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Total 5441 results found since Jan 2013.

Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring: Addition to the Expert Consensus
Source: Journal of Nuclear Medicine - February 1, 2019 Category: Nuclear Medicine Authors: Lu, Y., Sweiss, N. J. Tags: Letters Source Type: research

Reply: Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring: Addition to the Expert Consensus
Source: Journal of Nuclear Medicine - February 1, 2019 Category: Nuclear Medicine Authors: Chareonthaitawee, P., Blankstein, R. Tags: Letters Source Type: research

Diagnosis and differential diagnosis of large-vessel vasculitides
AbstractThere are no universally accepted diagnostic criteria for large-vessel vasculitides (LVV), including giant cell arteritis (GCA) and Takayasu arteritis (TAK). Currently, available classification criteria cannot be used for the diagnosis of GCA and TAK. Early diagnosis of these two diseases is quite challenging in clinical practice and may be accomplished only by combining the patient symptoms, physical examination findings, blood test results, imaging findings, and biopsy results, if available. Awareness of red flags which lead the clinician to investigate TAK in a young patient with persistent systemic inflammation...
Source: Rheumatology International - February 1, 2019 Category: Rheumatology Source Type: research

Evaluation of MyoStrain ™ in Clinical Practice
Conditions:   Cardiac Failure;   Coronary Artery Disease;   Sarcoidosis;   Amyloidosis;   Lupus;   Myocarditis;   Drug Toxicity Intervention:   Procedure: Diagnostic Test: Myostrain Sponsor:   University of Kansas Medical Center Not yet recruiting
Source: ClinicalTrials.gov - January 31, 2019 Category: Research Source Type: clinical trials

Neurosarcoidosis Occurring 6 Years after Onset of Vogt-Koyanagi-Harada Disease
We report a case of the concurrence of VKHD and sarcoidosis, which may share a common pathophysiology. Accumulation of further similar cases is necessary to elucidate the precise mechanism underlying the concurrence of these two diseases.Case Rep Ophthalmol 2019;10:32 –40
Source: Case Reports in Ophthalmology - January 27, 2019 Category: Opthalmology Source Type: research

Odontoid cervical gout causing atlantoaxial instability: case report.
Abstract The authors present a case report of a patient discovered to have a rotatory subluxation of the C1-2 joint and a large retroodontoid pannus with an enhancing lesion in the odontoid process eventually proving to be caused by gout. This patient represented a diagnostic conundrum as she had known prior diagnoses of not only gout but also sarcoidosis and possible rheumatoid arthritis, and was in the demographic range where concern for an oncological process cannot fully be ruled out. Because she presented with signs and symptoms of atlantoaxial instability, she required posterior stabilization to reduce the r...
Source: Journal of Neurosurgery.Spine - January 25, 2019 Category: Neurosurgery Authors: Slavin J, DiStasio M, Dellaripa PF, Groff M Tags: J Neurosurg Spine Source Type: research

Multiple huge “cluster” and “galaxy” signs on chest radiography in a patient with pulmonary tuberculosis
In this article, we present a unique case of active pulmonary tuberculosis, with multiple huge “cluster” signs like fireworks, together with multiple “galaxy” signs. The repeated acid‐fast sputum smears and both bronchial washings were all negative forMycobacterium tuberculosis, but the acid ‐fast culture of sputum taken soon after the first bronchoscopy, and pleural fluid, turned out to be positive forM. tuberculosis at six weeks after admission. The present case clearly demonstrates that the “galaxy” and “cluster” signs are red herring signs of the low rates of isolatingM. tuberculosis, which should b...
Source: Respirology Case Reports - January 25, 2019 Category: Respiratory Medicine Authors: Miku Oda, Takeshi Saraya, Tatsuya Shirai, Narishige Ishikawa, Masachika Fujiwara, Hajime Takizawa Tags: Case Report Source Type: research

The formation and disordered degradation of neutrophil extracellular traps in necrotizing lesions of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Abstract Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the production of ANCAs and systemic necrotizing vasculitis in small vessels. Disordered regulation of neutrophil extracellular traps (NETs) is critically involved in the pathogenesis of AAV. NETs are web-like DNA decorated with antimicrobial proteins; they are extruded from activated neutrophils. The principal degradation factor of NETs in vivo is DNase I; however, NETs resistant to DNase I can persist in tissues and lead to the production of ANCAs. Deposition of NETs has been demonstrated in glomerular crescents ...
Source: Am J Pathol - January 21, 2019 Category: Pathology Authors: Masuda S, Nonokawa M, Futamata E, Nishibata Y, Iwasaki S, Tsuji T, Hatanaka Y, Nakazawa D, Tanaka S, Tomaru U, Kawakami T, Atsumi T, Ishizu A Tags: Am J Pathol Source Type: research

