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Total 5691 results found since Jan 2013.

Mixed ventilatory defects in pulmonary sarcoidosis: prevalence and prognosis
Conclusion: Mixed disease may be underestimated in sarcoidosis using current ATS/ERS guidelines despite its high prognostic value in sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kouranos, V., Ward, S., Kokosi, M., Thomas, S., Castillo, D., Judge, E., van Tonder, F., Devaraj, A., Maher, T., Renzoni, E., Wells, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Autoreactivity in patients with respiratory sarcoidosis
Sarcoidosis (SC) is a granulomatous disease with unknown origin and autoimmune features. The autoantigen that triggers the pathological process is unknown.Aim: To study autoreactivity in patients with SC by determining the level of autoantibodies.Methods: In Institute of Phthisiopulmonology in 2017, patients with histologically verified pulmonary SC stage 2 (n=21, 13 men and 8 women, mean age 34.2 ± 7.3 years) were examined. The level of autoantibodies of the standard panel (15 indicators) was determined by ELISA. Statistical analysis was done by Statistica 7.0 with the methods of descriptive statistics (N, % or Mea...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Zinchenko, U., Starshinova, A., Denisova, N., Lapin, S., Mazing, A., Surkova, E., Yablonskii, P. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Optical coherence tomography in the diagnosis of sarcoidosis of lung and other organs
Conclusions: Degenerative-dystrophic eye processes for sarcoidosis can be diagnosed by optical coherence tomography. This makes it possible to identify specific eye lesions in the early stages.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Sabadash, E., Skornyakov, S., Medvinskiy, I., Egorov, E., Filatova, E., Peretrukhina, M., Chernenko, M., Ivanchikova, E., Diachkov, I. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Differential Expression of Plasma Metabolites in Patients with Pulmonary Sarcoidosis is Associated with Clinical Behavior
Conclusion: Metabolomics profiling for biomarker discovery in sarcoid is feasible, and candidate biomarkers should be prioritized for further testing.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kass, D., Strock, S., Nouraie, M., Chiarchiaro, J., Veraldi, K., Zhang, Y., Gibson, K. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Cardiac sarcoidosis: worse pulmonary function due to left ventricular ejection fraction ? A case-control study
Conclusions: Lung function impairment is more frequent in CS. Lower LVEF was associated with decreased values of FEV1.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Martusewicz-Boros, M., Boros, P., Wiatr, E., Zych, J., Kempisty, A., Kram, M., Piotrowska-Kownacka, D., Wesolowski, S., Baughman, R., Roszkowski-Sliz, K. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Ultrasonographic evaluation of lung parenchyma in sarcoidosis
Conclusion: The number of CTA is increased in sarcoidosis compared to healthy cases. Negative correlation between number of CTA and %DLCO with increased CTA counts in case of parenchymal involvement showed that horacic USG can be used in evaluation of parenchymal involvement of lung.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Dogan, C., Kıral, N., Parmaksız, E. T., Sagmen, S. B., Salepci, B., Fidan, A., Caglayan, B., Comert, S. S. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Differential expression of ubiquitin and PU.1 in granulomatous lesions of tuberculosis and sarcoidosis
Conclusion: Taken together, the characteristic expressional difference and mutual correlation between ubiquitin and PU.1 in the granuloma of tuberculosis and sarcoidosis may partly explain the mechanism of caseation necrosis and formation of granuloma in two diseases. We hope ubiquitin-related studies may contribute to define the etiology and pathogenesis in macrophage-involved granulomatous diseases.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Shin, J., Choi, B. W., Park, I. W. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Sarcoidosis treatment and outcomes: what is most important to patients?
Conclusion: Sarcoidosis patients ranked treatments which improved quality of life and functionality as most important outcomes. Patients ranked adverse events as a less important outcome than quality of life, survival, and functionality.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boyd, J., Baughman, R. P., Valeyere, D., Alvarez Rodriguez, A. R., Charvoz, L., Faber, H.-P., Knoet, C., Martone, F., Novel, D. I., Quadder, B., Richardson, J., Spitzer, G., Ziosi, G., Hochreiter, J. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

