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Total 4710 results found since Jan 2013.

Sarcoidosis: when the initial manifestations are musculoskeletal symptoms
Abstract The recent association between the increase in the number of neonates with microcephaly in northeastern Brazil and the outbreak of infection with the Zika virus, which has been occurring in the Americas, has been declared a public health emergency of international concern. The evidence that implicates the virus as the cause of this public health emergency has been demonstrated ever more consistently. This pictorial essay illustrates the imaging characteristics seen on computed tomography and magnetic resonance imaging scans of infants admitted to a rehabilitation hospital with a diagnosis of microcephaly and a mat...
Source: Radiologia Brasileira - May 28, 2018 Category: Radiology Source Type: research

Electrocardiogram and Imaging
This article focuses on the role of echocardiography and MRI in the diagnosis of these structural diseases. Cardiomyopathies with hypertrophic pattern (hypertrophic cardiomyopathy, restrictive cardiomyopathies, amyloidosis, Anderson-Fabry disease, and sarcoidosis), cardiomyopathies with dilated pattern, inflammatory cardiac diseases, and right ventricular arrhythmogenic cardiomyopathy are analyzed. Finally, anatomic predictors of arrhythmias and sudden cardiac death are discussed. Each paragraph is attended by clinical cases that are discussed on the electrocardiogram, after integrated with the anatomic, functional, and he...
Source: Cardiac Electrophysiology Clinics - May 24, 2018 Category: Cardiology Source Type: research

Coexisting Systemic Sclerosis-Polymyositis and Sarcoidosis: Case Report and Review of the Literature
No abstract available
Source: JCR: Journal of Clinical Rheumatology - May 23, 2018 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Hepatic infectious and inflammatory conditions: Role of 18F-FDG PET imaging with multimodality correlation and implications for management
Conclusion: Molecular imaging with FDG PET is traditionally thought of as a tool for management of malignant conditions. However it can be used in demonstrating and managing hepatic infectious and inflammatory conditions. Awareness of multimodality imaging features of some of these common conditions will help in their accurate diagnosis and appropriate management.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Garg, I., baladron, M., Samreen, N., Johnson, G., Goenka, A., Venkatesh, S., Kendi, A. Tags: Educational Exhibits Source Type: research

Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses
Clinical and Experimental Dermatology, EarlyView.
Source: Clinical And Experimental Dermatology - May 20, 2018 Category: Dermatology Authors: M. El ‐Khalawany , A. Mosbeh , S. Aboeldahab , S. Ali Source Type: research

Muscular sarcoidosis under anti TNF treatment in ankylosing spondylitis
Publication date: Available online 19 May 2018 Source:Joint Bone Spine Author(s): Daniel Wendling, Jean-Philippe Nueffer
Source: Joint Bone Spine - May 20, 2018 Category: Orthopaedics Source Type: research

Plasmapheresis in a Patient with Sarcoidosis Who Developed Multiple Myeloma and Massive Free Kappa Light Chains Nephropathy.
Authors: Markel A, Habashe N, Aviv A, Monich O, Elmalah I, Marei N, Tovbin D PMID: 29761682 [PubMed - in process]
Source: The Israel Medical Association Journal - May 19, 2018 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Paediatric sarcoidosis
Sarcoidosis, also called Besnier-Boeck-Schaumann disease, was first described in the 19th century as a systemic granulomatous disorder involving predominantly the lungs and the lymphatic system [1]. More than a century after, its pathogenesis remains unknown and its pathophysiology remains controversial [2,3]. The current hypothesis is a multifactorial disease associating a genetic susceptibility and an environmental exposure that triggers or enhances the inflammatory and granulomatous process. Sarcoidosis is mainly an adult disease, children being affected around 10 times less frequently.
Source: Paediatric Respiratory Reviews - May 18, 2018 Category: Respiratory Medicine Authors: Nadia Nathan, Chiara Sileo, Alain Calender, Yves Pacheco, Dominique Valeyre, Annick Clement, for the French Sarcoidosis Group (GSF), the Silicosis Group Tags: Review Source Type: research

A Clinical Study of Tranilast in the Treatment of Sarcoidosis
Condition:   Sarcoidosis Intervention:   Drug: Tranilast Sponsor:   The First Affiliated Hospital with Nanjing Medical University Not yet recruiting
Source: ClinicalTrials.gov - May 17, 2018 Category: Research Source Type: clinical trials

