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Total 5151 results found since Jan 2013.

Myocardial Blood Flow and Inflammatory Cardiac Sarcoidosis
Conclusions Sarcoid-mediated myocardial inflammation is associated with a regional impairment of coronary circulatory function. The association between immune-suppressive treatment-related alterations in myocardial inflammation and changes in coronary vasodilator capacity suggests direct adverse effect of inflammation on coronary circulatory function in cardiac sarcoidosis.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 5, 2017 Category: Radiology Authors: Kruse, M. J., Kovell, L., Kasper, E. K., Pomper, M. G., Moller, D. R., Solnes, L., Chen, E. S., Schindler, T. H. Tags: Original Research Source Type: research

Adalimumab-induced pulmonary sarcoidosis not progressing upon treatment with etanercept.
Abstract Tumor necrosis factor alpha (TNF-α) inhibitors effectively treat sarcoidosis, but can, paradoxically, induce sarcoidosis. The TNF-α inhibitor etanercept is most commonly associated with paradoxical sarcoidosis, which has previously been reported to be resolved by adalimumab. However, we describe the case of a patient with ankylosing spondylitis and adalimumab-induced sarcoidosis not aggravated by switching to etanercept, thus indicating that etanercept could be a treatment option for patients who develop paradoxical sarcoid-like reactions after treatment with other TNF-α inhibitors. PMID: 281247...
Source: Zeitschrift fur Rheumatologie - January 25, 2017 Category: Rheumatology Authors: Jung JH, Kim JH, Song GG Tags: Z Rheumatol Source Type: research

Annular lesions of cutaneous sarcoidosis with granulomatous vasculitis
ABSTRACT Sarcoidosis is known to be involved in diseases with vasculitis as sarcoid vasculitis. However, vasculitis in cutaneous sarcoidal lesions is extremely rare. Here we describe a case of sarcoidosis with multiple annular skin lesions with granulomatous vasculitis. A 62‐year‐old female was diagnosed with sarcoidosis by chest‐abdominal CT examination and laboratory tests. The skin lesions had appeared on her lower limbs 2 years before. Physical examination showed multiple infiltrated annular eruptions on the lower extremities. A skin biopsy of an area of erythema showed multiple non‐caseating epithelioid cell g...
Source: Journal of Cutaneous Pathology - January 24, 2017 Category: Pathology Authors: Kana Mizuno, Nguyen Thi Hong Chuyen, Ikuko Ueda ‐Hayakawa, Hiroyuki Okamoto Tags: CASE REPORT Source Type: research

Time-course of Serum Pro-inflammatory Cytokines and Chemokines Levels Observed in Granulomatosis with Polyangiitis: A Case Report.
Authors: Kozu Y, Gon Y, Takano Y, Noguchi T, Hayashi S, Kumasawa F, Mizumura K, Maruoka S, Hashimoto S Abstract A 77-year-old man visited our hospital with chief complaints of difficulty in hearing, nasal discharge and fever. The patients was diagnosed with otitis media, and his fever continued at approximately 38°C despite the administration of clarithromycin. After that, dyspnea on exertion developed and chest X-ray examination indicated multiple infiltrative shadows. PR3-ANCA levels were high (238-fold of the normal levels), and granulomatosis with polyangiitis (GPA) was diagnosed on the basis of clinical sympt...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Solely lung-involved IgG4-related disease : a case report and review of the literature.
Authors: Zhang XQ, Chen GP, Wu SC, Yu S, Wang H, Chen XY, Ren ZC Abstract By analyzing the clinical data of 1 case of IgG4-related lung disease(IgG4-RLD) and the review of literature, the author investigated the clinical characteristics of IgG4-RLD. IgG4-RLD is a rare disease characterized by significant elevation of serum IgG4 and infiltration of a large number of IgG4+ plasma cells. The clinical manifestations of the disease were nonspecific, and the imaging features were mixed with several types. The disease can only be involved in the lung, but also multiple organ involvement. Solely lung-involved IgG4-RD is no...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Corticosteroid and cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: a single center experience and literature review.
In conclusion, combined intravenous pulse doses of high-dose corticosteroid and cyclophosphamide could be a reasonable add-on therapy for AEx-IPF, considering the few side effects and safe profile. A complete and rapid diagnostic work-up associated to the proper management (e.g. support of respiratory failure with non-invasive ventilation) in the right setting, may also have a positive effect on patients' outcome. PMID: 28079851 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

