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Total 5698 results found since Jan 2013.

Primary oral presentation of sarcoidosis in a pediatric patient
Sarcoidosis is a granulomatous disease of unknown etiology that manifests as non-caseating granulomas in various organs throughout the body1 –3. Its prevalence worldwide is approximately 4.7-64 in 100,0001 and the disease has a bimodal age distribution with the first peak at 25-35 years and second peak at 45-65 years4. Sarcoid most often affects the lungs, presenting as bilateral hilar lymphadenopathy or pulmonary reticular opacities4, 5 . Pulmonary manifestations initially start as a persistent cough and can progress to worsening dyspnea1,5.
Source: Journal of Oral and Maxillofacial Surgery - January 23, 2019 Category: ENT & OMF Authors: Chad Dammling, Peter Waite, Tim Beukelman Tags: Case Report Source Type: research

Erythema nodosum and sarcoid granulomas - letting the cat out of the bag.
Abstract A 41-year-old woman presented with a violaceous papule on the dorsum of the hand, large ipsilateral axillary lymphadenopathy, and tender, erythematous, subcutaneous nodules on the legs. Accompanying signs included fever, ankle swelling, and bilateral red eye. She recalled having a previous exposure to kittens one month before and had a positive family history for sarcoidosis. Histological examination of the hand lesion showed sarcoidal granulomas with positive Bartonella henselae DNA, whereas a biopsy done on the leg nodules was compatible with erythema nodosum. Cat scratch disease (CSD) typically present...
Source: Dermatol Online J - December 15, 2018 Category: Dermatology Authors: Morgado F, Batista M, Coutinho I, Cardoso JC, Tellechea Ó Tags: Dermatol Online J Source Type: research

Pulmonary Sarcoidosis Mimicking Tuberculosis: Importance of the Galaxy Sign on Thoracic Computed Tomography
We present the case of a patient with sarcoidosis that was initially misdiagnosed as tuberculosis, in whom the galaxy sign on CT was useful as it suggested the correct diagnosis.ResumenLa sarcoidosis y la tuberculosis son 2 enfermedades granulomatosas frecuentes que comparten presentaciones clínicas y radiológicas. Entre los signos radiológicos característicos de sarcoidosis pulmonar descritos recientemente en la tomografía computarizada de tórax destaca el signo de la «galaxia». Presentamos un caso de sarcoidosis que inicialmente fue confundido con una tuberculosis en el que este signo radiológico fue útil para ...
Source: Reumatologia Clinica - November 30, 2018 Category: Rheumatology Source Type: research

Scalp Sarcoidosis Presenting as Cicatricial Alopecia.
Authors: Prohaska J, Demaree E, Powers J, Cook C Abstract Sarcoidosis is a granulomatous condition that has a highly variable presentation. One rare presentation of sarcoidosis is cutaneous scalp sarcoidosis. Usually scalp sarcoid presents as a scarring alopecia, but it can be nonscarring. The presence of sarcoidal lesions on the scalp is associated with systemic disease, as are other cutaneous manifestations of sarcoidosis. The authors present the case of a 64-year-old woman with a history of sarcoidosis who presented with alopecia and hypopigmented patches on her scalp. She also had papular sarcoid lesions on her...
Source: Journal of the American Osteopathic Association - November 28, 2018 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

