angiotensin gene (AGT) M235T and T174M genetic polymorphisms in Han and Uyghur patients with atrial fibrillation (AF) in Xinjiang, China. METHODS: 100 cases of patients with AF of Han and 100 cases of patients with AF of Uyghur were selected as the experimental group, and 100 cases of patients with non-AF of Uyghur and non-AF of Han were selected as the control group. We amplified the AGT M235T site and AGT T174M site by PCR in 4 groups of patients, verified the polymorphism of the sites by gene sequencing, and compared their differences in each group. ...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Kuken B, Yang Y, Liu Z, He P, Wulasihan M Tags: Int J Clin Exp Pathol Source Type: research

Electronic cigarettes promotes the lung colonization of human breast cancer in NOD-SCID-Gamma mice.
Abstract Electronic cigarettes (E-cigs) smoking or vaping is an emerging problem to public health due to its popularity. While its multi-faceted detrimental effects on human health are being reported, no current study addresses the effect of E-cigs on tumor metastasis, the main cause of tumor mortality. Using a well-established human breast cancer cell line MDA MB-231, we first showed that E-cig vapor extract (nicotine 24 mg/ml, propylene glycol 50%, vegetable glycerin 50%, no flavorings) significantly enhanced tumor cell migration (P0.05). To evaluate the metastasis-promoting effect of E-cigs in vivo, we used NOD...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Huynh D, Huang J, Le LTT, Liu D, Liu C, Pham K, Wang H Tags: Int J Clin Exp Pathol Source Type: research

Circulating miR-134 is a potential biomarker for diagnosis and monitoring of major depressive disorder.
Abstract AIM: to investigate the diagnostic value of circulating miR-134 in major depressive disorder (MDD). Plasma miR-134 levels were determined in patients with MDD, bipolar disorder (BD), and schizophrenia (SCZ), as well as in healthy controls using quantitative real-time PCR. The diagnostic value of circulating miR-134 was assessed using receiver-operator characteristic (ROC) curve analysis. A chronic unpredictable mild stress (CUMS) rat model was established to evaluate the miR-134 expression pattern in serum and diseased brain tissues. Plasma miR-134 levels in MDD patients were significantly lower than thos...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Chen X, Liu X, Zuo X, Cheng C, Huang W, Xie P Tags: Int J Clin Exp Pathol Source Type: research

Down-regulation of FOS-like antigen 1 enhances drug sensitivity in breast cancer.
This study investigates the relationship between FOSL1 and chemotherapy sensitivity of breast cancer and its molecular mechanism. METHODS: Doxorubicin-resistant MCF-7/ADR breast cancer cells were transfected with NC (control) or FOSL1 siRNA and assayed for cell viability and relative colony number by MTT assay and colony formation, respectively. The expression level of FOSL1 was detected by immunohistochemistry (IHC). The relationship between FOSL1 and chemotherapy sensitivity was analyzed by a one-way of variance analysis and Pearson's chi-square test among a total of 50 patients with stage II and III breast cancer b...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Duan L, Zhao M, Ang L, Hu H, Wu Z, Wang J, Huang J, Zheng L, Dong W Tags: Int J Clin Exp Pathol Source Type: research

SKA1 expression in oral squamous cell carcinoma and its relationship to P53 and clinicopathologic features.
In this study, 57 paraffin-embedded tissue specimens from patients with oral squamous cell carcinoma (OSCC) were collected and analyzed. Spindle and kinetochore-associated complex subunit 1 (SKA1) and P53 protein expression in selected samples was detected by immunohistochemistry. The positive expression rate of SKA1 and P53 was significantly higher in oral squamous cell carcinoma tissues than in normal controls. The expression of SKA1 protein was significantly associated with tumor-node-metastasis (TNM) stage, and p53 expression was significantly correlated with pathologic differentiation grade in oral squamous cell carci...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Zhao L, Zhang B, Li K, Sun P Tags: Int J Clin Exp Pathol Source Type: research

A DNA quantitative analysis of lung cancer cells with different pathological types from bronchial brush specimens and its clinical significance.
CONCLUSION: The reason why the DNA content of small-cell lung cancer is lower than SC and AC remains to be further studied. PMID: 32922607 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Du Y, Guo X, Liu Y, Wang R, Wu J, Ji X, Ma Y, Dong L Tags: Int J Clin Exp Pathol Source Type: research

