This page shows you the latest news items in this category. This is page number 13.

Total 4711 results found since Jan 2013.

G908R NOD2 variant in a family with sarcoidosis
Sarcoidosis is a systemic disease characterized by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Exaggerated granulomatous reaction might be triggered in resp...
Source: Respiratory Research - March 20, 2018 Category: Respiratory Medicine Authors: Val érie Besnard, Alain Calender, Diane Bouvry, Yves Pacheco, Catherine Chapelon-Abric, Florence Jeny, Hilario Nunes, Carole Planès and Dominique Valeyre Tags: Research Source Type: research

Diagnostic value of quantitative assessment of cardiac 18 F-fluoro-2-deoxyglucose uptake in suspected cardiac sarcoidosis
ConclusionsOur results suggest that quantitative analysis of cardiac dynamic18F-FDG PET/CT could be a useful tool for the diagnosis of cardiac sarcoidosis.
Source: Annals of Nuclear Medicine - March 20, 2018 Category: Nuclear Medicine Source Type: research

Symptomatic muscular sarcoidosis: Lessons from a nationwide multicenter study
Conclusion This nationwide study of muscular sarcoidosis allowed the identification of 4 patterns of granulomatous myositis, which differed by phenotypes and the clinical course.
Source: Neurology Neuroimmunology and Neuroinflammation - March 16, 2018 Category: Neurology Authors: Cohen Aubart, F., Abbara, S., Maisonobe, T., Cottin, V., Papo, T., Haroche, J., Mathian, A., Pha, M., Gilardin, L., Hervier, B., Soussan, M., Morlat, P., Nunes, H., Benveniste, O., Amoura, Z., Valeyre, D. Tags: All Neuromuscular Disease, Cohort studies Article Source Type: research

Treatment of Sarcoidosis.
PMID: 29543101 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - March 15, 2018 Category: Respiratory Medicine Authors: Raghu G, Berman JS, Govender P Tags: Am J Respir Crit Care Med Source Type: research

Primary Cavitary Sarcoidosis, an Extremely Rare Form of Presentation.
PMID: 29544860 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - March 12, 2018 Category: Respiratory Medicine Authors: Gil Guerra AB, López Pedreira MR, Cartón Sánchez P, Santos Velasco P Tags: Arch Bronconeumol Source Type: research

Skin and Nasal Involvement: Look for Sarcoidosis!
Sarcoidosis is a systemic, noncaseating, granulomatous disease affecting young adults between the ages of 25 and 40 years, most often of Black origin (35.5/100,000 vs 10.9 in the White population). Although the lower respiratory tract is affected in 90% of cases, ear, nose, and throat locations are very uncommon, with a prevalence varying between 1% and 6.5%.1 In addition, ear, nose, and throat manifestations are nonspecific, and may be difficult to differentiate from other granulomatous diseases such as actinomycosis, aspergillosis, antineutrophil cytoplasmic antibody-associated vasculitis and tuberculosis, thus, frequent...
Source: The American Journal of Medicine - March 12, 2018 Category: General Medicine Authors: Thomas Radulesco, Pierre-Andr é Jarrot, Raphael Cauchois, Nicolas Macagno, Gilles Kaplanski, Patrick Dessi, Justin Michel Tags: Clinical Communication to the Editor Source Type: research

Nuclear Imaging in Sarcoidosis
Sarcoidosis is a multisystem granulomatosis which may result in a wide variety of clinical and biological presentations. Symptoms are often nonspecific, and incidental abnormal findings on chest radiography is rather common. Although sarcoidosis resolves favorably in most cases, some localizations can provoke functional impairment or even impact on patients' prognosis. The diagnosis is based on a pathological hallmark which is the non-necrotizing epithelioid-cell rich granuloma.Owing to the ability to detect inflammation throughout the body with a high sensibility, FDG-PET/CT gained a central role in sarcoidosis because it...
Source: Seminars in Nuclear Medicine - March 9, 2018 Category: Nuclear Medicine Authors: Eve Piekarski, Khadija Benali, Fran çois Rouzet Source Type: research

Extrapulmonary Tumors and Sarcoidosis. An Incidental or Real association?
PMID: 29523377 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - March 6, 2018 Category: Respiratory Medicine Authors: Pereiro T, Golpe A, Lourido T, Valdés L Tags: Arch Bronconeumol Source Type: research

