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Total 5021 results found since Jan 2013.

Neurosarcoidosis Presenting with Obstructive Hydrocephalus Successfully Treated with Endoscopic Third Ventriculostomy.
Authors: Nakayasu H, Shirai T, Tanaka Y, Sato T, Muro H Abstract A 58-year-old Japanese woman complained of unstable gait and dizziness lasting for a month. She had been diagnosed histologically with pulmonary and cutaneous sarcoidosis and attended outpatient clinics for routine checkups. Head computed tomography and magnetic resonance imaging (MRI) indicated obstructive hydrocephalus caused by a contrast-enhanced lesion in the cerebral aqueduct. The patient underwent endoscopic third ventriculostomy and a biopsy of the lesion, leading to the diagnosis of neurosarcoidosis. This was a rare case of neurosarcoidosis p...
Source: Internal Medicine - August 29, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Comparing the Clinical Performance of the New 19-G ViziShot FLEX and 21- or 22-G ViziShot 2 Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Needles.
Conclusion EBUS-TBNA with a 19-G needle was useful for diagnosing retinal hemangioblastoma and tuberculous lymphadenitis as well as for PD-L1 testing after 21- and 22-G biopsies were unsuccessful. PMID: 30146572 [PubMed - as supplied by publisher]
Source: Internal Medicine - August 29, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Incidental Hepatic Granulomas in a Young Woman
Hepatic granulomas are identified in approximately 3% to 4% of liver biopsies in the Western world. Their presence raises a broad differential diagnosis for the pathologist to consider, including infectious, immune-mediated, and drug-induced etiologies. Certain histologic features of granulomas and the adjacent liver parenchyma can help narrow the differential diagnosis, although clinical and laboratory correlation is often necessary to establish a definitive diagnosis. The purpose of this article is to review the morphologic classification of hepatic granulomas and to discuss hepatic sarcoidosis, one of the most common im...
Source: Pathology Case Reviews - August 29, 2018 Category: Pathology Tags: Case Reviews Source Type: research

Forbearance with Bronchoscopy: A Review of Gratuitous Indications.
We present an overview on conditions where expectations from bronchoscopy exceeds the evidence in the literature and coin the term "Forbearance with Bronchoscopy" for situations where this popular tool may not be the most appropriate initial approach. PMID: 30171862 [PubMed - as supplied by publisher]
Source: Chest - August 29, 2018 Category: Respiratory Medicine Authors: Deshwal H, Avasarala SK, Ghosh S, Mehta AC Tags: Chest Source Type: research

Sarcoidosis secondary to lymphocyte active immunotherapy treated with infliximab
Abstract: A hospital-based cross-sectional study was performed, including 117 psoriatic patients and 117 controls matched for age, gender, and body mass index. Psoriatic patients had higher levels of serum uric acid (6.25 ± 1.62 vs 5.71 ± 1.35 mg/dl; P=0.019) and significantly greater prevalence of hyperuricemia (31.6% vs 16.2%; P=0.009) than individuals without psoriasis. Psoriatic patients had significantly higher serum uric acid than controls in subjects without metabolic syndrome. Multivariate logistic regressi on analysis showed that psoriasis can be a strong predictor of hyperuricemia (odds ratio 2.61; 95% confiden...
Source: Anais Brasileiros de Dermatologia - August 27, 2018 Category: Dermatology Source Type: research

Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?
Idiopathic Pulmonary Fibrosis (IPF) and Sarcoidosis are distinct clinical entities. Fibrotic disease in pulmonary sarcoidosis is typically upper lobe predominant. In IPF fibrosis is basilar and peripheral predominant [usual interstitial pneumonia (UIP) pattern]. Sarcoidosis and UIP have rarely been observed in the same patient. We sought to characterize patients manifesting both sarcoidosis and IPF and compare clinical features and survival to that of patients with “Lone-IPF” (IPF only) and pulmonary sarcoidosis with fibrosis in a non-UIP pattern.
Source: Respiratory Medicine - August 23, 2018 Category: Respiratory Medicine Authors: Bridget F. Collins, Robyn L. McClelland, Lawrence A. Ho, Carmen R. Mikacenic, Jennifer Hayes, Carolyn Spada, Ganesh Raghu Source Type: research