High-resolution computed tomography to differentiate chronic diffuse infiltrative lung diseases with chronic multifocal consolidation patterns using logical analysis of data.
CONCLUSION: LAD provides relevant models that can be used as a diagnosis support for the radiologist. It highlights the need to add clinical data in the analysis due to frequent overlap between diseases at HRCT. PMID: 28079848 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Relationship Between Abnormalities on High-Resolution Computerized Tomography, Pulmonary Function, and Bronchoalveolar Lavage in Progressive Systemic Sclerosis.
CONCLUSION: This study showed a strong correlation between the extent of x-ray abnormalities and FVC, RV, and DLCO, as well as an increase in the percentage of BAL fluid neutrophils in patients with SSc-PI. PMID: 28079847 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Serum interleukin-6 in systemic sclerosis and its correlation with disease parameters and cardiopulmonary involvement.
CONCLUSION: IL-6 level is increased in patients with SSc and significantly correlates with EUSTAR score, IRS, DLCO, 6MWD, HRCT scores, and echocardiographic abnormalities of the right side of the heart. These results support the role of IL-6 in the disease activity and in the development of cardiopulmonary manifestations in SSc patients. PMID: 28079844 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Increased erythrocyte aggregation and oxidative stress in patients with idiopathic interstitial pneumonia.
CONCLUSIONS: Increment of oxidative stress in IIP seems to depend on enhancement of oxidants, rather than alteration of antioxidants. The issue that, elevated erythrocyte aggregation may further impair tissue oxygenation by disturbing microcirculation in IIP, may be considered in the follow up and development of new treatment protocols for this disease. PMID: 28079842 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pathology of the Lung in Sarcoidosis: A Review
Abstract: Sarcoidosis is a multisystem disease of unknown etiology, often affecting the respiratory tract. The diagnosis depends on a compatible clinical and radiological presentation, the finding of nonnecrotizing epithelioid granulomas by biopsy, and exclusion of other possible causes of granulomas. The granulomas are distributed in a lymphangitic pattern in lung; interstitial pneumonitis is sparse and can be the only finding in early stages. Up to 40% of granulomas show small central foci of necrosis. Granulomatous vasculitis can be found in 42% to 69% of cases and likely is due to intrusion of perivascular granulomas o...
Source: Pathology Case Reviews - December 31, 2016 Category: Pathology Tags: Reviews Source Type: research

Mechanism of granuloma formation in sarcoidosis
Purpose of review: The formation of noncaseating granuloma is a hallmark of pulmonary sarcoidosis. This review summarizes recent progress made to explain the cellular dynamics within the granuloma structure that may considerably differ between the two clinically distinct variants, that is, acute and chronic sarcoidosis. Recent findings: Compelling evidence exists that in acute but not chronic sarcoidosis CD4+ T lymphocytes specifically recognizing the auto-antigen vimentin on human leukocyte antigen-DR3 molecules accumulate in sarcoid granuloma. These so-called TH17.1 cells produce high amounts of the TH17-related cytokin...
Source: Current Opinion in Hematology - December 29, 2016 Category: Hematology Tags: MYELOID BIOLOGY: Edited by David C. Dale Source Type: research

Sarcoidosis in the setting of combination ipilimumab and nivolumab immunotherapy: a case report & amp; review of the literature
ConclusionsTissue biopsy for evaluation of new lesions on immunotherapy is an important step to help guide decision making, as non-melanoma lesions can mimic disease progression.
Source: Journal for Immunotherapy of Cancer - December 19, 2016 Category: Cancer & Oncology Source Type: research

