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Total 4720 results found since Jan 2013.

Structured multidisciplinary discussion of HRCT scans for IPF/UIP diagnosis may result in indefinite outcomes.
Authors: Pezzuto G, Claroni G, Puxeddu E, Fusco A, Cavalli F, Altobelli S, Portalone S, Zompatori M, Simonetti G, Saltini C, Sergiacomi G Abstract Recent ATS/ERS/JRS/ALAT guidelines for the diagnosis and management of Idiopathic Pulmonary Fibrosis (IPF) have defined key features and specific high-resolution computerized tomography (HRCT) patterns for the diagnosis of UIP. The aim is the sorting of patients with suspected IPF into three subgroups, confident, possible or inconsistent with UIP patterns, after a multidisciplinary discussion (MDD). Specialists in respiratory diseases, radiologists and pathologists shoul...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Beneficial Impact of bFGF Antisense Therapy in a Rat Model of Pulmonary Fibrosis.
CONCLUSIONS: bFGF appears to promote collagen I synthesis and upregulates TGF-β1/Smad signaling to promote lung fibroblast proliferation and differentiation in pulmonary fibrosis. bFGF antisense oligonucleotide therapy shows promise in preventing the development of pulmonary fibrosis, likely though a TGF-β1/Smad-based signaling mechanism. PMID: 26237352 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Assessment and management of connective tissue disease-associated interstitial lung disease.
Authors: Fischer A, Chartrand S Abstract The intersection of the connective tissue diseases (CTD) and the interstitial lung diseases (ILD) is complex. Although often considered as a single entity, "CTD-ILD" actually reflects a heterogeneous spectrum of diverse CTDs and a variety of patterns of interstitial pneumonia. The evaluation of patients with CTD that develop ILD, or the assessment for underlying CTD in those presenting with presumed "idiopathic" ILD can be challenging and these evaluations can be optimized by effective multidisciplinary collaboration. When a diagnosis of CTD-ILD is confirmed, careful and tho...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis
Conclusions: These data suggest that TL1A/DR3 interactions are part of the extended and complex immune-inflammatory network that characterizes sarcoidosis during its active phase and may contribute to the pathogenesis and to the progression of the disease.
Source: Clinical and Molecular Allergy - August 3, 2015 Category: Allergy & Immunology Authors: M. FaccoA. CabrelleF. CalabreseA. TeramoF. CinettoS. CarraroV. MartiniF. CalzettiN. TamassiaM. CassatellaG. SemenzatoC. Agostini Source Type: research

Personalized medicine in sarcoidosis: predict responders and nonresponders
Purpose of review: Treatment of sarcoidosis, a granulomatous disease affecting multiple organs with predominance to the lung, is complicated by variable response of individual patients to treatment options ranging from corticosteroids to second-line steroid-sparing agents and further to biologicals. This is partially because of varying disease manifestation, but polymorphic genes affecting drug metabolization substantially contribute. This review deals with pharmacogenetic (PGx) factors underlying interindividual differences of treatment response in sarcoidosis regarding personalized approach to patient management. Recent ...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Marjolein Drent and Johan Grunewald Source Type: research

How are cancer and connective tissue diseases related to sarcoidosis?
Purpose of review: Several studies have suggested an association between sarcoidosis and cancer, and between sarcoidosis and connective tissue diseases (CTDs). In this review, we discuss the evidence supporting and refuting these associations. Recent findings: In terms of a cancer risk in sarcoidosis patients, the data are somewhat conflicting but generally show a very small increased risk. The data supporting an association between sarcoidosis and CTD are not as robust as for cancer. However, it appears that scleroderma is the CTD most strongly associated with sarcoidosis. Summary: There are several important clinical and...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Marjolein Drent and Johan Grunewald Source Type: research

Clinical trials in pulmonary sarcoidosis
Purpose of review: Several new agents have been investigated in sarcoidosis. As the outcome measures in these trials has varied, it is often difficult to compare different treatment regimens or to combine clinical trials of the same regimen. The present review will assess the various potential endpoints, including physiologic, chest imaging, and health-related quality of life. Recent findings: Individual endpoints in pulmonary sarcoidosis trials have been studied and compared to response to several drugs. A panel of sarcoidosis experts as convened to enumerate the various potential endpoints and also voted on the relative ...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Marjolein Drent and Johan Grunewald Source Type: research

