Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer
Int J Clin Exp Pathol. 2021 Jul 15;14(7):795-810. eCollection 2021.ABSTRACTThe transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues. In human embryonic kidney 293T cells, mutation of these sumoylation sites stimulated the transactivation potential of ETV1 at the matrix metalloproteinase 1 (MMP1), but not Yes-associated protein 1 gene promoter, while ETV1 protein stability and intracellular localization remained unchanged. In s...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Sangphil Oh Sook Shin Ralf Janknecht Source Type: research

CDC6 is a possible biomarker for hepatocellular carcinoma
CONCLUSIONS: The expression level of CDC6 in hepatocellular carcinoma is related tightly to clinical findings. Detecting the expression of CDC6 might provide a new biomarker for patients with hepatocellular carcinoma.PMID:34367412 | PMC:PMC8339721 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: De-Gang Kong Fu-Zhou Yao Source Type: research

Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle
Int J Clin Exp Pathol. 2021 Jul 15;14(7):819-826. eCollection 2021.ABSTRACTSubchondral insufficiency fracture (SIF) of the medial femoral condyle has been proposed to be a primary event in so-called 'spontaneous osteonecrosis of the knee'. SIF is also known to be associated with bone marrow lesions (BML), but the detailed histopathology of the BML has not been fully clarified. We thus investigated the pathophysiology of BML based on MRI and histology in the 4 consecutive patients diagnosed with SIF, whose onset was within 4 months. In all cases, BMLs were enhanced on T1 Gd-enhanced MRI. Histologically, BMLs comprised serou...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Hidetomo Kosaka Akira Maeyama Jun Nishio Kazuki Nabeshima Takuaki Yamamoto Source Type: research

Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature
Int J Clin Exp Pathol. 2021 Jul 15;14(7):827-830. eCollection 2021.ABSTRACTRosai-Dorfman disease is a rare malignant infirmity. Here, we present a case of a 57-year-old man with giddiness and unstable gait, as well as blurred vision in the left eye for four months. Radiologically the diagnosis before surgery was meningioma. The patient received a craniotomy, and the histopathologic diagnosis was Rosai-Dorfman disease. We reviewed the diagnosis, mechanism, and treatment of this disease.PMID:34367414 | PMC:PMC8339718 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Xia Li Zhang Yue Xiang Liping Liu Zonglin Jing Source Type: research

Inflammation in COVID-19: from pathogenesis to treatment
Int J Clin Exp Pathol. 2021 Jul 15;14(7):831-844. eCollection 2021.ABSTRACTThe coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). To date, there were> 163 million confirmed cases of COVID-19 and the disease has claimed> 3.3 million lives globally. As with many other diseases, inflammation is a key feature of COVID-19. When inflammation is overwhelming, it may lead to unfavorable outcomes or even death. Scientists all over the world are working tirelessly in search of therapeutic strategies to suppress or modulate inflammation in COVID-19. This review give...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Rebecca S Y Wong Source Type: research

ADAM17 and NF- κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability
In conclusion, we propose that ADAM17-activated NF-κB p65 signaling positively regulates ADAM17 expression, and facilitates ESCC cell viability.PMID:34367416 | PMC:PMC8339723 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Gao Hongbin Liu Rong Xu Jianwei Qiu Xiao Peng Yanmei Yang Dongmei Zhang Junbo Qian Source Type: research

Erratum: Expression of Tim-3 in breast cancer tissue promotes tumor progression
Int J Clin Exp Pathol. 2021 Jul 15;14(7):855. eCollection 2021.ABSTRACT[This corrects the article on p. 1157 in vol. 11, PMID: 31938210.].PMID:34367417 | PMC:PMC8339724 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Shiqing Cheng Fuyan Han Yanqiu Xu Teng Qu Ying Ju Source Type: research

Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):856. eCollection 2021.ABSTRACT[This retracts the article on p. 10061 in vol. 8, PMID: 26617713.].PMID:34367418 | PMC:PMC8339725 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14 [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):857. eCollection 2021.ABSTRACT[This retracts the article on p. 8452 in vol. 10, PMID: 31966697.].PMID:34367419 | PMC:PMC8339719 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer
Int J Clin Exp Pathol. 2021 Jul 15;14(7):795-810. eCollection 2021.ABSTRACTThe transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues. In human embryonic kidney 293T cells, mutation of these sumoylation sites stimulated the transactivation potential of ETV1 at the matrix metalloproteinase 1 (MMP1), but not Yes-associated protein 1 gene promoter, while ETV1 protein stability and intracellular localization remained unchanged. In s...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Sangphil Oh Sook Shin Ralf Janknecht Source Type: research

CDC6 is a possible biomarker for hepatocellular carcinoma
CONCLUSIONS: The expression level of CDC6 in hepatocellular carcinoma is related tightly to clinical findings. Detecting the expression of CDC6 might provide a new biomarker for patients with hepatocellular carcinoma.PMID:34367412 | PMC:PMC8339721 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: De-Gang Kong Fu-Zhou Yao Source Type: research

Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle
Int J Clin Exp Pathol. 2021 Jul 15;14(7):819-826. eCollection 2021.ABSTRACTSubchondral insufficiency fracture (SIF) of the medial femoral condyle has been proposed to be a primary event in so-called 'spontaneous osteonecrosis of the knee'. SIF is also known to be associated with bone marrow lesions (BML), but the detailed histopathology of the BML has not been fully clarified. We thus investigated the pathophysiology of BML based on MRI and histology in the 4 consecutive patients diagnosed with SIF, whose onset was within 4 months. In all cases, BMLs were enhanced on T1 Gd-enhanced MRI. Histologically, BMLs comprised serou...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Hidetomo Kosaka Akira Maeyama Jun Nishio Kazuki Nabeshima Takuaki Yamamoto Source Type: research

Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature
Int J Clin Exp Pathol. 2021 Jul 15;14(7):827-830. eCollection 2021.ABSTRACTRosai-Dorfman disease is a rare malignant infirmity. Here, we present a case of a 57-year-old man with giddiness and unstable gait, as well as blurred vision in the left eye for four months. Radiologically the diagnosis before surgery was meningioma. The patient received a craniotomy, and the histopathologic diagnosis was Rosai-Dorfman disease. We reviewed the diagnosis, mechanism, and treatment of this disease.PMID:34367414 | PMC:PMC8339718 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Xia Li Zhang Yue Xiang Liping Liu Zonglin Jing Source Type: research

Inflammation in COVID-19: from pathogenesis to treatment
Int J Clin Exp Pathol. 2021 Jul 15;14(7):831-844. eCollection 2021.ABSTRACTThe coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). To date, there were> 163 million confirmed cases of COVID-19 and the disease has claimed> 3.3 million lives globally. As with many other diseases, inflammation is a key feature of COVID-19. When inflammation is overwhelming, it may lead to unfavorable outcomes or even death. Scientists all over the world are working tirelessly in search of therapeutic strategies to suppress or modulate inflammation in COVID-19. This review give...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Rebecca S Y Wong Source Type: research

ADAM17 and NF- κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability
In conclusion, we propose that ADAM17-activated NF-κB p65 signaling positively regulates ADAM17 expression, and facilitates ESCC cell viability.PMID:34367416 | PMC:PMC8339723 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Gao Hongbin Liu Rong Xu Jianwei Qiu Xiao Peng Yanmei Yang Dongmei Zhang Junbo Qian Source Type: research

Erratum: Expression of Tim-3 in breast cancer tissue promotes tumor progression
Int J Clin Exp Pathol. 2021 Jul 15;14(7):855. eCollection 2021.ABSTRACT[This corrects the article on p. 1157 in vol. 11, PMID: 31938210.].PMID:34367417 | PMC:PMC8339724 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Shiqing Cheng Fuyan Han Yanqiu Xu Teng Qu Ying Ju Source Type: research

Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):856. eCollection 2021.ABSTRACT[This retracts the article on p. 10061 in vol. 8, PMID: 26617713.].PMID:34367418 | PMC:PMC8339725 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14 [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):857. eCollection 2021.ABSTRACT[This retracts the article on p. 8452 in vol. 10, PMID: 31966697.].PMID:34367419 | PMC:PMC8339719 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer
Int J Clin Exp Pathol. 2021 Jul 15;14(7):795-810. eCollection 2021.ABSTRACTThe transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues. In human embryonic kidney 293T cells, mutation of these sumoylation sites stimulated the transactivation potential of ETV1 at the matrix metalloproteinase 1 (MMP1), but not Yes-associated protein 1 gene promoter, while ETV1 protein stability and intracellular localization remained unchanged. In s...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Sangphil Oh Sook Shin Ralf Janknecht Source Type: research

CDC6 is a possible biomarker for hepatocellular carcinoma
CONCLUSIONS: The expression level of CDC6 in hepatocellular carcinoma is related tightly to clinical findings. Detecting the expression of CDC6 might provide a new biomarker for patients with hepatocellular carcinoma.PMID:34367412 | PMC:PMC8339721 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: De-Gang Kong Fu-Zhou Yao Source Type: research

Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle
Int J Clin Exp Pathol. 2021 Jul 15;14(7):819-826. eCollection 2021.ABSTRACTSubchondral insufficiency fracture (SIF) of the medial femoral condyle has been proposed to be a primary event in so-called 'spontaneous osteonecrosis of the knee'. SIF is also known to be associated with bone marrow lesions (BML), but the detailed histopathology of the BML has not been fully clarified. We thus investigated the pathophysiology of BML based on MRI and histology in the 4 consecutive patients diagnosed with SIF, whose onset was within 4 months. In all cases, BMLs were enhanced on T1 Gd-enhanced MRI. Histologically, BMLs comprised serou...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Hidetomo Kosaka Akira Maeyama Jun Nishio Kazuki Nabeshima Takuaki Yamamoto Source Type: research

Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature
Int J Clin Exp Pathol. 2021 Jul 15;14(7):827-830. eCollection 2021.ABSTRACTRosai-Dorfman disease is a rare malignant infirmity. Here, we present a case of a 57-year-old man with giddiness and unstable gait, as well as blurred vision in the left eye for four months. Radiologically the diagnosis before surgery was meningioma. The patient received a craniotomy, and the histopathologic diagnosis was Rosai-Dorfman disease. We reviewed the diagnosis, mechanism, and treatment of this disease.PMID:34367414 | PMC:PMC8339718 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Xia Li Zhang Yue Xiang Liping Liu Zonglin Jing Source Type: research

Inflammation in COVID-19: from pathogenesis to treatment
Int J Clin Exp Pathol. 2021 Jul 15;14(7):831-844. eCollection 2021.ABSTRACTThe coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). To date, there were> 163 million confirmed cases of COVID-19 and the disease has claimed> 3.3 million lives globally. As with many other diseases, inflammation is a key feature of COVID-19. When inflammation is overwhelming, it may lead to unfavorable outcomes or even death. Scientists all over the world are working tirelessly in search of therapeutic strategies to suppress or modulate inflammation in COVID-19. This review give...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Rebecca S Y Wong Source Type: research

ADAM17 and NF- κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability
In conclusion, we propose that ADAM17-activated NF-κB p65 signaling positively regulates ADAM17 expression, and facilitates ESCC cell viability.PMID:34367416 | PMC:PMC8339723 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Gao Hongbin Liu Rong Xu Jianwei Qiu Xiao Peng Yanmei Yang Dongmei Zhang Junbo Qian Source Type: research

Erratum: Expression of Tim-3 in breast cancer tissue promotes tumor progression
Int J Clin Exp Pathol. 2021 Jul 15;14(7):855. eCollection 2021.ABSTRACT[This corrects the article on p. 1157 in vol. 11, PMID: 31938210.].PMID:34367417 | PMC:PMC8339724 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Shiqing Cheng Fuyan Han Yanqiu Xu Teng Qu Ying Ju Source Type: research

Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):856. eCollection 2021.ABSTRACT[This retracts the article on p. 10061 in vol. 8, PMID: 26617713.].PMID:34367418 | PMC:PMC8339725 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14 [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):857. eCollection 2021.ABSTRACT[This retracts the article on p. 8452 in vol. 10, PMID: 31966697.].PMID:34367419 | PMC:PMC8339719 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer
Int J Clin Exp Pathol. 2021 Jul 15;14(7):795-810. eCollection 2021.ABSTRACTThe transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues. In human embryonic kidney 293T cells, mutation of these sumoylation sites stimulated the transactivation potential of ETV1 at the matrix metalloproteinase 1 (MMP1), but not Yes-associated protein 1 gene promoter, while ETV1 protein stability and intracellular localization remained unchanged. In s...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Sangphil Oh Sook Shin Ralf Janknecht Source Type: research

CDC6 is a possible biomarker for hepatocellular carcinoma
CONCLUSIONS: The expression level of CDC6 in hepatocellular carcinoma is related tightly to clinical findings. Detecting the expression of CDC6 might provide a new biomarker for patients with hepatocellular carcinoma.PMID:34367412 | PMC:PMC8339721 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: De-Gang Kong Fu-Zhou Yao Source Type: research

Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle
Int J Clin Exp Pathol. 2021 Jul 15;14(7):819-826. eCollection 2021.ABSTRACTSubchondral insufficiency fracture (SIF) of the medial femoral condyle has been proposed to be a primary event in so-called 'spontaneous osteonecrosis of the knee'. SIF is also known to be associated with bone marrow lesions (BML), but the detailed histopathology of the BML has not been fully clarified. We thus investigated the pathophysiology of BML based on MRI and histology in the 4 consecutive patients diagnosed with SIF, whose onset was within 4 months. In all cases, BMLs were enhanced on T1 Gd-enhanced MRI. Histologically, BMLs comprised serou...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Hidetomo Kosaka Akira Maeyama Jun Nishio Kazuki Nabeshima Takuaki Yamamoto Source Type: research

Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature
Int J Clin Exp Pathol. 2021 Jul 15;14(7):827-830. eCollection 2021.ABSTRACTRosai-Dorfman disease is a rare malignant infirmity. Here, we present a case of a 57-year-old man with giddiness and unstable gait, as well as blurred vision in the left eye for four months. Radiologically the diagnosis before surgery was meningioma. The patient received a craniotomy, and the histopathologic diagnosis was Rosai-Dorfman disease. We reviewed the diagnosis, mechanism, and treatment of this disease.PMID:34367414 | PMC:PMC8339718 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Xia Li Zhang Yue Xiang Liping Liu Zonglin Jing Source Type: research

Inflammation in COVID-19: from pathogenesis to treatment
Int J Clin Exp Pathol. 2021 Jul 15;14(7):831-844. eCollection 2021.ABSTRACTThe coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). To date, there were> 163 million confirmed cases of COVID-19 and the disease has claimed> 3.3 million lives globally. As with many other diseases, inflammation is a key feature of COVID-19. When inflammation is overwhelming, it may lead to unfavorable outcomes or even death. Scientists all over the world are working tirelessly in search of therapeutic strategies to suppress or modulate inflammation in COVID-19. This review give...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Rebecca S Y Wong Source Type: research

ADAM17 and NF- κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability
In conclusion, we propose that ADAM17-activated NF-κB p65 signaling positively regulates ADAM17 expression, and facilitates ESCC cell viability.PMID:34367416 | PMC:PMC8339723 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Gao Hongbin Liu Rong Xu Jianwei Qiu Xiao Peng Yanmei Yang Dongmei Zhang Junbo Qian Source Type: research

Erratum: Expression of Tim-3 in breast cancer tissue promotes tumor progression
Int J Clin Exp Pathol. 2021 Jul 15;14(7):855. eCollection 2021.ABSTRACT[This corrects the article on p. 1157 in vol. 11, PMID: 31938210.].PMID:34367417 | PMC:PMC8339724 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Shiqing Cheng Fuyan Han Yanqiu Xu Teng Qu Ying Ju Source Type: research

Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):856. eCollection 2021.ABSTRACT[This retracts the article on p. 10061 in vol. 8, PMID: 26617713.].PMID:34367418 | PMC:PMC8339725 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14 [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):857. eCollection 2021.ABSTRACT[This retracts the article on p. 8452 in vol. 10, PMID: 31966697.].PMID:34367419 | PMC:PMC8339719 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer
Int J Clin Exp Pathol. 2021 Jul 15;14(7):795-810. eCollection 2021.ABSTRACTThe transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues. In human embryonic kidney 293T cells, mutation of these sumoylation sites stimulated the transactivation potential of ETV1 at the matrix metalloproteinase 1 (MMP1), but not Yes-associated protein 1 gene promoter, while ETV1 protein stability and intracellular localization remained unchanged. In s...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Sangphil Oh Sook Shin Ralf Janknecht Source Type: research

CDC6 is a possible biomarker for hepatocellular carcinoma
CONCLUSIONS: The expression level of CDC6 in hepatocellular carcinoma is related tightly to clinical findings. Detecting the expression of CDC6 might provide a new biomarker for patients with hepatocellular carcinoma.PMID:34367412 | PMC:PMC8339721 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: De-Gang Kong Fu-Zhou Yao Source Type: research

Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle
Int J Clin Exp Pathol. 2021 Jul 15;14(7):819-826. eCollection 2021.ABSTRACTSubchondral insufficiency fracture (SIF) of the medial femoral condyle has been proposed to be a primary event in so-called 'spontaneous osteonecrosis of the knee'. SIF is also known to be associated with bone marrow lesions (BML), but the detailed histopathology of the BML has not been fully clarified. We thus investigated the pathophysiology of BML based on MRI and histology in the 4 consecutive patients diagnosed with SIF, whose onset was within 4 months. In all cases, BMLs were enhanced on T1 Gd-enhanced MRI. Histologically, BMLs comprised serou...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Hidetomo Kosaka Akira Maeyama Jun Nishio Kazuki Nabeshima Takuaki Yamamoto Source Type: research

Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature
Int J Clin Exp Pathol. 2021 Jul 15;14(7):827-830. eCollection 2021.ABSTRACTRosai-Dorfman disease is a rare malignant infirmity. Here, we present a case of a 57-year-old man with giddiness and unstable gait, as well as blurred vision in the left eye for four months. Radiologically the diagnosis before surgery was meningioma. The patient received a craniotomy, and the histopathologic diagnosis was Rosai-Dorfman disease. We reviewed the diagnosis, mechanism, and treatment of this disease.PMID:34367414 | PMC:PMC8339718 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Xia Li Zhang Yue Xiang Liping Liu Zonglin Jing Source Type: research

Inflammation in COVID-19: from pathogenesis to treatment
Int J Clin Exp Pathol. 2021 Jul 15;14(7):831-844. eCollection 2021.ABSTRACTThe coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). To date, there were> 163 million confirmed cases of COVID-19 and the disease has claimed> 3.3 million lives globally. As with many other diseases, inflammation is a key feature of COVID-19. When inflammation is overwhelming, it may lead to unfavorable outcomes or even death. Scientists all over the world are working tirelessly in search of therapeutic strategies to suppress or modulate inflammation in COVID-19. This review give...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Rebecca S Y Wong Source Type: research

ADAM17 and NF- κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability
In conclusion, we propose that ADAM17-activated NF-κB p65 signaling positively regulates ADAM17 expression, and facilitates ESCC cell viability.PMID:34367416 | PMC:PMC8339723 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Gao Hongbin Liu Rong Xu Jianwei Qiu Xiao Peng Yanmei Yang Dongmei Zhang Junbo Qian Source Type: research

