This page shows you the latest news items in this category. This is page number 13.

Total 5456 results found since Jan 2013.

Uveitis profile and treatment response in Iranian patients with sarcoidosis
This study disclosed a higher predominance of females and intermediate form of uveitis in Iranian patients with sarcoid uveitis. Use of immunomodulatory drugs combined with corticosteroids resulted in good visual outcome and control of uveitis with a possible fewer corticosteroid side effects.
Source: International Ophthalmology - April 30, 2015 Category: Opthalmology Source Type: research

Multimodality evaluation of musculoskeletal sarcoidosis: Imaging findings and literature review
Publication date: Available online 13 April 2015 Source:Diagnostic and Interventional Imaging Author(s): S. Aptel , S. Lecocq-Teixeira , P. Olivier , D. Regent , P. Gondim Teixeira , A. Blum Whilst the detailed X-ray features of thoracic manifestations of sarcoidosis are now clearly defined and known by most radiologists, the same does not apply to osteoarticular and muscular features of the disease, which may however raise major diagnostic problems, either because they are the presenting features of the disease (7% of cases) or because they develop during its course. The bony lesions of sarcoid dactylitis (classical Per...
Source: Diagnostic and Interventional Imaging - April 15, 2015 Category: Radiology Source Type: research

Clinical features and diagnostic evaluation of 83 biopsy-proven sarcoid uveitis cases.
CONCLUSIONS: In this largest European series of biopsy-proven sarcoidosis to date, the outstanding diagnostic ability of enzyme test plus imaging test couple suggests that the recourse to invasive procedures should be limited to patients with ocular involvement that would justify systemic treatments. PMID: 25837608 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - April 2, 2015 Category: Opthalmology Authors: Febvay C, Kodjikian L, Maucort-Boulch D, Perard L, Iwaz J, Jamilloux Y, Broussolle C, Burillon C, Seve P Tags: Br J Ophthalmol Source Type: research

Paraneoplastic sarcoid-like reactions and the eye
Conclusion: Sarcoid-like reactions can occur in the eye, and ocular malignancies may incite sarcoid-like reaction. Ocular sarcoid-like reactions have paraneoplastic features in that they can occur at a site distant from malignancy and may precede, occur simultaneously with, or follow malignancy.
Source: RETINA - March 28, 2015 Category: Opthalmology Tags: Original Study Source Type: research

Sarcoid polyneuropathy masquerading as chronic inflammatory demyelinating polyneuropathy
Conclusions: Sarcoid polyneuropathy presents a diagnostic challenge, but in patients with atypical neuropathy, characteristic systemic symptoms, or a poor response to standard treatment, nerve and muscle biopsies can help diagnose this treatable disorder. This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - March 18, 2015 Category: Internal Medicine Authors: Neel S. Singhal, Viktoriya S. Irodenko, Marta Margeta, Robert B. Layzer Tags: Case of the Month Source Type: research

TGF-β and SMADs mRNA Expression in Pulmonary Sarcoidosis.
Authors: Piotrowski WJ, Kiszałkiewicz J, Pastuszak-Lewandoska D, Antczak A, Górski P, Migdalska-Sęk M, Górski W, Czarnecka K, Nawrot E, Domańska D, Brzeziańska-Lasota E Abstract Lung fibrosis is a complication of sarcoidosis, in which TGF-β/Smad pathway may play an important role. We evaluated gene expression of TGF-β1, SMAD2, 3 and 7 in bronchoalveolar lavage (BAL) cells and peripheral blood (PB) lymphocytes of sarcoidosis patients (n = 94) to better understand the mechanisms of sarcoid inflammation. The relative gene expression was analyzed by qPCR method. Selected clinical/radiological features and b...
Source: Advances in Experimental Medicine and Biology - March 12, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Acute kidney injury caused by sarcoid granulomatous interstitial nephritis without extrarenal manifestations
We report a case of a 70-year-old man with a history of type 2 diabetes mellitus admitted with progressively worsening kidney function. The patient also exhibited anorexia, malaise and weight loss. Laboratory tests showed an elevated serum lysozyme level, but the serum angiotensin-converting enzyme (ACE) and serum calcium levels were normal. Increased uptake was evident only in kidney on gallium 67 scintigraphy. Although typical organ involvement of sarcoidosis was not evident, a renal biopsy showed granulomatous interstitial nephritis with non-caseating granulomas. No medications had been added in the 3 years preceding r...
Source: CEN Case Reports - March 5, 2015 Category: Urology & Nephrology Source Type: research