Diagnosing sarcoidosis
Purpose of review: The usual diagnostic criteria for sarcoidosis include the documentation of a compatible clinicoradiologic scenario, biopsy proof of granulomas, and exclusion of alternate causes for the findings. Establishing the presence of multisystem disease, and longitudinal assessment for the emergence of potential sarcoidosis mimics both strengthen the diagnosis. These principles have constituted a ‘diagnostic modus operandi’ for several decades, but the emergence of several new technologies has begun to transform their application. Recent findings: The widespread availability of high-resolution chest computed ...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Marjolein Drent and Johan Grunewald Source Type: research

Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro
Conclusions: Patients with sarcoidosis had elevated levels of specific antibodies against P. acnes which suggest contact with this bacterium in the past. Furthermore, BAL cells of sarcoid patients produced inflammatory cytokines (TNF-α and GM-CSF) upon stimulation with P. acnes indicating potential involvement of this pathogen in the pathogenesis of sarcoidosis in some patients.
Source: BMC Pulmonary Medicine - July 24, 2015 Category: Respiratory Medicine Authors: Jonas SchuppSandrine TchaptchetNiklas LützenPeggy EngelhardJoachim Müller-QuernheimMarina FreudenbergAntje Prasse Source Type: research

Computed Tomographic Diagnosis of Myocardial Fat Deposits in Sarcoidosis
Objective: Fat deposits in the left ventricle (LV) myocardium are uncommon and usually indicate scar due to chronic myocardial infarction. The purpose of this study was to determine the incidence of fatty lesions in the LV of patients with sarcoidosis. Materials and Methods: Review of noncontrast computed tomographic images (2-mm thickness) in 133 patients with documented extracardiac sarcoidosis (age, 35–82 years, 55 ± 10 years, 67% female) with no history of significant coronary artery disease (clinical and coronary calcium) was performed. A control group included noncontrast computed tomographies with no coronary cal...
Source: Journal of Computer Assisted Tomography - July 1, 2015 Category: Radiology Tags: Cardiothoracic Imaging Source Type: research

Effectiveness of infliximab in refractory FDG PET-positive sarcoidosis
In conclusion, infliximab causes significant improvement in FVC in refractory 18F-FDG PET positive sarcoidosis. Especially in pulmonary disease, high 18F-FDG PET SUVmax values at treatment initiation predict clinically relevant lung function improvement. These results suggest that inclusion of 18F-FDG PET is useful in therapeutic decision-making in complex sarcoidosis.
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Vorselaars, A. D. M., Crommelin, H. A., Deneer, V. H. M., Meek, B., Claessen, A. M. E., Keijsers, R. G. M., van Moorsel, C. H. M., Grutters, J. C. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Expression of HIF-1A/VEGF/ING-4 Axis in Pulmonary Sarcoidosis.
Authors: Piotrowski WJ, Kiszałkiewicz J, Pastuszak-Lewandoska D, Górski P, Antczak A, Migdalska-Sęk M, Górski W, Czarnecka KH, Domańska D, Nawrot E, Brzeziańska-Lasota E Abstract Angiogenesis/angiostasis regulated by hypoxia inducible factor-1A (HIF-1A)/vascular endothelial growth factor (VEGF)/inhibitor of growth protein 4 (ING-4) axis may be crucial for the course and outcome of sarcoidosis. Overexpression of angiogenic factors (activation of VEGF through HIF-1A) may predispose to chronic course and lung fibrosis, whereas immunoangiostasis (related to an overexpression of inhibitory ING-4) may be involved i...
Source: Advances in Experimental Medicine and Biology - May 30, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Peroxynitrite in Sarcoidosis: Relation to Mycobacterium Stationary Phase.
In this study, therefore, we evaluated NOx and ONOO(-) levels in supernatants of peripheral blood mononuclear cells cultures treated with Mtb-HSPs from 20 SA patients, 19 TB patients, and 21 healthy volunteers using Griess and rhodamine fluorescence methods. We found significantly greater NOx and ONOO(-) concentrations with/without Mtb-HSPs stimulation in SA and TB patients than in controls. However, there were significantly lower NOx and higher ONOO(-) levels after Mtb-HSPs induction in SA than TB patients. In summary, in contrast to active TB, increased ONOO(-) concentration may explain the low level of NOx with inducti...
Source: Advances in Experimental Medicine and Biology - May 30, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Etiologic link between sarcoidosis and Propionibacterium acnes
Publication date: June 2013 Source:Respiratory Investigation, Volume 51, Issue 2 Author(s): Yoshinobu Eishi Propionibacterium acnes is the only microorganism isolated from sarcoid lesions by bacterial culture. Numerous P. acnes genomes are found in lymph node samples from Japanese and European patients with sarcoidosis, whereas a few genomes are found in some non-sarcoid samples. The high frequency and specificity of detecting P. acnes within sarcoid granulomas suggests that this indigenous bacterium causes granuloma formation in many patients with sarcoidosis. P. acnes is the most common commensal bacterium in the lungs...
Source: Respiratory Investigation - May 18, 2015 Category: Respiratory Medicine Source Type: research