Hepatic sarcoidosis.
Authors: Watanabe T, Jodo S PMID: 30127039 [PubMed - in process]
Source: Canadian Medical Association Journal - August 22, 2018 Category: General Medicine Tags: CMAJ Source Type: research

IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.
Abstract The mechanisms underlying abnormal granuloma formation in patients with sarcoidosis are complex and remain poorly understood. A novel in vitro human granuloma model was used to determine the molecular mechanisms of granuloma-genesis in patients with sarcoidosis in response to putative disease-causing mycobacterial antigens. Peripheral blood mononuclear cells (PBMCs) from patients with active sarcoidosis and from normal, disease-free controls were incubated for 7 days with purified protein derivative (PPD)-coated polystyrene beads. Molecular responses were analyzed, as reflected by differential expression ...
Source: Am J Respir Cell Mol... - August 22, 2018 Category: Respiratory Medicine Authors: Locke LW, Crouser ED, White P, Julian MW, Guirado Caceres E, Papp AC, Le VT, Sadee W, Schlesinger LS Tags: Am J Respir Cell Mol Biol Source Type: research

Sarcoid-Like Granulomatosis Induced by Nivolumab Treatment in a Lung Cancer Patient
We describe the case of an 81-year-old male with cT1aN2M1b stage IV pleomorphic carcinoma of the left upper lobe of the lung. After primary treatment with carboplatin and paclitaxel, recurrence was observed in the left supraclavicular lymph node and left adrenal gland. We initiated the administration of nivolumab as a secondary treatment. Reduction was observed in the swelling of the left supraclavicular lymph node and left adrenal gland, but the tumor shadow in the right upper lobe appeared to increase. Bronchoscopy was performed, and the biopsy result showed granulomas; the findings resembled a sarcoid-like granulomatous...
Source: Case Reports in Oncology - August 17, 2018 Category: Cancer & Oncology Source Type: research

Fatal fulminant cryptococcemia complicating sarcoidosis: is it to be expected?
We describe a case of cryptococcemia that rapidly progressed toward fatality without apparent other sites of infection. We discuss on the importance of serum cryptococcal polysaccharide antigen testing for identifying at-risk patients who might benefit from timely diagnosis and treatment of cryptococcosis
Source: Medical Mycology Case Reports - August 17, 2018 Category: Biology Source Type: research

Familial aggregation and heritability of sarcoidosis: a Swedish nested case-control study
Sarcoidosis is believed to be caused by both genetic and environmental risk factors, but the proportion of the susceptibility to sarcoidosis that is mediated by genetics remains unknown. We aimed to estimate the familial aggregation and heritability of sarcoidosis using a case–control–family study design and population-based Swedish registers. We identified 23 880 individuals with visits for sarcoidosis in the Swedish National Patient Register using International Classification of Diseases codes (1964-2013). Information on Löfgren's syndrome was available for a subset diagnosed at Karolinska University ...
Source: European Respiratory Journal - August 16, 2018 Category: Respiratory Medicine Authors: Rossides, M., Grunewald, J., Eklund, A., Kullberg, S., Di Giuseppe, D., Askling, J., Arkema, E. V. Tags: Original Articles: Interstitial lung diseases Source Type: research

Balloon pulmonary angioplasty – efficient therapy of chronic thromboembolic pulmonary hypertension in the patient with advanced sarcoidosis – a case report
We report unusual case of confirmed chronic thromboembolic pulmonary hypertensi...
Source: BMC Pulmonary Medicine - August 16, 2018 Category: Respiratory Medicine Authors: Andrzej Labyk, Dominik Wretowski, Sabina Zybi ńska-Oksiutowicz, Aleksandra Furdyna, Katarzyna Ciesielska, Dorota Piotrowska-Kownacka, Olga Dzikowska –Diduch, Barbara Lichodziejewska, Andrzej Biederman, Piotr Pruszczyk and Marek Roik Tags: Case report Source Type: research