ETS-1 mRNA and its association with T-BET and Th1 cytokine expression in active pulmonary sarcoidosis
Conclusion: Elevated ETS-1 and T-BET expression in PB of sarcoidosis patients, monitors Th1 cytokines. Our data is suggestive of a regulatory effect of ETS-1 on pro-inflammation. This may have therapeutic implications in sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Sohal, P., Aggarwal, H., Madan, K., Hadda, V., Luthra, K., Mohan, A., Mitra, D. K., Guleria, R. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Mononuclear phagocytes in lungs, lymph nodes and blood of sarcoidosis patients
Conclusions: We show that cells from BAL fluid do not necessarily reflect cells from EBB, a tissue primarily affected by granuloma formation. Our work provides a foundation for future investigations of MNPs in non-LS and LS sarcoidosis patients, allowing improved stratification to identify patients at risk of developing severe disease and provide early treatment to slow down disease progression.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lepzien, R., Rankin, G., Pourazar, J., Muala, A., Eklund, A., Grunewald, J., Blomberg, A., Smed Sörensen, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Placebo-controlled randomised trial of dexamethasone for quality of life in pulmonary sarcoidosis
Many patients with pulmonary sarcoidosis experience reduced quality of life. Although oral corticosteroids are the most common agents used in sarcoidosis, very little is known on the effects on quality of life. We evaluated the efficacy of low dose oral dexamethasone in newly diagnosed patients without an indication for high dose immunosuppressive therapy.In this double-blind, placebo-controlled trial, patients were randomised to once-daily dexamethasone 1 mg (6.5 mg prednisone equivalent) or placebo for 6 months. The primary study parameter was the subscale physical functioning of the 36-item Short Form health survey (SF-...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Vis, R., van De Garde, E. M. W., Korenromp, I. H. E., Grutters, J. C. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Combination of endoscopic techniques - number of lymph nodes stations biopsies and application of cell blocks in the sarcoidosis diagnosis
Conclusions: Combining of EBUS-TBNA of at least two lymph nodes stations and EBB increase diagnostic yield of sarcoidosis. Cell block specimens have not further impact on the diagnostic yield of the procedure.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kasper, Łukasz, Andrychiewicz, A., Kasper, M., Tomaszewska, R., Soja, J., Sładek, K. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

The pulmonary microbiome in sarcoidosis is similar to other parenchymal lung diseases
Sarcoidosis is a chronic inflammatory disease that is characterized by noncaseating granuloma formation and that often affects the lung. The aetiology is largely unclear and there are speculations about a microbial component in the initial activation of adaptive immune mechanisms. The aim of the present study was to determine whether there are differences between the microbiota of patients with sarcoidosis and other parenchymal lung diseases.Patients were recruited at the Department of Internal Medicine V at the Saarland University Medical Center, the study was approved by the ethics committee and informed consent was obta...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Becker, A., Vella, G., Herr, C., Keller, A., Laczny, C., Beisswenger, C., Bals, R. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Advanced pulmonary sarcoidosis: long-term follow-up of 10 years or more
Conclusion: The signs of APS may include decreased exercise tolerance, decreased FVC, DLCO, increased ratio of pulmonary artery diameter to aortic diameter > 1.0. Modern radiologic methods can be used to support the diagnosis of PS progression.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Baranova, O. P., Ilkovich, M., Speranskaya, A., Perlei, V. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

