Long noncoding RNA NORAD regulates lung cancer cell proliferation, apoptosis, migration, and invasion by the miR-30a-5p/ADAM19 axis.
CONCLUSION: NORAD knockdown suppressed cell proliferation, migration and invasion but promoted cell apoptosis in lung cancer cells by regulating miR-30a-5p/ADAM19, providing a possible therapeutic strategy for lung cancer patients. PMID: 32055266 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Li J, Xu X, Wei C, Liu L, Wang T Tags: Int J Clin Exp Pathol Source Type: research

Clinical significance of RAD51C and its contribution to ovarian carcinogenesis.
Abstract AIM: The underlying mechanisms of chemoresistance-induced recurrence of ovarian carcinoma are largely unknown. The purpose of this study was to investigate the clinical significance of RAD51C and its role in ovarian tumorigenesis and progression. METHODS: 60 cases of ovarian epithelial tumors (30 benign and 30 malignant tumors, respectively) were enrolled from 2014 to 2016. Immunohistochemistry was used to evaluate RAD51C expression in tumor tissues, and RT-PCR was employed to test RAD51C mRNA levels in SKOV3, A2780, and CAOV3 cell lines. Targeted knockdown of RAD51C was achieved with siRNA to explor...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Lu XL, Liu SS, Xiong ZF, Wang F, Li XY, Deng H Tags: Int J Clin Exp Pathol Source Type: research

Lymphadenopathy in POEMS syndrome: a correlation between clinical features and imaging findings.
This study aimed to analyse the features of lymphadenopathy and estimate the role of imaging methods, including computed tomography (CT) and positron emission tomography-CT (PET/CT), in the diagnosis of lymphadenopathy in patients with POEMS syndrome. We conducted a retrospective analysis of 23 patients with confirmed POEMS syndrome. All of the patients received chest and abdominal CT scan and/or superficial ultrasound examinations. Four patients underwent PET/CT examinations, and 6 patients received lymph node biopsies. Enlarged lymph nodes (short diameter ≥ 1 cm) were found in 48% (11/23) of patients, but only 1 patie...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Shi XF, Hu SD, Wu LL, Chen XY, Wu JN, Yu XQ, Li DY, Chen M, Liu YC, Zhu Y, Xi XD Tags: Int J Clin Exp Pathol Source Type: research

Potential value of V-domain Ig suppressor of T-cell activation for assessing progn osis in cervical cancer and as a target for therapy.
Abstract V-domain Ig suppressor of T-cell activation (VISTA), which belongs to the B7 family and is expressed predominantly on hematopoetic cells, myeloid, granulocytic and T cells, can suppresses T-cell activation in vivo and vitro. The blockade of VISTA has displayed brilliant results in certain murine tumor models. But to date, little is known about the expression and impact of VISTA in human cervical cancer (CC). To fill this gap of information, we systemically investigated the expression of VISTA on tumor cells, intratumoral immune cells (ICs) and vascular endothelial cells (VECs) in a group of patients with ...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Kuang L, He Y Tags: Int J Clin Exp Pathol Source Type: research

Superficial CD34-positive fibroblastic tumor: report of two cases and review of literature.
CONCLUSIONS: SCPFT is a rare low-grade fibroblastic tumor that has typical morphologic features and unique biologic behavior. Familiarity with clinicopathologic characteristics of the tumor contributes to the differential diagnosis of similar tumors. PMID: 32055270 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Mao X, Sun YY, Deng ML, Ma T, Yu L Tags: Int J Clin Exp Pathol Source Type: research

Rapid intraoperative immunocytochemistry of central nervous system tumors.
In this study, we chose Cytokeratin-pan, GFAP, and LCA as three immunohistochemical indicators. Intraoperative IHC was done by Novodiax ihcDirect technology combined with Leica Bond auto-staining. Compared with the manual method recommended for the reagents (Novodiax ihcDirect), the results show that auto-staining has better stability and high reproducibility in coloration, which has broad prospects for future application. PMID: 32055271 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Zhang X, Liu J, Yan X Tags: Int J Clin Exp Pathol Source Type: research

A ruptured jejunal gastrointestinal stromal tumor with hemoperitoneum mimicking ovarian carcinoma.
CONCLUSION: The authors report an unusual case of ruptured jejunal GIST with hemoperitoneum mimicking ovarian carcinoma. Therefore, GIST, in addition to ovarian cancer, should be considered in patients with an increased serum level of CA-125 and an abdominopelvic mass. PMID: 32055272 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Hwang SY, Choi CI, Cho HJ, Kim DH, Hong SB, Choi KU, Suh DS Tags: Int J Clin Exp Pathol Source Type: research

Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible.
Abstract Although the mouse tail model of secondary lymphedema has been widely used in research, our knowledge regarding some of the characteristic changes in this model is lacking. Therefore, in the current study, we aimed to identify pathologic changes after surgery. Tail lymphedema was created in C57BL/6J mice by disconnecting both superficial and deep lymphatic vessels. The surgery resulted in chronic edema formation with the proliferation of subcutaneous adipose tissue, deposition of fibrotic tissue, and gradual increase in CD4+ T lymphocyte infiltration. Furthermore, dramatic expansion and an increased numbe...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Zhou C, Su W, Han H, Li N, Ma G, Cui L Tags: Int J Clin Exp Pathol Source Type: research

Co-expression of HIF-1 and TLR3 is associated with poor prognosis in oral squamous cell carcinoma.
This study investigates the prognostic impact of the expression of hypoxia inducible factor (HIF)-1α and Toll-like receptor (TLR) 3 detected by immunohistochemistry in oral squamous cell carcinoma (OSCC). The study also evaluates the treatment outcome by inhibition of the HIF-1α and TLR 3 pathway (nuclear factor [NF]-κB) in an OSCC transplantation model in nude mice. Statistical analysis of immunohistochemical results with clinical findings that included overall survival outcomes was performed for 90 OSCC patients. Forty nude mice were divided into four groups (control; inhibition of HIF-1α; inhibit...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Han S, Yin X, Wang Y, Xu W, Cheng W Tags: Int J Clin Exp Pathol Source Type: research

Discordant lymphoma consisting of mantle cell lymphoma and angioimmunoblastic T cell lymphoma: homology or heterogeneity?
CONCLUSIONS: This is the first report on discordant lymphoma consisting of mantle cell lymphoma and angioimmunoblastic T cell lymphoma. There seems to be no relation these two different kinds of lymphoma, and EBV infection might prompt the development of angioimmunoblastic T cell lymphoma after transplantation. Rash is a common clinical manifestation when T cell lymphoma develops after treatment for MCL. PMID: 32055275 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Li Q, Jiang L, Wu S, Wang Y, Wang X, Yu G Tags: Int J Clin Exp Pathol Source Type: research

Effect of antenatal tetramethylpyrazine on lung development and YAP expression in rat model of experimental congenital diaphragmatic hernia.
Abstract The aim of this study was to investigate the therapeutic effects and underlying mechanism of tetramethylpyrazine (TMP) on lung development using a rat model of congenital diaphragmatic hernia (CDH). Nitrofen was used to induce CDH. Pregnant rats were divided into three groups: control, CDH, and CDH+TMP. In the CDH and CDH+TMP, fetuses only with left diaphragmatic hernias were chosen for analysis. Lung and body weight were recorded and lung histologic evaluations, image analysis, and western blot analysis of YAP, p-YAP and LATS1 were performed after lung processing. A markedly abnormal structure was observ...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Liao J, Liu W, Zhang L, Li Q, Hou F, Zou P Tags: Int J Clin Exp Pathol Source Type: research

MicroRNA-21 and microRNA-155 promote the progression of Burkitt's lymphoma by the PI3K/AKT signaling pathway.
CONCLUSION: miR-21 and miR-155 promote the progression of Burkitt's lymphoma through PI3K/AKT signaling by targeting C1RL and TCAP. Our findings will provide a novel biomarker and therapeutic strategies for Burkitt's lymphoma. PMID: 32055277 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Han B, Wang S, Zhao H Tags: Int J Clin Exp Pathol Source Type: research

Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia.
Abstract The study aimed to investigate the effect of eukaryotic translation initiation factor 3 subunit B (EIF3B) on cell proliferation, migration, and apoptosis as well as the underlying mechanism in acute myeloid leukemia (AML). EIF3B expression was detected in AML-193, HL-60, OCI-AML2, and KG-1 cell lines and human primary bone marrow mononuclear cells (BMMC). EIF3B knockdown was realized by transfecting EIF3B ShRNA plasmids, and EIF3B knockdown and WNT2 overexpression were established by transfecting EIF3B ShRNA plasmids and WNT2 overexpression plasmids into KG-1 cells. The effect of EIF3B knockdown, and EIF3...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Feng Y, Wu L Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +558 new citations
558 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 25, 2020 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +558 new citations
558 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 24, 2020 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +422 new citations
422 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/18PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 18, 2020 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +504 new citations
504 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 15, 2020 Category: Pathology Tags: Report Source Type: research

Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system [Retraction].
Authors: Abstract [This retracts the article on p. 14493 in vol. 8, PMID: 26823768.]. PMID: 29874340 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 7, 2018 Category: Pathology Tags: Int J Clin Exp Pathol Source Type: research

Inhibitory effect of chloroquine derivatives on presenilin 1 and ubiquilin 1 expression in Alzheimer's disease [Retraction].
Authors: Abstract [This retracts the article on p. 7640 in vol. 8, PMID: 26261684.]. PMID: 29874341 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 7, 2018 Category: Pathology Tags: Int J Clin Exp Pathol Source Type: research

Primary parotid adenocarcinoma metastasis to the spleen with PIK3CA mutation: cytological findings and review of the literature.
Conclusion: Based on our review of the literature, we believe that this is the first report of such a case. Accurate diagnosis and molecular characterization of the splenic metastasis have a critical impact on the clinical management of the patient. PMID: 29263768 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - December 22, 2017 Category: Pathology Authors: Inouye CM, Anagnostou V, Li QK Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +229 new citations
229 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2016/01/30PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 30, 2016 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +230 new citations
230 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2016/01/13PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 14, 2016 Category: Pathology Tags: Report Source Type: research

Altered expression profile of apoptosis-related molecules correlated with clinicopathological factors in non-small-cell lung cancer.
This study was aimed to observe the expression patterns of apoptosis-related molecules in lung cancer and paired non-cancerous tissues, and to observe if there is a correlation between the expression of these apoptotic molecules and clinicopathologic parameters. Immunohistochemistry (IHC) was performed to analyze the expression level of CASP3, CASP8, CASP9, PARP1, Cleaved CASP3 (C-CASP3), Cleaved PARP1 (C-PARP1), XIAP, BIRC5 (Survivin) and BCL2 in lung cancer and paired non-cancerous tissues. We found that apoptosis-related molecules CASP3, CASP9, BCL2, BIRC5 and PARP1 are abnormally expressed in lung cancer cells and thei...
Source: International Journal of Clinical and Experimental Pathology - December 12, 2015 Category: Pathology Authors: Huang JQ, Liang HL, Jin TE, Xie Z Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +269 new citations
269 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/12/02PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - December 2, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +135 new citations
135 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/10/16PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - October 17, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +127 new citations
127 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/09/06PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 7, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +208 new citations
208 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/08/12PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 13, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +215 new citations
215 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/07/21PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 21, 2015 Category: Pathology Tags: Report Source Type: research

Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model.
CONCLUSIONS: This study demonstrated that HMWHA injections suppressed inflammatory, fibrotic, and hypoxic conditions observed in the immobilized joint capsule. PMID: 26097527 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Kanazawa K, Hagiwara Y, Tsuchiya M, Yabe Y, Sonofuchi K, Koide M, Sekiguchi T, Itaya N, Ando A, Saijo Y, Itoi E Tags: Int J Clin Exp Pathol Source Type: research

3,4-dihydroxyphenylethanol suppresses irradiation-induced pulmonary fibrosis in adult rats.
Abstract The present study demonstrates the effect of DHPEA on suppression of irradiation-induced pulmonary fibrosis. A (60)Co irradiator was used to induce pulmonary fibrosis in a rat model at a dose of 22 Gy. The rats of the treatment and positive control group were intraperitoneally injected DHPEA (10 mg/kg) or dexamethasone (DEX; 5 mg/kg) daily for 30 days. Hydroxyproline assay was used to evaluate the fibrosis of pulmonary and lung tissue sections after irradiation. Hematoxylin and eosin (H&E) and Masson's trichrome stained lung section were used for alveolitis and fibrosis score analyses, respectively. I...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu ZH, Fan W, Chen RC Tags: Int J Clin Exp Pathol Source Type: research

An enterovirus 71 strain causes skeletal muscle damage in infected mice.
CONCLUSION: The EV71 clinical isolate used in this study presented evident myotropism. Skeletal muscles are important target organs for EV71 in the infected suckling mice. To clarify the relationship between EV71 infection and muscle diseases may contribute to a better understanding of the pathogenesis of EV71. PMID: 26097530 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Lin P, Gao L, Huang Y, Chen Q, Shen H Tags: Int J Clin Exp Pathol Source Type: research

