This page shows you the latest news items in this category. This is page number 16.

Total 5692 results found since Jan 2013.

Blepharoptosis Due to Sarcoidosis-Induced Horner Syndrome.
PMID: 30789746 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 21, 2019 Category: Respiratory Medicine Authors: Takeda M, Sato K, Sano M, Sakamoto S, Izumiya Y, Kumagai N, Sudo K, Asano M, Okuda Y, Nakayama K Tags: Am J Respir Crit Care Med Source Type: research

An Unusual Hypoxia Patient
​BY GORDON MURPHY, PA-C, MPHThe patient was blue, her primary care physician noted. Quite literally, in fact.The 38-year-old woman had sought care for a recurrent urinary tract infection, and that's when her primary care physician found her pulse oximetry to be 74%. He was concerned about hypoxia and asked us to evaluate her.The patient reported taking an SSRI for anxiety and having a hormone-eluting IUD. She had previously had a Roux-en-Y gastric bypass. She said she had a headache, but had been instructed not to take NSAIDs. She said she had just finished a course of Cipro for her UTI, but continued to be symptomatic w...
Source: The Case Files - February 20, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Sarcoidosis
is a multisystemic granulomatous disease that affects individuals worldwide. The lungs are most commonly involved but any organ can be involved. It has variable manifestations and clinical course. Diagnosis of sarcoidosis is based on clinicopathologic findings and the exclusion of other causes of granulomatous disease. Its hallmark is the formation of granulomas in affected organs. Immunosuppressive therapy is the cornerstone of the management of sarcoidosis and is indicated when there is evidence of symptomatic or progressive disease or when critical organs (ocular, cardiac, nervous system) are involved.
Source: Medical Clinics of North America - February 20, 2019 Category: Primary Care Authors: Oscar Llanos, Nabeel Hamzeh Source Type: research

Association Between Cancer and Sarcoidosis
Conditions:   Sarcoidosis;   Cancer Intervention:   Sponsor:   University of Miami Recruiting
Source: ClinicalTrials.gov - February 18, 2019 Category: Research Source Type: clinical trials

The Burden of Sarcoidosis Symptoms from a Patient Perspective
ConclusionSarcoidosis patients in Denmark, Germany and the Netherlands present with similar self-reported symptoms, organ-related as well as non-specific, non-organ related. Fatigue (90%) and symptoms associated with SFN (86%) were highly prevalent in all three countries.
Source: Lung - February 16, 2019 Category: Respiratory Medicine Source Type: research

Radiologic Manifestations of Musculoskeletal Sarcoidosis
AbstractPurpose of ReviewThe purpose of this review article is to present the spectrum of abnormalities and multi-modality imaging evaluations in patients with musculoskeletal sarcoidosis.Recent FindingsThe articular manifestations of sarcoidosis are difficult to distinguish from those of the other inflammatory and degenerative arthropathies, and the muscular lesions in sarcoidosis are generally clinically silent and therefore often missed. Magnetic resonance imaging has shown these manifestations to be very common in active sarcoidosis, and should thus be included in the screening if musculoskeletal sarcoidosis is suspect...
Source: Current Rheumatology Reports - February 14, 2019 Category: Rheumatology Source Type: research

Advances in PET Imaging of Sarcoidosis
AbstractPurpose of ReviewThe purpose of this paper is to provide an updated review of recent advances in protocols for positron emission tomography (PET) or PET/computed tomography (PET/CT) imaging in patients with sarcoidosis.Recent FindingsThere has been more research focused on developing newer and improved PET imaging modalities to diagnose and follow-up cardiac sarcoidosis (CS). Fluorine-18-fluorodeoxyglucose (18F- FDG)-PET are widely used to diagnose CS, with or without concurrent rest nuclear myocardial perfusion study. There have been various patient preparation strategies for FDG PET/CT in CS. Interpretation crite...
Source: Current Cardiovascular Imaging Reports - February 14, 2019 Category: Radiology Source Type: research

Nivolumab and sarcoid reaction in lung cancer treatment.
Authors: Vergnon JM, Tissot CL PMID: 30745234 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - February 13, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients.
Abstract Sarcoidosis is a T-cell driven inflammatory disease characterized by granuloma formation. Mononuclear phagocytes (MNPs)-macrophages, monocytes, and dendritic cells (DCs)-are likely critical in sarcoidosis as they initiate and maintain T cell activation and contribute to granuloma formation by cytokine production. Granulomas manifest primarily in lungs and lung-draining lymph nodes (LLNs) but these compartments are less studied compared to blood and bronchoalveolar lavage (BAL). Sarcoidosis can present with an acute onset (usually Löfgren's syndrome (LS)) or a gradual onset (non-LS). LS patients typically...
Source: Journal of Leukocyte Biology - February 11, 2019 Category: Hematology Authors: Lepzien R, Rankin G, Pourazar J, Muala A, Eklund A, Grunewald J, Blomberg A, Smed-Sörensen A Tags: J Leukoc Biol Source Type: research