Expression of CD117, CD34, and VEGF proteins in progression from endometrial hyperplasia to endometrioid carcinoma.
CONCLUSION: Our data suggests a role for CD117, CD34, and VEGF in progression from hyperplasia to carcinoma. PMID: 32922608 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Hassan WA, Ibrahim R Tags: Int J Clin Exp Pathol Source Type: research

Patients with benign prostatic hyperplasia show shorter leukocyte telomere length but no association with telomerase gene polymorphisms in Han Chinese males.
Abstract OBJECTIVE: Benign prostatic hyperplasia (BPH) is an age-related disease, occurring in>70% of men of age>60. Because telomeres and telomerase play a key role in aging and age-related diseases, and certain telomerase gene single nucleotide polymorphisms (SNPs) are shown to be associated with the susceptibility to age-related diseases, we wanted to determine the relationship between BPH and leukocyte telomere length (LTL) and telomere length-related single nucleotide polymorphisms (SNPs) of the telomerase holoenzyme genes. METHODS: Peripheral blood was collected from both BPH patients and age-matc...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Cheng G, Dai M, Xin Q, Wang L, Kong F, Xu D Tags: Int J Clin Exp Pathol Source Type: research

The association of PD-L1 gene polymorphisms with non-small-cell lung cancer susceptibility and clinical outcomes in a Chinese population.
CONCLUSIONS: PD-L1 rs7866740 C>G may play a role in the pathogenesis of NSCLC. PD-L1 rs2890658 C>A and rs822336 G>C are related to the prognoses of patients receiving platinum-based chemotherapy. PMID: 32922610 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Zhao X, Peng Y, Li X, Zhang S, Peng Y, Shan J, Li M, Dai N, Feng Y, Xu C, Wang D Tags: Int J Clin Exp Pathol Source Type: research

A novel homozygous variant in CANT1 causes Desbuquois dysplasia type 1 in a Chinese family and review of literatures.
Abstract Desbuquois dysplasia (DBQD) is a severe chondrodysplasia characterized by short stature, retarded development, multiple joint dislocations, and a distinct radiological appearance of the proximal femur. Pathogenic variants in the calcium-activated nucleotidase 1 (CANT1) or xylosyltransferase 1 (XYLT1) gene have been previously reported to cause DBQD. Here we present a 12-year-old boy manifesting the typical features of DBQD type 1 caused by a homozygous intronic variant c.836-9G>A of CANT1. To our knowledge, this is the first DBQD case described in China revealing that a CANT1 variant was also responsib...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Kuang L, Liu B, Peng R, Xi D, Gao Y Tags: Int J Clin Exp Pathol Source Type: research

Proximal-type epithelioid sarcoma in the maxillary sinus: an unusual presentation.
Abstract Epithelioid sarcoma (ES) is a rare histological type of soft tissue sarcoma presenting as a subcutaneous or deep dermal mass in the distal extremities of young adults. Recently, a more aggressive, so called 'proximal-type' ES has been described. The literature is limited on the clinical features and management of ES originating in the head and neck area. We here report a case of 16-year-old female who initially presented with progressive swelling and pain in the left cheek. On physical and radiographic examination, a malignant neoplasm was found in the left maxillary sinus with bony invasion. The definite...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Gao W, Xue J, Ma C, Hu J Tags: Int J Clin Exp Pathol Source Type: research

Pilomatrix carcinoma of the male breast: a case report.
Abstract Pilomatrix carcinoma (PC) is a rare skin adnexal neoplasm derived from piliferous follicles, usually occurring in the head and neck region. An optimal treatment for PC has not yet been established, while surgery with wide margins is recommended, with radiation therapy (RT) and chemotherapy improving the curative effect. Location of this tumor in the breast is exceedingly rare, especially for a male. We now report an unusual case of a 53-year-old male who presented with 2 palpable masses in the right breast, which had been removed surgically about 4 and a half years prior, but recurred after 7 months. Ultr...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Weng G, Li F, Xu M Tags: Int J Clin Exp Pathol Source Type: research

Gardner syndrome with a giant mass in the thoracic cavity: a case report and analysis of the related complications.
Abstract Gardner syndrome (GS) is a form of familial adenomatous polyposis (FAP) and is characterized by colonic polyposis, osteomas, and soft-tissue tumors. Desmoid tumors (DT) are lesions of mesenchymal origin and are an extra-colonic manifestation of GS. Gardner-associated fibroma (GAF) is considered to be a benign soft-tissue lesion related to DT and FAP. Here we present a case of an 18-year-old female patient with a huge lump in her right thoracic cavity and another lump located in her left lumbar muscles who was diagnosed with GS through a colonoscopy and through adenomatous polyposis coli (APC) gene mutatio...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Yang D, Zeng X, Lv Y, Liao W, Tang S, Jiang J Tags: Int J Clin Exp Pathol Source Type: research

