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Total 5691 results found since Jan 2013.

Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare
Conditions:   Cutaneous Sarcoidosis;   Granuloma Annulare Intervention:   Drug: Tofacitinib 5 mg twice daily Sponsors:   Yale University;   Pfizer Recruiting
Source: - April 10, 2019 Category: Research Source Type: clinical trials

First patient-centred set of outcomes for pulmonary sarcoidosis: a multicentre initiative.
Discussion: Collecting outcomes in pulmonary sarcoidosis internationally and the use of a broadly accepted set can enable international comparison. Differences in outcomes can potentially be used as a starting point for quality improvement initiatives. PMID: 30956806 [PubMed]
Source: Respiratory Care - April 10, 2019 Category: Respiratory Medicine Authors: Kampstra NA, Grutters JC, van Beek FT, Culver DA, Baughman RP, Renzoni EA, Wuyts W, Kouranos V, Wijsenbeek MS, Biesma DH, van der Wees PJ, van der Nat PB Tags: BMJ Open Respir Res Source Type: research

Abstract Sarcoidosis is a multisystemic granulomatous disease that affects individuals worldwide. The lungs are most commonly involved but any organ can be involved. It has variable manifestations and clinical course. Diagnosis of sarcoidosis is based on clinicopathologic findings and the exclusion of other causes of granulomatous disease. Its hallmark is the formation of granulomas in affected organs. Immunosuppressive therapy is the cornerstone of the management of sarcoidosis and is indicated when there is evidence of symptomatic or progressive disease or when critical organs (ocular, cardiac, nervous system) a...
Source: The Medical Clinics of North America - April 10, 2019 Category: General Medicine Authors: Llanos O, Hamzeh N Tags: Med Clin North Am Source Type: research

IJERPH, Vol. 16, Pages 1291: Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure
Conclusions: WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution.
Source: International Journal of Environmental Research and Public Health - April 10, 2019 Category: Environmental Health Authors: Hena Murphy Zhang Shao Kazeros Reibman Tags: Article Source Type: research

Direct and indirect economic and health consequences related to sarcoidosis in Denmark: A national register-based study
This study evaluates overall the economic burden of sarcoidosis in Denmark before and after initial diagnosis.
Source: Respiratory Medicine - April 9, 2019 Category: Respiratory Medicine Authors: Melina Gade Sikj ær, Ole Hilberg, Rikke Ibsen, Kathrine Bock, Anders Løkke Source Type: research

Prognostic Biomarkers of Sarcoidosis: A Comparative Study of Serum Chitotriosidase, ACE, Lysozyme, and KL-6.
Conclusions: KL-6 is a reliable biomarker of fibrotic lung involvement in sarcoidosis patients. Among biomarkers, KL-6 showed the best sensitivity and serum chitotriosidase the best specificity, even in patients on chronic steroid therapy, and seemed to correlate with extrapulmonary localizations. PMID: 30944672 [PubMed - in process]
Source: Disease Markers - April 6, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Sarcoidosis in the renal allograft of a recipient whose primary disease was autosomal dominant polycystic kidney disease
We report a 55-year-old man with a renal allograft that developed sarcoidosis. His autosomal dominant polycystic kidney disease (ADPKD) progressed to end-stage stage renal disease when he was 52  years old, and he underwent living-donor kidney transplantation at the age of 53 years. His proteinuria worsened at 19 months post-transplantation, and his renal function began to decline at 29 months post-transplantation. A renal allograft biopsy performed at 31 months post-transplantation re vealed non-caseating granulomatous interstitial nephritis. The patient was treated with prednisolone (0.5 mg/kg/day), with gradual re...
Source: CEN Case Reports - April 5, 2019 Category: Urology & Nephrology Source Type: research