Selectively false-positive radionuclide scan in a patient with sarcoidosis and papillary thyroid cancer: a case report and review of the literature
Conclusions: We document a case of sarcoidosis causing a selectively false-positive thyroid scintigraphy scan. It is useful for clinicians to be aware of potential false-positives and deceptive patterns on radionuclide scans when managing patients with both well-differentiated thyroid cancer and a co-existing disease affecting the nodal basins draining the thyroid gland.
Source: Journal of Otolaryngology - Head and Neck Surgery - May 15, 2015 Category: ENT & OMF Authors: Nicole LeboFrancois RaymondMichael Odell Source Type: research

Lung sarcoidosis in children: update on disease expression and management
Discussion In the included children, mostly of Afro-Caribbean and Sub-Saharan origin, sarcoidosis seems severe, with multi-organic involvement and foreground general symptoms. Common prognosis factors are not suitable in paediatric patients, and a young age at diagnosis does not seem to be associated with a poorer prognosis. The study is ongoing to provide further information on the very-long-term follow-up of paediatric sarcoidosis.
Source: Thorax - May 14, 2015 Category: Respiratory Medicine Authors: Nathan, N., Marcelo, P., Houdouin, V., Epaud, R., de Blic, J., Valeyre, D., Houzel, A., Busson, P.-F., Corvol, H., Deschildre, A., Clement, A., for the RespiRare and the French Sarcoidosis groups Tags: Interstitial lung disease Paediatric lung disease Source Type: research

Uveitis profile and treatment response in Iranian patients with sarcoidosis
This study disclosed a higher predominance of females and intermediate form of uveitis in Iranian patients with sarcoid uveitis. Use of immunomodulatory drugs combined with corticosteroids resulted in good visual outcome and control of uveitis with a possible fewer corticosteroid side effects.
Source: International Ophthalmology - April 30, 2015 Category: Opthalmology Source Type: research

Multimodality evaluation of musculoskeletal sarcoidosis: Imaging findings and literature review
Publication date: Available online 13 April 2015 Source:Diagnostic and Interventional Imaging Author(s): S. Aptel , S. Lecocq-Teixeira , P. Olivier , D. Regent , P. Gondim Teixeira , A. Blum Whilst the detailed X-ray features of thoracic manifestations of sarcoidosis are now clearly defined and known by most radiologists, the same does not apply to osteoarticular and muscular features of the disease, which may however raise major diagnostic problems, either because they are the presenting features of the disease (7% of cases) or because they develop during its course. The bony lesions of sarcoid dactylitis (classical Per...
Source: Diagnostic and Interventional Imaging - April 15, 2015 Category: Radiology Source Type: research

Clinical features and diagnostic evaluation of 83 biopsy-proven sarcoid uveitis cases.
CONCLUSIONS: In this largest European series of biopsy-proven sarcoidosis to date, the outstanding diagnostic ability of enzyme test plus imaging test couple suggests that the recourse to invasive procedures should be limited to patients with ocular involvement that would justify systemic treatments. PMID: 25837608 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - April 2, 2015 Category: Opthalmology Authors: Febvay C, Kodjikian L, Maucort-Boulch D, Perard L, Iwaz J, Jamilloux Y, Broussolle C, Burillon C, Seve P Tags: Br J Ophthalmol Source Type: research