A Multiple Biomarker Approach in Patients with Cardiac Sarcoidosis.
Authors: Kiko T, Yoshihisa A, Kanno Y, Yokokawa T, Abe S, Miyata-Tatsumi M, Misaka T, Oikawa M, Kobayashi A, Ishida T, Takeishi Y Abstract Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide ...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Cardiac sarcoidosis - an expert review for the chest physician.
Authors: Ho JS, Chilvers ER, Thillai M Abstract INTRODUCTION: Sarcoidosis is a multisystem granulomatous disease predominantly affecting the lungs, with increased risk of cardiovascular disease, pulmonary hypertension and cardiac sarcoidosis (CS), the latter due to direct granuloma infiltration. Sarcoidosis is often managed by chest physicians who need to understand the diagnostic pathways and initial management plans for patients with cardiac involvement. Areas covered: The most serious consequence of CS is sudden cardiac death due to ventricular tachyarrhythmias or complete atrioventricular block. Additional comp...
Source: Expert Review of Respiratory Medicine - August 14, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis
ConclusionsCerebrovascular events may be the first manifestation of neurosarcoidosis, and have a prognosis impact in such patients, leading to death and permanent neurological impairment.
Source: Journal of Neurology - August 14, 2018 Category: Neurology Source Type: research

New Insights On Ocular Sarcoidosis: An Optical Coherence Tomography Angiography Study.
CONCLUSION: The depth-resolved nature of OCT-A allowed new insights on OS-induced microvascular and perfusion impairments. PMID: 30081683 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - August 11, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Optical Coherence Tomography and Management of a Retinal Granuloma in Presumed Ocular Sarcoidosis.
CONCLUSION: This case demonstrated marked granuloma regression occurring with improvement in visual acuity, highlighting the utility of OCT and PSTA in managing retinal sarcoid granulomas. PMID: 30096009 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - August 11, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Vitamin D Homeostasis in Sarcoidosis
Conditions:   Sarcoidosis;   Vitamin D Insufficiency Interventions:   Drug: Ergocalciferol;   Drug: Placebo;   Drug: Calcium Citrate with Vitamin D2 Sponsor:   University of Texas Southwestern Medical Center Not yet recruiting
Source: ClinicalTrials.gov - August 8, 2018 Category: Research Source Type: clinical trials

Uveitis and acute glaucoma as first presenting symptoms of sarcoidosis in a healthy male
Sarcoidosis is a disease characterized by the presence of noncaseating granulomas in many tissues. The granulomas most commonly affect the lungs and the disease commonly presents with bilateral hilar adenopathy, lesions on the eyes, skin, or joints, and pulmonary reticular opacities [1]. Between 30 and 60% cases of pulmonary sarcoidosis are found through routine chest X-rays and considered asymptomatic [2]. There is no known etiology. It is estimated to affect 10 to 20 per 100,000 [1]. (See Fig.
Source: The American Journal of Emergency Medicine - August 8, 2018 Category: Emergency Medicine Authors: Olivia Hallas, Andrew Yocum, Damien Jackson, Erin L. Simon Source Type: research

Updates on the Role of Imaging in Cardiac Sarcoidosis
AbstractPurpose of reviewThe non-specific symptom profile and subclinical nature of disease along with variable region of cardiac involvement in systemic sarcoidosis make the diagnosis particularly challenging. The yield of endomyocardial biopsy, a gold standard for diagnosis, is not high unless coupled with additional imaging modalities to detect regional involvement. This review is focused on highlighting the major recent advances in imaging modalities and diagnosis of cardiac sarcoidosis.Recent findingsThere has been much interest and increasing research focused on developing newer and improved imaging modalities to est...
Source: Current Treatment Options in Cardiovascular Medicine - August 7, 2018 Category: Cardiology Source Type: research