Anti ‐TNF‐α for necrotizing sarcoid granulomatosis of the liver
This article is protected by copyright. All rights reserved.
Source: Hepatology - December 15, 2016 Category: Internal Medicine Authors: Marcial Sebode, S ören Weidemann, Malte Wehmeyer, Ansgar W. Lohse, Christoph Schramm Tags: Clinical Observations in Hepatology Source Type: research

Diagnostic Categorization According to the First International Workshop on Ocular Sarcoidosis (FIWOS) Criteria in a Series of 11 Patients
Conclusions Ocular sarcoidosis was diagnosed in more than half of the patients who had no confirmatory biopsy. Bilateral panuveitis and chronic anterior uveitis were the patterns most frequently observed.
Source: Reumatologia Clinica - December 4, 2016 Category: Rheumatology Source Type: research

Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden
This study represents the largest epidemiological investigation of sarcoidosis using population-based individual-level data. Age at diagnosis in men was 10 years younger than in women and geographical variation was observed.
Source: European Respiratory Journal - November 29, 2016 Category: Respiratory Medicine Authors: Arkema, E. V., Grunewald, J., Kullberg, S., Eklund, A., Askling, J. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis
We evaluated mortality rates and underlying causes of death among French decedents with sarcoidosis from 2002 to 2011. We used data from the French Epidemiological Centre for the Medical Causes of Death to 1) calculate sarcoidosis-related mortality rates, 2) examine differences by age and gender, 3) determine underlying and nonunderlying causes of death, 4) compare with the general population (observed/expected ratios), and 5) analyse regional differences. 1662 death certificates mentioning sarcoidosis were recorded. The age-standardised mortality rate was 3.6 per million population and significantly increased over the stu...
Source: European Respiratory Journal - November 29, 2016 Category: Respiratory Medicine Authors: Jamilloux, Y., Maucort-Boulch, D., Kerever, S., Gerfaud-Valentin, M., Broussolle, C., Eb, M., Valeyre, D., Seve, P. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Solitary tentorial sarcoid granuloma associated with Propionibacterium acnes infection: case report.
Abstract Sarcoidosis is a systemic granulomatous disease with unknown cause, which very rarely occurs exclusively in the central nervous system. The authors performed biopsy sampling of a mass that developed in the left tentorium cerebelli that appeared to be a malignant tumor. The mass was diagnosed as a sarcoid granuloma, which was confirmed with the onset of antibody reaction product against Propionibacterium acnes. Findings suggesting sarcoidosis to be an immune response to P. acnes infection have recently been reported, and they give insight for diagnosis and treatment of this disease. The authors report the ...
Source: Journal of Neurosurgery - November 24, 2016 Category: Neurosurgery Authors: Akimoto J, Nagai K, Ogasawara D, Tanaka Y, Izawa H, Kohno M, Uchida K, Eishi Y Tags: J Neurosurg Source Type: research

The clinical characteristics of sarcoid arthropathy based on a prospective cohort study
Conclusions: Inflammatory arthritis occurs in a majority of patients with sarcoidosis. Acute arthritis with bilateral ankle involvement is the most common pattern of sarcoid arthropathy. Sarcoidosis can mimic many primary rheumatic diseases or may coexist with them. Sarcoidosis should be considered not only as a mimicker but also as a Th1-mediated primary rheumatologic pathology.
Source: Therapeutic Advances in Musculoskeletal Disease - November 20, 2016 Category: Orthopaedics Authors: Kobak, S., Sever, F., Usluer, O., Goksel, T., Orman, M. Tags: Original Research Source Type: research

Comprehensive Cardiovascular Magnetic Resonance Assessment in Patients With Sarcoidosis and Preserved Left Ventricular Ejection Fraction Cardiomyopathies
Conclusions— Patients with sarcoidosis demonstrate higher T1, extracellular volume, and T2 values compared with healthy controls, with most significant differences for native T1 and T2. While promising, the clinical significance of the newer mapping techniques with respect to early diagnosis and therapy of CS will have to be determined in future studies.
Source: Circulation: Cardiovascular Imaging - November 7, 2016 Category: Radiology Authors: Greulich, S., Kitterer, D., Latus, J., Aguor, E., Steubing, H., Kaesemann, P., Patrascu, A., Greiser, A., Groeninger, S., Mayr, A., Braun, N., Alscher, M. D., Sechtem, U., Mahrholdt, H. Tags: Fibrosis, Cardiomyopathy, Inflammatory Heart Disease, Magnetic Resonance Imaging (MRI) Cardiomyopathies Source Type: research