Sarcoid-Like Reaction—Computed Tomography Features in 12 Patients
Conclusions: Imaging features of patients with sarcoid-like reaction include lymphadenopathy, small nodules, and ultrafine nodules with confluence, mimicking GGO. Ultrafine nodules with confluence mimicking GGO were unexpectedly common in this series.
Source: Journal of Computer Assisted Tomography - March 1, 2015 Category: Radiology Tags: Thoracic and Breast Imaging Source Type: research

Ventricular Tachycardia in Cardiac Sarcoidosis: Characterization of Ventricular Substrate and Outcomes of Catheter Ablation Original Articles
Conclusions— Patients with cardiac sarcoidosis and VT exhibit ventricular substrate characterized by confluent right ventricular scarring and patchy left ventricular scarring capable of sustaining a large number of re-entrant circuits. Catheter ablation is effective in terminating VT storm and eliminating ≥1 inducible VT in the majority of patients, but recurrences are common. Ablation in conjunction with antiarrhythmic drugs can help palliate VT in this high-risk population.
Source: Circulation: Arrhythmia and Electrophysiology - February 17, 2015 Category: Cardiology Authors: Kumar, S., Barbhaiya, C., Nagashima, K., Choi, E.-K., Epstein, L. M., John, R. M., Maytin, M., Albert, C. M., Miller, A. L., Koplan, B. A., Michaud, G. F., Tedrow, U. B., Stevenson, W. G. Tags: Original Articles Source Type: research

Four decades of necrotizing sarcoid granulomatosis: what do we know now?
Conclusion s.- The data showed a striking overlap in the clinical, radiologic, and pathologic features of both entities, strongly supporting the conclusion that necrotizing sarcoid granulomatosis is a previously unrecognized manifestation of sarcoidosis and is essentially the same as nodular sarcoidosis. It is proposed that use of necrotizing sarcoid granulomatosis as a diagnostic term be discontinued and replaced by sarcoidosis with necrotizing sarcoid granulomatosis pattern provided that an infectious etiology can be reasonably excluded. Our concept of sarcoidosis should now be expanded to recognize that there is a conti...
Source: Archives of Pathology and Laboratory Medicine - January 26, 2015 Category: Laboratory Medicine Authors: Rosen Y Tags: Arch Pathol Lab Med Source Type: research

Treatment and outcome of lung cancer in idiopathic interstitial pneumonias.
CONCLUSIONS: LC is a frequent comorbidity in IIP, with a higher incidence and reduced survival in IPF compared to other IIPs. LC treatment is associated with significant toxicity, specifically in IPF. Interdisciplinary evaluation of therapeutic options in IIP patients diagnosed with LC is therefore mandatory. PMID: 25591137 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Seasonal variation of serum KL-6 and SP-D levels in bird-related hypersensitivity pneumonitis.
Authors: Okamoto T, Tsutsui T, Suhara K, Furusawa H, Miyazaki Y, Inase N Abstract N/A. PMID: 25591150 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Proceedings of the 2014 AASOG conference.
Authors: Crouser E, Judson M Abstract Not applicable. PMID: 25591149 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Intravascular large B cell lymphoma presenting in the lung: the diagnostic value of transbronchial cryobiopsy.
CONCLUSIONS: transbronchial cryobiopsy could be used as valid surrogate for surgical lung biopsy in lymphoprolipherative lung disorders (including intravascular lymphomas), as allows larger samples of tissue, greater  diagnostic yield, no crush artifacts and much less complications than surgical biopsy.  PMID: 25591148 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Granulomatous lung disease in a patient with a family history of hematological disorders.
Authors: Overbeek M, Van de Loosdrecht A, Vonk-Noordegraaf A Abstract A 29-year old patient presented with granulomatous lung disease and a family history of myelodysplastic syndrome/acute myeloid leukemia. She appeared to be a carrier of a mutation in the transcription factor GATA2. The case adds to the recent described heterogeneous clinical manifestations and syndromes in which, against a background of hematologic disorders, GATA2 mutations have been demonstrated, such as the Monomac and Emberger syndromes. In patients with a granulomatous disease and a history of (familial) hematologic disorders, the occurence ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A pilot study: a combined therapy using polymyxin-B hemoperfusion and extracorporeal membrane oxygenation for acute exacerbation of interstitial pneumonia.
CONCLUSION: A combined therapy of PMX-DHP and VV-ECMO might be a therapeutic option for AE of IP. PMID: 25591146 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