Sarcoidosis diagnostic score (SDS): a systematic evaluation to enhance the diagnosis of sarcoidosis.
CONCLUSIONS: For sarcoidosis, the presence of specific clinical features, especially multi-organ involvement, can enhance the diagnostic certainty. The SDS scoring system quantitated the clinical features consistent with sarcoidosis. PMID: 29778660 [PubMed - as supplied by publisher]
Source: Chest - May 17, 2018 Category: Respiratory Medicine Authors: Bickett AN, Lower EE, Baughman RP Tags: Chest Source Type: research

Histologic Review of Sarcoidosis in a Neck Lymph Node
AbstractSarcoidosis is a multisystem granulomatous disease of unknown etiology. It may occur at any age, but is most commonly seen in young to middle age adults. Sarcoidosis remains more common in women regardless of geographic or racial boundaries. Although the etiology remains unclear, the most common explanation is that sarcoidosis is a disease of immunologic dysregulation triggered by an as yet unidentified environmental or microbial antigen in genetically susceptible persons. We review a case of sarcoidosis with was initially diagnosed in a neck lymph node that was removed for evaluation of metastatic squamous cell ca...
Source: Head and Neck Pathology - May 15, 2018 Category: Pathology Source Type: research

Abdominal Sarcoidosis Mimicking Peritoneal Carcinomatosis.
We present a patient diagnosed with skin sarcoidosis, breast cancer, pulmonary tuberculosis, and peritoneal sarcoidosis with a past history of colorectal cancer. During stage work up for breast cancer, suspicious lesions on peritoneum were observed in imaging studies. Considering our patient's history and imaging findings, we initially suspected peritoneal carcinomatosis. However, the peritoneal lesion was diagnosed as sarcoidosis in laparoscopic biopsy. This case demonstrates that abdominal sarcoidosis might be considered as a differential diagnosis when there is a lesion suspected of being peritoneal carcinomatosis with ...
Source: Annals of Coloproctology - May 11, 2018 Category: Gastroenterology Tags: Ann Coloproctol Source Type: research

Clinical and prognostic significance of muscle biopsy in sarcoidosis.
Authors: Yanardag H, Tetikkurt C, Bilir M Abstract The main objective of this study was to evaluate the influence of muscle involvement on the clinical features, prognostic outcome, extrapulmonary organ, and endobronchial involvement in sarcoidosis patients. The second aim was to assess the diagnostic yield of muscle biopsy for the histopathologic identification of sarcoidosis.  Fifty sarcoidosis patients participated in the study. The patients were classified into two groups according to the histopathologic presence of non-caseating granulomatous inflammatory pattern of the muscle biopsy samples and were evaluate...
Source: Monaldi Archives for Chest Disease - May 11, 2018 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Cutaneous Manifestation of Sarcoidosis in Lower-Back Tattoo With Increased Uptake of 18F-FDG
We present a rare case of a 37-year-old woman with bihilar, mediastinal, and abdominal lymphadenopathy in conjunction with a histologically proven cutaneous manifestation of sarcoidosis in a tattoo of the lower back exhibiting an increased uptake of FDG.
Source: Clinical Nuclear Medicine - May 10, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

11C-4DST PET/CT Imaging of Cardiac Sarcoidosis: Comparison With 18F-FDG and Cardiac MRI
A 75-year-old woman with a history of sarcoidosis presenting with low cardiac output and complete right bundle-branch block underwent 4′-[methyl-11C]-thiothymidine (4DST) PET/CT after cardiac MRI and FDG PET/CT for the evaluation of suspected cardiac sarcoidosis (CS) before treatment. Cardiac MRI revealed late gadolinium enhancement on the anterior-to-lateral and posterior wall, indicating CS. FDG uptake was shown on the anterior-to-lateral wall, but not on the posterior wall. In contrast, 4DST uptake was demonstrated on both anterior-to-lateral and posterior walls. Use of 4DST appears promising for detecting CS without ...
Source: Clinical Nuclear Medicine - May 10, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Clinical features of sarcoidosis associated pulmonary hypertension: Results of a multi-national registry
Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in sarcoidosis. We established a multi-national registry of sarcoidosis associated PH (SAPH) patients.
Source: Respiratory Medicine - May 5, 2018 Category: Respiratory Medicine Authors: Robert P. Baughman, Oksana A. Shlobin, Athol U. Wells, Esam H. Alhamad, Daniel A. Culver, Joseph Barney, Francis C. Cordova, Eva M. Carmona, Mary Beth Scholand, Marlies Wijsenbeek, Sivagini Ganesh, Surinder S. Birring, Vasilis Kouranos, Lanier O'Hare, Joa Source Type: research