A web-based registry for patients with sarcoidosis.
Conclusions: A web-based registry is an effective method for establishing a cohort of patients with sarcoidosis invested in clinical research with DNA specimens. Despite limitations, opportunities for research in patient-oriented outcomes and broad internet-based research methodology are possible. Our results demonstrate that web-based approaches to recruit study subjects need to be focused to match different target populations. PMID: 30613131 [PubMed]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 10, 2019 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Erythema nodosum and sarcoid granulomas - letting the cat out of the bag.
Abstract A 41-year-old woman presented with a violaceous papule on the dorsum of the hand, large ipsilateral axillary lymphadenopathy, and tender, erythematous, subcutaneous nodules on the legs. Accompanying signs included fever, ankle swelling, and bilateral red eye. She recalled having a previous exposure to kittens one month before and had a positive family history for sarcoidosis. Histological examination of the hand lesion showed sarcoidal granulomas with positive Bartonella henselae DNA, whereas a biopsy done on the leg nodules was compatible with erythema nodosum. Cat scratch disease (CSD) typically present...
Source: Dermatol Online J - December 15, 2018 Category: Dermatology Authors: Morgado F, Batista M, Coutinho I, Cardoso JC, Tellechea Ó Tags: Dermatol Online J Source Type: research

Pulmonary Sarcoidosis Mimicking Tuberculosis: Importance of the Galaxy Sign on Thoracic Computed Tomography
We present the case of a patient with sarcoidosis that was initially misdiagnosed as tuberculosis, in whom the galaxy sign on CT was useful as it suggested the correct diagnosis.ResumenLa sarcoidosis y la tuberculosis son 2 enfermedades granulomatosas frecuentes que comparten presentaciones clínicas y radiológicas. Entre los signos radiológicos característicos de sarcoidosis pulmonar descritos recientemente en la tomografía computarizada de tórax destaca el signo de la «galaxia». Presentamos un caso de sarcoidosis que inicialmente fue confundido con una tuberculosis en el que este signo radiológico fue útil para ...
Source: Reumatologia Clinica - November 30, 2018 Category: Rheumatology Source Type: research

Scalp Sarcoidosis Presenting as Cicatricial Alopecia.
Authors: Prohaska J, Demaree E, Powers J, Cook C Abstract Sarcoidosis is a granulomatous condition that has a highly variable presentation. One rare presentation of sarcoidosis is cutaneous scalp sarcoidosis. Usually scalp sarcoid presents as a scarring alopecia, but it can be nonscarring. The presence of sarcoidal lesions on the scalp is associated with systemic disease, as are other cutaneous manifestations of sarcoidosis. The authors present the case of a 64-year-old woman with a history of sarcoidosis who presented with alopecia and hypopigmented patches on her scalp. She also had papular sarcoid lesions on her...
Source: Journal of the American Osteopathic Association - November 28, 2018 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

A Case of Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.
Authors: Ueda S, Murakami T, Ogino H, Matsuura M, Tamaki M, Kishi S, Hann M, Toyoda Y, Nagai K, Bando Y, Abe H, Nishioka Y, Doi T Abstract A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Corticosteroid improved the kidney function, and red...
Source: Internal Medicine - November 21, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