A Comparative Study of Characteristics and Outcomes of Patients with Proved and Suggested Sarcoid Uveitis Occurring after Ophthalmic Procedure.
Conclusions: Sarcoid uveitis has similar characteristics in patients with new onset sarcoid uveitis after or without ophthalmic procedure. As a consequence, ophthalmic intervention should be seen as a potential trigger of latent sarcoidosis. PMID: 30420915 [PubMed]
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Serum 1,25(OH)2 Vitamin D and 25(OH) Vitamin D Ratio for the Diagnosis of Sarcoidosis-Related Uveitis.
CONCLUSION: The measurement of serum 25(OH)D and 1,25(OH)2D levels is a useful tool in the etiological workup of patients with unexplained uveitis, since a high 1,25(OH)2D/25(OH)D ratio is suggestive of ocular sarcoidosis. PMID: 30395752 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - November 7, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Sarcoid uveitis in a patient with multiple neurological lesions: a case report and review of the literature
ConclusionsAccording to the literature, patients with multiple cranial nerve palsies associated with sarcoidosis respond well to orally administered steroid therapy. However, our findings suggest that careful follow-up is necessary for patients with neurosarcoidosis due to potential aggravation of neuropathy.
Source: Journal of Medical Case Reports - October 23, 2018 Category: General Medicine Source Type: research

The combination of EBUS-TBNA and the PAB antibody led to a successful treatment for lung cancer in a patient with asymptomatic sarcoidosis mimicking nodal metastasis
Publication date: Available online 18 October 2018Source: Respiratory Medicine Case ReportsAuthor(s): Mari Tone, Nobuyasu Awano, Minoru Inomata, Naoyuki Kuse, Tatsunori Jo, Hanako Yoshimura, Yoshiaki Furuhata, Tamiko Takemura, Toshio Kumasaka, Takehiro IzumoAbstractCorrect staging of lung cancer is important for the selection of the best therapy, but discriminating between lymphadenopathy from lung cancer and from sarcoidosis by imaging examinations is difficult. Additionally, distinguishing lymphadenopathy of sarcoidosis from sarcoid reactions which are sometimes caused by lung cancer is difficult on imaging and pathologi...
Source: Respiratory Medicine Case Reports - October 19, 2018 Category: Respiratory Medicine Source Type: research

Micropapular Cutaneous Sarcoidosis Reviewed
Conclusion: In our review there does not seem to be a clear link as to the definite cause of the MPCS. While the relationships to tuberculosis and autoimmunity seem to be often emphasized, there was no clear association with either etiology.Dermatology
Source: Dermatology - October 5, 2018 Category: Dermatology Source Type: research

Echocardiography in Sarcoidosis
AbstractPurpose of ReviewCardiac sarcoidosis (CS) is associated with significant morbidity and mortality. The diagnosis of CS is challenging and typically one that is only entertained after many other conditions have been ruled out. A high index of suspicion is necessary in order to correctly determine appropriate testing for the disease. Transthoracic echocardiography is the most readily available imaging modality available to help establish a diagnosis in a potential patient. However, no one echocardiographic feature is pathognomonic.Recent FindingsOn echocardiography, unusual wall motion abnormalities, which do not fit ...
Source: Current Cardiology Reports - September 26, 2018 Category: Cardiology Source Type: research

Sarcoidosis related uveitis: Clinical presentations, disease course and rates of systemic disease progression after uveitis diagnosis
To document the clinical presentation, treatment and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis.
Source: American Journal of Ophthalmology - September 20, 2018 Category: Opthalmology Authors: Shirley Ma, Sophie L. Rogers, Anthony J. Hall, Lauren Hodgson, Jessica Brennan, Richard Stawell, Lyndell L. Lim Tags: Original Articles Source Type: research

Sarcoidosis-related Uveitis: Clinical Presentation, Disease Course, and Rates of Systemic Disease Progression After Uveitis Diagnosis
To document the clinical presentation, treatment, and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis.
Source: American Journal of Ophthalmology - September 20, 2018 Category: Opthalmology Authors: Shirley P. Ma, Sophie L. Rogers, Anthony J. Hall, Lauren Hodgson, Jessica Brennan, Richard J. Stawell, Lyndell L. Lim Tags: Original article Source Type: research