Whole exome sequencing in three families segregating a pediatric case of sarcoidosis
Sarcoidosis (OMIM 181000) is a multi-systemic granulomatous disorder of unknown origin. Despite multiple genome-wide association (GWAS) studies, no major pathogenic pathways have been identified to date. To fi...
Source: BMC Medical Genomics - March 6, 2018 Category: Genetics & Stem Cells Authors: Alain Calender, Pierre Antoine Rollat Farnier, Adrien Buisson, St éphane Pinson, Abderrazzaq Bentaher, Serge Lebecque, Harriet Corvol, Rola Abou Taam, Véronique Houdouin, Claire Bardel, Pascal Roy, Gilles Devouassoux, Vincent Cottin, Pascal Seve, Jean-F Tags: Research article Source Type: research

Sarcoidosis presenting as Wallenberg syndrome and panuveitis
We report a case of a patient who presented with the lateral medullary syndrome and panuveitis as her initial manifestation of sarcoidosis. The patient's course was further complicated by renal involvement. Lacrimal gland and renal biopsies showed noncaseating granulomas without evidence of infection, establishing the diagnosis. Intracranial vertebral artery involvement was confirmed by brain imaging. Bilateral hilar lymphadenopathy with upper lobe predominant nodules on chest imaging was consistent with asymptomatic pulmonary involvement. Systemic steroid therapy is indicated for treatment of ocular sarcoidosis, with stan...
Source: Respiratory Medicine Case Reports - March 3, 2018 Category: Respiratory Medicine Source Type: research

Sarcoidosis-associated Pulmonary Hypertension: Pathophysiology, Diagnosis, and Treatment
Clinicians in pulmonary medicine frequently confront the challenge of screening, diagnosis, and management of pulmonary hypertension (PH) in sarcoidosis patients who present with unexplained dyspnea. Sarcoidosis-associated pulmonary hypertension (SAPH) is most prevalent in patients with pulmonary fibrosis, although it can be independent of airflow obstruction or restriction. SAPH is independently associated with significantly increased mortality and decreased functional capacity, outcomes that can be mitigated by early detection and focused treatment. In this review, we discuss the pathophysiology of SAPH, which may resemb...
Source: Clinical Pulmonary Medicine - March 1, 2018 Category: Respiratory Medicine Tags: Interstitial, Inflammatory and Occupational Lung Disease Source Type: research

Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes
In this study, we aimed to investigate 1) whether Th17.1 cells are also increased in the MLNs of sarcoidosis patients and 2) whether frequencies of the Th17.1 cells at diagnosis may correlate with disease progression. MLN cells from treatment-naive pulmonary sarcoidosis patients (n=17) and healthy controls (n=22) and peripheral blood mononuclear cells (n=34) and bronchoalveolar lavage fluid (BALF) (n=36) from sarcoidosis patients were examined for CD4+ T-cell subset proportions using flow cytometry. Higher proportions of Th17.1 cells were detected in sarcoidosis MLNs than in control MLNs. Higher Th17.1 cell proportions wer...
Source: European Respiratory Journal - March 1, 2018 Category: Respiratory Medicine Authors: Broos, C. E., Koth, L. L., van Nimwegen, M., in 't Veen, J. C. C. M., Paulissen, S. M. J., van Hamburg, J. P., Annema, J. T., Heller-Baan, R., Kleinjan, A., Hoogsteden, H. C., Wijsenbeek, M. S., Hendriks, R. W., van den Blink, B., Kool, M. Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung disease Source Type: research

Reassessing Th1 versus Th17.1 in sarcoidosis: new tricks for old dogma
Immunologically, sarcoidosis has been classically defined by the presence of a Th1-dominant environment localised to sites of disease, characterised by overexpression of interferon (IFN) and Th1-promoting interleukin (IL)12 and IL18 [1]. Accordingly, the downstream effects of enhanced Th1 are also observed in sarcoidosis, such as the expression of Th1-associated chemokines (MIG/CXCL9, IP10/CXCL10, ITAC/CXCL11, MCP1/CCL2, MIP1α/CCL3, MIP1β/CCL4, RANTES/CCL5) and their respective receptors (CXCR3, CCR5). Conversely, the presence of augmented Th2 has never been firmly documented in the sarcoidosis lung.
Source: European Respiratory Journal - March 1, 2018 Category: Respiratory Medicine Authors: Chen, E. S. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Pancreatitis as the presenting symptom of abdominal sarcoidosis.
We present a 60-year-old woman with non-pulmonary sarcoidosis manifesting as acute pancreatitis, possibly due to hypercalcaemia. Pancreatitis in sarcoidosis is rare, particularly as a presenting symptom. This case demonstrates that sarcoidosis should be included in the differential diagnosis of pancreatitis with hypercalcaemia, even without pulmonary signs of sarcoidosis. PMID: 29515009 [PubMed - in process]
Source: The Netherlands Journal of Medicine - March 1, 2018 Category: General Medicine Authors: Lucassen EA, Bootsma AH, Overbeek MJ Tags: Neth J Med Source Type: research