Sarcoidosis: a state of the art review from the Thoracic Society of Australia and New Zealand.
Authors: Ahmadzai H, Huang S, Steinfort C, Markos J, Allen RK, Wakefield D, Wilsher M, Thomas PS Abstract Sarcoidosis is a systemic disease of unknown aetiology, characterised by non-caseating granulomatous inflammation. It most commonly manifests in the lungs and intrathoracic lymph nodes but can affect any organ. This summary of an educational resource provided by the Thoracic Society of Australia and New Zealand outlines the current understanding of sarcoidosis and highlights the need for further research. Our knowledge of the aetiology and immunopathogenesis of sarcoidosis remains incomplete. The enigma of sarc...
Source: Medical Journal of Australia - May 4, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes
ConclusionRight ventricular involvement seems to be more common in patients who also have findings suggestive of suspected systemic sarcoidosis, compared with patients with PET findings indicative of isolated cardiac disease.
Source: Journal of Nuclear Cardiology - May 2, 2018 Category: Nuclear Medicine Source Type: research

The 39th Annual Meetingof Japan Society of Sarcoidosis and other Granulomatous Disorders
Date: Tuesday, May 1, 2018Year: 2018Location: Pacifico Yokohama, JapanContent-type: current_conferences
Source: The Aspergillus Website - updates - May 1, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976 –2013—supplementary presentation
AbstractIncidence of fragility fracture of a population-based cohort of 345 patients with sarcoidosis was compared with age- and sex-matched comparators. The incidence of fragility fracture was higher among patients with sarcoidosis with a hazard ratio (HR) of 2.18.
Source: Osteoporosis International - May 1, 2018 Category: Orthopaedics Source Type: research

Systemic sclerosis and sarcoidosis: a rare case of chronic intestinal pseudo-obstruction.
We report the case of a male with a diagnosis of sarcoidosis that was admitted due to abdominal distension and pain. After a thorough investigation, he was diagnosed with severe chronic intestinal pseudo-obstruction as a manifestation of SSc. PMID: 29699402 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - April 29, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

437 Efficacy and safety of tumor necrosis factor inhibitors in cutaneous sarcoidosis: A systematic review
Sarcoidosis is a multisystem disease of unknown etiology characterized by noncaseating granulomas that often affect the skin. Tumor necrosis factor (TNF) is essential in formation of granulomas. Growing evidence supports anti-TNF agents for refractory sarcoidosis, including infliximab (IFX), etanercept, adalimumab ( ADA ), golimumab (GOL) and certolizumab. We sought to characterize the efficacy and safety of anti-TNF in all types of sarcoidosis by performing a systematic review that included trials and case series.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: B. Adler, C. Wang, T. Bui, H. Schilperoort, A.W. Armstrong Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research

Diagnostic Yield of Transbronchial Biopsy in Comparison to High Resolution Computerized Tomography in Sarcoidosis Cases
This study aimed to evaluate the diagnostic yield of fiberoptic bronchoscopic (FOB) transbronchial biopsy and its relation with quantitative findings of high resolution computerized tomography (HRCT). A total of 83 patients, 19 males and 64 females with a mean age of 45.1 years diagnosed with sarcoidosis with complete records of high resolution computerized tomography were retrospectively recruited during the time period from Feb 2005 to Jan 2015. High resolution computerized tomography scans were retrospectively assessed in random order by an experienced observer without knowledge of the bronchoscopic results or lung func...
Source: Asian Pacific Journal of Cancer Prevention - April 27, 2018 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Utility of 18F-FDG PET/CT for Monitoring Response and Predicting Prognosis after Glucocorticoids Therapy for Sarcoidosis.
In conclusion, the present study shows that 18F-FDG PET/CT is an effective way to monitor the early therapeutic reaction and is helpful in predicting the long-term prognosis of sarcoidosis. PMID: 29686996 [PubMed - in process]
Source: Biomed Res - April 26, 2018 Category: Research Authors: Chen H, Jin R, Wang Y, Li L, Li K, He Y Tags: Biomed Res Int Source Type: research