Paraneoplastic sarcoid-like reactions and the eye
Conclusion: Sarcoid-like reactions can occur in the eye, and ocular malignancies may incite sarcoid-like reaction. Ocular sarcoid-like reactions have paraneoplastic features in that they can occur at a site distant from malignancy and may precede, occur simultaneously with, or follow malignancy.
Source: RETINA - March 28, 2015 Category: Opthalmology Tags: Original Study Source Type: research

Sarcoid polyneuropathy masquerading as chronic inflammatory demyelinating polyneuropathy
Conclusions: Sarcoid polyneuropathy presents a diagnostic challenge, but in patients with atypical neuropathy, characteristic systemic symptoms, or a poor response to standard treatment, nerve and muscle biopsies can help diagnose this treatable disorder. This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - March 18, 2015 Category: Internal Medicine Authors: Neel S. Singhal, Viktoriya S. Irodenko, Marta Margeta, Robert B. Layzer Tags: Case of the Month Source Type: research

TGF-β and SMADs mRNA Expression in Pulmonary Sarcoidosis.
Authors: Piotrowski WJ, Kiszałkiewicz J, Pastuszak-Lewandoska D, Antczak A, Górski P, Migdalska-Sęk M, Górski W, Czarnecka K, Nawrot E, Domańska D, Brzeziańska-Lasota E Abstract Lung fibrosis is a complication of sarcoidosis, in which TGF-β/Smad pathway may play an important role. We evaluated gene expression of TGF-β1, SMAD2, 3 and 7 in bronchoalveolar lavage (BAL) cells and peripheral blood (PB) lymphocytes of sarcoidosis patients (n = 94) to better understand the mechanisms of sarcoid inflammation. The relative gene expression was analyzed by qPCR method. Selected clinical/radiological features and b...
Source: Advances in Experimental Medicine and Biology - March 12, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Acute kidney injury caused by sarcoid granulomatous interstitial nephritis without extrarenal manifestations
We report a case of a 70-year-old man with a history of type 2 diabetes mellitus admitted with progressively worsening kidney function. The patient also exhibited anorexia, malaise and weight loss. Laboratory tests showed an elevated serum lysozyme level, but the serum angiotensin-converting enzyme (ACE) and serum calcium levels were normal. Increased uptake was evident only in kidney on gallium 67 scintigraphy. Although typical organ involvement of sarcoidosis was not evident, a renal biopsy showed granulomatous interstitial nephritis with non-caseating granulomas. No medications had been added in the 3 years preceding r...
Source: CEN Case Reports - March 5, 2015 Category: Urology & Nephrology Source Type: research

Sarcoid-Like Reaction—Computed Tomography Features in 12 Patients
Conclusions: Imaging features of patients with sarcoid-like reaction include lymphadenopathy, small nodules, and ultrafine nodules with confluence, mimicking GGO. Ultrafine nodules with confluence mimicking GGO were unexpectedly common in this series.
Source: Journal of Computer Assisted Tomography - March 1, 2015 Category: Radiology Tags: Thoracic and Breast Imaging Source Type: research

Ventricular Tachycardia in Cardiac Sarcoidosis: Characterization of Ventricular Substrate and Outcomes of Catheter Ablation Original Articles
Conclusions— Patients with cardiac sarcoidosis and VT exhibit ventricular substrate characterized by confluent right ventricular scarring and patchy left ventricular scarring capable of sustaining a large number of re-entrant circuits. Catheter ablation is effective in terminating VT storm and eliminating ≥1 inducible VT in the majority of patients, but recurrences are common. Ablation in conjunction with antiarrhythmic drugs can help palliate VT in this high-risk population.
Source: Circulation: Arrhythmia and Electrophysiology - February 17, 2015 Category: Cardiology Authors: Kumar, S., Barbhaiya, C., Nagashima, K., Choi, E.-K., Epstein, L. M., John, R. M., Maytin, M., Albert, C. M., Miller, A. L., Koplan, B. A., Michaud, G. F., Tedrow, U. B., Stevenson, W. G. Tags: Original Articles Source Type: research