Global longitudinal strain and long ‐term outcomes in asymptomatic extracardiac sarcoid patients with no apparent cardiovascular disease
ConclusionsIn conclusion, among patients with extracardiac sarcoidosis and no symptoms of cardiovascular disease, even when EF is preserved, GLS seems to be strongly associated with adverse future events.
Source: Echocardiography - February 28, 2018 Category: Cardiology Authors: Ioannis Felekos, Constantina Aggeli, Elias Gialafos, Vasileios Kouranos, Aggeliki Rapti, Petros Sfikakis, Nikolaos Koulouris, Dimitris Tousoulis Tags: ORIGINAL INVESTIGATION Source Type: research

Short-Term Effects of a Multimodal 3-Week Inpatient Pulmonary Rehabilitation Programme for Patients with Sarcoidosis: The ProKaSaRe Study
Conclusions: Our results provide the first documented evidence that PR is a promising complementary therapy option for sarcoidosis patients who remain subjectively symptomatic despite optimised outpatient medical treatment.Respiration
Source: Respiration - February 27, 2018 Category: Respiratory Medicine Source Type: research

Cryptococcal-related meningoencephalitis in a patient with sarcoidosis and CD4 lymphocytopenia: thorough immunological characterization of lymphocyte homeostasis.
We report on reduced production of new T cells observed in a patient with sarcoidosis, CD4 lymphocytopenia, and cryptococcal-related meningoencephalitis. Although T cells presented with an intact proliferative capacity, they were oligoclonally expanded showing an effector memory phenotype. However, the deleterious activity of effector memory cells could have been controlled by the expansion of the regulatory T cell subset with the highest suppressive capability. This information provide a better understanding of the immune response to cryptococcus occurring in non-HIV-associated cases, the predisposition to infection, and ...
Source: Journal of Neurosurgical Sciences - February 27, 2018 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

The Clinical Features of Sarcoidosis: A Comprehensive Review
Abstract Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoidosis. These manifestations are presented organ by organ, although additional sections describe systemic and multiorgan presentations of sarcoidosis. The lung is the organ most commonly involved with sarcoidosis with at least 90 % of sarcoidosis patients demonstrating lung involvement in mos...
Source: Clinical Reviews in Allergy and Immunology - October 2, 2014 Category: Allergy & Immunology Source Type: research

A cytomorphometric analysis of pulmonary and mediastinal granulomas: Differentiating histoplasmosis from sarcoidosis by fine‐needle aspiration
CONCLUSIONSDifferentiation between histoplasmosis and sarcoidosis is possible in the majority of cases. Histoplasmosis usually exhibits few angular, ragged granulomas (<2 granulomas per slide) in a background of bland necrosis. Yeasts are identified on special stains performed in aspirate smears. Sarcoidosis typically contains many more granulomas (often >10 per slide) than histoplasmosis and has a rounded morphology with crisp and sharp borders. Typically, there is no necrosis or acute inflammation, and giant cell infiltrates are frequent. Cancer (Cancer Cytopathol) 2014. © 2014 American Cancer Society.
Source: Cancer Cytopathology - October 1, 2014 Category: Pathology Authors: Michael P. Gailey, Matthew E. Keeney, Chris S. Jensen Tags: Original Article Source Type: research

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes
Previously, we demonstrated concordance in differentially expressed genes in sarcoidosis blood and lung, implicating shared dysfunction of specific immune pathways. In the present study, we hypothesised that expression levels of candidate genes in sarcoidosis blood could predict and track with disease outcomes longitudinally. We applied Ingenuity Pathway Analysis to a cross-sectional derivation microarray dataset (n=38) to identify canonical pathways and candidate genes associated with sarcoidosis. In a separate longitudinal sarcoidosis cohort (n=103), we serially measured 48 candidate gene transcripts, and assessed their ...
Source: European Respiratory Journal - September 30, 2014 Category: Respiratory Medicine Authors: Su, R., Li, M. M., Bhakta, N. R., Solberg, O. D., Darnell, E. P. B., Ramstein, J., Garudadri, S., Ho, M., Woodruff, P. G., Koth, L. L. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