Needs, Perceptions and Education in Sarcoidosis: A Live Interactive Survey of Patients and Partners
This study improves awareness of needs and perceptions of patients with sarcoidosis and their partners. Sarcoidosis leads to anxiety and psychological distress and impairs well-being of patients and their partners. Attention for psychological support, better disease education, and more supportive care for partners is warranted.
Source: Lung - August 7, 2018 Category: Respiratory Medicine Source Type: research

Variances of dietary preparation for suppression of physiological 18 F-FDG myocardial uptake in the presence of cardiac sarcoidosis: A systematic review
ConclusionsVariation in measures used, dietary prescriptions, fasting times, species and study quality makes result comparison and applicability difficult. Definitive dietary recommendations are not possible based on current evidence.
Source: Journal of Nuclear Cardiology - August 7, 2018 Category: Nuclear Medicine Source Type: research

Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
ConclusionNecrotising retinopathy-like lesions mimicking an infectious process or a lymphoproliferative disorder can be an atypical manifestation of ocular sarcoidosis.
Source: Journal of Ophthalmic Inflammation and Infection - August 3, 2018 Category: Opthalmology Source Type: research

Multisystemic manifestations of sarcoidosis and comorbidities
No abstract available
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Nutrition and corticosteroids in the treatment of sarcoidosis
Purpose of review Sarcoidosis is a chronic disease, which is routinely treated with corticosteroids. Steroid resistance or steroid-induced adverse effects require alternatives. Other immune-modulating pharmacological treatments have been developed, and therefore expanded tremendously. Until now, the role of nutrition in the overall management of sarcoidosis has been neglected although anti-inflammatory properties of nutritional components have been known for many years now. New nutritional possibilities emerge from already existing data and offer new therapeutic avenues in the treatment of sarcoidosis. Recent findings ...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Obesity and sarcoidosis: consequence or contributor?
Purpose of review Sarcoidosis is a multisystem disease of unknown cause. Obesity can affect many physiological factors. The relationship between obesity and sarcoidosis is unclear, and can been described as posing a ‘chicken and egg’ scenario for the patient as it is not always clear whether it is a consequence of, or a risk factor for any disease. The purpose of this review is to examine the dual roles of obesity on sarcoidosis morbidity and the incidence. Recent findings Obesity magnifies the symptoms of sarcoidosis and corticosteroid therapy increases BMI. Prospective epidemiologic studies started to explore th...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

