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Total 4711 results found since Jan 2013.

The granulomas morphology and clinical picture of sarcoidosis
Conclusion: The severity of pulmonary dissemination in sarcoidosis is directly proportional to the number of cellular elements of the granuloma, except for macrophages. Symptoms of the disease are caused by features of the granulomas structure.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Denisova, O., Palchikova, I., Purlik, I., Chernjavskaya, G., Chernogoryuk, G. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Echocardiographic parameters in suspected cardiac sarcoidosis patients-the role of speckle tracking strain analysis in the diagnosis of cardiac sarcoidosis
Conclusion: In a cohort of suspected CS patients GCS may provide significant diagnostic information and guide advanced imaging for CS.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kouranos, V., Minz, M., Danylenko, O., Baksi, J., Wechalekar, K., Kokosi, M., Sharma, R., Wells, A., Senior, R., Khattar, R., Cowie, M. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Human chitotriosidase analysis: a reliable biomarker of sarcoidosis severity
Conclusion: CTO is a non-invasive, reproducible and useful biomarker in the clinical practice; high CTO activity may predict extrapulmonary involvement of disease and could be useful to identify patients requiring pharmacological treatments.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Cameli, P., Bargagli, E., Bennett, D., Bianchi, N., Refini, R. M., Rottoli, P., Cillis, G. Tags: Diffuse Parenchymal Lung Disease Source Type: research

The role of 18-FDG PET/CT in lung sarcoidosis
Conclusion: 18F-FDG PET/CT evaluates the extent and inflammatory activity of lung sarcoidosis and was observed in 79% of patients and associated with functional and clinical parameters.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Pavlovic-Popovic, Z., Vukoja, M., Mihailovic, J., Prvulovic Bunovic, N., Lucic, S. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Functional and symptomatic burden of small fiber neuropathy in sarcoidosis
Sarcoidosis is frequently complicated by loss of unmyelinated small nerve fibers, leading to pain and dysautonomia. The implications of sarcoidosis–associated small fiber neuropathy (SFN) on quality of life and functional status are not well described. We systematically measured medication burden, pain (Brief Pain Inventory), fatigue, quality of life (SF-36) and 6 minute walk distance (6MWD) at baseline in a prospective study of 64 US and Dutch sarcoidosis patients. All patients had SFN confirmed by skin biopsy or corneal confocal microscopy. We assessed neuropathic symptoms using the Neuropathic Pain Symptom Invento...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Culver, D., Bjournas, D., Dahan, A., Brines, M. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Interleukin-2 and C-reactive protein in assessing the effectiveness of pulmonary sarcoidosis treatment
Conclusions: Identifying patterns of these disorders at the molecular level intercellular interaction in pulmonary sarcoidosis enables to determine the effectiveness and adequacy of prescribed therapy, by patient-specific assessment of the inflammatory process activity.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Ostrovskyy, M., Shvets, K., Ostrovska, K., Savelikhina, I., Kulynych-Miskiv, M., Varunkiv, O. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Evaluation of Impulse Oscillometry in patients with SarcoidosisEvaluation of Impulse Oscillometry system in patients with pulmonary Sarcoidosis
Conclusion: Characteristic changes in IOS indices were found in patients with Sarcoidosis. R5 may help be useful in detecting early manifestations of airflow limitation in pulmonary sarcoidosis patients.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Talwar, A., Akhtar, N., Sampath, M., Bade, G., Trivedi, A., Guleria, R. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Screening of?ardiac involvement in sarcoidosis
Conclusion: The developed method of screening can be used for the selection of patients who require further assessment to exclude cardiac involvement.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Zhurkin, D., Baradzina, H., Syty, V. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Development of a multivariate model to predict clinical deterioration in pulmonary sarcoidosis
Conclusions: We believe this is the first study to demonstrate the prognostic value of ALP and albumin in predicting decline in pulmonary sarcoidosis. Interestingly, MRC breathlessness score outperformed baseline DLCO in this model. We plan to remove confounders such as treatment and validate our model in a second cohort of patients presenting to a separate clinic. Further validation of this model may assist in decisions of when to initiate treatment.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Yung, H., Thillai, M., Fiddler, C., Simler, N., Chilvers, E., Parfrey, H. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Noninvasive Arterial Stiffness Measurement in Patients with Sarcoidosis
Conclusions: Opposed the previous study, we could not demonstrate arterial wall impairement in sarcoidosis patients compared to controls. The patient population was heterogonous concerning disease duration and the sample size, especially in control group was relatively small.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Demirdogen Cetinoglu, E., Uysal, A., Aydin Guclu, O., Ozkaya, G., Uzaslan, E., Karadag, M., Serdar, O. A. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Gene variants and clinical course of pulmonary sarcoidosis in a Slavic population
Conclusions: Our data confirm MHC-related SNPs (TNFA, HLA) and nominate further variants as plausible prognostic markers for resolution/progression of sarcoidosis, respectively among West Slavs. Further investigations should be performed in other ethnicities and include additional clinical information such as chest X-ray stage and/or treatment requirement/response.Grant: IGA_PU_LF_2016_009/2017_014 and LO1304.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kishore, A., Sikorova, K., Doubkova, M., Rebała, K., Dubaniewicz, A., Kolek, V., Petrek, M. Tags: Genes and Environment Source Type: research