Fallopian tube lipoleiomyoma with degeneration: a case report and literature review.
Abstract Lipoleiomyoma is a rare, benign leiomyoma variant. It is relatively common in the uterine area of the female reproductive system but rare in other areas and has not been reported in the fallopian tubes. In this paper, we report a perimenopausal woman with a lipoleiomyoma arising from the ampulla of the fallopian tube with hydropic degeneration. What makes this case even rarer is the combination of hydrops of the pelvis and the abdominal cavity. Microscopically, the tumor was composed of smooth muscle tissue mixed with varying amounts of mature adipose tissue. The immunohistochemical markers were Des(+), S...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Sun D, Yang P, Liu Y, Yu G Tags: Int J Clin Exp Pathol Source Type: research

Pulmonary crystal-storing histiocytosis: a case report and literature review.
Abstract Crystal-storing histiocytosis is a rare non-neoplastic histiocytic proliferation disorder which can occur in many anatomic sites. Fewer than 20 cases of pulmonary crystal-storing histiocytosis have been reported, most of which were associated with clonal lymphoproliferative disorder. Herein we report the first case of pulmonary crystal-storing histiocytosis with underlying Sjögren syndrome. PMID: 32922616 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Wu PS Tags: Int J Clin Exp Pathol Source Type: research

Secondary NK/T cell lymphoma after radiotherapy for non-HPV-related squamous cell carcinoma of the penis: an early warning event and literature review.
Abstract Squamous cell carcinoma is the most common malignant tumor of the penis. The new World Health Organization (WHO) classifies it into two types: non-HPV-related and HPV-related. There is a certain proportion of recurrence and metastasis after the first operation on the tumor. Radiotherapy is one of the effective methods to improve prognosis, but there is a risk of secondary primary malignant tumor. Primary NK/T cell lymphoma of the penis is rare, and secondary primary NK/T cell lymphoma of penile stump after radiotherapy for penile cancer has not been reported. Here we report a case of a 75-year-old man who...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Sun D, Yang P, Zhang L, Jiang L, Yu G Tags: Int J Clin Exp Pathol Source Type: research

Primary pulmonary lymphoma manifesting as diffuse ground glass opacities: a case report and literature review.
Abstract Primary pulmonary lymphoma is a rare clinical neoplasm, and its atypical manifestation frequently leads to misdiagnosis. Here, we have reported a rare case of a 55-year-old man who presented with cough, dizziness, and fatigue. His chest computed tomography (CT) revealed diffuse ground glass pulmonary opacities. Bronchoscope lavage demonstrated lymphocyte predominance, while transbronchial biopsy indicated chronic inflammation. The administration of a broad-spectrum antibiotic regime supplemented with a high dosage of methylprednisolone was ineffective in improving the general condition of the patient, and...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Dong N, Jin Y, Li Y, Ye J Tags: Int J Clin Exp Pathol Source Type: research

The coexistence of invasive stratified mucin-producing carcinoma, mucinous carcinoma and non-specific type and squamous cell carcinoma of the uterine cervix: a case report.
Abstract Located in the uterine cervix, cervical invasive stratified mucin-producing carcinoma (i-SMILE) is a rare, recently-identified tumor about which little is known. In extremely rare cases, other kinds of invasive carcinoma can accompany i-SMILE, such as squamous cell carcinoma (SCC) and adenocarcinoma, with different proportions. Here, we report a case of cervical carcinoma coexisting with i-SMILE, mucinous carcinoma, non-specific type (NOS), and SCC. We review the pathological diagnosis and describe the clinical pathological characteristics. PMID: 32922619 [PubMed] (Source: International Journal of Cl...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Zhao X, Qin Y, Shen X, Zhang G Tags: Int J Clin Exp Pathol Source Type: research

High risk HPV detection by RNAscope in situ hybridization combined with Cdc2 protein expression by immunohistochemistry for prognosis of oropharyngeal squamous cell carcinoma.
In this study, high risk HPV, the expression of P53, P21, and Cdc2 in OPSCC tissues was detected and the prognostic factors and clinical value of OPSCC were discussed. According to the WHO classification and diagnosis standard for head and neck tumors (2017 Edition), 49 OPSCC cases with complete clinical data were collected from Tangshan Head and Neck Disease Pathology Research Base from January 1, 2012 to December 31, 2018. The E6 and E7 mRNA of HPV 16 and HPV 18 were detected by RNAscope in situ hybridization. The expression of P53, P21, and Cdc2 protein was observed by SP immunohistochemical method and all cases were fo...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Yang JQ, Wu M, Han FY, Sun YM, Zhang L, Liu HX Tags: Int J Clin Exp Pathol Source Type: research

EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.
In this study, we searched possible targets of miR-200a in these subsets by IHC analyses focusing on the expression of known target proteins of miR-200a: beta-catenin, EphA2, ZEB1, PTEN, and YAP-1, as well as E-cadherin, the expression of which is suppressed by ZEB1. Among those 6 proteins, when all 38 cases of surgically resected specimens were analyzed as a whole, IHC score of ZEB1 was inversely (ρ=-.417) and E-cadherin was positively (ρ=.345) correlated with miR-200a expression. However, only EphA2 was inversely correlated with the expression of miR-200a in adenocarcinoma (ρ=-.496) and in pStage I/II group (...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Tsubochi H, Minegishi K, Goto A, Nakamura R, Matsubara D, Dobashi Y Tags: Int J Clin Exp Pathol Source Type: research

Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst.
Abstract Secretory carcinoma (SC) of the salivary gland was identified in 2010, and it is characterized by a specific ETV6 gene arrangement. The most common primary site for SC is the parotid gland; however, SC around the Stensen's duct is rare. Here we describe a rare case of a SC around the Stensen's duct that was initially misdiagnosed as a salivary duct cyst. A 59-year-old woman presented with a mass in the region of the left parotid papilla. Magnetic resonance imaging (MRI) revealed a well-circumscribed lesion and enhancement with a rim and an inner wall-like part that appeared in the late phase. Based on the...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Shibata E, Morita KI, Kayamori K, Maruiwa M, Michi Y, Sato Y, Takeuchi K, Ikeda T, Harada H, Yoda T Tags: Int J Clin Exp Pathol Source Type: research

Sudden death in lambda light chain AL cardiac amyloidosis: a review of literature and update for clinicians and pathologists.
Abstract Light chain (AL) amyloidosis is the most common type of systemic amyloidosis, affecting around 10 people per million per year. In Europe, approximately 5000 new diagnosis per year are reported. Deposition of amyloid fibrils derived from antibody light chains are key pathogenic agents in AL amyloidosis. They can be deposited in multiple organs but cardiac involvement carries a major risk of mortality. The prognosis is poor in cases associated with multiple myeloma. The average survival is around 1 year. Up to half of all patients with cardiac amyloidosis die suddenly; 75% ofthose deaths are due to heart fa...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: D'Errico S, Mazzanti A, Baldari B, Maiese A, Frati P, Fineschi V Tags: Int J Clin Exp Pathol Source Type: research

HIF-1 α suppresses myeloma progression by targeting Mcl-1.
HIF-1α suppresses myeloma progression by targeting Mcl-1. Int J Clin Exp Pathol. 2020;13(7):1483-1491 Authors: Wu F, Tong DD, Ni L, Wang LM, Wang MC Abstract HIF-1α is involved in the carcinogenesis and progression of multiple types of cancer. However, the precise role of HIF-1α is unclear in multiple myeloma. Through the qRT-PCR and CCK-8 assays, we demonstrated that silencing the expression of HIF-1α and Mcl-1, MM proliferation can be decreased and apoptosis can be induced. Next, using the GEO database, we found that Mcl-1 was increased in MMs. Mcl-1 overexpression counterbal...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Wu F, Tong DD, Ni L, Wang LM, Wang MC Tags: Int J Clin Exp Pathol Source Type: research

The combined application of rat bone marrow mesenchymal stem cells and bioceramic materials in the regeneration of dental pulp-like tissues.
This study aims to observe the effects of the combined application of rat bone marrow mesenchymal stem cells (rBMSCs) and a bioceramic material on pulp-like tissue formation. Rat incisor root fragments without pulp tissues were prepared and filled with a collagen scaffold seeded with rBMSCs, while one side of the root segment was covered by a bioceramic material (iRoot BP). After they were cultured for 12 hours, the root fragments were implanted subcutaneously for 3 months. Hematoxylin and eosin (HE) staining was applied to observe the biocompatibility and the formation of pulp-like tissues. The incisor root fragments were...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Wen R, Wang X, Lu Y, Du Y, Yu X Tags: Int J Clin Exp Pathol Source Type: research