A challenging case: spinal cord sarcoidosis
A 54-year old man with severe ankylosing spondylitis presented with rapidly progressing bilateral lower limb weakness and altered sensation, associated with urinary retention. Examination showed flaccid paraparesis with lower limb areflexia and a sensory level to T10. His upper limbs were normal. MR scan of whole spine showed marked ankylosing spondylitis changes, including canal narrowing, and extensive, discontinuous signal change within the spinal cord at C7–T1, T3–T4 and T7–T11. There was no leptomeningeal enhancement. Severe ankylosing spondylitis meant we were unable to obtain CSF, MR scan of head o...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Wynford-Thomas, R., Smith, P. Tags: Abstracts Source Type: research

Sarcoidosis of the Head and Neck
This article seeks to provide a comprehensive review of head and neck sarcoidosis, as this fascinating disorder often poses a diagnostic and therapeutic challenge. A brief discussion of surgical treatment for pituitary lesions is also provided. Articles from 1997 to 2013 were selected and reviewed by three researchers utilizing the most recent literature regarding sarcoidosis in the head and neck. PubMed searches were conducted using search terms such as “sarcoidosis”, “neurosarcoid”, and “extra-pulmonary sarcoid”, among many others. A large collection of articles was generated and reviewed by the team of autho...
Source: Head and Neck Pathology - September 3, 2014 Category: Pathology Source Type: research

Esophageal cancer associated with bilateral hilar lymphadenopathy caused by sarcoid-like reactions: a report of two cases
We report two patients with esophageal cancer accompanied by bilateral hilar lymphadenopathy or accumulation on [18F]-fluorodeoxyglucose positron emission tomography–computed tomography. The first patient underwent surgery because the enlarged bilateral hilar lymph nodes were considered to be nonmalignant lesions owing to superficial carcinoma and symmetric distribution of the hilar lymph nodes. The second patient received chemotherapy, which caused the main tumor to shrink and decreased [18F]-fluorodeoxyglucose uptake. However, chemotherapy did not affect the hilar lymphadenopathy, which suggests that it was caused by r...
Source: Esophagus - September 2, 2014 Category: Gastroenterology Source Type: research

Application of medical thoracoscopy in diagnosis of sarcoidosis‐related pleural effusion
Abstract Pleural effusion caused by sarcoidosis is unusual. Medical thoracoscopy could help clinicians detect associated pleural disease, yet studies on thoracoscopic observations in sarcoidosis pleural involvement are rare. In this article, we report the utility of medical thoracoscopy in diagnosing sarcoid‐related pleural disease for three patients. Pleural nodularity was common with solitary and multiple nodules evident; biopsies confirmed the presence of diagnostic noncaseating granulomas. Medical thoracoscopy showed that sarcoidosis pleural involvement was variable from multiple nodules to subtle change in the pleura.
Source: Respirology Case Reports - July 2, 2014 Category: Respiratory Medicine Authors: Feng Wang, Zhaohui Tong, Zhen Wang, Xiaojuan Wang, Xi Zhan, Huanzhong Shi Tags: Case Report Source Type: research

Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis
Abstract: A 52-year-old Japanese woman complaining of horizontal double vision for 10days was admitted to our hospital. Neurological examination revealed left abducent nerve palsy and muscle swelling in her thighs. Brain MRI showed obstruction in the spinal fluid space of the left Dorello's canal, which transmits a portion of the abducent nerve. In Ga-67-enhanced citrate scintigraphy, wide accumulation was seen in her bilateral thighs, lower legs, and gluteus muscles. Muscular MRI showed a star-shaped central structure on short tau inversion recovery (STIR) images, and the three stripes sign on T2-weighted images. These MR...
Source: Journal of the Neurological Sciences - June 2, 2014 Category: Neurology Authors: Ayako Shioya, Hiroshi Takuma, Masanari Shiigai, Akiko Ishii, Akira Tamaoka Tags: Short Communications Source Type: research