Long-term results obtained by cardiovascular magnetic resonance imaging and somatostatin receptor PET in cardiac sarcoidosis
Cardiac affection constitutes a major limiting condition in systemic sarcoidosis.We performed cardiovascular magnetic resonance (CMR) imaging and somatostatin receptor scintigraphy to define the course in cardiac sarcoidosis (CS).In a pilot study, we identified cardiac involvement – diagnosed by CMR imaging – to be present in 29 of 188 patients (15.4%) with histologically proven, extracardiac sarcoidosis. Out of these initial 29 CS-positive patients, 27 patients (49.9 ± 11.8 years, 59.3% male) were presently re-examined and underwent a second CMR-study. 68Ga-DOTATOC PET/CT was performed when clinically i...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Pizarro, C., Kluenker, F., Dabir, D., Gärtner, F., Grohe, C., Nickenig, G., Skowasch, D. Tags: 1.3 Imaging Source Type: research

MR imaging of lung parenchymal changes in sarcoidosis
CONCLUSION: There is substantial correlation and agreement between MRI and CT in the scoring of pulmonary sarcoidosis especially using T2w sequences. However, improvement in detection of small pulmonary nodules seems warrant.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Ley, S., Schenk, H., Karl, M., Pforte, A. Tags: 1.3 Imaging Source Type: research

Incidence and prognostic factors for airflow obstruction in sarcoidosis
Conclusion: AO is frequent (36%) in sarcoid patients requiring treatment for disease deterioration. Several prognostic factors were disclosed, however randomised study is necessary to evaluate AO nature in sarcoid patients.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Bednarek, M., Goljan-Geremek, A., Puscinska, E., Nowinski, A., Korzybski, D., Sliwinski, P. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Prevalence of smoking among Polish sarcoid patients
Conclusions: Results from the present study showed a fairly high smoking prevalence among our sarcoid pts and draws attention to relationship between parental smoking and the risk of smoking initiation.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Puscinska, E., Goljan Geremek, A., Radzikowska, E., Wyrostkiewicz, D., Soszka, A., Nowinski, A., Bednarek, M., Sliwinski, P. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Prevalence of ocular sarcoidosis in patients with intra thoracic sarcoidosis
Discussion: 76.6.% had histological diagnosis. 23 out of 36 had bronchoscopy/EBUS..Study revealed fairly high prevalence of ocular symptoms amongest sarcoid patients (51%) & 37% of them had abnormal eye examination finding. Non of our patient had conjunctival biopsy. literature review indicate that conjunctival biopsy is positive in up to 66% of cases with conjunctival follicles & up to 31% without it. conjunctival biopsy in presence of pulmonary infiltrate is reported to be positive in 51.6% patients.Considering our study finding we may conclude that requesting conjuntival biopsy will reduced our need of transbron...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Hussain, M., Mahdi, H., Hassan, M. Tags: 1.13 Clinical Problems - Other Source Type: research