Fraxetin inhibits the proliferation of RL95-2 cells through regulation of metabolism.
CONCLUSION: Fraxetin can inhibit the proliferation of RL95-2 cells, promote apoptosis, inhibit mitochondrial oxidation of endometrial cancer cells, promote anaerobic metabolism of cells, and exert an inhibitory effect on endometrial cancer cells by inhibiting mitochondria. PMID: 32782668 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Xu H, Zhang J, Wang Q, Li Y, Zhang B Tags: Int J Clin Exp Pathol Source Type: research

Oxysophocarpine reduces oxidative stress and inflammation in tuberculosis-infected neutrophils and mouse lungs.
g T Abstract Tuberculosis (TB) is a chronic inflammatory infectious disease caused by Mycobacterium tuberculosis (Mtb), which induces irreversible pulmonary damage. Oxysophocarpine (OSC) is a natural alkaloid that exhibits multiple pharmacological activities, including anti-inflammation; however, the protective effects of OSC against TB and the mechanisms involved are unknown. Here, we established murine and cellular models of TB with C3HeB/FeJ mice and neutrophils infected with H37Rv to investigate the biological functions of OSC in TB. We found that OSC reduced the mortality, inhibited the pulmonary H37Rv growth...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Yang D, Chen F, Gu Z, Lü L, Ding G, Peng Z, Shang J, Zhang T Tags: Int J Clin Exp Pathol Source Type: research

MiR-194 promotes hepatocellular carcinoma through negative regulation of CADM1.
Abstract Aberrant expression of microRNAs may contribute to the initiation and progression of various types of human cancer and they may also constitute biomarkers for cancer diagnosis and treatment. However, the specific function of miR-194 in hepatocellular carcinoma (HCC), and the potential mechanism of its involvement in HCC were unclear. In the present study, we found that miR-194 inhibited CADM1 protein level expression by inhibiting mRNA translation of CADM1; the expression of CADM1 was low in liver cancer cells and tumor tissues, and the high expression of miR-194 was closely related to HCC. MiR-194 promot...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Niu X, Nong S, Gong J, Zhang X, Tang H, Zhou T, Li W Tags: Int J Clin Exp Pathol Source Type: research

Clinicopathologic features and prognosis of epithelioid glioblastoma.
CONCLUSION: E-GBM is a highly invasive and rare malignant nervous system tumor, with poor prognosis and lack of clinical specificity. Immunohistochemically, the higher expression of CK, GFAP and Ki67 proliferation index is more conducive to the diagnosis and differential diagnosis of E-GBM. Smoking, brain MR showing tumor invasion of cortex, TERT mutation, radiotherapy, and chemotherapy are independent risk factors affecting the prognosis (survival time) of patients. PMID: 32782671 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Wang S, He Q, Zhang Q, Guan B, Zhou X Tags: Int J Clin Exp Pathol Source Type: research

Efficacy of interleukin-6 in the induction of liver cell proliferation after hemi-hepatectomy: histopathologic and immunohistochemical study.
CONCLUSION: IL-6 is valuable in the induction of liver cell regeneration. Correlation with biochemical assay and flow cytometric studies is recommended. PMID: 32782672 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Al-Ghamdi TH, Atta IS Tags: Int J Clin Exp Pathol Source Type: research

ER- α36 mediates gastric cancer cell invasion.
ER-α36 mediates gastric cancer cell invasion. Int J Clin Exp Pathol. 2020;13(7):1550-1559 Authors: Wang X, Yuan C, Jin Y, Huang H, Sheng X, Wei W, Huang X, Li L, Lv K, Qiu Z, Liu L, Wang Z, Zeng S Abstract Estrogen evidently exerts a protective role against gastric cancer. Accordingly, we evaluated the relationship between the expression of the estrogen receptor ER-α36 and the clinicopathologic features in gastric cancer. ER-α36 expression levels differed among the tumor center, invasion front, and vascular metastases. The effects of E2β (17β-Estradiol, E2β) on invasio...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Wang X, Yuan C, Jin Y, Huang H, Sheng X, Wei W, Huang X, Li L, Lv K, Qiu Z, Liu L, Wang Z, Zeng S Tags: Int J Clin Exp Pathol Source Type: research