Four decades of necrotizing sarcoid granulomatosis: what do we know now?
Conclusion s.- The data showed a striking overlap in the clinical, radiologic, and pathologic features of both entities, strongly supporting the conclusion that necrotizing sarcoid granulomatosis is a previously unrecognized manifestation of sarcoidosis and is essentially the same as nodular sarcoidosis. It is proposed that use of necrotizing sarcoid granulomatosis as a diagnostic term be discontinued and replaced by sarcoidosis with necrotizing sarcoid granulomatosis pattern provided that an infectious etiology can be reasonably excluded. Our concept of sarcoidosis should now be expanded to recognize that there is a conti...
Source: Archives of Pathology and Laboratory Medicine - January 26, 2015 Category: Laboratory Medicine Authors: Rosen Y Tags: Arch Pathol Lab Med Source Type: research

Treatment and outcome of lung cancer in idiopathic interstitial pneumonias.
CONCLUSIONS: LC is a frequent comorbidity in IIP, with a higher incidence and reduced survival in IPF compared to other IIPs. LC treatment is associated with significant toxicity, specifically in IPF. Interdisciplinary evaluation of therapeutic options in IIP patients diagnosed with LC is therefore mandatory. PMID: 25591137 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Seasonal variation of serum KL-6 and SP-D levels in bird-related hypersensitivity pneumonitis.
Authors: Okamoto T, Tsutsui T, Suhara K, Furusawa H, Miyazaki Y, Inase N Abstract N/A. PMID: 25591150 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Proceedings of the 2014 AASOG conference.
Authors: Crouser E, Judson M Abstract Not applicable. PMID: 25591149 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Intravascular large B cell lymphoma presenting in the lung: the diagnostic value of transbronchial cryobiopsy.
CONCLUSIONS: transbronchial cryobiopsy could be used as valid surrogate for surgical lung biopsy in lymphoprolipherative lung disorders (including intravascular lymphomas), as allows larger samples of tissue, greater  diagnostic yield, no crush artifacts and much less complications than surgical biopsy.  PMID: 25591148 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Granulomatous lung disease in a patient with a family history of hematological disorders.
Authors: Overbeek M, Van de Loosdrecht A, Vonk-Noordegraaf A Abstract A 29-year old patient presented with granulomatous lung disease and a family history of myelodysplastic syndrome/acute myeloid leukemia. She appeared to be a carrier of a mutation in the transcription factor GATA2. The case adds to the recent described heterogeneous clinical manifestations and syndromes in which, against a background of hematologic disorders, GATA2 mutations have been demonstrated, such as the Monomac and Emberger syndromes. In patients with a granulomatous disease and a history of (familial) hematologic disorders, the occurence ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A pilot study: a combined therapy using polymyxin-B hemoperfusion and extracorporeal membrane oxygenation for acute exacerbation of interstitial pneumonia.
CONCLUSION: A combined therapy of PMX-DHP and VV-ECMO might be a therapeutic option for AE of IP. PMID: 25591146 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

In vitro and in vivo study of anti-tuberculosis effect of extracts isolated from Ranunculi Ternati Radix.
CONCLUSIONS: EEPMR possessed better anti-tuberculosis effects than other extracts and Radix Ranunculi Ternati Capsules. This supported the use of macroporous resin to enrich the active part of Ranunculi Ternati Radix to cure mycobacterium tuberculosis infections. PMID: 25591145 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Reconsideration of discrepancies between clinical and histopathological features in acute eosinophilic pneumonia.
Conclusion) Characteristic histopathological findings of AEP consist of alveolar edema with infiltration of eosinophils and lymphocytes and edema of perivascular area and interlobular septa. The alveolar spaces showed fibrinous exudates. There were no hyaline membranes or massive intraluminal fibrosis. These histopathological findings of interstitial edema and fluid exudates are consistent with radiological findings of lung edema and can explain the rapid and complete improvement.Because AEP does not exhibit lung fibrosis histopathologically, it should not to be included in DAD which is associated with lung fibrosis.  ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pulmonary hypertension in idiopathic pulmonary fibrosis does not influence six-minute walk distance: results from a retrospective study.
CONCLUSIONS: Our data suggested that 6MWD does not differ between IPF patients with or without PH. Thus, 6MWD should not be used as a surrogate endpoint in clinical study in patients affected by IPF and PH. PMID: 25591141 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Association between idiopathic pulmonary fibrosis and coronary artery disease: a case-control study and cohort analysis.
CONCLUSIONS: IPF itself was an independent risk factor for CAD after the adjustment of age, hypertension, diabetes, and hypercholesterolemia. PMID: 25591140 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Immunologic finding of disseminated granuloma reaction in patients with Mycobacterium tuberculosis and sarcoidosis
Conclusion This is the first case report from patients with unique features of NSG combined with MTB.
Source: International Journal of Mycobacteriology - January 10, 2015 Category: Infectious Diseases Source Type: research

