This page shows you the latest news items in this category. This is page number 17.

Total 5143 results found since Jan 2013.

Importance of Early Diagnosis of Cardiac Sarcoidosis in Patients with Complete Atrioventricular Block.
Authors: Kaida T, Inomata T, Minami Y, Yazaki M, Fujita T, Iida Y, Ikeda Y, Nabeta T, Ishii S, Naruke T, Maekawa E, Koitabashi T, Ako J Abstract Our aim is to clarify the factors for early diagnosis of cardiac sarcoidosis (CS) in patients with complete atrioventricular block (CAVB) and its impact on cardiac function after corticosteroid therapy.A total of 15 CS patients with CAVB who underwent corticosteroid therapy were retrospectively analyzed. Patients were divided into two groups according to the time from the first CAVB onset to the diagnosis of CS. Clinical characteristics and outcomes were compared between t...
Source: International Heart Journal - May 30, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Sarcoidosis Clinician's Perspective of MHC Functional Elements Outside the Antigen Binding Site.
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. This manuscript provides a brief clinical description of sarcoidosis, and a clinician's perspective of the immunopathogenesis of sarcoidosis in terms of the MHC binding site, MHC functional elements beyond the binding site, and other possible alternative mechanisms. Input from cl...
Source: Human Immunology - May 30, 2018 Category: Allergy & Immunology Authors: Judson MA Tags: Hum Immunol Source Type: research

Prognostic significance of ventricular late potentials in patients with pulmonary sarcoidosis
Early detection of cardiac involvement in sarcoidosis is difficult but essential to achieve optimal treatment. Signal-averaged electrocardiography (SAECG) can detect subtle cardiac electrical abnormalities termed late potentials (LPs) and would be useful for the early diagnosis of cardiac involvement.
Source: Heart Rhythm - May 29, 2018 Category: Cardiology Authors: Kenji Yodogawa, Yoshihiko Seino, Toshihiko Ohara, Yu-ki Iwasaki, Meiso Hayashi, Yasushi Miyauchi, Arata Azuma, Wataru Shimizu Tags: Featured Article Source Type: research

Three Cases of Scalp Sarcoidosis with Alopecia.
PMID: 29857946 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - May 29, 2018 Category: Dermatology Authors: Ishikawa M, Ohtsuka M, Yamamoto T Tags: Actas Dermosifiliogr Source Type: research

Unusual presentation of a skull base mass lesion in sarcoidosis mimicking malignant neoplasm: a case report
Sarcoidosis is a multi-organ disease of unknown etiology characterised by the presence of epithelioid granulomas, without caseous necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis i...
Source: BMC Neurology - May 29, 2018 Category: Neurology Authors: Katsunori Shijo, Nobuhiro Moro, Mari Sasano, Mitsuru Watanabe, Hiroshi Yagasaki, Shori Takahashi, Taku Homma and Atsuo Yoshino Tags: Case report Source Type: research

IJERPH, Vol. 15, Pages 1077: Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis
This study aimed to determine if short-term exposure to particulate matter (PM2.5) and ozone (O3) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM2.5 and O3 estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline > 10%) and questionnaire outcomes (Leicester cough quest...
Source: International Journal of Environmental Research and Public Health - May 26, 2018 Category: Environmental Health Authors: Cheryl S. Pirozzi Daniel L. Mendoza Yizhe Xu Yue Zhang Mary Beth Scholand Robert P. Baughman Tags: Article Source Type: research

Importance of differential diagnosis post-treatment of adenocarcinoma of the uterine cervix: a case report of sarcoidosis.
This study shows the importance of differential diagnosis during the oncologic monitoring of cervical cancer patients to avoid unnecessary treatments at the expense of better therapeutic options. PMID: 29787017 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea.
Conclusions: In patients with biopsy-proven pulmonary sarcoidosis, the presence of ocular involvement and uveitis as a first sign could be significant factors associated with higher systemic treatment rate, especially with immunosuppressive agents. Biopsy site determined by location and size had no influence on clinical features. PMID: 29785303 [PubMed]
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Quantification of global FDG uptake as a novel imaging modality to assess Sarcoidosis in the diseased organs and the entire body
Conclusions: Currently, FDG-PET is not used as a first-line imaging modality in sarcoidosis, as it is considered to be of value for advanced and relapsing stages of the disease. However, having a score that allows assessment of global disease activity in the body will provide potential for expanding the clinical utility of FDG-PET to evaluate disease behavior, treatment response and disease relapse at any stage of this common inflammatory disorder.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Al-zaghal, A., Jahangiri, P., Pournazari, K., Khosravi, M., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research