Spontaneous Reduction in Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxygluose in a Patient with Cardiac Sarcoidosis.
Authors: Terasaki F, Fujita SI, Kanzaki Y, Hirose Y, Ishizaka N Abstract Fluorine-18 fluorodeoxygluose (18F-FDG) positron emission tomography (PET) is a useful tool for evaluating disease activity in sarcoidosis including cardiac involvement. A 67-year-old patient who developed atrioventricular block requiring permanent pacemaker implantation was diagnosed with cardiac sarcoidosis. The patient did not undergo steroid or immunosuppressive therapy but underwent serial 18F-FDG PET examination, which showed spontaneous reduction in the myocardial FDG uptake, indicating the remission of immune-inflammatory activity. Alt...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Sarcoid-like reactions in patients receiving modern melanoma treatment
The development of cancer immunotherapy and targeted therapy has reached an important inflection point in the history of melanoma. Immune checkpoint inhibitors and kinase inhibitors are today’s standard of care treatments in advanced melanoma patients. Treatment-related toxicities can be very intriguing and quite challenging. Sarcoidosis is a multisystemic granulomatous disease characterized by an aberrant immune response to unknown antigens, whereas sarcoid-like reactions (SLRs) refer to localized clinical features. We carried out a single-center observational study in patients with stage IIB–IV melanoma treated with ...
Source: Melanoma Research - April 24, 2018 Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clinical research Source Type: research

Specific Skin Lesions of Sarcoidosis Located at Venipuncture Points for Blood Sample Collection
Abstract: It has been suggested that the predilection of sarcoidosis to affect scars is due to the presence of antigens or foreign bodies that can serve as a stimulus for granuloma formation. Several patients with sarcoidosis-specific skin lesions in venous puncture sites have been reported. However, in these patients the pathogenesis of the cutaneous lesions is not clear because the presence of foreign bodies is not to be expected. Our objective was to describe 3 patients who developed specific lesions of sarcoidosis in areas of venipuncture and to discuss their possible pathogenesis. The database of the Sarcoid Clinic ...
Source: The American Journal of Dermatopathology - April 24, 2018 Category: Pathology Tags: Brief Report Source Type: research

Hypoalbuminemia is related to inflammation rather than malnutrition in sarcoidosis.
PMID: 29703691 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - April 24, 2018 Category: Internal Medicine Authors: Mirsaeidi M, Omar HR, Sweiss N Tags: Eur J Intern Med Source Type: research

Proangiogenic and Profibrotic Markers in Pulmonary Sarcoidosis.
Authors: Tuleta I, Biener L, Pizarro C, Nickenig G, Skowasch D Abstract The aim of our study was to determine the blood levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-AB in different stages of pulmonary sarcoidosis. There were 92 patients in sarcoidosis stages I + II, III, and IV enrolled into the study. All the patients underwent lung diffusing capacity and blood sampling. We found that VEGF levels differed significantly between the stage groups with the peak VEGF concentrations in stage III. T...
Source: Advances in Experimental Medicine and Biology - April 23, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Drug-induced sarcoidosis-like reactions (DISR).
Abstract A drug-induced sarcoidosis-like reaction (DISR) is a systemic granulomatous reaction that is indistinguishable from sarcoidosis and occurs in temporal relationship with initiation of an offending drug. DISRs typically improve or resolve after the withdrawal of offending drug. Four common categories of drugs that have been associated with the development of a DISR are immune checkpoint inhibitors (ICIs), highly active anti-retroviral therapy (HAART), interferons (IFNs) and tumor necrosis factor alpha antagonists (TNF-alpha antagonists). Similar to sarcoidosis, DISRs do not necessarily require treatment, as...
Source: Chest - April 23, 2018 Category: Respiratory Medicine Authors: Chopra A, Nautiyal A, Kalkanis A, Judson MA Tags: Chest Source Type: research

437 Efficacy and safety of tumor necrosis factor inhibitors in cutaneous sarcoidosis: A systematic review
Sarcoidosis is a multisystem disease of unknown etiology characterized by noncaseating granulomas that often affect the skin. Tumor necrosis factor (TNF) is essential in formation of granulomas. Growing evidence supports anti-TNF agents for refractory sarcoidosis, including infliximab (IFX), etanercept, adalimumab ( ADA ), golimumab (GOL) and certolizumab. We sought to characterize the efficacy and safety of anti-TNF in all types of sarcoidosis by performing a systematic review that included trials and case series.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: B. Adler, C. Wang, T. Bui, H. Schilperoort, A.W. Armstrong Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research