Possible antiosteoporotic mechanism of Cicer arietinum extract in ovariectomized rats.
CONCLUSION: The ongoing study speculates that the CAE exerts its action through regulation of RANK/RANKL/OPG system. As, CAE not only promotes osteoblast differentiation, but also up-regulates OPG and downregulates RANKL secretion in osteoblasts, subsequently prevents bone loss and osteoporosis. PMID: 26097532 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Fahmy SR, Soliman AM, Sayed AA, Marzouk M Tags: Int J Clin Exp Pathol Source Type: research

CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion.
In this study, we used selective agonist or antagonist of CB2R to observe the role of CB2R on inflammation and fibrogenesis during the repair of contused skeletal muscles in rats. Our results revealed that treatment with Gp1a, a selective CB2R agonist, significantly decreased the infiltration of neutrophils and macrophages, the expression of pro-inflammatory cytokines MCP-1, TNF-α, IL-1β and IL-6, the expression of pro-fibrotic cytokines IL-4, IL-13, TGF-β and P-Smad3 while increased anti-fibrotic cytokine IL-10 production as compared with Vehicle. The opposite results were observed in the CB2R inhibition g...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhang M, Jiang SK, Tian ZL, Wang M, Zhao R, Wang LL, Li SS, Liu M, Li JY, Zhang MZ, Guan DW Tags: Int J Clin Exp Pathol Source Type: research

Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat.
Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat. Int J Clin Exp Pathol. 2015;8(4):3503-12 Authors: Yu R, Mao J, Yang Y, Zhang Y, Tian Y, Zhu J Abstract OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-β1) and Cdc42 interacting protein-4 (CIP4). METHODS: Streptozotocin-induced diabetic nephropathy rats (n=36) were randomly divided into control group (control-H, control-M, control-L) and calcitriol...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yu R, Mao J, Yang Y, Zhang Y, Tian Y, Zhu J Tags: Int J Clin Exp Pathol Source Type: research

Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma.
Abstract Cancer testis antigens (CTAs) are selectively expressed in malignant cells and can serve as ideal targets for immunotherapy. We investigated the expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 to determine if combinatorial expressions of CTAs might be as potential prognostic markers for patients with hepatocellular carcinoma (HCC). In tumor tissues of 142 HCC patients, the mRNA expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 were 78.9%, 33.8%, 74.6% and 14.1% respectively. Furthermore, the expressions of MAGE-A3, MAGE-A4 and combination of MAGE-A3, MAGE-A4 and NY-ESO-1 (CTAs-A3/A4/NY) showed p...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wang M, Li J, Wang L, Chen X, Zhang Z, Yue D, Ping Y, Shi X, Huang L, Zhang T, Yang L, Zhao Y, Ma X, Li D, Fan Z, Zhao L, Tang Z, Zhai W, Zhang B, Zhang Y Tags: Int J Clin Exp Pathol Source Type: research

Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium.
Abstract Calcium is a strong inducer of keratinocyte differentiation. We have previously demonstrated that extracellular calcium promotes keratinocyte differentiation via E-cadherin-catenin complex-mediated phospholipase C-γ1 (PLC-γ1) activation in the plasma membrane. However, it is unclear whether dietary calcium regulates keratinocyte proliferation, differentiation or carcinogenesis. To address this issue, the rates of oral tumor and levels of proliferation and differentiation in the oral epithelium were assessed in mice on different calcium diets and the carcinogen 4-nitroquinoline-1-oxide. The res...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Jiang Y, Liao L, Shrestha C, Li D, Li M, Mu Y, Crumrine D, Wang L, Xie Z Tags: Int J Clin Exp Pathol Source Type: research

Anti-neoplastic activities of sepia officinalis ink and coelatura aegyptiaca extracts against Ehrlich ascites carcinoma in Swiss albino mice.
CONCLUSION: Both IE and CE were effective in inhibiting the tumor growth in ascitic tumor models. The biochemical, antioxidants and histopathological studies were also supported their antitumor properties. PMID: 26097537 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Soliman AM, Fahmy SR, El-Abied SA Tags: Int J Clin Exp Pathol Source Type: research

Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis.
Abstract Pituitary adenomas (PAs) are noncancerous tumors, and about 35% of those reported to be invasive have been classified as "invasive pituitary adenomas (IPAs)". In clinical, operative complications, total resection failures, and high relapse rates result from invasive features during the therapeutic process. Invasive mechanism is a complex process, including metalloproteases, inhibitors and tumor microenvironment factors etc. Thus, studying invasive mechanism of PAs might contribute to understanding its biological behavior. In our research, three type tissue samples of human, pituitaries, PAs, IPA...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Hui P, Xu X, Xu L, Hui G, Wu S, Lan Q Tags: Int J Clin Exp Pathol Source Type: research