A Case of Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.
Authors: Ueda S, Murakami T, Ogino H, Matsuura M, Tamaki M, Kishi S, Hann M, Toyoda Y, Nagai K, Bando Y, Abe H, Nishioka Y, Doi T Abstract A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Corticosteroid improved the kidney function, and red...
Source: Internal Medicine - November 21, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Risk of underdiagnoses of cardiac sarcoidosis by routine electrocardiogram and echocardiogram in patients with biopsy-proven extracardiac sarcoidosis
Conclusions: The prevalence of CS exceeds 20% in extra-CS patients even with normal ECG and Echo. Physicians should keep in mind such an unrecognized population and risk of underdiagnosis of CS.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ohira, H., Yoshinaga, K., Sakiyama, S., Nakaya, T., Suzuki, N., Sugimoto, A., Hayashishita, A., Aikawa, T., Sato, T., Manabe, O., Oyama-Manabe, N., Watanabe, T., Nishimura, M., Tsujino, I. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Diminished peripheral T cell activity in sarcoidosis associates with progressive disease.
Conclusions: Our findings suggest that decreased anabolism and impaired peripheral T cell activation are not only markers of sarcoidosis, but may also contribute to disease progression.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Schott, C., Ascoli, C., Huang, Y., Perkins, D., Finn, P. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Cardiac sarcoidosis: a tertiary centre experience
Conclusion: Integration of signal from advanced imaging modalities with the clinical information is required in a multidisciplinary setting for diagnosis of cardiac sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kouranos, V., Sharma, R., Khattar, R., Baksi, J., Kokosi, M., Prasad, S., Wechalekar, K., Underwood, R., Cowie, M., Wells, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Peripheral blood memory T-helper (Th) 17 subsets in patients with chronic and acute pulmonary sarcoidosis
Conclusion: Variation in Th1 and Th17 subsets found in PB from CPS and APS can help to design new immunological biomarkers that will characterize the immunopathogenesis of sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Baranova, O. P., Ses, T., Kudryvzev, I., Lazareva, N., Serebryakova, M., Ilkovich, M., Totolyan, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Clinical phenotypes of extra-pulmonary sarcoidosis. The EpiSarc study
Conclusion: We identified 5 clinical phenotypes of sarcoidosis with distinct demographic features and outcomes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lhote, R., Cohen-Aubart, F., Nunes, H., Launay, D., Sacre, K., Borie, R., Schleinitz, N., Hamidou, M., Devilliers, H., Bonniaud, P., Mahevas, M., Lhote, F., Papo, T., Haroche, J., Godeau, B., Michel, M., Amoura, Z., Valeyre, D., Annesi-Maesano, I. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Genetic Profiles of Clinical Features in Sarcoidosis
Conclusions: In the hitherto tested variables, we found that the GenPhenReSa cohort is suitable for genetic analysis of European Caucasians. We could show that genetic risk factor associate with distinct clinical features in sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Freitag-Wolf, S., Schupp, J., Fischer, A., Mihailovic-Vucinic, V., Rottoli, P., Prasse, A., Schreiber, S., Krawczak, M., Müller-Quernheim, J. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Late Breaking Abstract - Characteristics of macrophagal formula and cytokine spectrum of the bronchoalveolar lavage fluid in patients with newly diagnosed and those with recurring sarcoidosis of respiratory apparatus.
Materials and Methods: The bronchial examination with BALwas performed in 72 patients with newly diagnosed and recurrent sarcoidosis. The cytological investigation included the study of the lavage cytogram, calculation of the macrophage formula (MF) with examining of the percentage of young and mature macrophages with varies phenotypes, levels of the proinflammatory and anti-inflammatory cytokine.Results: In the newly diagnosed sarcoidosis, increase in the concentration of proinflammatory cytokines is observed in the BAL compared to the reference value of IL-2 (647.1 pg/ml versus 469), IL-8, IL-1β (2038.2 pg / ml vs. ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Makaryants, N., Ergeshov, A., Demyanenko, N., Lepekha, L., Shmelev, E. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Late Breaking Abstract - Reduced activity of energy-transducing NADH-quinone oxidoreductase (complex I) indicates mitochondrial respiratory chain dysfunction in patients with sarcoidosis
Conclusion: For the first time, reduced activity of complex I has been detected in sarcoidosis group compared to controls. Our findings indicate that sarcoidosis is closely related to mitochondrial respiratory chain dysfunction.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kotsiou, O., Daniil, Z., Bouzetos, E., Panagiotidou, H., Fouka, M., Malli, F., Bardaka, F., Antoniou, K., Psara, A.-M., Mamuris, Z., Gourgoulianis, K., Zifa, E. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Retrospective analysis of sarcoidosis characteristics and psychological impact between civilian and military populations.