A Multiple Biomarker Approach in Patients with Cardiac Sarcoidosis.
Authors: Kiko T, Yoshihisa A, Kanno Y, Yokokawa T, Abe S, Miyata-Tatsumi M, Misaka T, Oikawa M, Kobayashi A, Ishida T, Takeishi Y Abstract Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide ...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Optical Coherence Tomography and Management of a Retinal Granuloma in Presumed Ocular Sarcoidosis.
CONCLUSION: This case demonstrated marked granuloma regression occurring with improvement in visual acuity, highlighting the utility of OCT and PSTA in managing retinal sarcoid granulomas. PMID: 30096009 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - August 11, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Updates on the Role of Imaging in Cardiac Sarcoidosis
AbstractPurpose of reviewThe non-specific symptom profile and subclinical nature of disease along with variable region of cardiac involvement in systemic sarcoidosis make the diagnosis particularly challenging. The yield of endomyocardial biopsy, a gold standard for diagnosis, is not high unless coupled with additional imaging modalities to detect regional involvement. This review is focused on highlighting the major recent advances in imaging modalities and diagnosis of cardiac sarcoidosis.Recent findingsThere has been much interest and increasing research focused on developing newer and improved imaging modalities to est...
Source: Current Treatment Options in Cardiovascular Medicine - August 7, 2018 Category: Cardiology Source Type: research

Nutrition and corticosteroids in the treatment of sarcoidosis
Purpose of review Sarcoidosis is a chronic disease, which is routinely treated with corticosteroids. Steroid resistance or steroid-induced adverse effects require alternatives. Other immune-modulating pharmacological treatments have been developed, and therefore expanded tremendously. Until now, the role of nutrition in the overall management of sarcoidosis has been neglected although anti-inflammatory properties of nutritional components have been known for many years now. New nutritional possibilities emerge from already existing data and offer new therapeutic avenues in the treatment of sarcoidosis. Recent findings ...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Obesity and sarcoidosis: consequence or contributor?
Purpose of review Sarcoidosis is a multisystem disease of unknown cause. Obesity can affect many physiological factors. The relationship between obesity and sarcoidosis is unclear, and can been described as posing a ‘chicken and egg’ scenario for the patient as it is not always clear whether it is a consequence of, or a risk factor for any disease. The purpose of this review is to examine the dual roles of obesity on sarcoidosis morbidity and the incidence. Recent findings Obesity magnifies the symptoms of sarcoidosis and corticosteroid therapy increases BMI. Prospective epidemiologic studies started to explore th...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

The Fatigue Assessment Scale: quality and availability in sarcoidosis and other diseases
Purpose of review Fatigue is a problem experienced by many patients suffering from chronic diseases, including sarcoidosis patients. It has a substantial influence on patients’ quality of life (QoL). It is, therefore, important to properly assess fatigue with a valid and reliable measure. The Fatigue Assessment Scale (FAS) is the only validated self-reporting instrument classifying fatigue in sarcoidosis. The aim of this review was to examine the psychometric properties of the FAS and the diseases and languages in which it has been used. Studies among sarcoidosis patients were also reviewed in terms of outcomes. Recen...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Sarcoidosis and autoimmune diseases: differences, similarities and overlaps
Purpose of review Sarcoidosis is a rare, multisystem granulomatous disease of incompletely understood pathogenesis. Clinically, it shares common features with several systemic and organ-specific autoimmune diseases, although known autoantibodies or useful serologic markers for diagnosis and monitoring of disease activity are lacking. Sarcoidosis can both coexist with or mimic connective tissue diseases or vasculitis. Here, we review possible common etiologic factors between sarcoidosis and autoimmune disease, comparing clinical, laboratory and imaging features. Recent findings Autoimmune diseases may precede or follow...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Renal sarcoidosis: approach to diagnosis and management
Purpose of review The purpose of this article is to provide understanding of renal sarcoidosis, the different types of renal sarcoidosis, disease burden of renal involvement, and treatment options. Recent findings The frequency of renal involvement seems to be underestimated, but renal sarcoidosis represents a relevant group of organ manifestations and significantly adds to the patient's morbidity. Because histopathological analysis of renal biopsy specimens can reveal various entities, a diagnostic workup is necessary in every patient with sarcoidosis. Summary If systematically screened for renal manifestations ar...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Role of imbalance between Th17 and regulatory T-cells in sarcoidosis
Purpose of review A relatively new class of CD4 expressing T cells that also express and release interleukin-17 (Th17 cells) is gaining attention based on their capacity to regulate inflammatory responses in a spectrum of chronic autoimmune diseases. The purpose of this review is to consider recent studies relating to the critical role played by Th17 cells in the pathogenesis of sarcoidosis. Recent findings Th17 cells are unique in their capacity to adapt to local molecular cues to variably promote or suppress inflammation. On the basis of knowledge established originally in the context of autoimmune disorders, recent...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Why do people die from pulmonary sarcoidosis?
Purpose of review In sarcoidosis, the design and validation of an appropriate risk stratification strategy is hampered by the considerable variability in initial presentation, disease evolution, and outcome. Although spontaneous resolution of the disease is described in a large proportion of patients, approximately 20–30% would present with chronic or progressive lung disease that has been associated with morbidity and mortality. Higher morbidity and mortality can be related to both the disease severity and extent as well as its treatments. We review the utility of integration of clinical, pathological, and radiologica...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Peter Korsten and Marjolein Drent Source Type: research