The Fatigue Assessment Scale: quality and availability in sarcoidosis and other diseases
Purpose of review Fatigue is a problem experienced by many patients suffering from chronic diseases, including sarcoidosis patients. It has a substantial influence on patients’ quality of life (QoL). It is, therefore, important to properly assess fatigue with a valid and reliable measure. The Fatigue Assessment Scale (FAS) is the only validated self-reporting instrument classifying fatigue in sarcoidosis. The aim of this review was to examine the psychometric properties of the FAS and the diseases and languages in which it has been used. Studies among sarcoidosis patients were also reviewed in terms of outcomes. Recen...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Sarcoidosis and autoimmune diseases: differences, similarities and overlaps
Purpose of review Sarcoidosis is a rare, multisystem granulomatous disease of incompletely understood pathogenesis. Clinically, it shares common features with several systemic and organ-specific autoimmune diseases, although known autoantibodies or useful serologic markers for diagnosis and monitoring of disease activity are lacking. Sarcoidosis can both coexist with or mimic connective tissue diseases or vasculitis. Here, we review possible common etiologic factors between sarcoidosis and autoimmune disease, comparing clinical, laboratory and imaging features. Recent findings Autoimmune diseases may precede or follow...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Renal sarcoidosis: approach to diagnosis and management
Purpose of review The purpose of this article is to provide understanding of renal sarcoidosis, the different types of renal sarcoidosis, disease burden of renal involvement, and treatment options. Recent findings The frequency of renal involvement seems to be underestimated, but renal sarcoidosis represents a relevant group of organ manifestations and significantly adds to the patient's morbidity. Because histopathological analysis of renal biopsy specimens can reveal various entities, a diagnostic workup is necessary in every patient with sarcoidosis. Summary If systematically screened for renal manifestations ar...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Role of imbalance between Th17 and regulatory T-cells in sarcoidosis
Purpose of review A relatively new class of CD4 expressing T cells that also express and release interleukin-17 (Th17 cells) is gaining attention based on their capacity to regulate inflammatory responses in a spectrum of chronic autoimmune diseases. The purpose of this review is to consider recent studies relating to the critical role played by Th17 cells in the pathogenesis of sarcoidosis. Recent findings Th17 cells are unique in their capacity to adapt to local molecular cues to variably promote or suppress inflammation. On the basis of knowledge established originally in the context of autoimmune disorders, recent...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Why do people die from pulmonary sarcoidosis?
Purpose of review In sarcoidosis, the design and validation of an appropriate risk stratification strategy is hampered by the considerable variability in initial presentation, disease evolution, and outcome. Although spontaneous resolution of the disease is described in a large proportion of patients, approximately 20–30% would present with chronic or progressive lung disease that has been associated with morbidity and mortality. Higher morbidity and mortality can be related to both the disease severity and extent as well as its treatments. We review the utility of integration of clinical, pathological, and radiologica...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Mycobacterium marinum infection associated with infliximab therapy in a patient with pulmonary and skin sarcoidosis
We present one of the first cases of M. marinum infection associated with infliximab therapy in a patient with pulmonary and skin sarcoidosis.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Localized sarcoidosis in an old tattoo: Illustrating the principle of locus minoris resistentiae
We present a case of a 33-year-old man with history of systemic sarcoidosis who presented with firm papules within multiple old tattoos. Pathology of one lesion revealed granulomatous infiltration consistent with sarcoidosis within an old tattoo. The patient was also found to have erythema nodosum, hilar lymphadenopathy, and arthralgias, and was diagnosed with Lofgren syndrome. This case of cutaneous sarcoid manifesting in an old tattoo illustrates the principle of locus minoris resistentiae (LMR).
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Late-onset childhood sarcoidosis misdiagnosed as cutaneous T-cell non-Hodgkin lymphoma, successfully treated with oral prednisone and acitretin: A case report
Introduction: Childhood sarcoidosis is a rare multisystem granulomatous disorder of unknown etiology. Two distinct forms are described: early-onset and late-onset disease. Older children usually present with a multisystem disease similar to the adult manifestations. This case report illustrates the challenges faced by dermatologists when considering a diagnosis of childhood sarcoidosis. The uniqueness of the case is the fact that for 6 years he was misdiagnosed, being treated for cutaneous T-cell non-Hodgkin lymphoma.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Histomorphologic and histomorphometric approach to differentiate skin lesions of tuberculoid leprosy from sarcoidosis
Background: More than 200,000 new cases of leprosy are detected worldwide annually. Owing to the increment of the immigration flows from endemic areas, leprosy cases might be more frequently observed in nonendemic areas as well. Physicians commonly have difficulty in differentiating tuberculoid form of leprosy (TL) from sarcoidosis ’ cutaneous manifestation. Histologically in TL, epithelioid granulomas are well defined with evident lymphocyte rim distributed around the appendages and nerves, whereas in sarcoidosis, granulomas are classically naked.
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Diagnostic value of cardiac magnetic resonance and fluorodeoxyglucose-positron emission tomography for cardiac sarcoidosis with previous myocardial infarction: A case report
Rationale: Diagnostic difficulty due to overlapped clinical findings exists in cardiac sarcoidosis (CS) patients who also have coronary artery disease. Since cardiac magnetic resonance (CMR) and fluorodeoxyglucose-positron emission tomography (FDG-PET) evaluate different pathological processes, that is, fibrosis and inflammation respectively, the combination may be useful in such a case. Patient concerns: A 77-year-old man was admitted due to heart failure and advanced atrioventricular block who was previously diagnosed with cutaneous sarcoidosis and old myocardial infarction (MI) with angiographical evidence. Diagno...
Source: Medicine - August 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Borderline tuberculoid leprosy mimicking sarcoidosis: A case report
Conclusion: The use of auxiliary tests including real-time PCR to amplify an M leprae-specific DNA sequence, enzyme-linked immunosorbent assay, and dipstick detection of serum antibodies specific to M leprae antigens are good methods to obtain a correct diagnosis of BT leprosy.
Source: Medicine - August 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Sarcoid-like reaction mimicking disease progression in an ALK-positive lung cancer patient receiving lorlatinib
SummaryThe administration of target inhibitors is paramount to grant the longest survival in patients with ALK-positive non-small cell lung cancer (NSCLC). The eventual resistance to tyrosine kinase inhibitors (TKI) is monitored clinically and radiologically for prompt molecule shift to further generation TKI, if available. However, the early radiological detection of progression pattern (e.g. nodule onset) should be regarded with caution because overlaps exist with non-tumor cell proliferation and/or accumulation. Here we report the case of a stage IVALK-rearranged NSCLC patient exposed to serial crizotinib, brigatinib, c...
Source: Investigational New Drugs - August 1, 2018 Category: Drugs & Pharmacology Source Type: research