In vitro and in vivo study of anti-tuberculosis effect of extracts isolated from Ranunculi Ternati Radix.
CONCLUSIONS: EEPMR possessed better anti-tuberculosis effects than other extracts and Radix Ranunculi Ternati Capsules. This supported the use of macroporous resin to enrich the active part of Ranunculi Ternati Radix to cure mycobacterium tuberculosis infections. PMID: 25591145 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Reconsideration of discrepancies between clinical and histopathological features in acute eosinophilic pneumonia.
Conclusion) Characteristic histopathological findings of AEP consist of alveolar edema with infiltration of eosinophils and lymphocytes and edema of perivascular area and interlobular septa. The alveolar spaces showed fibrinous exudates. There were no hyaline membranes or massive intraluminal fibrosis. These histopathological findings of interstitial edema and fluid exudates are consistent with radiological findings of lung edema and can explain the rapid and complete improvement.Because AEP does not exhibit lung fibrosis histopathologically, it should not to be included in DAD which is associated with lung fibrosis.  ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pulmonary hypertension in idiopathic pulmonary fibrosis does not influence six-minute walk distance: results from a retrospective study.
CONCLUSIONS: Our data suggested that 6MWD does not differ between IPF patients with or without PH. Thus, 6MWD should not be used as a surrogate endpoint in clinical study in patients affected by IPF and PH. PMID: 25591141 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Association between idiopathic pulmonary fibrosis and coronary artery disease: a case-control study and cohort analysis.
CONCLUSIONS: IPF itself was an independent risk factor for CAD after the adjustment of age, hypertension, diabetes, and hypercholesterolemia. PMID: 25591140 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Immunologic finding of disseminated granuloma reaction in patients with Mycobacterium tuberculosis and sarcoidosis
Conclusion This is the first case report from patients with unique features of NSG combined with MTB.
Source: International Journal of Mycobacteriology - January 10, 2015 Category: Infectious Diseases Source Type: research

Identifying Toll-like Receptor Expression in Cutaneous Sarcoidosis
Abstract:Toll-like receptors (TLRs) are known to be expressed in the skin. Antigenic stimulation of TLRs in the skin has been implicated in several inflammatory dermatologic diseases including psoriasis, syphilis, atopic dermatitis, and cutaneous T-cell lymphoma. However, the expression of TLRs in cutaneous sarcoidosis has not yet been defined. Expression of TLRs 1–9 was examined in cutaneous sarcoid by immunohistochemical staining. It was found that TLRs 5 and 6 stained most intensely in both the granulomas and epidermis of the sarcoid cases. TLRs 2, 3, 4, 7, and 8 stained more intensely compared with normal skin. All s...
Source: The American Journal of Dermatopathology - January 1, 2015 Category: Pathology Tags: Brief Report Source Type: research

Sarcoid-Like Reaction in Sentinel Lymph Node Draining Conjunctival Melanoma
A sarcoid-like reaction is the presence of noncaseating granulomas due to a T-cell mediated inflammatory reaction in draining lymph nodes of tumors or in the vicinity of tumors. Breast cancer, lymphoma, and cutaneous melanoma have been observed to induce a sarcoid-like reaction. Herein, a patient is reported with conjunctival melanoma in whom multiple noncaseating granulomas were observed in the sentinel lymph node without evidence of micrometastasis. Fungal and mycobacterium stainings were negative and further systemic workup excluded sarcoidosis. This case identifies conjunctival melanoma as a cause of a sarcoid-like reaction.
Source: Ophthalmic Plastic and Reconstructive Surgery - January 1, 2015 Category: Opthalmology Tags: Case Reports Source Type: research

Refractory Sarcoid Arthritis in World Trade Center–Exposed New York City Firefighters: A Case Series
Conclusions: Chronic inflammatory polyarthritis appears to be an important manifestation of sarcoidosis in FDNY firefighters with sarcoidosis and WTC exposure. Their arthritis is chronic and, unlike arthritis in non–WTC-exposed sarcoid patients, inadequately responsive to conventional oral disease-modifying antirheumatic drugs, often requiring anti–tumor necrosis factor α agents. Further studies are needed to determine the generalizability of these findings to other groups with varying levels of WTC exposure or with other occupational/environmental exposures.
Source: JCR: Journal of Clinical Rheumatology - December 30, 2014 Category: Rheumatology Tags: Original Articles Source Type: research

