Altered microRNA expression in patients with sarcoidosis
Conclusion This is the first miRNA report of differentially expressed miRNAs in the serum of patients with sarcoidosis and matched healthy controls in South Africa. The results obtained suggest that miRNAs may play a role in sarcoidosis pathogenesis. Whether these molecules have diagnostic or prognostic implications, needs future studies recruiting larger patient cohorts.PMID:37712378 | DOI:10.36141/svdld.v40i3.13399
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Rajen Morar Caroline Dickens Therese Dix-Peek Raquel Duarte Charles Feldman Source Type: research

Pulmonary vasculitis in Beh çet's disease: reference atlas computed tomography pulmonary angiography (CTPA) findings and risk assessment-management proposal
CONCLUSION: Peripheral arterial thrombosis and/or aneurysms, intracardiac thrombosis and haemoptysis severity are predictor of fatal outcomes in BD pulmonary vasculitis. PAPs with perianeurysmal alveolar haemorrhage and/or bronchial indentation are serious CTPA signs that require prompt identification and aggressive treatment. PAPs are a more serious aneurysmal pattern than true PAAs because they are a contained rupture of a PA branch in the context of pulmonary vasculitis.PMID:37712377 | DOI:10.36141/svdld.v40i3.13726
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Yasser Emad Yasser Ragab Diletta Cozzi Ossama Ibrahim Walaa Abdelrahman Mabrouk Abdelali Melek Kechida Manal Hassanin Samar Tharwat Shaimaa Salah Nashwa Elshaarawy Faten Frikha Sara Hassanein Pablo Young Sonia Pankl Bhupen Barman Alaa Abou-Zeid Johannes R Source Type: research

Protective efficacy of pirfenidone in rats with pulmonary fibrosis induced by bleomycin
CONCLUSIONS: Pirfenidone had a statistically significant protective effect in bleomycin-induced lung fibrosis and pleuritis in rats. Despite the presence of inflammation in the tissue, no significant changes were observed in inflammation markers in the peripheral blood. Novel serum biomarkers are needed to indicate the presence of inflammation and fibrosis in the lung.PMID:37712376 | DOI:10.36141/svdld.v40i3.13847
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Baris Demirkol Sule Gul Mustafa C örtük Neslihan Akan ıl Fener Emineg ül Yavuzsan Ramazan Eren Kursad Nuri Baydili Mustafa Baki Çekmen Erdogan Cetinkaya Source Type: research

Sarcoidosis and burn pit exposure in military deployers to Iraq, Afghanistan, and Southwest Asia
Conclusions: Our study suggests that the sarcoidosis in military personnel to Southwest Asia can be diagnosed many years after deployment. To our knowledge, this is the first case series to describe a group of military personnel diagnosed with sarcoidosis and exposures specific to military deployment to Southwest Asia.PMID:37712375 | DOI:10.36141/svdld.v40i3.13956
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Divya Patel Johnny Jaber Jennifer Loso Hassan Perera Salim Daouk Ayoub Innabi Diana Gomez-Manjarres Silpa Krefft Robert Miller Source Type: research

Disease progression in idiopathic pulmonary fibrosis under anti-fibrotic treatment
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023034. doi: 10.36141/svdld.v40i3.14048.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is the most common progressive interstitial disease of unknown etiology. The course of disease is not possible to predict. Frequent monitoring using multiple assessments is important to evaluate disease progression. Currently, there is no consensus on how progression should be defined. Nintedanib and pirfenidone slow the progression of IPF, but the disease can progress even under anti-fibrotic treatment. The goal of this review is to examine and summarize the current data about IPF prog...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Aykut Cilli Fatih Uzer Source Type: research

A single-center rheumatology experience of sarcoidosis: observations from 70 patients
CONCLUSIONS: Sarcoidosis is a disease that mimics many diseases, misdiagnosis and treatment should be avoided with a good and fast differential diagnosis. Clinicians, especially rheumatologists, should remember sarcoidosis more frequently and keep it in mind in the differential diagnosis.PMID:37712373 | DOI:10.36141/svdld.v40i3.14063
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Hatice Ecem Konak Serdar Can G üven Ebru Atalar P ınar Akyüz Dağlı Rezan Ko çak Ulucaköy Esra Kayacn Erdo ğan Hakan Babao ğlu Kevser Orhan İsmail Doğan Y üksel Maraş Ahmet Omma Orhan K üçükşahin Şükran Erten Source Type: research

Diagnostic and therapeutic practices of cardiac sarcoidosis in the United States: a nationwide questionnaire based study
CONCLUSIONS: The prevalence of CS in this cohort was higher than previously described. CS was a common initial presentation of sarcoidosis. The diagnosis was most likely made using cMRI. Steroids, methotrexate and infliximab are the most common medications used. Conduction abnormalities and arrhythmias often occurred.PMID:37712372 | DOI:10.36141/svdld.v40i3.14218
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Moustafa Younis Abdullah Abu Kar Mohammad Abdel Jawad Yazan Al-Zamer Diala Alawneh Divya Patel Borna Mehrad Bashar Alzghoul Source Type: research