Sarcoidosis in the Middle East
B Jayakrishnan, Nasser Al-Busaidi, Saif Al-Mubaihsi, Omar A Al-RawasAnnals of Thoracic Medicine 2019 14(2):106-115Sarcoidosis, a systemic granulomatous disease of unknown cause, has been described worldwide and in all populations with notable differences in clinical characteristics, organ involvement, disease severity, and prognosis among different ethnic and racial groups. While the exact prevalence of sarcoidosis in the Middle East is unknown, studies from various countries in the region have reported the clinical characteristics of affected patients, along with a few anecdotal reports. A search of the MEDLINE and Google...
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: B Jayakrishnan Nasser Al-Busaidi Saif Al-Mubaihsi Omar A Al-Rawas Source Type: research

Scar sarcoidosis 10 years after videothoracoscopy: incidental diagnosis at 18fdg-pet-ct.
SCAR SARCOIDOSIS 10 YEARS AFTER VIDEOTHORACOSCOPY: INCIDENTAL DIAGNOSIS AT 18FDG-PET-CT. Arch Bronconeumol. 2019 Apr 05;: Authors: Viteri Jusué A, Peña AM PMID: 30962034 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - April 5, 2019 Category: Respiratory Medicine Authors: Viteri Jusué A, Peña AM Tags: Arch Bronconeumol Source Type: research

Peritoneal sarcoidosis mimicking peritoneal carcinomatosis.
CONCLUSION: Despite a peritoneal carcinomatosis was suspeted, this case shows that abdominal sarcoidosis might be considered as a differential diagnosis when a lesion suspected of being peritoneal carcinomatosis shows non-typical clinical presentations. KEY WORDS: Peritoneal sarcoidosis, Small bowel obstruction. PMID: 30938712 [PubMed - in process]
Source: Annali Italiani di Chirurgia - April 4, 2019 Category: Surgery Tags: Ann Ital Chir Source Type: research

HIF-1 α regulates IL-1β and IL-17 in sarcoidosis
Sarcoidosis is a complex systemic granulomatous disease of unknown etiology characterized by the presence of activated macrophages and Th1/Th17 effector cells. Data mining of our RNA-Seq analysis of CD14+ monocytes showed enrichment for metabolic and hypoxia inducible factor (HIF) pathways in sarcoidosis. Further investigation revealed that sarcoidosis macrophages and monocytes exhibit higher protein levels for HIF- α isoforms, HIF-1β, and their transcriptional co-activator p300 as well as glucose transporter 1 (Glut1). In situ hybridization of sarcoidosis granulomatous lung tissues showed abundance of HIF-1α in the cen...
Source: eLife - April 4, 2019 Category: Biomedical Science Tags: Human Biology and Medicine Immunology and Inflammation Source Type: research

Routine Cardiac Screening in Sarcoidosis Patients
Conditions:   Sarcoidosis;   Cardiac Sarcoidosis;   Boeck's Disease;   Besnier-Boeck Disease Interventions:   Diagnostic Test: Enhanced Screening Protocol for Cardiac Sarcoidosis.;   Diagnostic Test: Routine Screening for Suspected Cardiac Sarcoidosis Sponsor:   Foundation for Sarcoidosis Research Not yet recruiting
Source: - April 3, 2019 Category: Research Source Type: clinical trials

Sarcoidosis and idiopathic pulmonary fibrosis: The same tale or a tale of two diseases in one
We read with interest the letter submitted by Bianchi et al. regarding patients similar to those we recently described with combined sarcoidosis and idiopathic pulmonary fibrosis (CSIPF) [1]. We appreciate the interest in CSIPF and the presentation of additional patient cases. The question remains whether CSIPF represents a distinct phenotype, a coincidence or whether UIP is the common final pathway of fibrotic lung diseases such as sarcoidosis as the UIP pattern is not unique to IPF. Reports such as this demonstrate the need for further study of such patients.
Source: Respiratory Medicine - April 1, 2019 Category: Respiratory Medicine Authors: Bridget Collins, Ganesh Raghu Tags: Correspondence Source Type: research