Sarcoidosis in India: Investigation into vitamin D and calcium metabolism
Conclusions:Our study shows hypovitaminosis D in both cases and controls. Although these patients escape the brunt of hypercalcemia, they may suffer from adverse effects of hypovitaminosis D which can be attributed to inherent prevalence of Vitamin D deficiency in Indian population.Hence, they may rather need calcium and vitamin D supplementation under close monitoring.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Chandrashekariah, S., Rosha, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Does the BTNL2 genotype influence the course of disease in Danish sarcoidosis patients?
Conclusions: BTNL2 AA genotype is prevalent in patients with sarcoidosis and may be of use to help establish a diagnosis. There appeared to be no association between BTNL2 genotype and outcome of disease.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Milman, N., Van Overeem Hansen, T., Skov Jensen, M. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Heat shock proteins as 'danger signals' in sarcoidosis
Sarcoidosis (SA) is a multisystem granulomatous disease with unknown etiology. Like other autoimmunological disorders, SA develops due to a combination of genetic and non-infectious/infectious factors.We evidenced, that the same mycobacterial heat shock proteins (Mtb-HSPs, especially HSP16, the main marker of dormant stage of (myco)bacteria), occurring in sarcoid tissues and in precipitated immune complexes (CIs), were inducing immune response dependently on different genetic background of host (HLA and non-HLA-NRAMP1,FCGRIIA,IIC,IIIA), developing acute sarcoidosis/Löfgren syndrome, chronic SA, latent, or active TB. I...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Dubaniewicz, A. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Comorbidities associated with sarcoidosis - Results from long-term observational study
Conclusion: We have found significant number of comorbidities in patients with sarcoidosis. Screening for these conditions, especially thyroid and neoplastic disorders, should be considered in these patients.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Nowinski, A., Puscinska, E., Goljan-Geremek, A., Bednarek, M., Kaminski, D., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Mortality in sarcoidosis, results from one centre, long term observational study
Conclusion:The leading cause of death in sarcoid patients in our Department were cancers, but just as often, sarcoidosis was the underlying cause of death.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Puscinska, E., Nowinski, A., Goljan-Geremek, A., Bednarek, M., Kaminski, D., Kowalska, A., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Impulse oscillometry measurements are correlated to quality of life in patients with pulmonary sarcoidosis
ConclusionIOS measurements correlate with symptom burden more strongly than conventional lung function markers in sarcoidosis. Whether this reflects their higher sensitivity to small airway changes requires further study.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Karagiannis, K., Bikov, A., Bonifazi, M., Kalsi, H., Lota, H., Meah, S., Barnes, P., Wells, A. U., Paredi, P., Usmani, O. S., Renzoni, E. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Proteomic investigation of pulmonary sarcoidosis
Pulmonary Sarcoidosis is characterised by hystiopatological features of noncaseating epithelioid cell granulomas originated from alveolar macrophages. Despite sarcoidosis occurs more frequent in never-smoker subjects than smokers, it has been speculated that unknown inhaled antigens may induce aberrant leukocytes stimulation leading to formation of sarcoid granuloma.Our group of research applied the proteomic approach to the analysis of bronchoalveolar lavage (BAL) in order to contribute to the study of the pathogenetic mechanisms of the disease and to differentiate potential disease biomarkers.BALF samples were resolved b...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bargagli, E., Landi, C., Carleo, A., Cillis, G., Refini, R. M., Bennett, D., Perari, M. G., Bini, L., Rottoli, P. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Differential bronchoalveolar expression of candidate microRNAs in chronic obstructive pulmonary disease, asthma bronchiale and pulmonary sarcoidosis
Conclusion: The differences in BAL miRNA expression between the investigated pulmonary diseases may contribute to variation of inflammatory response in their pathomechanisms. Characterisation of typical miRNA expression profiles is the next step of this work.Grant support IGAPULF2014_012, IGAMZ11117, CZ.1.05./2.1.00/01.0030.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Navratilova, Z., Novosadova, E., Krsjakova, T., Kolek, V., Petrek, M. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Detection of exosomal miRNA in pulmonary sarcoidosis
Conclusions: The implemented methodology for detection of miRNA in exosomes from BALF enabled to detect exosomal miR-21, -26a and -146a in sarcoidosis. Future analyses will focus on detailed characterization of exosomal expression profile in sarcoidosis, also in comparison with healthy subjects / diffuse lung disease. Grant support: CZ.1.07/2.3.00/30.0041, CZ.1.05./2.1.00/01.0030.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Kishore, A., Navratilova, Z., Kolek, V., Petrek, M. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Tracheal epithelial-myoepithelial carcinoma associated with sarcoid-like reaction: a case report
We report the first case of epithelial-myoepithelial carcinoma associated with sarcoidosis. A 61 year old Hispanic man presented with altered mental status and hypercalcemia. Imaging revealed diffuse intra-thoracic and intra-abdominal lymphadenopathy. A diagnostic bronchoscopy was performed where an incidental tracheal nodule was discovered and biopsied. Pathology was consistent with epithelial-myoepithelial carcinoma. Lymph node biopsy demonstrated non-caseating granulomas consistent with sarcoidosis. Patient underwent tracheal resection of the primary tumor with primary tracheal reconstruction. Hypercalcemia subsequently...
Source: Respiratory Medicine Case Reports - December 17, 2014 Category: Respiratory Medicine Source Type: research