Identifying Toll-like Receptor Expression in Cutaneous Sarcoidosis
Abstract:Toll-like receptors (TLRs) are known to be expressed in the skin. Antigenic stimulation of TLRs in the skin has been implicated in several inflammatory dermatologic diseases including psoriasis, syphilis, atopic dermatitis, and cutaneous T-cell lymphoma. However, the expression of TLRs in cutaneous sarcoidosis has not yet been defined. Expression of TLRs 1–9 was examined in cutaneous sarcoid by immunohistochemical staining. It was found that TLRs 5 and 6 stained most intensely in both the granulomas and epidermis of the sarcoid cases. TLRs 2, 3, 4, 7, and 8 stained more intensely compared with normal skin. All s...
Source: The American Journal of Dermatopathology - January 1, 2015 Category: Pathology Tags: Brief Report Source Type: research

Sarcoid-Like Reaction in Sentinel Lymph Node Draining Conjunctival Melanoma
A sarcoid-like reaction is the presence of noncaseating granulomas due to a T-cell mediated inflammatory reaction in draining lymph nodes of tumors or in the vicinity of tumors. Breast cancer, lymphoma, and cutaneous melanoma have been observed to induce a sarcoid-like reaction. Herein, a patient is reported with conjunctival melanoma in whom multiple noncaseating granulomas were observed in the sentinel lymph node without evidence of micrometastasis. Fungal and mycobacterium stainings were negative and further systemic workup excluded sarcoidosis. This case identifies conjunctival melanoma as a cause of a sarcoid-like reaction.
Source: Ophthalmic Plastic and Reconstructive Surgery - January 1, 2015 Category: Opthalmology Tags: Case Reports Source Type: research

Refractory Sarcoid Arthritis in World Trade Center–Exposed New York City Firefighters: A Case Series
Conclusions: Chronic inflammatory polyarthritis appears to be an important manifestation of sarcoidosis in FDNY firefighters with sarcoidosis and WTC exposure. Their arthritis is chronic and, unlike arthritis in non–WTC-exposed sarcoid patients, inadequately responsive to conventional oral disease-modifying antirheumatic drugs, often requiring anti–tumor necrosis factor α agents. Further studies are needed to determine the generalizability of these findings to other groups with varying levels of WTC exposure or with other occupational/environmental exposures.
Source: JCR: Journal of Clinical Rheumatology - December 30, 2014 Category: Rheumatology Tags: Original Articles Source Type: research