The clininical value of vascular endothelial growth factor (VEGF) in the development of lung sarcoidosis
Conclusions: Implementation in clinical practice tests for estimation of serum VEGF will allow more detailed deciphering fluctuations of sarcoidosis activity and use medicine with anti-inflammatory and antibiogenic activity in time.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ponomareva, L., Popova, E., Ponomarev, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Risk of underdiagnoses of cardiac sarcoidosis by routine electrocardiogram and echocardiogram in patients with biopsy-proven extracardiac sarcoidosis
Conclusions: The prevalence of CS exceeds 20% in extra-CS patients even with normal ECG and Echo. Physicians should keep in mind such an unrecognized population and risk of underdiagnosis of CS.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ohira, H., Yoshinaga, K., Sakiyama, S., Nakaya, T., Suzuki, N., Sugimoto, A., Hayashishita, A., Aikawa, T., Sato, T., Manabe, O., Oyama-Manabe, N., Watanabe, T., Nishimura, M., Tsujino, I. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Diminished peripheral T cell activity in sarcoidosis associates with progressive disease.
Conclusions: Our findings suggest that decreased anabolism and impaired peripheral T cell activation are not only markers of sarcoidosis, but may also contribute to disease progression.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Schott, C., Ascoli, C., Huang, Y., Perkins, D., Finn, P. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Cardiac sarcoidosis: a tertiary centre experience
Conclusion: Integration of signal from advanced imaging modalities with the clinical information is required in a multidisciplinary setting for diagnosis of cardiac sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kouranos, V., Sharma, R., Khattar, R., Baksi, J., Kokosi, M., Prasad, S., Wechalekar, K., Underwood, R., Cowie, M., Wells, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Peripheral blood memory T-helper (Th) 17 subsets in patients with chronic and acute pulmonary sarcoidosis
Conclusion: Variation in Th1 and Th17 subsets found in PB from CPS and APS can help to design new immunological biomarkers that will characterize the immunopathogenesis of sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Baranova, O. P., Ses, T., Kudryvzev, I., Lazareva, N., Serebryakova, M., Ilkovich, M., Totolyan, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Clinical phenotypes of extra-pulmonary sarcoidosis. The EpiSarc study
Conclusion: We identified 5 clinical phenotypes of sarcoidosis with distinct demographic features and outcomes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lhote, R., Cohen-Aubart, F., Nunes, H., Launay, D., Sacre, K., Borie, R., Schleinitz, N., Hamidou, M., Devilliers, H., Bonniaud, P., Mahevas, M., Lhote, F., Papo, T., Haroche, J., Godeau, B., Michel, M., Amoura, Z., Valeyre, D., Annesi-Maesano, I. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Genetic Profiles of Clinical Features in Sarcoidosis
Conclusions: In the hitherto tested variables, we found that the GenPhenReSa cohort is suitable for genetic analysis of European Caucasians. We could show that genetic risk factor associate with distinct clinical features in sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Freitag-Wolf, S., Schupp, J., Fischer, A., Mihailovic-Vucinic, V., Rottoli, P., Prasse, A., Schreiber, S., Krawczak, M., Müller-Quernheim, J. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Late Breaking Abstract - Characteristics of macrophagal formula and cytokine spectrum of the bronchoalveolar lavage fluid in patients with newly diagnosed and those with recurring sarcoidosis of respiratory apparatus.
Materials and Methods: The bronchial examination with BALwas performed in 72 patients with newly diagnosed and recurrent sarcoidosis. The cytological investigation included the study of the lavage cytogram, calculation of the macrophage formula (MF) with examining of the percentage of young and mature macrophages with varies phenotypes, levels of the proinflammatory and anti-inflammatory cytokine.Results: In the newly diagnosed sarcoidosis, increase in the concentration of proinflammatory cytokines is observed in the BAL compared to the reference value of IL-2 (647.1 pg/ml versus 469), IL-8, IL-1β (2038.2 pg / ml vs. ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Makaryants, N., Ergeshov, A., Demyanenko, N., Lepekha, L., Shmelev, E. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Late Breaking Abstract - Reduced activity of energy-transducing NADH-quinone oxidoreductase (complex I) indicates mitochondrial respiratory chain dysfunction in patients with sarcoidosis
Conclusion: For the first time, reduced activity of complex I has been detected in sarcoidosis group compared to controls. Our findings indicate that sarcoidosis is closely related to mitochondrial respiratory chain dysfunction.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kotsiou, O., Daniil, Z., Bouzetos, E., Panagiotidou, H., Fouka, M., Malli, F., Bardaka, F., Antoniou, K., Psara, A.-M., Mamuris, Z., Gourgoulianis, K., Zifa, E. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Retrospective analysis of sarcoidosis characteristics and psychological impact between civilian and military populations.
Conclusion: Without difference of sarcoidosis characteristics, the best respiratory parameter of military population could be explained by more physical training. Scores of anxiety, depression and quality of life scales were significantly more altered in the civilian population, not seem to be attributable with sarcoidosis; we can make hypothesis of possible protective effect of social link in military population, in spite of indisputable factors of stress.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ranc, C., Bylicki, O., Le Floch, H., Gaspard, W., Zhang, L., Grassin, F., Riviere, F. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Spirometry, cardiopulmonary exercise testing and the six-minute walk test results in sarcoidosis patients
Conclusions: According to this study the ventilatory limitation and pulmonary involvement are the main causes of activity limitations in sarcoidosis patients.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kiani, A., Eslaminejad, A., Shafie Pour, M., Razavi, F., Seyyedi, S. R., Sharif- Kashani, B., Taghavi, K., Abedini, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Gender and smoking - does it matter for lung function in sarcoidosis? An analysis of large cohort (n=1260) Caucasian patients.