The predictors of mortality in IPF - Does emphysema change the prognosis?
CONCLUSION: In present study, IPF with emphysema was more common in male smokers. When emphysema accompanies IPF, life expectancy is remarkably worse, but not independently so. PMID: 27758993 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 21, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Long-term efficacy of macrolide treatment in idiopathic pulmonary fibrosis: a retrospective analysis.
CONCLUSION: Our results indicate the potential beneficial efficacy of macrolide therapy combined with oral corticosteroids, immunosuppressive or anti-fibrotic agents in IPF. PMID: 27758989 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 21, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Lung transplantation for high-risk patients with idiopathic pulmonary fibrosis.
CONCLUSIONS: Although lung transplantation in patients with IPF and high LAS values is associated with increased risk of early post-transplant complications, long-term post-transplant survival for our high-LAS cohort was equivalent to that for the lower LAS recipients. PMID: 27758988 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 21, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The Value of Biomarkers as Predictors of Outcome in Patients with Rheumatoid Arthritis-Associated Usual Interstitial Pneumonia.
CONCLUSIONS: The results of this retrospective study suggested that KL-6 and IL-6 could be used as predictors of short-term disease progression. In addition, high levels of KL-6 could be used as a predictor of mortality. Additional studies involving a larger patient cohort are warranted. PMID: 27758986 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 21, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Role of Pulmonary Evaluation in Diagnosis of Neurosarcoidosis.
CONCLUSION: Patients with neurosarcoidosis may not have any pulmonary symptoms. However, they are most likely to have abnormal chest CT, hilar lymphadenopathy and reduction in DLCO.  These data suggest that pulmonary evaluation is warranted in patients who are suspected to have neurosarcoidosis. PMID: 27758985 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 21, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoid-like reaction in a patient with uveitis and underlying cancer
ConclusionSarcoid-like reactions may be due to incipient malignancies. Any diagnosis of sarcoidosis requires ruling out other diseases that can produce secondary sarcoid-like reactions. In addition, any choroidal mass suggestive of metastasis requires exclusion of metastatic disease even in the absence of clinical signs indicating tumor extension.
Source: International Ophthalmology - October 18, 2016 Category: Opthalmology Source Type: research

Characteristics of sarcoidosis in Maori and Pacific Islanders
ConclusionPeople of Polynesian ancestry appear to have less pulmonary and more extra‐pulmonary manifestations of sarcoidosis. This adds to our knowledge that sarcoidosis heterogeneity is influenced by ethnicity.
Source: Respirology - October 11, 2016 Category: Respiratory Medicine Authors: Margaret L. Wilsher, Lisa M. Young, Raewyn Hopkins, Megan Cornere Tags: Original Article Source Type: research

CD4/CD8 Ratio in Mediastinal Lymph Nodes Involved by Sarcoidosis: Analysis of Flow Cytometry Data Obtained by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Conclusion: As in BAL fluid, the CD4/CD8 ratio in mediastinal lymph nodes involved by sarcoid granulomas is highly variable and does not reliably confirm or exclude sarcoidosis.
Source: Journal of Bronchology and Interventional Pulmonology - October 1, 2016 Category: Respiratory Medicine Tags: Original Investigations Source Type: research

Intra-cardiac distribution of late gadolinium enhancement in cardiac sarcoidosis and dilated cardiomyopathy.
This article describes the value of LE in patients with CS who have impaired LV systolic function, particularly the diagnostic and clinical significance of LE distribution in comparison with DCM. LE existed at all LV segments and myocardial layers in patients with CS, whereas it was localized predominantly in the midwall of basal to mid septum in those with DCM. Transmural (nodular), circumferential, and subepicardial and subendocardial LE distribution were highly specific in patients with CS, whereas the prevalence of striated midwall LE were high both in patients with CS and with DCM. Since sarcoidosis patients with LE h...
Source: World Journal of Cardiology - September 25, 2016 Category: Cardiology Authors: Sano M, Satoh H, Suwa K, Saotome M, Urushida T, Katoh H, Hayashi H, Saitoh T Tags: World J Cardiol Source Type: research

Skeletal sarcoidosis.
Abstract OBJECTIVE: Presentation of the etiology, pathology, clinical course, radiology and differential diagnostics of skeletal sarcoidosis. PATHOANATOMICAL PRINCIPLES: Noncaseating epithelioid cell granulomas can trigger solitary, multiple or disseminated osteolysis, reactive osteosclerosis and/or granulomatous synovitis. INCIDENCE: The incidence of sarcoidosis is 10-12 per 100,000 inhabitants per year. Skeletal involvement is approximately 14 %. CLINICAL ASPECTS: Skeletal involvement occurs almost exclusively in the stage of lymph node and pulmonary manifestation. Most cases of skeletal involve...
Source: Der Radiologe - September 14, 2016 Category: Radiology Authors: Freyschmidt J, Freyschmidt P Tags: Radiologe Source Type: research