Sarcoidosis in India: Investigation into vitamin D and calcium metabolism
Conclusions:Our study shows hypovitaminosis D in both cases and controls. Although these patients escape the brunt of hypercalcemia, they may suffer from adverse effects of hypovitaminosis D which can be attributed to inherent prevalence of Vitamin D deficiency in Indian population.Hence, they may rather need calcium and vitamin D supplementation under close monitoring.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Chandrashekariah, S., Rosha, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Does the BTNL2 genotype influence the course of disease in Danish sarcoidosis patients?
Conclusions: BTNL2 AA genotype is prevalent in patients with sarcoidosis and may be of use to help establish a diagnosis. There appeared to be no association between BTNL2 genotype and outcome of disease.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Milman, N., Van Overeem Hansen, T., Skov Jensen, M. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Heat shock proteins as 'danger signals' in sarcoidosis
Sarcoidosis (SA) is a multisystem granulomatous disease with unknown etiology. Like other autoimmunological disorders, SA develops due to a combination of genetic and non-infectious/infectious factors.We evidenced, that the same mycobacterial heat shock proteins (Mtb-HSPs, especially HSP16, the main marker of dormant stage of (myco)bacteria), occurring in sarcoid tissues and in precipitated immune complexes (CIs), were inducing immune response dependently on different genetic background of host (HLA and non-HLA-NRAMP1,FCGRIIA,IIC,IIIA), developing acute sarcoidosis/Löfgren syndrome, chronic SA, latent, or active TB. I...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Dubaniewicz, A. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Comorbidities associated with sarcoidosis - Results from long-term observational study
Conclusion: We have found significant number of comorbidities in patients with sarcoidosis. Screening for these conditions, especially thyroid and neoplastic disorders, should be considered in these patients.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Nowinski, A., Puscinska, E., Goljan-Geremek, A., Bednarek, M., Kaminski, D., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Mortality in sarcoidosis, results from one centre, long term observational study
Conclusion:The leading cause of death in sarcoid patients in our Department were cancers, but just as often, sarcoidosis was the underlying cause of death.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Puscinska, E., Nowinski, A., Goljan-Geremek, A., Bednarek, M., Kaminski, D., Kowalska, A., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Impulse oscillometry measurements are correlated to quality of life in patients with pulmonary sarcoidosis
ConclusionIOS measurements correlate with symptom burden more strongly than conventional lung function markers in sarcoidosis. Whether this reflects their higher sensitivity to small airway changes requires further study.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Karagiannis, K., Bikov, A., Bonifazi, M., Kalsi, H., Lota, H., Meah, S., Barnes, P., Wells, A. U., Paredi, P., Usmani, O. S., Renzoni, E. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Proteomic investigation of pulmonary sarcoidosis
Pulmonary Sarcoidosis is characterised by hystiopatological features of noncaseating epithelioid cell granulomas originated from alveolar macrophages. Despite sarcoidosis occurs more frequent in never-smoker subjects than smokers, it has been speculated that unknown inhaled antigens may induce aberrant leukocytes stimulation leading to formation of sarcoid granuloma.Our group of research applied the proteomic approach to the analysis of bronchoalveolar lavage (BAL) in order to contribute to the study of the pathogenetic mechanisms of the disease and to differentiate potential disease biomarkers.BALF samples were resolved b...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bargagli, E., Landi, C., Carleo, A., Cillis, G., Refini, R. M., Bennett, D., Perari, M. G., Bini, L., Rottoli, P. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Differential bronchoalveolar expression of candidate microRNAs in chronic obstructive pulmonary disease, asthma bronchiale and pulmonary sarcoidosis
Conclusion: The differences in BAL miRNA expression between the investigated pulmonary diseases may contribute to variation of inflammatory response in their pathomechanisms. Characterisation of typical miRNA expression profiles is the next step of this work.Grant support IGAPULF2014_012, IGAMZ11117, CZ.1.05./2.1.00/01.0030.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Navratilova, Z., Novosadova, E., Krsjakova, T., Kolek, V., Petrek, M. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Detection of exosomal miRNA in pulmonary sarcoidosis
Conclusions: The implemented methodology for detection of miRNA in exosomes from BALF enabled to detect exosomal miR-21, -26a and -146a in sarcoidosis. Future analyses will focus on detailed characterization of exosomal expression profile in sarcoidosis, also in comparison with healthy subjects / diffuse lung disease. Grant support: CZ.1.07/2.3.00/30.0041, CZ.1.05./2.1.00/01.0030.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Kishore, A., Navratilova, Z., Kolek, V., Petrek, M. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Tracheal epithelial-myoepithelial carcinoma associated with sarcoid-like reaction: a case report
We report the first case of epithelial-myoepithelial carcinoma associated with sarcoidosis. A 61 year old Hispanic man presented with altered mental status and hypercalcemia. Imaging revealed diffuse intra-thoracic and intra-abdominal lymphadenopathy. A diagnostic bronchoscopy was performed where an incidental tracheal nodule was discovered and biopsied. Pathology was consistent with epithelial-myoepithelial carcinoma. Lymph node biopsy demonstrated non-caseating granulomas consistent with sarcoidosis. Patient underwent tracheal resection of the primary tumor with primary tracheal reconstruction. Hypercalcemia subsequently...
Source: Respiratory Medicine Case Reports - December 17, 2014 Category: Respiratory Medicine Source Type: research