Combination Therapy with Prednisone and Mycophenolate Mofetil in the Management of Cardiac Sarcoidosis
Cardiac sarcoidosis (CS) is characterized histologically by the presence of noncaseating granulomas and manifests as conduction abnormality, ventricular arrhythmia and progressive heart failure. With advances in imaging techniques, CS is being increasingly recognized as an underlying cause of cardiomyopathy. To date, there are no randomized trials or published guidelines to direct treatment strategies in CS, specifically in regards to optimal immunosuppressive therapy. We sought to describe our experience using a combination of prednisone and mycophenolate mofetil (MMF) in the treatment of patients (pts) with CS.
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Jan M. Griffin, Edward Chen, Hari Tandri, Edward K. Kasper, Nisha A. Gilotra Tags: 271 Source Type: research

Isolated Right Ventricular Cardiac Sarcoidosis Presenting as Complete Heart Block
Sarcoidosis is a multi-organ disease with formation of granulomas. Involvement of the heart causes inflammation, leading to atrioventricular block (AVB) or ventricular arrhythmias, and portends a poor prognosis. Cardiac sarcoidosis is detected in only 2% of patients, and most have left ventricular (LV) involvement. Isolated right ventricular (RV) involvement is rare. High suspicion is necessary to make the diagnosis, and advanced testing is required. Recognizing cardiac sarcoid is imited to the RV and determining presence of pulmonary hypertension (PH), is imperative for management.
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Katherine Dodd Tags: 233 Source Type: research

Monitoring cardiac sarcoidosis: The next frontier
Cardiac sarcoidosis is a potentially life-threatening form of the disease. Although most sarcoidosis-related deaths result from lung involvement, most of these deaths occur after years of the slow development of lung fibrosis from granulomatous inflammation [1,2]. Contrary to pulmonary sarcoidosis, cardiac sarcoidosis may cause life-threatening events and severe organ dysfunction relatively quickly because of myocardial granulomas deposited in unfortunate locations. Furthermore, myocardial sarcoid granulomas tend to progress relatively quickly to scar [3] that does not respond to anti-granulomatous therapy and is permanent.
Source: Respiratory Medicine - July 26, 2018 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

Invasive Hemodynamics and Rejection Rates in Patients With Cardiac Sarcoidosis After Heart Transplantation
ConclusionsPatients with CS have similar post-transplant hemodynamics as patients without CS, without evidence of right ventricular dysfunction or pulmonary hypertension. Neither significant rejection nor recurrence of sarcoid in the allograft was observed in this cohort of patients with CS. Survival is similar between patients with CS and those without CS. Heart transplant is a viable strategy in selected patients with CS with excellent outcomes.RésuméIntroductionLa transplantation cardiaque orthotopique (TCO) est de plus en plus utilisée lors d’insuffisance cardiaque terminale liée à une sarcoïdose cardiaque (SC)...
Source: Canadian Journal of Cardiology - July 24, 2018 Category: Cardiology Source Type: research