Conclusion: Without difference of sarcoidosis characteristics, the best respiratory parameter of military population could be explained by more physical training. Scores of anxiety, depression and quality of life scales were significantly more altered in the civilian population, not seem to be attributable with sarcoidosis; we can make hypothesis of possible protective effect of social link in military population, in spite of indisputable factors of stress.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ranc, C., Bylicki, O., Le Floch, H., Gaspard, W., Zhang, L., Grassin, F., Riviere, F. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Spirometry, cardiopulmonary exercise testing and the six-minute walk test results in sarcoidosis patients
Conclusions: According to this study the ventilatory limitation and pulmonary involvement are the main causes of activity limitations in sarcoidosis patients.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kiani, A., Eslaminejad, A., Shafie Pour, M., Razavi, F., Seyyedi, S. R., Sharif- Kashani, B., Taghavi, K., Abedini, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Gender and smoking - does it matter for lung function in sarcoidosis? An analysis of large cohort (n=1260) Caucasian patients.
Conclusion: Sex differences seems to not have any influence on lung function while smoking affects TL, CO results but not spirometry, particularly signs of airway obstruction, in sarcoidosis patients.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boros, P., Martusewicz-Boros, M., Wesolowski, S. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Health-related quality of life and health status among patients with sarcoidosis, chronic obstructive pulmonary disease and interstitial lung disease
Conclusion: In these three distinct groups of patients dyspnea limiting exercise capacity is the common predictor of deterioration of HRQOL/HS.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Labor, M., Pavlisa, G., Alilovic, M. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Exhaled Breath Biomarkers in Sarcoidosis: A Systematic Review
Conclusions: Evidence for breath biomarkers remains inconclusive with many studies limited by small sample sizes. VOCs have shown promising potential but further research is required to evaluate their prognostic role.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Terrington, D., Hayton, C., Peel, A., Fowler, S., Wilson, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Does the peripheral blood neutrophil lymphocyte ratio increase as the stage of sarcoidosis progresses?
Conclusions: Peripheral blood NLR increases with the stage progresses in patients with sarcoidosis and it can be valuable to follow up sarcoidosis clinical activity.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Alparslan Bekir, S., Sonkaya, E., Ozbaki, F., Aydogan Eroglu, S., Sertcelik, L., Duman, D., Kavas, M., Coban Agca, M., Erdem, I., Özmen, I., Boga, S., Armagan Hazar, F., Sevim, T., Türker, H., Karakurt, Z. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Glucocorticosteroid therapy as predisposing factor for pulmonary sarcoidosis relapse
Conclusion: CS therapy is a risk factor for sarcoidosis relapse. Therefore, despite their high efficacy, corticosteroids are recommended in asymptomatic patients only in cases of progressive disease or lack of improvement after 3 months follow-up period.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Merenkova, I., Dziublyk, Y., Gumeniuk, G., Gumeniuk, M. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Predictive value of Neutrophil-to-lymphocyte ratio(NLR) and Platelet-to-lymphocyte ratio(PLR) in patients with Sarcoidosis
Conclusion: PLR and NLR elevation in sarcoidosis patients may be a marker of pulmonary involvement and advanced stage.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Yalnız, E., Ucsular, F., Karadeniz, G., Polat, G., Vayısoglu, G. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Monocytes and dendritic cells with hyperinflammatory profile in lungs of sarcoidosis patients
Conclusion: Monocytes and DCs in lungs of sarcoidosis patients showed altered frequencies compared to healthy controls and exhibited an inflammatory phenotype with spontaneous, high TNF production particularly in non-LS patients, possibly contributing to the chronic course of the disease.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lepzien, R., Liu, S., Kullberg, S., Eklund, A., Grunewald, J., Smed-Sörensen, A. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Long-term follow-up of patients with pulmonary sarcoidosis
Conclusion: The pathology discovered after many years indicates the need for an expanded involvement of specialists in primary and dynamic examination of patients with sarcoidosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Garmash, Y., Borisov, S. E., Ivanova, D. Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research

Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects.
Authors: Kuroda H, Saijo Y, Fujiuchi S, Takeda H, Ohsaki Y, Hasebe N Abstract Several susceptibility genes for sarcoidosis have been identified, but their relationship to the clinical state and prognosis remains to be elucidated. The aim of this study was to elucidate the relationship between sarcoidosis and five single nucleotide polymorphisms (SNPs) of three cytokines expected to play an important role in the inflammatory response. A case-control study was performed with 208 unrelated patients who met the diagnostic criteria for sarcoidosis used in Japan since 2006, and 328 control subjects. Five SNPs were analyz...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Role of Propionibacterium Acnes in Sarcoidosis: A Meta-analysis.
Conclusions: The present data and meta-analysis supports an association between P. acnes and some cases of sarcoidosis. PMID: 24351617 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

An analysis of seasonality of sarcoidosis in the United States veteran population: 2000-2007.
CONCLUSION: The lack of seasonality in this study indicates that season is not a dominant factor in complex gene-environment-host interaction that precedes presentation of new sarcoidosis cases in the United States Veteran population. PMID: 23461080 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidosis: vaginal wall and vulvar involvement.
We report the case of a 45-year-old married woman who presented with 2 months history of a vulval mass as large as a soybean, and did not reveal any remarkable pulmonary signs. Biopsy results showed non-caseous granulomatous inflammation consistent with sarcoidosis in the vulvar lesion. To our knowledge, this is the first reported case of this entity in the world. Based on the related literature, we highlight the possibility of gynecologic involvement in sarcoidosis. PMID: 23461079 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Om Prakash Sharma, MD, FRCP, FCCP - 4 July 1936 - 19 August 2012. Internationally acclaimed specialist in sarcoidosis.
Authors: Baughman RP, Drent M, Costabel U Abstract Internationally acclaimed specialist in sarcoidosis. PMID: 24284301 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Seasonality of Sarcoidosis: the 'heat' is on…
Authors: Gupta D Abstract Letter to the editor. PMID: 24284300 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Anxiety and depression in sarcoidosis: the influence of age, gender, affected organs, concomitant diseases and dyspnea.
CONCLUSIONS: The analysis of mental distress should take into account comparisons with normative values. Young patients deserve special social support. Dyspnea proved to be an important symptom in the prediction of anxiety and depression. PMID: 23461077 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Cardiac sarcoidosis and coronary artery disease: a two-hit mechanism to left ventricular dysfunction (Or is It)?
This report describes a case of cardiac sarcoidosis in a 40-year-old man with minimal risk factors for coronary artery disease who was found to have a critical coronary lesion on angiography performed for declining left ventricular function. The case highlights the diagnostic and therapeutic issues surrounding cardiac sarcoidosis and raises the question of a possible link between sarcoidosis and premature coronary artery disease. It also stresses the importance of ruling out ischemia in any patient with declining left ventricular function. PMID: 24284299 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sulfasalazine induced lung toxicity masquerading as sarcoidosis - case report and review of the literature.
We report a case of a 46 year old female being treated with Sulfasalazine for Ulcerative Colitis, who developed shortness of breath and a radiographic pattern of hilar adenopathy. Biopsy showed granulomas that resembled Sarcoidosis. We review different presentations of Sulfasalazine induced lung disease and describe the first known case of Sulfasalazine lung toxicity mimicking Sarcoidosis. PMID: 24284297 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States.
CONCLUSIONS: The analysis indicates that sarcoidosis tends to improve over time in terms of pulmonary function and medication requirements. The disease was found to be more severe in blacks than whites. Treatment was not necessarily required. These results provide a comprehensive model of the course and treatment of sarcoidosis in the clinical setting. PMID: 23461074 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Association of sarcoidosis and ulcerative colitis: a review of 20 cases.
We report a case of this association and describe its clinical, radiological and functional characteristics based on a review of the literature. This association must be recognized by the physician and must be clearly distinguished from a systemic site of ulcerative colitis or drug-related pneumonitis. PMID: 24284294 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Bronchial hyperreactivity in sarcoidosis patients: correlation with airflow limitation indices.
CONCLUSION: BHR occurs frequently in sarcoidosis patients and should be considered especially in patients with airflow limitation. PMID: 23461071 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis.
ConclusionsThe CLEAR regimen is associated with improved absolute FVC, as well as increased functional capacity and quality-of-life in selected chronic pulmonary sarcoidosis patients.  Larger, randomized, controlled trials are needed to confirm these findings and to identify patients most likely to benefit from therapy. ClinicalTrials.gov number NCT01169038. PMID: 24284293 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Endpoints for clinical trials of sarcoidosis.
Authors: Baughman RP, Drent M, Culver DA, Grutters JC, Handa T, Humbert M, Judson MA, Lower EE, Mana J, Pereira CA, Prasse A, Sulica R, Valyere D, Vucinic V, Wells AU Abstract Over the past few years an increasing number of prospective controlled sarcoidosis treatment trials have been completed. Unfortunately, these studies utilize different endpoints making comparisons between studies difficult. At the recent World Association of Sarcoidosis and other Granulomatous disease (WASOG) meeting, a session was dedicated to the evaluation of clinical endpoints for various disease manifestations. These included pulmonary, ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Oncostatin m in bronchoalveolar lavage correlates with the severity of sarcoidosis.
Conclusions: Direct correlation was found between clinical parameters including lung function tests (FEV1 and FVC) and OSM secretion from mast cells in patients with sarcoidosis. These findings suggest that mast cells and OSM have a role in sarcoidosis. Further studies to confirm these preliminary results are suggested. PMID: 24284292 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Socio-demographic profile of patients with sarcoidosis vis-à-vis tuberculosis.
Conclusions: Patients with sarcoidosis are likely to be better educated and more affluent compared to those with tuberculosis and healthy controls and this can be useful in clinical differential diagnosis of the two conditions in populations with high prevalence of TB. PMID: 24284291 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sharma O.P. Gerry James and the sarcoidosis movement. Biography of a Medical Luminary.
Authors: Peros-Golubicic T PMID: 24071891 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