Diagnostic value of elevated serum angiotensin-converting enzyme and lymphopenia in patients with granulomatous hepatitis
CONCLUSIONS: Those results suggests that lymphopenia and sACE may be valuable biomarkers for sarcoidosis diagnosis in GH when combined, especially in younger patients.PMID:37712371 | DOI:10.36141/svdld.v40i3.14221
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Thomas El Jammal Fran çois Dhelft Pierre Pradat Fran çois Bailly Fabien Zoulim Arnaud Hot Maxime Fauter Ayoub Drissi-Bakhkhat Isabelle Durieu Jean-Christophe Lega Yvan Jamilloux Pascal S ève Source Type: research

Bleomycin and perioperative care: a case report
We report here the successful management and perioperative care of a patient with documented bleomycin pulmonary toxicity who had to undergo an eight hour long retroperitoneal surgery. With proper preoperative assessment, chest physiotherapy, inhaled steroids and bronchodilators, antibiotics, operative restriction of oxygen and fluids and good postoperative care no further pulmonary insult was inflicted.PMID:37712370 | DOI:10.36141/svdld.v40i3.14385
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: B Jayakrishnan Rajini Kausalya Hilal A Al-Rashdi Kirubakaran Davis Jahfar Ali Munjid Al-Harthy Sami M Bennji Source Type: research

Risk factors for the development of interstitial lung disease following severe COVID-19 pneumonia and outcomes of systemic corticosteroid therapy: 3-month follow-up
CONCLUSIONS: In conclusion, after severe COVID-19 pneumonia, persistent clinical symptoms and pulmonary parenchymal involvement would be inevitable in elder and smoker patients. Moreover, corticosteroid treatment in patients with severe parenchymal involvement was found to be effective in the improvement of radiological and functional parameters.PMID:37712369 | DOI:10.36141/svdld.v40i3.14418
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Sibel G ünay Izzet Selcuk Parlak Habibe Hezer Ebru Şengül Şeref Parlak Melike Sanem Umut Zeynep Hanc ıoğlu H ülya Çelenk Ergüden Yasin Kocaman Aynil Dalk ıran Ümran Sertçelik İrem Şerifoğlu Esmehan Akp ınar Muhammet Furkan G öktaş Meltem Source Type: research

Life threating onset of Cardiac Sarcoidosis with mediastinal involvement
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023042. doi: 10.36141/svdld.v40i3.14519.ABSTRACTWe have described a clinical case with atypical onset of sarcoidosis. A young patient presented to the emergency room with acute heart failure and severe cardiac dysfunction simulating dilated cardiomyopathy or severe myocarditis. Hypoxic respiratory failure refractory to oxygen therapy was treated with steroids. The diagnosis was made by a multidisciplinary team who decided to perform EndoBronchial UltraSound-guided TransBronchial Needle Aspiration (EBUS TBNA) in addition to a cardiac MRI. The result was to obtain, in th...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Marcello Ciuffreda Valentina Valenti Giuseppe Manfr è Antonio Barberi Patrizia Porzi Francesco Versaci Antonella Sarni Source Type: research

The role of systemic immune-inflammation index (SII) in the differential diagnosis of granulomatous and reactive LAP diagnosed by endobronchial ultrasonography
CONCLUSION: SII may be an easily applicable parameter in the differentiation of tuberculosis and sarcoidosis LAP with granuloma and in the differentiation of granulomatous diseases from reactive LAP.PMID:37712366 | DOI:10.36141/svdld.v40i3.14743
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Bu ğra Kerget Dursun Erol Af şin Alperen Aksakal Source Type: research

Elderly-onset pulmonary sarcoidosis: A radiological approach to diagnosis
CONCLUSIONS: Presentation of elderly-onset sarcoidosis appears to differ from young-onset sarcoidosis. Radiologically, lymph node enlargement and the pattern of fibrosis may be distinctive.PMID:37712365 | DOI:10.36141/svdld.v40i3.14829
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Sevtap Do ğan Onural Öztürk Sevil Aydo ğan Diş Serap Argun Bar ış Nurettin Özgür Doğan Source Type: research

Pulmonary fibrosis in sarcoidosis
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023027. doi: 10.36141/svdld.v40i3.14830.ABSTRACTSarcoidosis may progress to pulmonary fibrosis in 5% of patients with significantly increased mortality. Histopathology shows fibrosis in a lymphangitic pattern surrounding the granulomas. Th1 to Th2 shift in environment along with angiogenesis is implicated in exuberant fibrosis. Clinical features include dyspnea, cough, and frequently with pulmonary function tests showing a mixed ventilatory defect with severely decreased diffusion capacity of carbon monoxide. Serologic markers including soluble interleukin 2 receptor, ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Huda Asif Manuel Ribeiro Neto Daniel Culver Source Type: research

In Memory of Professor Takateru Izumi
Sarcoidosis Vasc Diffuse Lung Dis. 2023 Sep 13;40(3):e2023025. doi: 10.36141/svdld.v40i3.15024.ABSTRACTPMID:37712363 | DOI:10.36141/svdld.v40i3.15024
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Azuma Arata Source Type: research

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