Sarcoidosis of the Intra- and Extrahepatic Bile Ducts with Concomitant Cholangitis in a Patient with Ulcerative Colitis
Cholangitis in patients with ulcerative colitis (UC) can lead to misdiagnosis of primary sclerosing cholangitis (PSC). Furthermore, it can mimic cholangiocellular carcinoma, which also can lead to inappropriate and potentially harmful treatment of the patient. An 18-year-old male patient with known UC presented with pain in his right upper abdomen and elevation of the cholestatic liver enzymes (alkaline phosphatase: 197 U/L, γ-glutamyltransferase: 229 U/L) and increased inflammatory parameters (leukocytosis and CrP of 13.6 mg/L). Magnetic resonance cholangiopancreatography revealed unclear stenosis in the bifurcation of t...
Source: Case Reports in Gastroenterology - March 31, 2019 Category: Gastroenterology Source Type: research

Giant optic disc granuloma secondary to sarcoidosis.
Authors: El Ikhloufi M, Albaroudi N, Tijani M, Boutimzine N, Cherkaoui O PMID: 30904285 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - March 25, 2019 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

“Elderly sarcoidosis: A comparative study from a 42-year single-centre experience”
To describe the clinical features and outcomes in elderly patients with sarcoidosis and to compare them with younger patients.
Source: Respiratory Medicine - March 25, 2019 Category: Respiratory Medicine Authors: Manuel Rubio-Rivas, Xavier Corbella, Juan Ma ñá Source Type: research

Testicular pain as an atypical presentation of sarcoidosis.
We describe the case of a 25-year-old man who was referred with testicular pain. Scrotal ultrasonography demonstrated multiple bilateral hypoechoic testicular lesions that were of similar size and distributed unusually throughout the testicular parenchyma. Computed tomography detected a nodule in the middle lobe of the right lung, multiple small volume nodes in the retrocaval and left para-aortic regions, and enlarged bilateral external iliac and inguinal nodes, similar to those found in metastatic testicular cancer. Following ultrasound guided excision of one of the lesions, histopathological examination confirmed granulo...
Source: Annals of the Royal College of Surgeons of England - March 25, 2019 Category: Surgery Authors: Chierigo F, Alnajjar HM, Haider A, Walkden M, Shaikh T, Muneer A Tags: Ann R Coll Surg Engl Source Type: research

Quantifying the relationship between symptoms at presentation and the prognosis of sarcoidosis
Although it is the general consensus that sarcoidosis patients who present with sarcoidosis-related symptoms have a worse outcome than patients whose disease is detected incidentally without symptoms, this premise has not been rigorously examined.
Source: Respiratory Medicine - March 23, 2019 Category: Respiratory Medicine Authors: Marc A. Judson, Sara Preston, Kurt Hu, Robert Zhang, Stephanie Jou, Aakash Modi, Indrawattie Sukhu, Furqan Ilyas, Gavril Rosoklija, Recai Yucel Source Type: research

Biologic Therapy in the Treatment of Cutaneous Sarcoidosis: A Literature Review
AbstractSarcoidosis is an inflammatory disease defined by the presence of non-caseating granulomas. It can affect a number of organ systems, most commonly the lungs, lymph nodes, and skin. Cutaneous manifestations of sarcoidosis can impose a significant detriment to patients ’ quality of life. The accepted first-line therapy for cutaneous sarcoidosis consists of intralesional and oral corticosteroids, but these can fail in the face of resistant disease and corticosteroid-induced adverse effects. Second-line agents include tetracyclines, hydroxychloroquine, and methotr exate. Biologics are an emerging treatment option for...
Source: American Journal of Clinical Dermatology - March 20, 2019 Category: Dermatology Source Type: research

Physical Inactivity in Pulmonary Sarcoidosis
ConclusionPhysical activity is significantly reduced in sarcoidosis and is associated with reduced functional exercise capacity (6MWD). Fatigue, exertional symptoms and health status were more closely associated with time spent upright and the number of bouts of physical activity, as compared to step counts. Further studies are warranted to identify the factors that determine different physical activity profiles in sarcoidosis.
Source: Lung - March 19, 2019 Category: Respiratory Medicine Source Type: research

Identification of Active Sarcoidosis Using Chitotriosidase and Angiotensin-Converting Enzyme
ConclusionsThe algorithm involving CHITO, hs-CRP, and ACE could be a suitable strategy for differentiation between sarcoidosis activity/remission status.
Source: Lung - March 19, 2019 Category: Respiratory Medicine Source Type: research