PPAR γ Deficiency Exacerbates Fibrotic Response to Mycobacteria Peptide in Murine Sarcoidosis Model.
PPARγ Deficiency Exacerbates Fibrotic Response to Mycobacteria Peptide in Murine Sarcoidosis Model. Am J Respir Cell Mol Biol. 2019 Feb 11;: Authors: Malur A, Mohan A, Barrington RA, Leffler N, Malur A, Muller-Borer B, Murray G, Kew K, Zhou C, Russell J, Jones JL, Wingard CJ, Barna BP, Thomassen MJ Abstract We established a murine model of multiwall carbon nanotube (MWCNT)-elicited chronic granulomatous disease which bears similarities to human sarcoidosis pathology including alveolar macrophage deficiency of peroxisome-proliferator-activated receptor gamma (PPARγ). Because lymphocyte reactivity to ...
Source: American Journal of Respiratory Cell and Molecular Biology - February 11, 2019 Category: Molecular Biology Authors: Malur A, Mohan A, Barrington RA, Leffler N, Malur A, Muller-Borer B, Murray G, Kew K, Zhou C, Russell J, Jones JL, Wingard CJ, Barna BP, Thomassen MJ Tags: Am J Respir Cell Mol Biol Source Type: research

Echogenic lymph nodes in the differential diagnosis of pediatric sarcoidosis
We present a delayed diagnosis of sarcoidosis in an 11-year-old girl by demonstrating ultrasonographic imaging findings of granulomatous cervical and abdominal lymph node involvement. Pulmonary interstitial fibrosis in addition to multi-compartmental enlarged echogenic lymph nodes could be considered sarcoidosis. Punctate echogenic foci in the cervical lymph nodes should be considered in the differential diagnosis of sarcoidosis.
Source: Journal of Medical Ultrasonics - February 8, 2019 Category: Radiology Source Type: research

Effective steroid therapy in an elderly patient with cardiac sarcoidosis and severe left ventricular dysfunction
Publication date: Available online 6 February 2019Source: Journal of Cardiology CasesAuthor(s): Kyoko Odawara, Takahiro Inoue, Yoshitaka HirookaAbstractA 75-year-old woman with no significant medical history was admitted to our hospital with congestive heart failure. Echocardiography revealed left ventricle (LV) systolic dysfunction [LV ejection fraction (LVEF) 18%] and diffuse LV hypokinesis mimicking dilated cardiomyopathy. Her brain natriuretic peptide (BNP) level was elevated (1214.3 pg/mL). Standard medications for heart failure failed to ameliorate her cardiac failure symptoms. Echocardiography on admission reveale...
Source: Journal of Cardiology Cases - February 7, 2019 Category: Cardiology Source Type: research

Serum Angiotensin-Converting Enzyme Has a High Negative Predictive Value in the Investigation for Systemic Sarcoidosis
We thank Dr Groen and Dr Eurelings for their interest in our recent publication1 and for the opportunity to discuss screening investigations for systemic sarcoidosis in further detail.
Source: American Journal of Ophthalmology - February 7, 2019 Category: Opthalmology Authors: Rachael L. Niederer, Ahmed Al-Janabi, Sue L. Lightman, Oren Tomkins-Netzer Tags: Correspondence Source Type: research

Editorial Title: “Sarcoidosis: No longer a benign disease?”
Sarcoidosis is a multi-system disease of unknown cause characterized by noncaseating granulomatous inflammation that results in symptoms and organ dysfunction due to persistent inflammation and fibrosis. It predominately affects the lungs in over 90% of patients, but can injure any organ in the body. Sarcoidosis can be a life-threatening disease, particularly in those with pulmonary fibrosis, pulmonary hypertension, or cardiac involvement (1, 2). Opportunistic infections may also play a role in mortality in patients on immunosuppression (2, 3).
Source: Respiratory Medicine - February 6, 2019 Category: Respiratory Medicine Authors: Alicia K. Gerke Tags: Editorial Source Type: research