Sarcoidosis: Role of non-tuberculosis mycobacteria and Mycobacterium tuberculosis
Publication date: December 2014 Source:International Journal of Mycobacteriology, Volume 3, Issue 4 Author(s): Esmaeil Mortaz , Ian M. Adcock , Peter J. Barnes Sarcoidosis is a granulomatous inflammatory disease that is induced by unknown antigen(s) in a genetically susceptible host. Although the direct link between Mycobacterium tuberculosis (MTB) infection and sarcoidosis can be excluded on the basis of current knowledge, non-infectious mechanisms may explain the causative role of mycobacterial antigens. Ever since sarcoidosis was first described, its relationship with tuberculosis (TB) has been under-investigated. Whe...
Source: International Journal of Mycobacteriology - November 29, 2014 Category: Infectious Diseases Source Type: research

A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ.
We report the case of a 64-year-old Japanese woman who suffered from concomitant or sequential infections of the skin, lungs, bronchi, uterus, andbladder with nontuberculous mycobacteriosis, cerebellar toxoplasmosis, measles,herpes zoster, and vulvar herpes. Blood mononuclear cells from the patient displayed intact cytokine production in response to various stimuli and interferon-γ. High-titer anti-interferon-γ autoantibodies were detected in her serum. The atypical pathology hampered early diagnosis, but indeterminate results of an interferon-γ release assay could offer a simple clue suggesting the presence of autoanti...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The many faces of Pulmonary Langerhans Cell Histiocytosis.
We present two cases, one with choroidal involvement with asymptomatic nodulo-cystic changes in the lungs and another case with advanced single organ pulmonary involvement. We discuss the various treatment modalities and highlight the lack of adequate guidelines to treat adults. Most of the current guidelines are based on evidence derived from pediatric literature. We would also like to draw attention to the asymptomatic nature of the lung involvement and suggest that imaging of the lung be obtained in all cases of Langerhans Cell Histiocytosis. PMID: 25363226 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Clinical experience with pirfenidone in five patients with scleroderma-related interstitial lung disease.
Authors: Miura Y, Saito T, Fujita K, Tanaka T, Tsunoda Y, Azuma A, Nei T, Yatagai Y, Rin S, Sekine A, Hayashihara K Abstract Interstitial lung disease is the most common complication and cause of death among patients with scleroderma. Scleroderma-related interstitial lung disease has usually been treated with cyclophosphamide; however, its effect was evaluated to be modest and long-term administration of this drug is associated with adverse effects. Herein, we report our clinical experience of administering pirfenidone, which is an antifibrotic agent, in five patients with scleroderma-related interstitial lung dise...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Prevention of Pulmonary Fibrosis via Trichostatin A (TSA) in Bleomycin Induced Rats.
CONCLUSION: Non selective histone deacetylase inhibitors of Trichostatin A (TSA) can reduce the bleomycin induced pulmonary fibrosis in rats. TSA attenuates pulmonary fibrosis and it can inhibit HDAC2 expression at the gene and protein level. Bleomycin induced fibrosis has the relationship with p-SMAD2 in gene and protein levels, but TSA inhibit bleomycin-induced lung fibrosis effect with no relation with SMAD2 phosphorylation pathways. PMID: 25363222 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Analysis of lung function and survival in RECAP: An open-label extension study of pirfenidone in patients with idiopathic pulmonary fibrosis.
CONCLUSION: FVC and survival outcomes in IPF patients newly treated with pirfenidone in RECAP were similar to those in the CAPACITY pirfenidone group. These data provide further evidence to support the use of pirfenidone in patients with IPF. PMID: 25363219 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Idiopathic Pulmonary Fibrosis (IPF) incidence and prevalence in Italy.
CONCLUSION: The data provide a first estimate of IPF incidence in Italy and indicate that incidence and prevalence in southern European regions may be similar to those observed in northern Europe and North America. PMID: 25363218 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Transbronchial cryobiopsy in diffuse parenchymal lung disease. A new star in the horizon.