Localized sarcoidosis in an old tattoo: Illustrating the principle of locus minoris resistentiae
We present a case of a 33-year-old man with history of systemic sarcoidosis who presented with firm papules within multiple old tattoos. Pathology of one lesion revealed granulomatous infiltration consistent with sarcoidosis within an old tattoo. The patient was also found to have erythema nodosum, hilar lymphadenopathy, and arthralgias, and was diagnosed with Lofgren syndrome. This case of cutaneous sarcoid manifesting in an old tattoo illustrates the principle of locus minoris resistentiae (LMR).
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Isolated Right Ventricular Cardiac Sarcoidosis Presenting as Complete Heart Block
Sarcoidosis is a multi-organ disease with formation of granulomas. Involvement of the heart causes inflammation, leading to atrioventricular block (AVB) or ventricular arrhythmias, and portends a poor prognosis. Cardiac sarcoidosis is detected in only 2% of patients, and most have left ventricular (LV) involvement. Isolated right ventricular (RV) involvement is rare. High suspicion is necessary to make the diagnosis, and advanced testing is required. Recognizing cardiac sarcoid is imited to the RV and determining presence of pulmonary hypertension (PH), is imperative for management.
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Katherine Dodd Tags: 233 Source Type: research

Monitoring cardiac sarcoidosis: The next frontier
Cardiac sarcoidosis is a potentially life-threatening form of the disease. Although most sarcoidosis-related deaths result from lung involvement, most of these deaths occur after years of the slow development of lung fibrosis from granulomatous inflammation [1,2]. Contrary to pulmonary sarcoidosis, cardiac sarcoidosis may cause life-threatening events and severe organ dysfunction relatively quickly because of myocardial granulomas deposited in unfortunate locations. Furthermore, myocardial sarcoid granulomas tend to progress relatively quickly to scar [3] that does not respond to anti-granulomatous therapy and is permanent.
Source: Respiratory Medicine - July 26, 2018 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

Invasive Hemodynamics and Rejection Rates in Patients With Cardiac Sarcoidosis After Heart Transplantation
ConclusionsPatients with CS have similar post-transplant hemodynamics as patients without CS, without evidence of right ventricular dysfunction or pulmonary hypertension. Neither significant rejection nor recurrence of sarcoid in the allograft was observed in this cohort of patients with CS. Survival is similar between patients with CS and those without CS. Heart transplant is a viable strategy in selected patients with CS with excellent outcomes.RésuméIntroductionLa transplantation cardiaque orthotopique (TCO) est de plus en plus utilisée lors d’insuffisance cardiaque terminale liée à une sarcoïdose cardiaque (SC)...
Source: Canadian Journal of Cardiology - July 24, 2018 Category: Cardiology Source Type: research