Erratum: Expression of Tim-3 in breast cancer tissue promotes tumor progression
Int J Clin Exp Pathol. 2021 Jul 15;14(7):855. eCollection 2021.ABSTRACT[This corrects the article on p. 1157 in vol. 11, PMID: 31938210.].PMID:34367417 | PMC:PMC8339724 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Shiqing Cheng Fuyan Han Yanqiu Xu Teng Qu Ying Ju Source Type: research

Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):856. eCollection 2021.ABSTRACT[This retracts the article on p. 10061 in vol. 8, PMID: 26617713.].PMID:34367418 | PMC:PMC8339725 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14 [Retraction]
Int J Clin Exp Pathol. 2021 Jul 15;14(7):857. eCollection 2021.ABSTRACT[This retracts the article on p. 8452 in vol. 10, PMID: 31966697.].PMID:34367419 | PMC:PMC8339719 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Source Type: research

Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer
Int J Clin Exp Pathol. 2021 Jul 15;14(7):795-810. eCollection 2021.ABSTRACTThe transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues. In human embryonic kidney 293T cells, mutation of these sumoylation sites stimulated the transactivation potential of ETV1 at the matrix metalloproteinase 1 (MMP1), but not Yes-associated protein 1 gene promoter, while ETV1 protein stability and intracellular localization remained unchanged. In s...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Sangphil Oh Sook Shin Ralf Janknecht Source Type: research

CDC6 is a possible biomarker for hepatocellular carcinoma
CONCLUSIONS: The expression level of CDC6 in hepatocellular carcinoma is related tightly to clinical findings. Detecting the expression of CDC6 might provide a new biomarker for patients with hepatocellular carcinoma.PMID:34367412 | PMC:PMC8339721 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: De-Gang Kong Fu-Zhou Yao Source Type: research

Histopathologic evaluation of bone marrow lesions in early stage subchondral insufficiency fracture of the medial femoral condyle
Int J Clin Exp Pathol. 2021 Jul 15;14(7):819-826. eCollection 2021.ABSTRACTSubchondral insufficiency fracture (SIF) of the medial femoral condyle has been proposed to be a primary event in so-called 'spontaneous osteonecrosis of the knee'. SIF is also known to be associated with bone marrow lesions (BML), but the detailed histopathology of the BML has not been fully clarified. We thus investigated the pathophysiology of BML based on MRI and histology in the 4 consecutive patients diagnosed with SIF, whose onset was within 4 months. In all cases, BMLs were enhanced on T1 Gd-enhanced MRI. Histologically, BMLs comprised serou...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Hidetomo Kosaka Akira Maeyama Jun Nishio Kazuki Nabeshima Takuaki Yamamoto Source Type: research

Intracranial Rosai-Dorfman disease mimicking isolated meningioma: a case report and review of the literature
Int J Clin Exp Pathol. 2021 Jul 15;14(7):827-830. eCollection 2021.ABSTRACTRosai-Dorfman disease is a rare malignant infirmity. Here, we present a case of a 57-year-old man with giddiness and unstable gait, as well as blurred vision in the left eye for four months. Radiologically the diagnosis before surgery was meningioma. The patient received a craniotomy, and the histopathologic diagnosis was Rosai-Dorfman disease. We reviewed the diagnosis, mechanism, and treatment of this disease.PMID:34367414 | PMC:PMC8339718 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Lin Xia Li Zhang Yue Xiang Liping Liu Zonglin Jing Source Type: research

Inflammation in COVID-19: from pathogenesis to treatment
Int J Clin Exp Pathol. 2021 Jul 15;14(7):831-844. eCollection 2021.ABSTRACTThe coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). To date, there were> 163 million confirmed cases of COVID-19 and the disease has claimed> 3.3 million lives globally. As with many other diseases, inflammation is a key feature of COVID-19. When inflammation is overwhelming, it may lead to unfavorable outcomes or even death. Scientists all over the world are working tirelessly in search of therapeutic strategies to suppress or modulate inflammation in COVID-19. This review give...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2021 Category: Pathology Authors: Rebecca S Y Wong Source Type: research