Authors: Poletti V, Benzaquen S Abstract IntroductionSurgical lung biopsy is still considered the gold standard to obtain enough lung tissue in the clinical context of diffuse parenchymal lung disease... PMID: 25363216 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Metformin/glibenclamide-related interstitial lung disease: a case report.
Authors: Zuccarini G, Bocchino M, Assante LR, Rea G, Sanduzzi A Abstract Interstitial lung disease (ILD) may be caused by a wide panel of recognized drugs. Despite the increasing number of reports in the literature, high-lightings of ILD related to oral hypoglycemic drugs are very infrequent.  Herein, we describe the case of a 78-yr-old Caucasian diabetic woman who developed mild dyspnoea at rest, asthenia and fever while on treatment with oral metformin (2000 mg/day) and glibenclamide (12.5 mg/day). On hospital admission, pulmonary function testing (PFT), chest x-ray and thorax high resolution computed tomography...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Clinical course and characterisation of lymphangioleiomyomatosis in a Brazilian reference centre.
CONCLUSIONS: Clinical and functional features of the LAM patients from our centre are similar to those from other countries. Our sample showed preserved exercise capacity, with desaturation in the 6MWT, and impaired quality of life. Survival was similar, whereas the annual rate of decline of FEV1 was slightly lower than in recent studies. PMID: 25078640 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The clinical and integrated management of COPD.
This article is being simultaneusly published in Multidisciplinary Respiratory Medicine 2014; 9:25(Sarcoidosis Vasc Diffuse Lung Dis 2014; 31 Suppl 1: 3-21). PMID: 24820963 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Decreased sputum caveolin-1 is associated with systemic sclerosis related lung disease.
CONCLUSION:    These results suggest that decreased sputum Cav-1 levels is associated with SSc related-ILD and may be used as a marker for the detection of SSc-ILD.   PMID: 24751454 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Features and outcome of familial idiopathic pulmonary fibrosis.
Conclusion:familial IPF seems indistinguishable from sporadic IPF with respectto most clinical and physiologic findings; however the age of onsetwas slightly lower among the familial cases than in the sporadiccases of IPF and the phenomenon of anticipation could be observed. PMID: 24751451 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Multi-dimensional indices to stage idiopathic pulmonary fibrosis: a systematic review.
Authors: Rozanski C, Mura M Abstract Idiopathic pulmonary fibrosis (IPF) has the highest mortality rate among all interstitial lung diseases, with a mean survival time of 2 to 3 years from the time of diagnosis. Prognosis is difficult to determine, due to the recognized heterogeneous progression of the disease, as well as lack of a well recognized staging system. This in turn raises challenges when considering therapeutic options for IPF patients, such as lung transplantation, versus a more conservative approach.  Multiple independent factors have been identified as prognostic indicators in IPF, and a number of st...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Wire brushing wood furniture, granulomatosis and microscopic mineralogical analysis.
Authors: Catinon M, Chemarin C, Assaad S, Vuillermoz-Blas S, Roux E, Traverse-Glehen A, Cavalin C, Rosental PA, Vincent M Abstract IntroductionThere is increasing evidence that sarcoidosis can occur in workplaces in which there is exposure to inorganic triggers (1-3). Moreover, transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) analysis may contribute to identifying micro and/or nanoparticles in granulomatous tissues  (4-6) and, out of the workplace, hobby activities may also involve dangerous exposure... PMID: 25363230 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Transthoracic lung ultrasonography in pulmonary alveolar proteinosis - case report.
We present a patient in whom repeated transthoracic lung ultrasonography (TLUS) brought parallel to HRCT data in assessing PAP extent. It may indicate that TLUS might be potentially a relevant tool in monitoring of PAP. PMID: 24351624 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research