The possible role of Stomoxys calcitrans in equine sarcoid transmission
This study aimed to investigate whether BPV-negative stable flies (Stomoxys calcitrans) become positive for BPV DNA after exposure to equine sarcoid or bovine papilloma tissue under experimental conditions and, if so, for how long. A total of 420 stable flies were caught alive and exposed to BPV positive equine sarcoid or bovine papilloma tissue. During the following week, dead flies were collected daily and BPV loads were determined by quantitative PCR. There was a significant rise in BPV load after tissue exposure both in sarcoid and papilloma exposed flies, but the viral load was higher and remained high for a longer ti...
Source: The Veterinary Journal - December 6, 2017 Category: Veterinary Research Source Type: research

Changes in anxiety and depression after pulmonary rehabilitation in distressed patients with sarcoidosis in ProKaSaRe
Conclusion: Multidisciplinary PR seems to have a long lasting positive effect on psychological distress in patients with sarcoidosis even one year after PR.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Nowik, D., Schultz, K., Buhr-Schinner, H., Heitmann, R., Hummel, S., Tönnesmann, U., van der Meyden, J., Lingner, H. Tags: Rehabilitation and Chronic Care Source Type: research

Epidemiology of sarcoidosis in the Leningrad region of Russia
Conclusion: The increasing incidence and prevalence of PS in the last years can be explained by new management of PS patients in Russia and the use modern methods of examination and treatment.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Baranova, O. P., Ermolova, S. O., Speranskaya, A. Tags: Clinical Problems Others Source Type: research

68 Gallium DOTA-NOC PET/CT as a predictor of disease activity in sarcoidosis
Conclusion: 68Ga-DOTA-NOC PET/CT emerged as a useful tool to detect clinical activity, treatment response in sarcoidosis patients with thoracic involvement.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Singh, A., Sharma, S., Tripathi, M., Mian, A., Sharma, S. K. Tags: Imaging Source Type: research

Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis.
In conclusion, an integrated network and transcriptomics approach revealed substantial functional similarities between a murine model and human sarcoidosis particularly with respect to activation of immune-specific pathways. PMID: 29212802 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 6, 2017 Category: Cytology Authors: Mohan A, Malur A, McPeek M, Barna BP, Schnapp LM, Thomassen MJ, Gharib SA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Clinico-radiological diagnosis of atypical forms of pulmonary sarcoidosis
Conclusions: Accumulation of experience in clinical-radiological examination of patients with PS requires a revision of the existing classification and addition of atypical forms of PS that are difficult to diagnose, require adjustment of the diagnostic algorithm, and development of new approaches to treatment.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Baranova, O. P., Speranskaya, A., Vasilieva, M. Tags: Imaging Source Type: research

Expression of mRNA of selected inflammatory markers in BALf cells from patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF)
Conclusions: the inflammatory and immune pathways in sarcoidosis and IPF show some similarities. However, the clinical implication of the expression of inflammatory markers is different in both diseases.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Maskey-Warzechowska, M., Paplinska-Goryca, M., Witkowska, A., Nejman-Gryz, P., Korczynski, P., Krenke, R. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Urinary 8-Hydroxy-2'-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis Cardiomyopathies
Conclusions— U-8-OHdG levels are associated with VT in patients with active CS diagnosed by 18F-flurodeoxyglucose positron-emission tomography, providing additive and relevant information about the arrhythmia substrate.
Source: Circulation: Cardiovascular Imaging - December 5, 2017 Category: Radiology Authors: Ishiguchi, H., Kobayashi, S., Myoren, T., Kohno, M., Nanno, T., Murakami, W., Oda, S., Oishi, K., Okuda, S., Okada, M., Suga, K., Yano, M. Tags: Cardiomyopathy, Heart Failure, Nuclear Cardiology and PET Cardiomyopathies Source Type: research

