Diagnostic value of elevated serum angiotensin-converting enzyme and lymphopenia in patients with granulomatous hepatitis
CONCLUSIONS: Those results suggests that lymphopenia and sACE may be valuable biomarkers for sarcoidosis diagnosis in GH when combined, especially in younger patients.PMID:37712371 | DOI:10.36141/svdld.v40i3.14221
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Thomas El Jammal Fran çois Dhelft Pierre Pradat Fran çois Bailly Fabien Zoulim Arnaud Hot Maxime Fauter Ayoub Drissi-Bakhkhat Isabelle Durieu Jean-Christophe Lega Yvan Jamilloux Pascal S ève Source Type: research

Bleomycin and perioperative care: a case report
We report here the successful management and perioperative care of a patient with documented bleomycin pulmonary toxicity who had to undergo an eight hour long retroperitoneal surgery. With proper preoperative assessment, chest physiotherapy, inhaled steroids and bronchodilators, antibiotics, operative restriction of oxygen and fluids and good postoperative care no further pulmonary insult was inflicted.PMID:37712370 | DOI:10.36141/svdld.v40i3.14385
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: B Jayakrishnan Rajini Kausalya Hilal A Al-Rashdi Kirubakaran Davis Jahfar Ali Munjid Al-Harthy Sami M Bennji Source Type: research

Risk factors for the development of interstitial lung disease following severe COVID-19 pneumonia and outcomes of systemic corticosteroid therapy: 3-month follow-up
CONCLUSIONS: In conclusion, after severe COVID-19 pneumonia, persistent clinical symptoms and pulmonary parenchymal involvement would be inevitable in elder and smoker patients. Moreover, corticosteroid treatment in patients with severe parenchymal involvement was found to be effective in the improvement of radiological and functional parameters.PMID:37712369 | DOI:10.36141/svdld.v40i3.14418
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Sibel G ünay Izzet Selcuk Parlak Habibe Hezer Ebru Şengül Şeref Parlak Melike Sanem Umut Zeynep Hanc ıoğlu H ülya Çelenk Ergüden Yasin Kocaman Aynil Dalk ıran Ümran Sertçelik İrem Şerifoğlu Esmehan Akp ınar Muhammet Furkan G öktaş Meltem Source Type: research

Life threating onset of Cardiac Sarcoidosis with mediastinal involvement
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023042. doi: 10.36141/svdld.v40i3.14519.ABSTRACTWe have described a clinical case with atypical onset of sarcoidosis. A young patient presented to the emergency room with acute heart failure and severe cardiac dysfunction simulating dilated cardiomyopathy or severe myocarditis. Hypoxic respiratory failure refractory to oxygen therapy was treated with steroids. The diagnosis was made by a multidisciplinary team who decided to perform EndoBronchial UltraSound-guided TransBronchial Needle Aspiration (EBUS TBNA) in addition to a cardiac MRI. The result was to obtain, in th...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Marcello Ciuffreda Valentina Valenti Giuseppe Manfr è Antonio Barberi Patrizia Porzi Francesco Versaci Antonella Sarni Source Type: research

Test-retest repeatability for Fatigue Assessment Scale, Short-Form 6-Dimension and King's Sarcoidosis Questionnaire in people with sarcoidosis associated fatigue
CONCLUSIONS: There was good repeatability of FAS, SF-36, SF-6D and KSQ in free living people with sarcoidosis associated fatigue. Fatigue, general and disease specific health related quality of life showed no significant change over a 12 week period. Studies identifying changes in these outcomes can confidently report a true change and not measurement error or regression to the mean.PMID:37712367 | DOI:10.36141/svdld.v40i3.13253
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Rebecca Ferris Tun Maung Christopher Atkins Dayle Terrington Allan Clark Surya Prasad Manivarmane Andrew Wilson Source Type: research

The role of systemic immune-inflammation index (SII) in the differential diagnosis of granulomatous and reactive LAP diagnosed by endobronchial ultrasonography
CONCLUSION: SII may be an easily applicable parameter in the differentiation of tuberculosis and sarcoidosis LAP with granuloma and in the differentiation of granulomatous diseases from reactive LAP.PMID:37712366 | DOI:10.36141/svdld.v40i3.14743
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Bu ğra Kerget Dursun Erol Af şin Alperen Aksakal Source Type: research

Elderly-onset pulmonary sarcoidosis: A radiological approach to diagnosis
CONCLUSIONS: Presentation of elderly-onset sarcoidosis appears to differ from young-onset sarcoidosis. Radiologically, lymph node enlargement and the pattern of fibrosis may be distinctive.PMID:37712365 | DOI:10.36141/svdld.v40i3.14829
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Sevtap Do ğan Onural Öztürk Sevil Aydo ğan Diş Serap Argun Bar ış Nurettin Özgür Doğan Source Type: research