Clinical and biochemical presentation of sarcoidosis with high and normal serum angiotensin-converting enzyme.
CONCLUSION: Our study demonstrates that serum ionized calcium is significantly higher in the high sACE group but there was no statistical correlation to sACE. No other clinical or biochemical differences were observed. PMID: 29929412 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - June 22, 2018 Category: Rheumatology Authors: Sejdic A, Graudal N, Baslund B Tags: Scand J Rheumatol Source Type: research

Thoracic and cutaneous sarcoid-like reaction associated with anti-PD-1 therapy: longitudinal monitoring of PD-1 and PD-L1 expression after stopping treatment
ConclusionThis case sheds the light on a complex regulation of PD-L1 expression in vivo on PBMC after nivolumab arrest and triggers the question of monitoring the expression of immune checkpoint on immune cells during and after treatment with ICI.
Source: Journal for Immunotherapy of Cancer - June 13, 2018 Category: Cancer & Oncology Source Type: research

Identify sarcoid-like reaction in cancer patients receiving chemotherapy and immunotherapy: dont get into the weeds of SUVmax
Conclusions: To avoid pitfall in PET/CT interpretation, it is important to recognize the sarcoid-like pattern of FDG uptake, which regardless of SUV value is favored to represent a benign rather than a malignant process.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Lu, Y., Macapinlac, H. Tags: Educational Exhibits Source Type: research

SUV-based analysis of Metabolic Priming of Myocardium for improved Diagnosis of Cardiac Sarcoidosis using 18F-FDG PET
Conclusion: These metrics can prove to be a useful part of the visual criteria for satisfactory quality assurance in cardiac FDG PET imaging for the purposes of sarcoidosis assessment.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Mohiuddin, S., Ezuddin, S., Foley, M., Sfakianaki, E., Cassuto, J., Otero Cure, J., Kuker, R., Zhu, H., Serafini, A., Georgiou, M. Tags: Educational Exhibits Source Type: research

Utility of N-13 Ammonia and F-18 Fluorodeoxyglucose Cardiac Positron Emission Tomography in Assessing Regional Prevalence of Cardiac Sarcoidosis
Conclusion: This study shows a significant amount of cardiac sarcoidosis occurring in the basal region of the myocardium, specifically in the basal anterior and basal anteroseptal segments. This is valuable because most patients with CS present with complete heart block or ventricular arrhythmias, which originate from the basal anterior and basal septal regions. Understanding the regional distribution of CS may lead to better-informed prevention of these debilitating cardiac events.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Lee, J., Flaherty, K., Cogan, J., Bokhari, N., Marshall, D., Jin, Z., Bokhari, S. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

Paediatric sarcoidosis
Sarcoidosis, also called Besnier-Boeck-Schaumann disease, was first described in the 19th century as a systemic granulomatous disorder involving predominantly the lungs and the lymphatic system [1]. More than a century after, its pathogenesis remains unknown and its pathophysiology remains controversial [2,3]. The current hypothesis is a multifactorial disease associating a genetic susceptibility and an environmental exposure that triggers or enhances the inflammatory and granulomatous process. Sarcoidosis is mainly an adult disease, children being affected around 10 times less frequently.
Source: Paediatric Respiratory Reviews - May 18, 2018 Category: Respiratory Medicine Authors: Nadia Nathan, Chiara Sileo, Alain Calender, Yves Pacheco, Dominique Valeyre, Annick Clement, for the French Sarcoidosis Group (GSF), the Silicosis Group Tags: Review Source Type: research

Sarcoid-like reactions in patients receiving modern melanoma treatment
The development of cancer immunotherapy and targeted therapy has reached an important inflection point in the history of melanoma. Immune checkpoint inhibitors and kinase inhibitors are today’s standard of care treatments in advanced melanoma patients. Treatment-related toxicities can be very intriguing and quite challenging. Sarcoidosis is a multisystemic granulomatous disease characterized by an aberrant immune response to unknown antigens, whereas sarcoid-like reactions (SLRs) refer to localized clinical features. We carried out a single-center observational study in patients with stage IIB–IV melanoma treated with ...
Source: Melanoma Research - April 24, 2018 Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clinical research Source Type: research