Electrophysiology study for risk stratification in patients with cardiac sarcoidosis and abnormal cardiac imaging
ConclusionEPS may help with risk stratification in patients with CS and abnormal imaging, especially those without conventional indications for ICD placement. Among patients with LVEF>35% and no history of prior VA, a negative EPS has good positive and negative predictive value for future VA events.
Source: IJC Heart and Vasculature - March 17, 2019 Category: Cardiology Source Type: research

Safety of the use of anti-IL17A treatment in a patient with certolizumab-induced sarcoidosis.
Authors: Toussirot E, Bernard C, Bossert M Abstract PMID: 30873944 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - March 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sarcoidosis Associated Pulmonary Hypertension: Correlation of Cascular Morphologic Changes with Hemodynamic Data in Explanted Lungs
We present a series of patients with sarcoidosis associated PH and describe correlation between the pre-transplant hemodynamic data from a right heart catheterization (RHC) and vascular morphologic changes in the native explanted lungs.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Chung, K. Warrior, M. Reid, R. Nigdelioglu, S. Boyes, V. Ananthanarayanan, S. Quddus Tags: 117 Source Type: research

Undiagnosed Cardiac Sarcoidosis Has a Significant First Presentation as Sudden Cardiac Death: An Autopsy Review
Clinical findings of cardiac sarcoidosis are evident in only about 5% of patients with sarcoidosis however approximately 20% of autopsies demonstrate myocardial involvement. The epidemiology and prognosis of cardiac sarcoidosis remains poorly understood.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: D. Pedrotty, A. Rosenbaum, S. Kapa, L. Blauwet, J. Maleszewski Tags: 488 Source Type: research

Absence of Pre-Transplant Pulmonary Features of Sarcoidosis is of Low Negative Predictive Value in End-Stage Cardiac Sarcoidosis
Cardiac sarcoidosis is a potentially reversible etiology of heart failure if identified and managed in a timely fashion. Given the multisystem nature of the disease and need for a high index of suspicion, diagnosis of cardiac sarcoidosis is difficult, and the underlying cause remains speculative.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: H.K. Rokadia, A.K. Jamil, R. El Tomi, H. Zafar, T. Nisar, M. Petrozzi, R.L. Gottlieb Tags: 487 Source Type: research

Combined sarcoidosis and idiopathic pulmonary fibrosis (CSIPF): a novel disease phenotype?
we recently read with interest the case series on the novel disease entity of combined sarcoidosis and idiopathic pulmonary fibrosis (IPF/UIP) identified by Raghu et al. and defined as CSIPF (1). The association of these interstitial lung diseases (ILD) with different ethiopathogenesis and clinical course in a single patient is a real rare event, and the above description of 25 patients raises the question whether this association represents a mere coincidence or a novel phenotype consequent to a genetic undefined mutation.
Source: Respiratory Medicine - March 16, 2019 Category: Respiratory Medicine Authors: F. Bianchi, C. Piccioli, E. Rosi, L. Carobene, D. Spina, M.A. Mazzei, M. Bartolucci, C. Moroni, L. Novelli, P. Rottoli, E. Bargagli Tags: Correspondence Source Type: research

Risk factors of relapse in pulmonary sarcoidosis treated with corticosteroids
ConclusionsThis study provided useful information that the relapse and associated risk factors should be taken into considerations when determining treatment strategies for patients with pulmonary sarcoidosis.
Source: Clinical Rheumatology - March 15, 2019 Category: Rheumatology Source Type: research

Diagnosis and Therapy of Cardiac Sarcoidosis: A Clinical Perspective
Although less common than other forms of cardiomyopathy, cardiac sarcoidosis (CS), both as part of a systemic process and in its isolated form, is an important, and increasingly recognized disorder. This is felt to be due, in part, to advances in cardiac imaging and heightened awareness of the disorder.1,2 CS is associated with high rates of morbidity and mortality, including sudden cardiac death.
Source: Radcliffe Cardiology - March 13, 2019 Category: Cardiology Authors: mehul Source Type: research