TLR7 Gln11Leu single nucleotide polymorphism in patients with sarcoidosis.
Authors: Bordignon M, Bargagli E, Agostini Et Al C Abstract Sarcoidosis is a multi-factorial systemic disease with increased activity of the cellular immune components which is responsible of the formation of non-caseating granulomas in involved organs. Recent views on the etiology indicate interactions between inherited susceptibility and environmental or lifestyle factors. Concerning genes that may influence susceptibility to sarcoidosis Toll-like receptors (TLRs) may represent plausible candidates. In this present study, we investigated the X-linked TLR7 rs179008/Gln11Leu polymorphism situated on exon 3. SNP gen...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Massive splenomegaly and pancytopenia reuealing sarcoidosis in a child.
Authors: Viprey M, Donadieu J, Epaud Et Al R Abstract Clinical presentation of sarcoidosis in children is very variable and dependant upon age. Herein, we report the first association of massive splenomegaly and pancytopenia as the revealing mode of sarcoidosis in an 8-year-old girl who, despite bone marrow involvement, had a remarkable good outcome following steroid therapy. PMID: 24071888 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

First presentation of sarcoidosis with severe obstructive sleep apnoea and epiglottic invilvement.
We present a patient whose first presentation with sarcoidosis was with dysphonia, upper airways obstruction and severe obstructive sleep apnoea (OSA) . Systemic steroids and hydroxycholoroquine led to improvement in phonation, endoscopic appearance and upper airway obstruction with significant improvement in Apnoea Hypopnoea Index (AHI) on polysomnography. PMID: 24071887 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Detection of sarcoidosis associated fasciitis by uptake on a FDG PET scan: a novel finding.
We report a case of a sarcoidosis patient with bilateral calf and thigh stiffness who was noted to ha ve intense linear FDG uptake on a PET scan that localized to the fascia of his calves and theighs. His serum creatine kinase level was normal. Fasciitis has rarely been reported to be detected on FDG PET scans, and, to our knowledge, never in a sarcoidosis patient. FDG PET may have a role in identifying fasciitis or myositis when a patient has muscular complaints and no clinical or laboratory evidence of muscle injury. PMID: 24071886 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Mortality among African American women with sarcoidosis: data from the Black Women's Health Study.
CONCLUSIONS: In the Black Women's Health Study, women with sarcoidosis were more than twice as likely to die as women without the disease, with many of the deaths directly attributable to sarcoidosis.  Sarcoidosis is an important cause of premature death among black women with the disease. PMID: 24071884 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Calcium and vitamin D metabolism in sarcoidosis.
Conclusion: Sarcoidosis associated hypercalcemia, which is often accompanied by renal insufficiency, responds to treatment of sarcoidosis and withdrawal of vitamin D supplementation. Measurement of serum vitamin 1,25(OH)2 vitamin D3 appears to best evaluate vitamin D status in sarcoidosis patients. PMID: 24071882 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Verrucous sarcoidosis of the skin simulating squamous cell carcinoma.
Authors: Pezzetta S, Zarian H, Agostini C, Salmaso R, Alaibac M Abstract Here, we report a case of a 38-year-old woman with a history of systemic sarcoidosis who developed cutaneous verrucous sarcoidosis simulating a squamous cell carcinoma. This modality of presentation is unusual in both caucasic patients and in woman and may represent a diagnostic challenge for dermatologists. PMID: 24003538 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Disseminated nocardiosis mimicking exacerbation of pulmonary sarcoidosis.
We present an unusual case of disseminated nocardiosis in a patient diagnosed before with sarcoidosis and treated with glucocorticoids. Clinical symptoms initially mimicked exacerbation of pulmonary sarcoidosis. The course of disease was severe. PMID: 24003537 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The internal consistency of PRO fatigue instruments in sarcoidosis: superiority of the PFI over the FAS.
CONCLUSION: We found that the PFI had "excellent" consistency in our sarcoidosis clinic. The FAS did not demonstrate the same degree of internal consistency. The Cronbach's estimate of the FAS with items #4 and #10 removed was vastly superior to the FAS. These data support our contention that FAS items #4 and #10 detract from the internal consistency of this PRO. They also suggest that the PFI is superior to the FAS in terms of reliability. PMID: 24003536 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Differentiation of lymphoma versus sarcoidosis in the setting of mediastinal-hilar lymphadenopathy: assessment with diffusion-weighted MR imaging.
CONCLUSIONS: Diffusion-weighted imaging may be useful besides other modalities in differentiating lymphoma from sarcoidosis in mediastinal-hilar lymphadenopathy. PMID: 24003535 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research