Expression of TAZ, YAP, and β-catenin in cervical squamous cell carcinoma and their clinical significance.
Expression of TAZ, YAP, and β-catenin in cervical squamous cell carcinoma and their clinical significance. Int J Clin Exp Pathol. 2020;13(7):1560-1568 Authors: Zhang QS, Li YH, Wang BB, Ma SS Abstract YAP/TAZ and β-catenin are important effectors in the Hippo and Wnt signaling pathways, respectively, which are involved in the development of human tumors. Using immunohistochemistry, the expression levels of the three proteins were determined in 151 cervical tissue samples (including 28 normal cervical, 31 cervical intraepithelial neoplasia, and 92 cervical squamous cell carcinoma [CSC] tissue...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Zhang QS, Li YH, Wang BB, Ma SS Tags: Int J Clin Exp Pathol Source Type: research

Endoplasmic reticulum stress mediates cortical neuron apoptosis after experimental subarachnoid hemorrhage in rats.
CONCLUSION: Our study clearly demonstrated that ER stress mediates cortical neuron apoptosis after experimental subarachnoid hemorrhage in rats. PMID: 32782675 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Tian XS, Xu H, He XJ, Li Y, He B, Zhao D Tags: Int J Clin Exp Pathol Source Type: research

A genome-wide analysis reveals the MeCP2-dependent regulation of genes in BGC-823 cells.
This study aimed to evaluate the effect of MeCP2 on the global gene expression profile of human gastric adenocarcinoma to determine the potential molecular mechanism of MeCP2. To identify the gene targets of MeCP2 in gastric cancer cells, we combined the expression microarray and chromatin immunoprecipitation approaches of MeCP2, followed by sequencing (ChIP-seq) to define the MeCP2-binding sites across the whole genome. The methylation levels of the promoters in BGC-823 cells were downloaded from the National Center for Biotechnology Information Gene Expression Omnibus database (GSM1093053). A total of 5,684 ChIP-enriched...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Liu YX, Li LY, Diao ZJ, He YM, Chen Y, Hou N, Zhao LY, Huang C Tags: Int J Clin Exp Pathol Source Type: research

Early diagnostic and prognostic value of serum exosomal miR-1246 in non-small cell lung cancer.
In conclusion, serum exosomal miR-1246 might be a useful diagnostic and prognostic biomarker for NSCLC. PMID: 32782678 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Huang D, Qu D Tags: Int J Clin Exp Pathol Source Type: research

Prognostic values of CEA, CA19-9, and CA72-4 in patients with stages I-III colorectal cancer.
Abstract OBJECTIVE: The purpose of this study was to explore the relationship between the levels of three tumor markers (TMs), carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, and CA72-4, and the prognoses of colorectal cancer patients. METHODS: From January 2012 to December 2015, 101 patients with stages I-III colorectal cancer treated in the general surgery department of Nanfang Hospital, Southern Medical University were included in this retrospective study. The patients' blood was collected at different time points to determine their biochemical index values. The CA19-9 and CEA levels were m...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Wu T, Mo Y, Wu C Tags: Int J Clin Exp Pathol Source Type: research

Patterns of metastases in cervical cancer: a population-based study.
CONCLUSIONS: This large-population based study showed that the most common metastatic site of cervical cancer is lung. Although lung metastatic patients harbor older ages and poorer differentiation and higher stage tumors than other sites, the prognosis of lung metastasis is similar to other single metastatic sites. However, the single-site metastatic patients survive longer than multi-site metastatic patients. Surgery, radiotherapy, and chemotherapy all bring benefit to patients with metastases, which may guide the treatment in metastatic cervical cancers. PMID: 32782680 [PubMed] (Source: International Journal of Cli...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Zhou S, Peng F Tags: Int J Clin Exp Pathol Source Type: research

Prostaglandin E1 prevents histopathological changes improving renal function in experimental nephropathy induced by renal microembolism.
This study investigated the effect of prostaglandin E1 (PGE-1) treatment on the biochemical and histopathological changes in a model of nephropathy that was induced using renal microembolism in rats. Wistar rats were assigned to three groups: a control group (C, normal), a renal microembolism (RM) group, and a renal microembolism treated with PGE-1 (RM + PGE-1) group. The renal microembolism was induced by an arterial injection of polymethylmethacrylate microbeads into the remaining kidney of nephrectomized rats. Intramuscular treatment with PGE-1 was initiated on the day of the induction of the renal microembolism and con...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2020 Category: Pathology Authors: Bersani-Amado LE, da Rocha BA, Schneider LCL, Ames FQ, do Nascimento MP, Bersani-Amado CA, Cuman RKN Tags: Int J Clin Exp Pathol Source Type: research