Radiologic Features of World Trade Center–related Sarcoidosis in Exposed NYC Fire Department Rescue Workers
Conclusions: The majority of cases of WTC-related sarcoidosis demonstrated typical radiographic appearances of sarcoidosis, with symmetric hilar and mediastinal lymphadenopathy and mid to upper lung perilymphatic nodules; these findings were consistent with other previously reported cases of sarcoid-like granulomatous disease in association with various alternate underlying etiologies. There was no correlation between disease patterns or extent on CT and pulmonary function testing, likely at least in part due to the overall mild extent of disease in this population.
Source: Journal of Thoracic Imaging - August 26, 2016 Category: Radiology Tags: Original Articles Source Type: research

Hemorrhagic sarcoid pleural effusion: A rare entity
We report a case of active pulmonary sarcoidosis presenting as hemorrhagic pleural effusion requiring tissue diagnosis to rule out malignancy. The rarity of the presentation prompted us to report this case.
Source: Lung India - August 23, 2016 Category: Respiratory Medicine Authors: Onkar Jha Vidya Nair Deepak Talwar Source Type: research

Repositioning 'old' drugs to treat rare diseases: arguing from the mechanism of action.
Authors: Drent M, Bast A, Bootsma HP, Deneer V PMID: 27537726 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Successful management of acute respiratory failure in an Idiopathic Pulmonary Fibrosis patient using an extracorporeal carbon dioxide removal system.
Authors: Vianello A, Arcaro G, Paladini L, Iovino S Abstract Patients with Idiopathic Pulmonary Fibrosis (IPF) requiring Invasive Mechanical Ventilation (IMV) following unsuccessful treatment with Non-Invasive Ventilation (NIV) have a high mortality rate. IMV is, moreover, an independent predictor of poor outcome during the post-transplantation period in patients on waiting lists for Lung Transplantation (LT). Here we describe the successful management of an IPF patient with acute respiratory failure (ARF) using a pump-assisted veno-venous system for extracorporeal CO2 removal (ECCO2R) (ProLUNG® system) as an alte...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Polishing surgical metal pieces, granulomatosis and mineralogical analysis.
This study suggests that mineralogical analysis combined with a questionnaire on dust exposure could help redirect the diagnosis of a dust-related disease. PMID: 27537720 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Exercise related ventilation dynamics and clinical correlates in patients with fibrotic idiopathic interstitial pneumonias.
Authors: De Martino M, Cobuccio R, Bruzzese D, Rea G, Meoli I, Stefanelli F, Canora A, Capaccio A, Sanduzzi A, Matarese A, Bocchino M Abstract Assessment of exercise performance is a key component in the management of interstitial lung diseases, as its limitation may occur very early. Aim of the present study was to assess ventilation dynamics in combination with pulse-oximetry changes in 54 clinically stable patients affected by idiopathic pulmonary fibrosis or idiopathic fibrotic nonspecific interstitial pneumonia. Testing was successfully performed with the Spiropalm 6-MWT Hand-held spirometer by the majority of...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Platelet aggregability in patients with interstitial pneumonias.
CONCLUSIONS: Serum coagulation and fibrinolysis markers significantly increased in IIPs and CTD-IPs. In contrast, platelet aggregability was only weakly enhanced in CTDs, but not in IIPs. PMID: 27537717 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

High-resolution CT predictors of hypersensitivity pneumonitis.
CONCLUSION: Our results provide evidence that HRCT can accurately distinguish HP from other DPLDs. PMID: 27537713 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Multisystemic Sarcoidosis Presenting as Pretibial Leg Ulcers
We report the case of a 45-year-old female patient with chronic multisystemic sarcoidosis presenting with pretibial leg ulcers. Other etiology could be excluded. Histology revealed nonspecific findings. Therefore, the diagnosis of nonspecific leg ulcers in sarcoidosis was confirmed. Treatment consisted of oral prednisolone and good ulcer care. Complete healing was achieved within 6 months. Sarcoidosis is a rare cause of leg ulcers and usually sarcoid granulomas can be found. Our patient illustrates that even in the absence of sarcoid granulomas, leg ulcers can be due to sarcoidosis.
Source: The International Journal of Lower Extremity Wounds - August 9, 2016 Category: Surgery Authors: Wollina, U., Baunacke, A., Hansel, G. Tags: Case Reports Source Type: research