Pulmonary fibrosis in sarcoidosis
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023027. doi: 10.36141/svdld.v40i3.14830.ABSTRACTSarcoidosis may progress to pulmonary fibrosis in 5% of patients with significantly increased mortality. Histopathology shows fibrosis in a lymphangitic pattern surrounding the granulomas. Th1 to Th2 shift in environment along with angiogenesis is implicated in exuberant fibrosis. Clinical features include dyspnea, cough, and frequently with pulmonary function tests showing a mixed ventilatory defect with severely decreased diffusion capacity of carbon monoxide. Serologic markers including soluble interleukin 2 receptor, ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Huda Asif Manuel Ribeiro Neto Daniel Culver Source Type: research

In Memory of Professor Takateru Izumi
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023025. doi: 10.36141/svdld.v40i3.15024.ABSTRACTPMID:37712363 | DOI:10.36141/svdld.v40i3.15024
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Azuma Arata Source Type: research

Fibrosing mediastinitis: 'haemoptysis in the Heartland
Fibrosing mediastinitis (FM) is an uncommon cause of haemoptysis, characterised by sclerosis of the mediastinum that may occur as an inflammatory sequela of histoplasmosis, lymphoma, sarcoidosis or an idiopathic process. Bleeding is predominantly due to concomitant collateral vessels and engorgement. However, the endobronchial findings obtained via flexible bronchoscopy are not clearly defined in the literature.1 Here, we present the case of a 41-year-old woman with no prior medical history who presented with a 2-month history of exertional dyspnoea and recurrent haemoptysis. Chest CT showed complete obstruction of the rig...
Source: Thorax - September 15, 2023 Category: Respiratory Medicine Authors: Ntiamoah, P., Shah, J. R., Ghosh, S., Mehta, A. Tags: Images in Thorax, Thorax Source Type: research

Sarcoidosis presenting as progressive multifocal leukoencephalopathy in an apparently immunocompetent adult
Neurological involvement in sarcoidosis is termed as neurosarcoidosis. It usually leads to cranial neuropathies, although it can involve any part of the neuroaxis. Although sarcoidosis is a proinflammatory state, there is an associated anergic state demonstrable by a feeble tuberculin response. Lymphocytic sequestration in granulomas can be associated with peripheral CD4 lymphocytopenia (40% of patients with sarcoidosis) predisposing to opportunistic infections. Here we have described a young, otherwise immunocompetent male presenting with subacute onset right hemiparesis with motor aphasia, who was diagnosed to have progr...
Source: Journal of Neuroimmunology - September 15, 2023 Category: Allergy & Immunology Authors: Shiny Joy, Ayush Agarwal, Divyani Garg, Ajay Garg, Divya M. Radhakrishnan, Awadh K. Pandit, Achal Kumar Srivastava Tags: Short Communication Source Type: research

Sarcoidosis-like reaction induced by immune checkpoint inhibitor in a patient with hepatocellular carcinoma: a case report
We present the case of a 41-year-old male patient who has been diagnosed with advanced hepatocellular carcinoma (HCC) with metastatic retroperitoneal lymph nodes and a subdiaphragmatic metastatic lesion, undergoing second-line treatment with a combination of nivolumab and ipilimumab. After completing four cycles, the patient was admitted to the hospital due to intermittent fever and profuse sweating. A CT scan showed multiple pathologically enlarged lymph nodes in several locations, raising suspicion of disease progression. The patient’s clinical progress was favorable after symptomatic treatment (antipyretics) and was d...
Source: Frontiers in Immunology - September 13, 2023 Category: Allergy & Immunology Source Type: research

Coexistence of open-angle glaucoma and sarcoidosis-associated optic neuropathy
We present a case of preexisting open-angle glaucoma and concurrent invol...
Source: BMC Ophthalmology - September 13, 2023 Category: Opthalmology Authors: Eun Hye Jung, Woonghee Kim, Ra Gyoung Yoon and Ko Eun Kim Tags: Case Report Source Type: research

Exploring sarcoidosis systemic treatment: Patient factors and therapeutic strategies
Eur J Intern Med. 2023 Sep 7:S0953-6205(23)00321-7. doi: 10.1016/j.ejim.2023.09.001. Online ahead of print.NO ABSTRACTPMID:37689550 | DOI:10.1016/j.ejim.2023.09.001
Source: European Journal of Internal Medicine - September 9, 2023 Category: Internal Medicine Authors: Rafiqur Rahman Fnu Samiullah Satesh Kumar Source Type: research

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