Novel approach of FDG PET for diagnosing of cardiac sarcoidosis -application possibility of the texture analysis-
Conclusions: Our findings revealed that the texture analysis could apply for the diagnosis of CS with high inter-operator and inter-scan reproducibility. Reference: Ref1 Manabe O, Kroenke M, Aikawa T, Murayama A, Naya M, Masuda A, Oyama-Manabe N, Hirata K, Watanabe S, Shiga T, Katoh C, Tamaki N. J Nucl Cardiol. 2017 Dec 14. doi: 10.1007/s12350-017-1122-6. Ref2 Orlhac F, Soussan M, Maisonobe JA, Garcia CA, Vanderlinden B, Buvat I. Tumor texture analysis in 18F-FDG PET: relationships between texture parameters, histogram indices, standardized uptake values, metabolic volumes, and total lesion glycolysis. J Nucl Med 2014;55:414-22.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Manabe, O., Hirata, K., Ohira, H., Tsujino, I., Naya, M., Aikawa, T., Oyama-Manabe, N., Tamaki, N. Tags: Cardiovascular Basic Science Poster Session Source Type: research

18F-FDG PET-CT in the clinical management of cardiac sarcoidosis: A regional academic referral center experience.
Conclusion 18F-FDG PET-CT is an effective tool in the clinical management of CS, including its initial diagnosis and assessment following therapy. Although not statistically significant, patients treated for a longer duration were more likely to respond to the therapy. Additionally, dual immunomodulator therapy with prednisone and methotrexate may improve therapeutic response in CS. Figure 1. F-18 FDG PET-CT MIP and axial fused PET-CT images showing (A) focal on diffuse hypermetabolic activity in the left ventricular myocardium consistent with cardiac sarcoidosis, and (B) resolution of the myocardial activity following imm...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Rieter, W., Burchett, P., De Cecco, C., James, W., Hargrave, P., Nance, J., Gordon, L. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

Exploring the optimal reference to estimate the effect of anti-inflammatory therapy for the cardiac sarcoidosis -metabolic volume assessment of FDG PET-
Conclusions: We measured the FDG uptake in the liver and blood pool before and during steroid therapy. Steroid therapy might be increase the liver FDG uptake because of its effect on glyceroneogenesis in the liver and adipose tissue. However, the blood pool uptake didn’t show significant differences. Our findings revealed that the DA is suitable threshold rather than liver uptake to evaluate the therapy effect using volume-based analysis of cardiac FDG PET.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Furuya, S., Hirata, K., Manabe, O., Hiroshi, O., Naya, M., Aikawa, T., Koyanagawa, K., Tsujino, I., Shiga, T., Kudo, K. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

Low downstream event rate in patients without clinical cardiac sarcoidosis referred for cardiac FDG-PET imaging
Conclusion: In patients not meeting clinical criteria for CS and without extra-cardiac sarcoidosis, the overall event rate was similar between patients with and without abnormal FDG uptake. The overall low event rate suggests a potential lack of clinical utility in obtaining FDG PET imaging for all patients with non-ischemic cardiomyopathy to evaluate for CS. Future investigations are needed to determine if FDG PET imaging may be better targeted to certain subgroups of patients with non-ischemic cardiomyopathy.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Varghese, M., Miller, E. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

FDG-PET/CT performances to detect systemic sarcoidosis in patients from a general hospital in Europe
Conclusions: Our retrospective study shows that FDG PET/CT examination is a reliable method to detect systemic sarcoidosis (high sensibility, specificity, PPV, NPV and accuracy). However further evaluation of cost effectiveness of this examination, and a more comprehensive understanding on which patients would benefit from this intervention are warranted.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Trabelsi, K., Muteganya, R., Garcia, C. Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research