Sarcoidosis: No longer a benign disease?
Sarcoidosis is a multi-system disease of unknown cause characterized by noncaseating granulomatous inflammation that results in symptoms and organ dysfunction due to persistent inflammation and fibrosis. It predominately affects the lungs in over 90% of patients, but can injure any organ in the body. Sarcoidosis can be a life-threatening disease, particularly in those with pulmonary fibrosis, pulmonary hypertension, or cardiac involvement [1,2]. Opportunistic infections may also play a role in mortality in patients on immunosuppression [2,3].
Source: Respiratory Medicine - February 6, 2019 Category: Respiratory Medicine Authors: Alicia K. Gerke Tags: Editorial Source Type: research

In-vivo assessment of a case of cutaneous sarcoidosis using reflectance confocal microscopy
Abstract: Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that allows visualization of the epidermis and papillary dermis with cellular-level resolution. Granulomatous reactions such as sarcoidosis could be assessed using RCM. The identification of bright beaded-like structures that could correspond to reticulin fibers overlying granulomas, in association with dermoscopy, may be a very useful approach in the diagnosis of sarcoidosis and for the differentiation of this granulomatous entity with superficial cutaneous metastasis.
Source: Anais Brasileiros de Dermatologia - February 4, 2019 Category: Dermatology Source Type: research

The development of sarcoidosis in patients receiving daclizumab: A case series from multiple clinical trials
Several drugs have been associated with druginduced sarcoidosis-like reactions (DISRs) that are clinically indistinguishable from sarcoidosis. Daclizumab is a humanized monoclonal IgG1 antibody that binds to CD25 that has been studied for the treatment of multiple sclerosis (MS). During MS clinical trials of daclizumab, 12 subjects developed clinical conditions potentially consistent with sarcoidosis. Therefore, an independent adjudication committee of individuals with expertise in sarcoidosis was organized to determine the likelihood of these cases representing sarcoidosis.
Source: Respiratory Medicine - February 1, 2019 Category: Respiratory Medicine Authors: Marc A. Judson, Brett M. Elicker, Thomas V. Colby, Sooyeon Kwon, Elizabeth de Windt, Spyros Chalkias, Claudia Prada, Karen Smirnakis, Priya Singhal Source Type: research

Management of Arrhythmias Associated with Cardiac Sarcoidosis.
Authors: Yada H, Soejima K Abstract Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. The annual incidence of systemic sarcoidosis is estimated at 10-20 per 100,000 individuals. Owing to the recent advances in imaging modalities, cardiac sarcoidosis (CS) is diagnosed more frequently. The triad of CS includes conduction abnormality, ventricular tachycardia, and heart failure. Atrial and ventricular arrhythmias are caused by either inflammation or scar formation. Inflammation should be treated with immunosuppression and antiarrhythmic agents and scar formation should be treated with antiarrhyth...
Source: Korean Circulation Journal - January 31, 2019 Category: Cardiology Tags: Korean Circ J Source Type: research

Study of Intravenous ATYR1923 for Pulmonary Sarcoidosis
Condition:   Pulmonary Sarcoidosis Interventions:   Biological: ATYR1923 1.0 mg/kg or placebo;   Biological: ATYR1923 3.0 mg/kg or placebo;   Biological: ATYR1923 5.0 mg/kg or placebo Sponsors:   aTyr Pharma, Inc.;   Foundation for Sarcoidosis Research Recruiting
Source: ClinicalTrials.gov - January 31, 2019 Category: Research Source Type: clinical trials

PET/CT Evaluation of Cardiac Sarcoidosis
The increasing implementation of advanced cardiovascular imaging in the form of cardiac PET/CT has had a significant impact on the management of cardiac sarcoidosis, which continues to evolve. This review summarizes the role of PET/CT imaging in sarcoidosis with a specific focus on (1) indications, (2) patient preparation, (3) test performance, (4) study interpretation, (5) clinical relevance of findings, (6) comparison to alternative imaging modalities, and finally (7) introduction of areas of anticipated development and research.
Source: PET Clinics - January 31, 2019 Category: Radiology Authors: John P. Bois, Daniele Muser, Panithaya Chareonthaitawee Source Type: research

Sinonasal and Laryngeal Sarcoidosis-An Uncommon Presentation and Management Challenge.
Abstract Sarcoidosis is a chronic inflammatory disease of uncertain etiology characterized by the formation of noncaseating granulomas. The thorax is involved in 95% of cases, but any organ can be involved. Sinonasal or laryngeal involvement is uncommon and can be difficult to diagnose. The reported incidence of sarcoidosis in the upper airway clearly depends on study characteristics, and this creates uncertainty about the actual incidence. In a large prospective study in the United States, upper respiratory tract involvement occurred in 3% of the patients. Some patients have upper airway involvement without thora...
Source: The American Journal of the Medical Sciences - January 24, 2019 Category: General Medicine Authors: Edriss H, Kelley JS, Demke J, Nugent K Tags: Am J Med Sci Source Type: research

Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
Conditions:   Sarcoidosis;   Precapillary Pulmonary Hypertension;   Interstitial Lung Disease Intervention:   Drug: Inhaled Treprostinil Sponsors:   University of Florida;   United Therapeutics Not yet recruiting
Source: ClinicalTrials.gov - January 24, 2019 Category: Research Source Type: clinical trials

Coexistence of sarcoidosis with seminoma - a case report.
Abstract A 30-year-old patient, with diagnosis of seminoma (T1 Nx Mx) was treated radically with orchidectomy. In chest CT performed postoperatively numerous diffuse nodules were revealed in both lungs. Lesions were situated particularly in the upper and middle pulmonary zones. In order to verify the nature of pulmonary abnormalities videothoracoscopy of the right pleural cavity was performed with specimen collection. Histopathological examination excluded the possibility of cancer metastases to pulmonary parenchyma and revealed the presence of sarcoid-like granulomas. Coexistence of seminoma and diffuse sarcoid-l...
Source: Pneumonologia i Alergologia Polska - February 22, 2013 Category: Respiratory Medicine Authors: Kita-Milczarska K, Górska L, Kuziemski K, Sejda A, Jassem E, Biernat W Tags: Pneumonol Alergol Pol Source Type: research

Preliminary characterizations of a serum biomarker for sarcoidosis by comparative proteomic approach with tandem-mass spectrometry in ethnic Han Chinese patients
Background: The diagnosis of sarcoidosis is still a significant challenge in China because of the need to exclude other diseases including granulomatous infections and malignancies that may be clinically and radiographically similar. The specific aim of the study is to search for serum protein biomarkers of sarcoidosis and to validate their clinical usefulness in differential diagnosis. Methods: Serum samples were collected from patients with sarcoidosis (n = 37), and compared to those from patients with tuberculosis (n = 20), other pulmonary diseases (n = 20), and healthy volunteers (n = 20) for determination of sarcoidos...
Source: Respiratory Research - February 11, 2013 Category: Respiratory Medicine Authors: Yuan ZhangXianqiu ChenYang HuShanshan DuLi ShenYifan HeYuxuan ZhangXia ZhangHuiping LiRex Yung Source Type: research

Splenic sarcoidosis mimicking neoplastic disease
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause that commonly involves the spleen. Sarcoid can produce either homogeneous splenomegaly or multiple splenic nodules. Although other organ system involvement usually occurs, this is not invariable. Herein, we report on the clinical, histological, and radiological features—including sonography and MRI—of an isolated splenic sarcoidosis that mimicked neoplastic disease in a 37‐year‐old female. Knowledge of this atypical sonographic presentation may prevent unnecessary splenectomy. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013
Source: Journal of Clinical Ultrasound - January 1, 2013 Category: Radiology Authors: Salem Bauones, Thomas Le Corroller, Olivier Durieux, Daphné Guenoun, Jean Del Grande, Nicolas Pirro, Pierre Champsaur Tags: Case Report Source Type: research

Sarcoid-like granulomatosis induced by Propionibacterium acnes in mice; role of ICAM-1 in prevention of granuloma formation
Sarcoidosis is a systemic granulomatous disease which is characterized by a variable clinical presentation and course. The etiology of the disease has remained unknown. Propionibacterium acnes (P. acnes), an anaerobic nonspore-forming gram-positive rod bacterium, has been implicated as one of the suggested causative antigens of sarcoidosis since this bacterium has been isolated from sarcoid lesions. In order to clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we first established an in vivo model of sarcoid-like skin granulomatosis by injecting heat-killed P. acnes into the back of C57BL/6J mice. These...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Masahiro Kamata, Yayoi Tada, Yoshihide Asano, Makoto Sugaya, Takafumi Kadono, Shinichi Sato Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Primary Sarcoid of the Breast with Incidental Malignancy
We report a very unusual case of primary breast sarcoidosis with incidentally discovered breast carcinoma. The roles of mammography, ultrasound, and MRI in the diagnosis as well as other potential differential diagnosis are discussed.
Source: Journal of Clinical Imaging Science - July 28, 2012 Category: Radiology Authors: Laura M IsleyAbbie R CluverRebecca J LeddyMegan K Baker Source Type: research