Cardiac sarcoidosis presenting as constrictive pericarditis.
We report the case of a 57-year-old man who presented with clinical and hemodynamic features of constrictive pericarditis, of unclear cause. He was admitted for treatment of recurrent pleural effusion. After a complicated hospital course, he underwent pericardiectomy. His clinical and hemodynamic conditions improved substantially, and he was discharged from the hospital in good condition. The pathologic findings, the patient's clinical course, and his response to pericardiectomy led to our diagnosis of cardiac sarcoidosis presenting as constrictive pericarditis. In addition to the patient's case, we discuss the nature and ...
Source: Texas Heart Institute Journal - June 1, 2014 Category: Cardiology Authors: Darda S, Zughaib ME, Alexander PB, Machado CE, David SW, Saba S Tags: Tex Heart Inst J Source Type: research

Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis.
Abstract Sarcoidosis is an immune-mediated multisystem disease characterized by the formation of non-caseating granulomas. The pathogenesis of sarcoidosis is unclear, with proposed infectious or environmental antigens triggering an aberrant immune response in susceptible hosts. Multiple pro-inflammatory signaling pathways have been implicated in mediating macrophage activation and granuloma formation in sarcoidosis, including IFN-γ/STAT-1, IL-6/STAT-3, and NF-κB. It is difficult to distinguish sarcoidosis from other granulomatous diseases or assess disease severity and treatment response with histopathology alon...
Source: Experimental and Molecular Pathology - April 21, 2014 Category: Pathology Authors: Christophi GP, Caza T, Curtiss C, Gumber D, Massa PT, Landas SK Tags: Exp Mol Pathol Source Type: research

Sarcoidosis and uveitis.
Abstract Uveitis is a frequent (20-50%) and early feature of sarcoidosis. Typical sarcoid uveitis presents with mutton-fat keratic precipitates, iris nodules, and anterior and posterior synechiae. Posterior involvement includes vitreitis, vasculitis, and choroidal lesions. Cystoid macular edema is the most important and sight-threatening consequence. Histologic proof from a biopsy is the gold standard for the diagnosis of ocular sarcoidosis An international workshop has recently established diagnostic criteria for sarcoidosis uveitis when biopsy is unavailable or negative: these are based on a combination of ophth...
Source: Autoimmunity Reviews - April 3, 2014 Category: Allergy & Immunology Authors: Jamilloux Y, Kodjikian L, Broussolle C, Sève P Tags: Autoimmun Rev Source Type: research

Cardiac Sarcoid: A Chameleon Masquerading as Hypertrophic Cardiomyopathy and Dilated Cardiomyopathy in the Same Patient
We describe a case of cardiac sarcoid in a young patient wherein a distinctive appearance of the cardiac sarcoid spectrum from “hypertrophic” stage to thinned/scarred stage, masquerading as hypertrophic cardiomyopathy followed by dilated cardiomyopathy, is demonstrated.
Source: Echocardiography - February 8, 2014 Category: Cardiology Authors: Anushree Agarwal, Nasir Z. Sulemanjee, Omar Cheema, Francis X. Downey, A. Jamil Tajik Tags: Case Report Source Type: research

Necrotizing sarcoid granulomatosis with an uncommon manifestation: clinicopathological features and review of literature.
We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-year-old non smoker male. The patient was admitted to the hospital for sudden back pain. Chest X-ray revealed areas of parenchymal consolidation and high resolution computed tomography demonstrated a pulmonary nodular pattern without any lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a lung surgical biopsy and by excluding other cau...
Source: Respiratory Care - December 10, 2013 Category: Respiratory Medicine Authors: Giraudo C, Nannini N, Balestro E, Meneghin A, Lunardi F, Polverosi R, Calabrese F Tags: Respir Care Source Type: research

Morphologic Features of Cardiac Sarcoidosis in Native Hearts of Patients Having Cardiac Transplantation
Described herein are 10 patients who underwent cardiac transplantation (CT) for severe chronic systolic heart failure resulting from cardiac sarcoidosis. None had the diagnosis of sarcoidosis established before CT except for the 3 patients who earlier had had a portion of left ventricular wall excised for insertion of a left ventricular assist device and non-caseating granulomas were present in the removed myocardium. Although none of the 10 patients had significant narrowing of any of the epicardial coronary arteries, all had focal scarring of the walls of the left and right ventricles and ventricular septum and all had d...
Source: The American Journal of Cardiology - November 25, 2013 Category: Cardiology Authors: William C. Roberts, Monica S. Chung, Jong Mi Ko, John E. Capehart, Shelley A. Hall Tags: Cardiomyopathy Source Type: research