Conclusion: Sex differences seems to not have any influence on lung function while smoking affects TL, CO results but not spirometry, particularly signs of airway obstruction, in sarcoidosis patients.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boros, P., Martusewicz-Boros, M., Wesolowski, S. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Health-related quality of life and health status among patients with sarcoidosis, chronic obstructive pulmonary disease and interstitial lung disease
Conclusion: In these three distinct groups of patients dyspnea limiting exercise capacity is the common predictor of deterioration of HRQOL/HS.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Labor, M., Pavlisa, G., Alilovic, M. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Exhaled Breath Biomarkers in Sarcoidosis: A Systematic Review
Conclusions: Evidence for breath biomarkers remains inconclusive with many studies limited by small sample sizes. VOCs have shown promising potential but further research is required to evaluate their prognostic role.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Terrington, D., Hayton, C., Peel, A., Fowler, S., Wilson, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Does the peripheral blood neutrophil lymphocyte ratio increase as the stage of sarcoidosis progresses?
Conclusions: Peripheral blood NLR increases with the stage progresses in patients with sarcoidosis and it can be valuable to follow up sarcoidosis clinical activity.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Alparslan Bekir, S., Sonkaya, E., Ozbaki, F., Aydogan Eroglu, S., Sertcelik, L., Duman, D., Kavas, M., Coban Agca, M., Erdem, I., Özmen, I., Boga, S., Armagan Hazar, F., Sevim, T., Türker, H., Karakurt, Z. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Glucocorticosteroid therapy as predisposing factor for pulmonary sarcoidosis relapse
Conclusion: CS therapy is a risk factor for sarcoidosis relapse. Therefore, despite their high efficacy, corticosteroids are recommended in asymptomatic patients only in cases of progressive disease or lack of improvement after 3 months follow-up period.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Merenkova, I., Dziublyk, Y., Gumeniuk, G., Gumeniuk, M. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Predictive value of Neutrophil-to-lymphocyte ratio(NLR) and Platelet-to-lymphocyte ratio(PLR) in patients with Sarcoidosis
Conclusion: PLR and NLR elevation in sarcoidosis patients may be a marker of pulmonary involvement and advanced stage.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Yalnız, E., Ucsular, F., Karadeniz, G., Polat, G., Vayısoglu, G. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Monocytes and dendritic cells with hyperinflammatory profile in lungs of sarcoidosis patients
Conclusion: Monocytes and DCs in lungs of sarcoidosis patients showed altered frequencies compared to healthy controls and exhibited an inflammatory phenotype with spontaneous, high TNF production particularly in non-LS patients, possibly contributing to the chronic course of the disease.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lepzien, R., Liu, S., Kullberg, S., Eklund, A., Grunewald, J., Smed-Sörensen, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Long-term follow-up of patients with pulmonary sarcoidosis
Conclusion: The pathology discovered after many years indicates the need for an expanded involvement of specialists in primary and dynamic examination of patients with sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Garmash, Y., Borisov, S. E., Ivanova, D. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Evaluation of specific immune complexes in patients with pulmonary sarcoidosis.
Conclusion: The significant differences in the formation of IC, may indicate the participation of autoimmune reactions to the pulmonary tissue in the development of SC. The formation of IC containing IgE may contribute to the emergence and maintenance of the pathological process.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Zinchenko, U., Starshinova, A., Filatov, M., Burdakov, V., Landa, S., Denisova, N., Yablonskiy, P. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Clinical features and prognosis of Chinese sarcoidosis patients.
Conclusions: Elevated serum angiotensin converting enzyme (ACE) is a risk factor for recurrence in sarcoidosis patients, that may suggesting that patients with high granulomatous burden at the time of diagnose are more likely to relapse.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ma, X., Dai, H., Wang, C. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Dynamics of the incidence and primary disability of sarcoidosis in Belarus
Conclusion: The introduction of modern therapeutic and diagnostic tactics led to decreasing the primary disability rate by 2.4% per year, the general level of disability by 10.9% per year and the increasing of the average age of the disabled due to sarcoidosis from 40.1 ± 2.1 to 45.4 ± 2.5 years for the last 10 years.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Baradzina, H. L. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Sarcoidosis: imagiological findings and their impact on the disease outcome
Conclusion: The outcome of pts was influenced by the initial radiological findings, as well as the development of new radiological findings.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Estevao Gomes, R., Barata, M., Monge, C., Lopes, M., Soares, J., Duarte, J. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Microbiological study of mediastinal lymph node biopsy from patients with sarcoidosis and lung cancer
Conclusion: Positive microbiological findings in mediastinal lymph node biopsy were infrequent in patients with sarcoidosis and lung cancer with generally similar microbiological profiles.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Durakovic, A., Fuursted, K., Richter Larsen, K., Naqibullah, M., Burhan Shaker, S. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

ETS-1 mRNA and its association with T-BET and Th1 cytokine expression in active pulmonary sarcoidosis
Conclusion: Elevated ETS-1 and T-BET expression in PB of sarcoidosis patients, monitors Th1 cytokines. Our data is suggestive of a regulatory effect of ETS-1 on pro-inflammation. This may have therapeutic implications in sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Sohal, P., Aggarwal, H., Madan, K., Hadda, V., Luthra, K., Mohan, A., Mitra, D. K., Guleria, R. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research