Tuberculosis and Sarcoidosis Imaging in 18F-FDG-PET/CT: Consistencies and Inconsistencies
Conclusions: Apart from the common capability of showing anatomic spread of disease in the whole body in one single examination for both TB and SC, in TB 18F-FDG seems to be a good predictor for the extent of disease by assessment of the highest SUV seen in any pathological lesion and for therapy control, too, as indicated in earlier work. In SC, FDG-uptake markedly focuses on lymph nodes, consistent with the natural history of the disease. However, we see uptake behavior clearly different from TB in respect of the prediction of disease extent and some other features. Evaluation of the relevance of these facts for initial ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Huber, H., Lang, D., Fellner, F., Lamprecht, B., Gabriel, M. Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research

Use of deep convolutional neural network-based features for detection of cardiac sarcoidosis from polar map
Conclusions: The classification performance of DCNN-based features outperformed the CoV-based classification performance. Experimental results suggested that DCNN-based high-dimensional features have a potential of semi-automated diagnosis of CS.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Togo, R., Hirata, K., Manabe, O., Ohira, H., Tsujino, I., Ogawa, T., Haseyama, M., Shiga, T. Tags: Deep Learning In Molecular Imaging Studies Source Type: research

Sarcoidosis
Source: eMedicineHealth.com - May 22, 2018 Category: General Medicine Source Type: news

Sarcoidosis-Like Granulomatous Reaction Associated With Pembrolizumab Immunotherapy.
PMID: 29801680 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - May 22, 2018 Category: Respiratory Medicine Authors: Gayá García-Manso I, García Ródenas MDM, Barroso Medel ME, Illán Gambín FJ Tags: Arch Bronconeumol Source Type: research

Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses.
CONCLUSION: Our results suggest that sarcoidosis is a new subset in the spectrum of paraneoplastic syndrome. We propose that lymphoproliferative disorders should be considered in patients with cutaneous sarcoidosis who have a poor response to conventional therapy or whose skin biopsy shows a significant number of mitoses. PMID: 29779211 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - May 20, 2018 Category: Cancer & Oncology Authors: El-Khalawany M, Mosbeh A, Aboeldahab S, Ali S Tags: Clin Exp Dermatol Source Type: research

Plasmapheresis in a Patient with Sarcoidosis Who Developed Multiple Myeloma and Massive Free Kappa Light Chains Nephropathy.
Authors: Markel A, Habashe N, Aviv A, Monich O, Elmalah I, Marei N, Tovbin D PMID: 29761682 [PubMed - in process]
Source: The Israel Medical Association Journal - May 19, 2018 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

A Clinical Study of Tranilast in the Treatment of Sarcoidosis
Condition:   Sarcoidosis Intervention:   Drug: Tranilast Sponsor:   The First Affiliated Hospital with Nanjing Medical University Not yet recruiting
Source: ClinicalTrials.gov - May 17, 2018 Category: Research Source Type: clinical trials

Sarcoidosis diagnostic score (SDS): a systematic evaluation to enhance the diagnosis of sarcoidosis.
CONCLUSIONS: For sarcoidosis, the presence of specific clinical features, especially multi-organ involvement, can enhance the diagnostic certainty. The SDS scoring system quantitated the clinical features consistent with sarcoidosis. PMID: 29778660 [PubMed - as supplied by publisher]
Source: Chest - May 17, 2018 Category: Respiratory Medicine Authors: Bickett AN, Lower EE, Baughman RP Tags: Chest Source Type: research

Histologic Review of Sarcoidosis in a Neck Lymph Node
AbstractSarcoidosis is a multisystem granulomatous disease of unknown etiology. It may occur at any age, but is most commonly seen in young to middle age adults. Sarcoidosis remains more common in women regardless of geographic or racial boundaries. Although the etiology remains unclear, the most common explanation is that sarcoidosis is a disease of immunologic dysregulation triggered by an as yet unidentified environmental or microbial antigen in genetically susceptible persons. We review a case of sarcoidosis with was initially diagnosed in a neck lymph node that was removed for evaluation of metastatic squamous cell ca...
Source: Head and Neck Pathology - May 15, 2018 Category: Pathology Source Type: research