Specific Skin Lesions of Sarcoidosis Located at Venipuncture Points for Blood Sample Collection
Abstract: It has been suggested that the predilection of sarcoidosis to affect scars is due to the presence of antigens or foreign bodies that can serve as a stimulus for granuloma formation. Several patients with sarcoidosis-specific skin lesions in venous puncture sites have been reported. However, in these patients the pathogenesis of the cutaneous lesions is not clear because the presence of foreign bodies is not to be expected. Our objective was to describe 3 patients who developed specific lesions of sarcoidosis in areas of venipuncture and to discuss their possible pathogenesis. The database of the Sarcoid Clinic ...
Source: The American Journal of Dermatopathology - April 24, 2018 Category: Pathology Tags: Brief Report Source Type: research

A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report
ConclusionsAtypical manifestations of pulmonary sarcoidosis are diagnostically challenging because the clinical and radiographic features of the disease mimic those of a malignancy. We aimed to illustrate a unique etiology of a lung mass and the importance of maintaining a broad differential diagnosis. Nonetheless, with the possibility of a malignancy, a high index of suspicion is necessary for timely diagnosis and optimal management.
Source: Journal of Medical Case Reports - April 13, 2018 Category: General Medicine Source Type: research

Invasive Hemodynamics and Rejection Rates in Patients with Cardiac Sarcoidosis After Heart Transplantation
Conclusions CS patients have similar post-transplant hemodynamics as non-CS patients, without evidence of RV dysfunction or pulmonary hypertension. No significant rejection nor recurrence of sarcoid in the allograft were observed in this cohort of patients with CS. Survival is similar between CS and non-CS patients. Heart transplant is a viable strategy in selected CS patients with excellent outcomes. Teaser Orthotopic heart transplant (OHT) is utilized for end-stage heart failure due to cardiac sarcoidosis (CS). There is a lack of data on long-term outcomes. We explored changes in hemodynamics, allograft rejection and sur...
Source: Canadian Journal of Cardiology - April 7, 2018 Category: Cardiology Source Type: research

Sarcoidosis With Pleural Effusion as the Presenting Symptom
A 65-year-old woman, never smoker, with medical history of hypertension, nonischemic cardiomyopathy, and moderate pulmonary hypertension presented with symptomatic bilateral pleural effusions. Thoracentesis revealed a lymphocyte predominant transudate and was negative for malignancy, microbiologic cultures were negative for an infectious cause. Chest tomography showed mediastinal and bilateral hilar lymphadenopathy, lymph node biopsy with endobronchial ultrasound-guided transbronchial needle aspiration showed non-necrotizing granulomas compatible with sarcoidosis. Echocardiogram showed ejection fraction of 45% and cardiac ...
Source: Journal of Bronchology and Interventional Pulmonology - April 1, 2018 Category: Respiratory Medicine Tags: Case Reports Source Type: research

A Contemporary Analysis of Heart Transplantation and Bridge-to-Transplantation Mechanical Circulatory Support Outcomes in Cardiac Sarcoidosis
• Heart transplantation for cardiac sarcoidosis is increasing• Mechanical support as bridge to transplant is an option in cardiac sarcoid• Post-transplant outcomes are favorable in cardiac sarcoid patients
Source: Journal of Cardiac Failure - February 23, 2018 Category: Cardiology Authors: Todd C. Crawford, David R. Okada, J. Trent Magruder, Charles Fraser, Nishant Patel, Brian A. Houston, Glenn J. Whitman, Kaushik Mandal, Kenton J. Zehr, Robert S. Higgins, Edward S. Chen, Hari Tandri, Edward K. Kasper, Ryan J. Tedford, Stuart D. Russell, N Tags: Clinical Investigation Source Type: research