Foreign Body Granulomatous Reaction to Silica, Silicone, and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis.
We report the case of a patient who developed sarcoid granulomas 11 months after starting treatment with pegylated interferon alfa and ribavirin for chronic hepatitis C. The sites of the lesions were related to 3 different foreign bodies: silica in old scars on the skin, hyaluronic acid that had been injected into facial tissues, and silicone in an axillary lymph node draining the area of a breast implant. Systemic sarcoidosis was diagnosed on the basis of a history of dry cough and fever and blood tests that revealed elevated angiotensin converting enzyme and liver enzymes. Interruption of the antiviral therapy led to nor...
Source: Actas Dermo-Sifiliograficas - November 13, 2013 Category: Dermatology Authors: Novoa R, Barnadas MA, Torras X, Curell R, Alomar A Tags: Actas Dermosifiliogr Source Type: research

Fatal clinical outcome in a patient with sarcoidosis-lymphoma syndrome.
Abstract A 62-year-old female suspected of malignant disease underwent a splenectomy that revealed noncaseating granulomas in the histological specimen. Chest X-ray (CXR) and lung CT scans suggested sarcoidosis stage II. TBLB showed noncaseating granulomas. A diagnosis of sarcoidosis was made. Initially no treatment was needed as partial remission on CXR and normal lung function were observed. During the follow up she underwent open lung biopsy and axillary lymph node biopsy because of radiological progression with presence of CXR opacities imitating metastases and recurrent lymphadenopathy. No malignant cells wer...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Goljan-Geremek A, Puścińska E, Bednarek M, Nowiński A, Kamiński D, Ptak J, Bestry I, Langfort R, Staszewska M, Gorecka D Tags: Pneumonol Alergol Pol Source Type: research

ICAM-1 Deficiency Exacerbates Sarcoid-Like Granulomatosis Induced by Propionibacterium acnes through Impaired IL-10 Production by Regulatory T Cells.
Abstract Propionibacterium acnes has been implicated as one of the suggested causative antigens for sarcoidosis, a systemic granulomatous disease. By injecting heat-killed P. acnes into the dorsal skin of C57BL/6J mice on days 1, 3, 5, and 14, sarcoid-like granulomatosis was induced in skin and lungs of these mice on day 28. To clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we induced sarcoid-like granulomatosis in mice deficient of intercellular adhesion molecule (ICAM)-1, L-selectin, P-selectin, or E-selectin via repeated P. acnes injection. Histopathologic analysis revealed that granuloma...
Source: The American Journal of Pathology - October 5, 2013 Category: Pathology Authors: Kamata M, Tada Y, Mitsui A, Shibata S, Miyagaki T, Asano Y, Sugaya M, Kadono T, Sato S Tags: Am J Pathol Source Type: research

Atypical radiological manifestations of thoracic sarcoidosis: A review and pictorial essay
We present a review of literature and illustrate the review with unpublished data, intended to provide a more recent single comprehensive reference to assist with the diagnosis when atypical radiographic findings of thoracic sarcoidosis are encountered. Thoracic involvement accounts for most of morbidity and mortality associated with sarcoidosis. An accurate timely identification is required to minimize morbidity and mortality. It is essential to recognize atypical imaging findings and relate these to clinical manifestations and histology.
Source: Annals of Thoracic Medicine - September 20, 2013 Category: Respiratory Medicine Authors: Hamdan Al-JahdaliPrabhakar RajiahShyam Sunder KoteyarCarolyn AllenAli Nawaz Khan Source Type: research

Microbial and human heat shock proteins as 'danger signals' in sarcoidosis.
Abstract In the light of the Matzinger's model of immune response, human heat shock proteins (HSPs) as main 'danger signals' (tissue damage-associated molecular patterns-DAMPs) or/and microbial HSPs as pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors (PRR), may induce sarcoid granuloma by both infectious and non-infectious factors in genetically different predisposed host. Regarding infectious causes of sarcoid models, low-virulence strains of, e.g. mycobacteria and propionibacteria recognized through changed PRR and persisting in altered host phagocytes, generate increase...
Source: Human Immunology - August 27, 2013 Category: Allergy & Immunology Authors: Dubaniewicz A Tags: Hum Immunol Source Type: research

Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition.
We present a patient with sarcoidosis who developed acute kidney injury (AKI). He had a high 1,25-OH vitamin D level and hypercalciuria. As his renal function declined he developed hypercalcemia. A kidney biopsy showed acute tubular necrosis (ATN) with giant cell formation around calcium phosphate crystals. Calcium phosphate deposition is uncommon in sarcoid. We speculate that early interstitial calcium phosphate deposition may in time lead to the development of Randall's plaques and to the more typical calcium oxalate nephrolithiasis seen in sarcoidosis. PMID: 23845267 [PubMed - in process]
Source: Clinical Nephrology - July 16, 2013 Category: Urology & Nephrology Authors: Manjunath V, Moeckel G, Dahl NK Tags: Clin Nephrol Source Type: research

Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes.
Abstract Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. Many P. acnes have been detected in sarcoid lymph nodes using quantitative PCR and in sarcoid granulomas by in situ hybridization. P. acnes trigger factor protein causes a cellular immune response only in sarcoid patients and induces pulmonary granulomas in mice sensitized with the protein and adjuvant, but only those with latent P. acnes infection in their lungs. Eradication of P. acnes by antibiotics prevents the development of granulomas in ...
Source: Biomed Res - July 16, 2013 Category: Research Authors: Eishi Y Tags: Biomed Res Int Source Type: research

Heart Transplantation for End-Stage Heart Failure Due to Cardiac Sarcoidosis
Conclusions: Patients with cardiac sarcoidosis undergoing heart transplantation have acceptable long-term outcomes without evidence of recurrence of sarcoidosis in the allograft when maintained on low-dose corticosteroids. Progression of extracardiac sarcoid was uncommon, possibly related to immunosuppression. In patients with cardiac sarcoidosis, heart transplantation is a viable treatment modality.
Source: Transplantation Proceedings - July 1, 2013 Category: Transplant Surgery Authors: D. Perkel, L.S.C. Czer, R.P. Morrissey, A. Ruzza, M. Rafiei, M. Awad, J. Patel, J.A. Kobashigawa Tags: Thoracic Transplantation Source Type: research

Sarcoidosis Lung Nodules in Colorectal Cancer Follow-Up: Sarcoidosis or Not?
Conclusion: Our cases focused on the usefulness of histologic proof in patients with cancer with sarcoidosis.
Source: The American Journal of Medicine - June 20, 2013 Category: Journals (General) Authors: Marie Lequoy, Romain Coriat, Alexandre Rouquette, Olivier Mir, Géraldine Perkins, Jean-François Regnard, Catherine Brezault, Stanislas Chaussade Tags: Brief observation Source Type: research

Sarcoidosis Manifesting as a Pseudotumorous Renal Mass
A 53 year-old African American woman with a three-year history of pulmonary sarcoidosis had a follow-up computed tomographic scan to evaluate the status of her disease and response to treatment. On the scan, an abnormal, hypodense mass on the left renal superior pole, which was not present on previous scans, was incidentally discovered. The initial concern was of carcinoma, despite her lack of any urinary symptoms. She underwent further evaluation with magnetic resonance, and the enhancement pattern and the shape of the mass were more suggestive of lymphoma or infarction than a carcinoma. A review of literature revealed sp...
Source: Journal of Radiology Case Reports - June 3, 2013 Category: Radiology Source Type: research

Correlation of late gadolinium enhancement MRI and quantitative T2 measurement in cardiac sarcoidosis
ConclusionLGE‐MRI can identify cardiac involvement in systemic sarcoidosis. MCLE might be more sensitive at detecting subtle myocardial lesion. The decreased T2 observed in cardiac sarcoid may reflect its inactive phase, thus might provide a noninvasive method for monitoring disease activity or therapy.J. Magn. Reson. Imaging 2013;00:000–000. © 2013 Wiley Periodicals, Inc.
Source: Journal of Magnetic Resonance Imaging - May 29, 2013 Category: Radiology Authors: Yuesong Yang, Katherine Safka, John J. Graham, Idan Roifman, Mohammad I. Zia, Graham A. Wright, Meyer Balter, Alexander J. Dick, Kim A. Connelly Tags: Original Research Source Type: research