Complementary Role of CMR to Conventional Screening in the Diagnosis and Prognosis of Cardiac Sarcoidosis
Conclusions Of all cardiac tests, CMR was the most valuable in the diagnosis and prognosis of cardiac sarcoidosis in a general sarcoidosis population. Echocardiography had an overall limited diagnostic value as a screening test, and an abnormal study, despite a high positive predictive value, may still need confirmation with CMR.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - December 4, 2017 Category: Radiology Authors: Kouranos, V., Tzelepis, G. E., Rapti, A., Mavrogeni, S., Aggeli, K., Douskou, M., Prasad, S., Koulouris, N., Sfikakis, P., Wells, A., Gialafos, E. Tags: Original Research Source Type: research

Radiological and nuclear medicine imaging of sarcoidosis.
Authors: Larici AR, Glaudemans AW, Del Ciello A, Slart RH, Calandriello L, Gheysens O Abstract Sarcoidosis is a multisystem chronic inflammatory disease of unknown etiology characterized by widespread growth of non-caseating granulomas. The diagnosis of sarcoidosis is based on clinical and imaging presentation, histologic confirmation and the absence of alternative diseases. Radiology and Nuclear Medicine play an essential role in the diagnostic work-up of patients with sarcoidosis to assess disease extent and activity. In addition, imaging modalities have shown their potential in managing these patients in terms o...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - December 3, 2017 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Severe infections in sarcoidosis: Incidence, predictors and long-term outcome in a cohort of 585 patients
Abstract Sarcoidosis is associated with cell-mediated immunodeficiency and treatment of symptomatic sarcoidosis usually includes systemic immunosuppressants. Data relative to incidence, prognosis factors, and outcome of infections are scarce. Retrospective cohort study of 585 patients with biopsy proven sarcoidosis in a tertiary referral specialist clinic, with a nested case-control analysis. Twenty nine patients (4.9%) with severe infections were compared to 116 controls subjects with sarcoidosis, matched according to their gender, ethnicity, age at diagnosis, and treatment with corticosteroids. After a median follow-...
Source: Medicine - December 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

GSE100500 Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis
Conclusions: Our MWCNT murine model has an alveolar macrophage signature that varies significantly from control mice. Application of an unbiased transcriptomic approach revealed substantial functional similarities between a murine MWCNT model and human sarcoidosis particularly with respect to activation of immune-specific pathways.
Source: GEO: Gene Expression Omnibus - December 1, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Acute orbital sarcoidosis with preceding fever and erythema nodosum.
PMID: 29217052 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - December 1, 2017 Category: Opthalmology Authors: Simpson SM, Farmer J, Kratky V Tags: Can J Ophthalmol Source Type: research

PET MRI Study in Patients With Cardiac Sarcoidosis
Conditions:   Inflammatory Cardiomyopathy;   Sarcoidosis Intervention:   Diagnostic Test: simultaneous combined 18F-FDG PET and cardiac MRI imaging Sponsor:   University Health Network, Toronto Recruiting
Source: ClinicalTrials.gov - November 29, 2017 Category: Research Source Type: clinical trials

The necessity of external validation in exhaled breath research: a case study of sarcoidosis
In this study, we hypothesized that sarcoidosis patients and healthy controls could be discriminated based on a group of volatile organic compounds (VOCs) in exhaled breath and that these discriminating VOCs could be validated in an external population. The first dataset consisted of 87 sarcoidosis patients and 27 healthy controls, whereas the validation dataset consisted of 25 patients and 29 controls. Using the first dataset, nine VOCs were found that cou...
Source: Journal of Breath Research - November 29, 2017 Category: Respiratory Medicine Authors: Rianne R R Fijten, Agnieszka Smolinska, Marjolein Drent, Jan W Dallinga, Remy Mostard, Dani ëlle M Pachen, Frederik J van Schooten and Agnes W Boots Source Type: research

Pulmonary Sarcoidosis Activation following Neoadjuvant Pembrolizumab plus Chemotherapy Combination Therapy in a Patient with Non-Small Cell Lung Cancer: A Case Report
Conclusion: The pathogenesis of immunotherapy-induced sarcoidosis is not yet known but has been reported in different cancers and using different checkpoint inhibitors. To our knowledge, this case is the first in the literature displaying pulmonary sarcoidosis in a patient with NSCLC 4 months after having initiated chemotherapy plus pembrolizumab combination therapy.Case Rep Oncol 2017;10:1070 –1075
Source: Case Reports in Oncology - November 27, 2017 Category: Cancer & Oncology Source Type: research

A case of acute kidney injury caused by granulomatous interstitial nephritis associated with sarcoidosis
We present a case of acute kidney injury caused by granulomatous interstitial nephritis as a renal manifestation of sarcoidosis proven by renal biopsy, which can be confirmed by18F-fluorodeoxyglucose positron emission tomography/computed tomography. Glucocorticoid therapy was helpful for improving and maintaining her renal function over a 6-year period.
Source: CEN Case Reports - November 27, 2017 Category: Urology & Nephrology Source Type: research