Abdominal Sarcoidosis Mimicking Peritoneal Carcinomatosis.
We present a patient diagnosed with skin sarcoidosis, breast cancer, pulmonary tuberculosis, and peritoneal sarcoidosis with a past history of colorectal cancer. During stage work up for breast cancer, suspicious lesions on peritoneum were observed in imaging studies. Considering our patient's history and imaging findings, we initially suspected peritoneal carcinomatosis. However, the peritoneal lesion was diagnosed as sarcoidosis in laparoscopic biopsy. This case demonstrates that abdominal sarcoidosis might be considered as a differential diagnosis when there is a lesion suspected of being peritoneal carcinomatosis with ...
Source: Annals of Coloproctology - May 11, 2018 Category: Gastroenterology Tags: Ann Coloproctol Source Type: research

Clinical and prognostic significance of muscle biopsy in sarcoidosis.
Authors: Yanardag H, Tetikkurt C, Bilir M Abstract The main objective of this study was to evaluate the influence of muscle involvement on the clinical features, prognostic outcome, extrapulmonary organ, and endobronchial involvement in sarcoidosis patients. The second aim was to assess the diagnostic yield of muscle biopsy for the histopathologic identification of sarcoidosis.  Fifty sarcoidosis patients participated in the study. The patients were classified into two groups according to the histopathologic presence of non-caseating granulomatous inflammatory pattern of the muscle biopsy samples and were evaluate...
Source: Monaldi Archives for Chest Disease - May 11, 2018 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Cutaneous Manifestation of Sarcoidosis in Lower-Back Tattoo With Increased Uptake of 18F-FDG
We present a rare case of a 37-year-old woman with bihilar, mediastinal, and abdominal lymphadenopathy in conjunction with a histologically proven cutaneous manifestation of sarcoidosis in a tattoo of the lower back exhibiting an increased uptake of FDG.
Source: Clinical Nuclear Medicine - May 10, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

11C-4DST PET/CT Imaging of Cardiac Sarcoidosis: Comparison With 18F-FDG and Cardiac MRI
A 75-year-old woman with a history of sarcoidosis presenting with low cardiac output and complete right bundle-branch block underwent 4′-[methyl-11C]-thiothymidine (4DST) PET/CT after cardiac MRI and FDG PET/CT for the evaluation of suspected cardiac sarcoidosis (CS) before treatment. Cardiac MRI revealed late gadolinium enhancement on the anterior-to-lateral and posterior wall, indicating CS. FDG uptake was shown on the anterior-to-lateral wall, but not on the posterior wall. In contrast, 4DST uptake was demonstrated on both anterior-to-lateral and posterior walls. Use of 4DST appears promising for detecting CS without ...
Source: Clinical Nuclear Medicine - May 10, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Clinical features of sarcoidosis associated pulmonary hypertension: Results of a multi-national registry
Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in sarcoidosis. We established a multi-national registry of sarcoidosis associated PH (SAPH) patients.
Source: Respiratory Medicine - May 5, 2018 Category: Respiratory Medicine Authors: Robert P. Baughman, Oksana A. Shlobin, Athol U. Wells, Esam H. Alhamad, Daniel A. Culver, Joseph Barney, Francis C. Cordova, Eva M. Carmona, Mary Beth Scholand, Marlies Wijsenbeek, Sivagini Ganesh, Surinder S. Birring, Vasilis Kouranos, Lanier O'Hare, Joa Source Type: research

Sarcoidosis: a state of the art review from the Thoracic Society of Australia and New Zealand.
Authors: Ahmadzai H, Huang S, Steinfort C, Markos J, Allen RK, Wakefield D, Wilsher M, Thomas PS Abstract Sarcoidosis is a systemic disease of unknown aetiology, characterised by non-caseating granulomatous inflammation. It most commonly manifests in the lungs and intrathoracic lymph nodes but can affect any organ. This summary of an educational resource provided by the Thoracic Society of Australia and New Zealand outlines the current understanding of sarcoidosis and highlights the need for further research. Our knowledge of the aetiology and immunopathogenesis of sarcoidosis remains incomplete. The enigma of sarc...
Source: Medical Journal of Australia - May 4, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes
ConclusionRight ventricular involvement seems to be more common in patients who also have findings suggestive of suspected systemic sarcoidosis, compared with patients with PET findings indicative of isolated cardiac disease.
Source: Journal of Nuclear Cardiology - May 2, 2018 Category: Nuclear Medicine Source Type: research