Expanded lung T-bet+ROR{gamma}T+ CD4+ T-cells in sarcoidosis patients with a favourable disease phenotype
Disease phenotypes of pulmonary sarcoidosis are distinguished by clinical rather than immunological criteria. We aimed to characterise patterns of CD4+ T-cell lineage plasticity underlying the differences in clinical presentation and disease course between the acute form, Löfgren's syndrome, and the heterogeneous, potentially progressive "non-Löfgren" form. 33 pulmonary sarcoidosis patients and nine controls underwent bronchoscopy with bronchoalveolar lavage. CD4+ T-cell transcription factor, chemokine receptor and T-cell receptor expression, proliferation and cytokine production were assessed in the lavage...
Source: European Respiratory Journal - July 30, 2016 Category: Respiratory Medicine Authors: Kaiser, Y., Lepzien, R., Kullberg, S., Eklund, A., Smed-Sörensen, A., Grunewald, J. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Innate immunity in sarcoidosis pathobiology
Purpose of review: The immunopathogenesis of sarcoidosis is considered to involve contributions from both adaptive and innate immune responses. Although the identification of adaptive responses to candidate pathogenic antigens will elucidate mechanisms that regulate inflammation in sarcoidosis, innate mechanisms likely represent the ‘missing link’ to the initiation, maintenance, and resolution of noncaseating granulomatous inflammation, the hallmark feature of sarcoidosis. Furthermore, environments that expose patients to candidate pathogenic antigens for sarcoidosis also provide opportunities for engagement with innat...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

T-cell immunology in sarcoidosis: Disruption of a delicate balance between helper and regulatory T-cells
Purpose of review: Although the aetiology of sarcoidosis is not yet completely understood, immunological changes within the T-cell compartment are characteristic for an exaggerated antigen-driven immune response. In this review, we describe the most recent findings on T-cell subset responses and regulation in sarcoidosis. We discuss how future immunological research can advance the field to unravel pathobiological mechanisms of this intriguingly complex disease. Recent findings: Research into the field of T-cell plasticity has recently challenged the long-held T helper type 1 (Th1) paradigm in sarcoidosis and striking par...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

From granuloma to fibrosis: sarcoidosis associated pulmonary fibrosis
Purpose of review: Up to twenty percent of patients with sarcoidosis develop pulmonary fibrosis, transforming an often benign disease into a highly morbid and potentially fatal one. We highlight the fibrotic pulmonary sarcoidosis phenotype as an area of intense clinical and translational investigation, review recent developments in treatment, and provide a roadmap for future research in sarcoidosis associated pulmonary fibrosis. Recent findings: Granulomatous inflammation in a lymphatic distribution is the hallmark finding of pulmonary sarcoidosis and the nidus for fibrosis. Recent research demonstrates that fibrotic sarc...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

Experimental models of sarcoidosis
Purpose of review: Sarcoidosis is a disease caused by a complex combination of genetic susceptibility, immune networks and infectious and/or environmental agents. The onset and phenotypic variability of sarcoidosis remain poorly elucidated, not only due to the lack of clearly identified causes, but also because it is widely considered that no reliable model of this disease is available. In this review, we discuss the various models of granulomatous diseases in order to challenge this assertion. Recent findings: A large number of models of granulomatous diseases are available, both cellular models used to study the natural...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

Biomarkers in sarcoidosis: the contribution of system biology
Purpose of review: System biology is an interdisciplinary approach with the purpose to evaluate the experimental results of ‘-omics’ sciences as a whole. The ‘-omics’ sciences do not start generally from a-priori assumptions and are aimed to study the constituents of a specific biological domain (genome, transcriptome, proteome and metabolome) in a given state, using different high-throughput technologies (as polymerase chain reaction, arrays, liquid chromatography, mass spectrometry, etc.) and allowing a hermeneutical integration and recomposition of the experimental information. The aim of the present review is t...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research