The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis
Conclusions: Neurosarcoidosis is an elusive diagnosis and can cause hearing loss and psychiatric symptoms. Cochlear implantation for patients with severe hearing loss should be considered once the diagnosis is confirmed, as it is possible to achieve a successful level of hearing. Psychiatric symptoms can manifest with the onset of neurosarcoidosis, result from CN deficits, or develop as a side effect from long-term, high-dose corticosteroids, and should be monitored carefully in patients with neurosarcoidosis.Audiol Neurotol 2017;22:205-217
Source: Audiology and Neurotology - November 22, 2017 Category: Audiology Source Type: research

Isolated cardiac sarcoidosis: the crucial role of multimodal imaging with positron emission tomography/magnetic resonance imaging in diagnosis and therapy surveillance
A 48-year-old male presented with symptomatic ventricular tachycardia of 226 b.p.m. After external cardioversion, electrocardiogram revealed a complete right bundle branch block but no other abnormalities. Echocardiography showed a reduced left ventricular-function (ejection fraction: 49%) with dyskinesia of the basal septum and anterior wall; however, coronary heart disease was excluded by angiography. On subsequent simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI), a diffuse, band-shaped, mostly subendocardial late gadolinium enhancement was observed within both ventricles particularly within...
Source: European Heart Journal - November 22, 2017 Category: Cardiology Source Type: research

Emergency Radiotherapy for Spinal Cord Compression due to Bone Sarcoidosis.
Authors: Tanaka Y, Taima K, Tanaka H, Itoga M, Ishioka Y, Shiratori T, Tsuchiya J, Sakamoto H, Takanashi S, Tasaka S Abstract Sarcoidosis is an inflammatory granulomatous disease that is systemic, but bone involvement is uncommon. A 68-year-old man was referred to our hospital complaining of right shoulder pain with numbness. Computed tomography revealed systemic lymphadenopathy and multiple bone lesions. Because malignant lymphoma with a mass lesion protruding into the vertebral canal was considered, he underwent urgent radiotherapy. Thereafter, a needle biopsy of the left parasternal node was performed and showed...
Source: Internal Medicine - November 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Cardiac Sarcoidosis Presenting as Acute Progressive Heart Failure with Abdominal Lymphadenopathy.
Authors: Oka S, Umetani K, Harama T, Shimizu T, Makino A, Sano K, Nakamura M Abstract A 77-year-old Japanese woman presented with asymptomatic abdominal lymphadenopathy. Soluble interleukin-2 receptor (sIL2R) and angiotensin-converting enzyme (ACE) levels were elevated, and a pathological examination of lymph-node biopsies revealed non-caseating granulomas, which was consistent with sarcoidosis. Fluorodeoxyglucose-positron emission tomography did not show a clear accumulation in the mediastinal lymph-nodes or heart. Five months later, she presented with acute progressive heart failure that was refractory to convent...
Source: Internal Medicine - November 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Clinical Characteristics and Computed Tomography Findings in Arab Patients Diagnosed with Pulmonary Sarcoidosis
CONCLUSION: At presentation, clinical manifestations of sarcoidosis among this sample of Arab patients were similar to reports from other nations. Further studies are needed to explore the effects of race and ethnicity on disease severity in the Middle East. Ann Saudi Med 2009; 29(6): 454-459PMID: 19847083 DOI: 10.4103/0256-4947.57168
Source: Annals of Saudi Medicine - November 20, 2017 Category: General Medicine Tags: ISSUE 6 Source Type: research

Endpoints in sarcoidosis: More like IPF or asthma?
Sarcoidosis remains an enigmatic disease. Its cause is unknown, the indications for treatment are often unclear, and its natural history is variable. An additional important enigmatic issue that has hampered clinical sarcoidosis research is the failure to develop reliable and universally accepted clinical endpoints.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study
Fatigue is a major and disabling problem in sarcoidosis. Knowledge concerning correlates of the development of fatigue and possible interrelationships is lacking.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Celine Hendriks, Marjolein Drent, Willemien De Kleijn, Marjon Elfferich, Petal Wijnen, Jolanda De Vries Source Type: research

Endpoints in sarcoidosis: More like IPF or asthma?
Sarcoidosis remains an enigmatic disease. Its cause is unknown, the indications for treatment are often unclear, and its natural history is variable. An additional important enigmatic issue that has hampered clinical sarcoidosis research is the failure to develop reliable and universally accepted clinical endpoints.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study
Fatigue is a major and disabling problem in sarcoidosis. Knowledge concerning correlates of the development of fatigue and possible interrelationships is lacking.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Celine Hendriks, Marjolein Drent, Willemien De Kleijn, Marjon Elfferich, Petal Wijnen, Jolanda De Vries Source Type: research