The frequency of granulomatous lacrimal gland inflammation as a cause of lacrimal gland enlargement in patients without a diagnosis of systemic sarcoidosis.
Discussion: In patients with clinical lacrimal gland enlargement, incisional biopsy led to a diagnosis of sarcoidosis in 20% of patients. An elevated ACE level may help predict which patients have a greater diagnostic yield with biopsy. PMID: 23480843 [PubMed - in process]
Source: Orbit - May 26, 2013 Category: Opthalmology Authors: Rabinowitz MP, Halfpenny CP, Bedrossian EH Tags: Orbit Source Type: research

Coexistence of sarcoidosis with seminoma - a case report.
Abstract A 30-year-old patient, with diagnosis of seminoma (T1 Nx Mx) was treated radically with orchidectomy. In chest CT performed postoperatively numerous diffuse nodules were revealed in both lungs. Lesions were situated particularly in the upper and middle pulmonary zones. In order to verify the nature of pulmonary abnormalities videothoracoscopy of the right pleural cavity was performed with specimen collection. Histopathological examination excluded the possibility of cancer metastases to pulmonary parenchyma and revealed the presence of sarcoid-like granulomas. Coexistence of seminoma and diffuse sarcoid-l...
Source: Pneumonologia i Alergologia Polska - February 22, 2013 Category: Respiratory Medicine Authors: Kita-Milczarska K, Górska L, Kuziemski K, Sejda A, Jassem E, Biernat W Tags: Pneumonol Alergol Pol Source Type: research

Preliminary characterizations of a serum biomarker for sarcoidosis by comparative proteomic approach with tandem-mass spectrometry in ethnic Han Chinese patients
Background: The diagnosis of sarcoidosis is still a significant challenge in China because of the need to exclude other diseases including granulomatous infections and malignancies that may be clinically and radiographically similar. The specific aim of the study is to search for serum protein biomarkers of sarcoidosis and to validate their clinical usefulness in differential diagnosis. Methods: Serum samples were collected from patients with sarcoidosis (n = 37), and compared to those from patients with tuberculosis (n = 20), other pulmonary diseases (n = 20), and healthy volunteers (n = 20) for determination of sarcoidos...
Source: Respiratory Research - February 11, 2013 Category: Respiratory Medicine Authors: Yuan ZhangXianqiu ChenYang HuShanshan DuLi ShenYifan HeYuxuan ZhangXia ZhangHuiping LiRex Yung Source Type: research

Splenic sarcoidosis mimicking neoplastic disease
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause that commonly involves the spleen. Sarcoid can produce either homogeneous splenomegaly or multiple splenic nodules. Although other organ system involvement usually occurs, this is not invariable. Herein, we report on the clinical, histological, and radiological features—including sonography and MRI—of an isolated splenic sarcoidosis that mimicked neoplastic disease in a 37‐year‐old female. Knowledge of this atypical sonographic presentation may prevent unnecessary splenectomy. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013
Source: Journal of Clinical Ultrasound - January 1, 2013 Category: Radiology Authors: Salem Bauones, Thomas Le Corroller, Olivier Durieux, Daphné Guenoun, Jean Del Grande, Nicolas Pirro, Pierre Champsaur Tags: Case Report Source Type: research

Sarcoid-like granulomatosis induced by Propionibacterium acnes in mice; role of ICAM-1 in prevention of granuloma formation
Sarcoidosis is a systemic granulomatous disease which is characterized by a variable clinical presentation and course. The etiology of the disease has remained unknown. Propionibacterium acnes (P. acnes), an anaerobic nonspore-forming gram-positive rod bacterium, has been implicated as one of the suggested causative antigens of sarcoidosis since this bacterium has been isolated from sarcoid lesions. In order to clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we first established an in vivo model of sarcoid-like skin granulomatosis by injecting heat-killed P. acnes into the back of C57BL/6J mice. These...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Masahiro Kamata, Yayoi Tada, Yoshihide Asano, Makoto Sugaya, Takafumi Kadono, Shinichi Sato Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Primary Sarcoid of the Breast with Incidental Malignancy
We report a very unusual case of primary breast sarcoidosis with incidentally discovered breast carcinoma. The roles of mammography, ultrasound, and MRI in the diagnosis as well as other potential differential diagnosis are discussed.
Source: Journal of Clinical Imaging Science - July 28, 2012 Category: Radiology Authors: Laura M IsleyAbbie R CluverRebecca J LeddyMegan K Baker Source Type: research