Enhanced circulating ILC2s accompany by upregulated MDSCs in patients with asthma.
In this study, we sought to determine whether MDSCs are also participation in immune imbalance and its relationship with ILC2s in asthma. The data showed that the circulatory ILC2s or MDSCs and their characteristic cytokines or transcription factors were significantly enhanced in asthmatic patients, as well as in chronic obstructive pulmonary disease (COPD) or respiratory viral infections (RVI). Meanwhile, a Th2-dominated phenotype was found in patients with asthma which closely related to the expression levels of ILC2s and MDSCs associated moleculars. These findings indicated that Th2 polarization was close related to syn...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wu Y, Yan Y, Su Z, Bie Q, Wu J, Wang S, Yu Y, Ding H, Lu P, Xu H Tags: Int J Clin Exp Pathol Source Type: research

LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway.
Abstract The radiotherapy as a local and regional modality is widely applied in treatment of glioma, but most glioblastomas are commonly resistant to irradiation treatment. It remains challengeable to seek out efficient strategies to conquer the resistance of human glioblastoma cells to radiotherapy. Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is a newly discovered tumor suppressor which involved in regulation of chemosensitivity in various human cancer cells. In the present study, we established a radioresistant U251 cell line (U251R) to investigate the role of LRIG1 in regulation of ra...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yang JA, Liu BH, Shao LM, Guo ZT, Yang Q, Wu LQ, Ji BW, Zhu XN, Zhang SQ, Li CJ, Chen QX Tags: Int J Clin Exp Pathol Source Type: research

Elevated DNA polymerase iota (Poli) is involved in the acquisition of aggressive phenotypes of human esophageal squamous cell cancer.
Abstract DNA polymerase iota (Polι) can repair several types of DNA damage but has extremely low fidelity. Previous studies have shown an aberrantly elevated Polι expression in human esophageal squamous cell cancer tissues. However, there were few reports describing the role of Polι in esophageal cancer progression. Based on Real-time PCR assay, we found Polι expression was up-regulated in esophageal cancer tissues compared to adjacent normal tissues and overexpression of Polι was correlated to lymph node metastasis. Clonogenic assay and transwell chamber assay showed that overexpression o...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Sun H, Zou S, Zhang S, Liu B, Meng X, Li X, Yu J, Wu J, Zhou J Tags: Int J Clin Exp Pathol Source Type: research

Effects of nicotine on a rat model of early stage osteoarthritis.
In conclusion, nicotine prevented cartilage damage and had an anti-inflammatory effect in a rat model of early stage OA. Thus nicotine may have potential as a therapeutic strategy for early stage OA. PMID: 26097542 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Gu Q, Li D, Wei B, Guo Y, Yan J, Mao F, Zhang X, Wang L Tags: Int J Clin Exp Pathol Source Type: research

HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma.
Abstract Although HOX genes are best known for acting in the regulation of important events during embryogenesis, including proliferation, differentiation and migration, alterations in their expression patterns have been frequently described in cancers. In previous studies we analyzed the expression profile of the members of the HOX family of homeobox genes in oral samples of normal mucosa and squamous cell carcinoma (OSCC) and identified differently expressed genes such as HOXA10. The present study aimed to validate the increased expression of HOXA10 in OSCCs, and to investigate the effects arising from its knock...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Carrera M, Bitu CC, de Oliveira CE, Cervigne NK, Graner E, Manninen A, Salo T, Coletta RD Tags: Int J Clin Exp Pathol Source Type: research

Effects of early and late adverse experiences on morpho-quantitative characteristics of Sprague-Dawley rat spleen subjected to stress during adulthood.
Sol M Abstract Morpho-quantitative studies of the spleen indicate that the proportions of the compartments and sub-compartments are stable in normal conditions. However, disorders due to stress can influence the number and function of the immune cells in this organ. The aim of this study was to determine, through the model of altering the early mother-infant bond and altering the late social bond through isolation, the effect on the morpho-quantitative characteristics of the spleen in adult Sprague-Dawley rats subjected to intermittent chronic stress in adulthood. Twenty-five newborn female rats were used, kept un...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Vásquez B, Sandoval C, Smith RL, Del Sol M Tags: Int J Clin Exp Pathol Source Type: research