Childhood Sarcoidosis Presenting as Recurrent Facial Palsy.
Abstract BACKGROUND: Recurrent facial palsy in a patient merits investigation for underlying etiology. CASE CHARACTERISTICS: 8-year-old boy with erythematous itchy skin lesion and recurrent facial palsy. OBSERVATION: He had a past history of aseptic meningitis and nephrocalcinosis. Raised angiotensin converting enzyme levels, interstitial lung disease on CT chest, and non caseating granulomas on skin biopsy clinched the diagnosis of sarcoidosis. MESSAGE: Multisystem involvement and recurrent lower motor facial nerve palsy is a clinical clue for sarcoidosis. PMID: 29726829 [PubMed - in process]
Source: Indian Pediatrics - April 15, 2018 Category: Pediatrics Authors: Passi GR, Arora K, Gokhale N Tags: Indian Pediatr Source Type: research

A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report
ConclusionsAtypical manifestations of pulmonary sarcoidosis are diagnostically challenging because the clinical and radiographic features of the disease mimic those of a malignancy. We aimed to illustrate a unique etiology of a lung mass and the importance of maintaining a broad differential diagnosis. Nonetheless, with the possibility of a malignancy, a high index of suspicion is necessary for timely diagnosis and optimal management.
Source: Journal of Medical Case Reports - April 13, 2018 Category: General Medicine Source Type: research

High frequency ultrasound: a novel instrument to quantify granuloma burden in cutaneous sarcoidosis.
Conclusions: These results confirm high frequency ultrasound is a valid, objective measure of granuloma burden in cutaneous sarcoidosis and represents a novel, non-invasive measure of disease severity that correlates to the previously validated CSAMI clinical severity score and histopathology evaluation. PMID: 29628755 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 12, 2018 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Serial observation of electrocardiographic responses to corticosteroid therapy in a patient with right ventricular-predominant cardiac sarcoidosis
Predominant or isolated right ventricular involvement in cardiac sarcoidosis is uncommon, but should always be considered in a case of right ventricular hypertrophy combined with ventricular arrhythmia and/or conduction disturbance. Although improvement in right ventricular hypertrophy and atrioventricular conduction disturbance following corticosteroid therapy has been reported, the detailed serial electrocardiographic responses during corticosteroid therapy, as well as temporal changes in the electrocardiographic, biochemical, and morphological responses, have not been reported.
Source: Journal of Electrocardiology - April 11, 2018 Category: Cardiology Authors: Hiroyuki Toh, Shumpei Mori, Marika Keno, Shun Yokota, Yuto Shinkura, Yu Izawa, Yuichi Nagamatsu, Shinsuke Shimoyama, Koji Fukuzawa, Tomofumi Doi, Ken-ichi Hirata Source Type: research

Invasive Hemodynamics and Rejection Rates in Patients with Cardiac Sarcoidosis After Heart Transplantation
Conclusions CS patients have similar post-transplant hemodynamics as non-CS patients, without evidence of RV dysfunction or pulmonary hypertension. No significant rejection nor recurrence of sarcoid in the allograft were observed in this cohort of patients with CS. Survival is similar between CS and non-CS patients. Heart transplant is a viable strategy in selected CS patients with excellent outcomes. Teaser Orthotopic heart transplant (OHT) is utilized for end-stage heart failure due to cardiac sarcoidosis (CS). There is a lack of data on long-term outcomes. We explored changes in hemodynamics, allograft rejection and sur...
Source: Canadian Journal of Cardiology - April 7, 2018 Category: Cardiology Source Type: research

Sarcoidosis With Pleural Effusion as the Presenting Symptom
A 65-year-old woman, never smoker, with medical history of hypertension, nonischemic cardiomyopathy, and moderate pulmonary hypertension presented with symptomatic bilateral pleural effusions. Thoracentesis revealed a lymphocyte predominant transudate and was negative for malignancy, microbiologic cultures were negative for an infectious cause. Chest tomography showed mediastinal and bilateral hilar lymphadenopathy, lymph node biopsy with endobronchial ultrasound-guided transbronchial needle aspiration showed non-necrotizing granulomas compatible with sarcoidosis. Echocardiogram showed ejection fraction of 45% and cardiac ...
Source: Journal of Bronchology and Interventional Pulmonology - April 1, 2018 Category: Respiratory Medicine Tags: Case Reports Source Type: research