The 39th Annual Meetingof Japan Society of Sarcoidosis and other Granulomatous Disorders
Date: Tuesday, May 1, 2018Year: 2018Location: Pacifico Yokohama, JapanContent-type: current_conferences
Source: The Aspergillus Website - updates - May 1, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976 –2013—supplementary presentation
AbstractIncidence of fragility fracture of a population-based cohort of 345 patients with sarcoidosis was compared with age- and sex-matched comparators. The incidence of fragility fracture was higher among patients with sarcoidosis with a hazard ratio (HR) of 2.18.
Source: Osteoporosis International - May 1, 2018 Category: Orthopaedics Source Type: research

Systemic sclerosis and sarcoidosis: a rare case of chronic intestinal pseudo-obstruction.
We report the case of a male with a diagnosis of sarcoidosis that was admitted due to abdominal distension and pain. After a thorough investigation, he was diagnosed with severe chronic intestinal pseudo-obstruction as a manifestation of SSc. PMID: 29699402 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - April 29, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

437 Efficacy and safety of tumor necrosis factor inhibitors in cutaneous sarcoidosis: A systematic review
Sarcoidosis is a multisystem disease of unknown etiology characterized by noncaseating granulomas that often affect the skin. Tumor necrosis factor (TNF) is essential in formation of granulomas. Growing evidence supports anti-TNF agents for refractory sarcoidosis, including infliximab (IFX), etanercept, adalimumab ( ADA ), golimumab (GOL) and certolizumab. We sought to characterize the efficacy and safety of anti-TNF in all types of sarcoidosis by performing a systematic review that included trials and case series.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: B. Adler, C. Wang, T. Bui, H. Schilperoort, A.W. Armstrong Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research

Diagnostic Yield of Transbronchial Biopsy in Comparison to High Resolution Computerized Tomography in Sarcoidosis Cases
This study aimed to evaluate the diagnostic yield of fiberoptic bronchoscopic (FOB) transbronchial biopsy and its relation with quantitative findings of high resolution computerized tomography (HRCT). A total of 83 patients, 19 males and 64 females with a mean age of 45.1 years diagnosed with sarcoidosis with complete records of high resolution computerized tomography were retrospectively recruited during the time period from Feb 2005 to Jan 2015. High resolution computerized tomography scans were retrospectively assessed in random order by an experienced observer without knowledge of the bronchoscopic results or lung func...
Source: Asian Pacific Journal of Cancer Prevention - April 27, 2018 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Utility of 18F-FDG PET/CT for Monitoring Response and Predicting Prognosis after Glucocorticoids Therapy for Sarcoidosis.
In conclusion, the present study shows that 18F-FDG PET/CT is an effective way to monitor the early therapeutic reaction and is helpful in predicting the long-term prognosis of sarcoidosis. PMID: 29686996 [PubMed - in process]
Source: Biomed Res - April 26, 2018 Category: Research Authors: Chen H, Jin R, Wang Y, Li L, Li K, He Y Tags: Biomed Res Int Source Type: research

Spontaneous Reduction in Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxygluose in a Patient with Cardiac Sarcoidosis.
Authors: Terasaki F, Fujita SI, Kanzaki Y, Hirose Y, Ishizaka N Abstract Fluorine-18 fluorodeoxygluose (18F-FDG) positron emission tomography (PET) is a useful tool for evaluating disease activity in sarcoidosis including cardiac involvement. A 67-year-old patient who developed atrioventricular block requiring permanent pacemaker implantation was diagnosed with cardiac sarcoidosis. The patient did not undergo steroid or immunosuppressive therapy but underwent serial 18F-FDG PET examination, which showed spontaneous reduction in the myocardial FDG uptake, indicating the remission of immune-inflammatory activity. Alt...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research