Chromosomal imbalances revealed in primary renal cell carcinomas by comparative genomic hybridization.
Abstract Renal cell carcinoma (RCC) accounts for approximately 3% of all new cancer cases. Although the classification of RCC is based mainly on histology, this method is not always accurate. We applied comparative genomic hybridization (CGH) to determine genomic alterations in 46 cases of different RCC histological subtypes [10 cases of clear cell RCC (CCRCC), 13 cases of papillary RCC (PRCC), 12 cases of chromophobe RCC (CRCC), 9 cases of Xp11.2 translocation RCC (Xp11.2RCC), 2 cases of undifferentiated RCC (unRCC)], and investigated the relationships between clinical parameters and genomic aberrations. Changes ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Kang XL, Zou H, Pang LJ, Hu WH, Zhao J, Qi Y, Liu CX, Hu JM, Tang JX, Li HA, Liang WH, Yuan XL, Li F Tags: Int J Clin Exp Pathol Source Type: research

Intestinal mucosal barrier dysfunction participates in the progress of nonalcoholic fatty liver disease.
Abstract Intestinal mucosal barrier dysfunction is closely related to liver diseases, which implies impaired gut-liver axis may play a role in the pathogenesis of NAFLD. In our study, rats were divided into three groups: normal chow diet (NCD) group, high-fat diet (HFD) group and TNBS-induced colitis with high-fat diet (C-HFD) group. Liver tissues were obtained for histological observation and TNF-α, IL-6 mRNA determination and blood samples were collected for liver enzymes and LPS analysis. Ultrastructural changes of jejuna epithelium, SIBO and amounts of CD103(+)MHCII(+)DCs and CD4(+)CD25(+)FoxP3(+)T-regs ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Mao JW, Tang HY, Zhao T, Tan XY, Bi J, Wang BY, Wang YD Tags: Int J Clin Exp Pathol Source Type: research

Abnormal immunomodulatory ability on memory T cells in humans with severe aplastic anemia.
In this study we investigate the quantities and functions of memory T cells in SAA patients before and after immunosuppressive therapy (IST) to further clarify the mechanism of SAA apoptosis of bone marrow hematopoietic cells. Results showed that the percentage of CD4+ effector T cells in peripheral blood and bone marrow lymphocytes was decreased in SAA patients. The ratio of CD4+ memory T lymphocytes to CD8+ memory T subsets (CD4+/CD8+TM) in SAA patients was also lower. The percentage of CD8+ effector T cells in peripheral blood and CD8+ central memory T cells in the bone marrow lymphocytes was significantly higher in new...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zheng M, Liu C, Fu R, Wang H, Wu Y, Li L, Liu H, Ding S, Shao Z Tags: Int J Clin Exp Pathol Source Type: research

Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin.
ın A Abstract INTRODUCTION: The pathological diagnosis of papillary thyroid carcinoma (PTC) is generally easy on routine sections stained with hematoxylin and eosin (H&E). However, the differentiation of the follicular variant of PTC (FVPTC) from other suspected follicular-patterned lesions of the thyroid is highly difficult. Among these, the lesions for which FVPTC cannot be excluded are classified as well-differentiated tumors of uncertain malignant potential (WDT-UMP). The most common immunohistochemical (IHC) markers used in the differential diagnosis include HBME-1, galectin-3, and CK19. However, none of...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Ceyran AB, Şenol S, Şimşek BÇ, Sağıroğlu J, Aydın A Tags: Int J Clin Exp Pathol Source Type: research

Ursolic acid derivative ameliorates streptozotocin-induced diabestic bone deleterious effects in mice.
CONCLUSIONS: These results demonstrated that UAD could ameliorate STZ-induced bone deterioration through improving adipocyte dysfunction and enhancing new bone formation and inhibiting absorptive function of osteoclast in the bone of diabetic mice. PMID: 26097549 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yu SG, Zhang CJ, Xu XE, Sun JH, Zhang L, Yu PF Tags: Int J Clin Exp Pathol Source Type: research

Krüppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas.
This study examined expression of KLF4 and KLF 5 in the carcinomas by immunohistochemistry (n = 67) and the involvement in proliferation and differentiation of carcinoma cells. KLF4 was detected in keratinizing carcinoma cells and KLF5 in non-keratinizing cells. KLF4 staining declined in the patient with lymph node metastasis (P
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Shibata M, Chiba T, Matsuoka T, Mihara N, Kawashiri S, Imai K Tags: Int J Clin Exp Pathol Source Type: research