This page shows you the latest news items in this category. This is page number 17.

Total 4720 results found since Jan 2013.

Emergency Radiotherapy for Spinal Cord Compression due to Bone Sarcoidosis.
Authors: Tanaka Y, Taima K, Tanaka H, Itoga M, Ishioka Y, Shiratori T, Tsuchiya J, Sakamoto H, Takanashi S, Tasaka S Abstract Sarcoidosis is an inflammatory granulomatous disease that is systemic, but bone involvement is uncommon. A 68-year-old man was referred to our hospital complaining of right shoulder pain with numbness. Computed tomography revealed systemic lymphadenopathy and multiple bone lesions. Because malignant lymphoma with a mass lesion protruding into the vertebral canal was considered, he underwent urgent radiotherapy. Thereafter, a needle biopsy of the left parasternal node was performed and showed...
Source: Internal Medicine - November 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Cardiac Sarcoidosis Presenting as Acute Progressive Heart Failure with Abdominal Lymphadenopathy.
Authors: Oka S, Umetani K, Harama T, Shimizu T, Makino A, Sano K, Nakamura M Abstract A 77-year-old Japanese woman presented with asymptomatic abdominal lymphadenopathy. Soluble interleukin-2 receptor (sIL2R) and angiotensin-converting enzyme (ACE) levels were elevated, and a pathological examination of lymph-node biopsies revealed non-caseating granulomas, which was consistent with sarcoidosis. Fluorodeoxyglucose-positron emission tomography did not show a clear accumulation in the mediastinal lymph-nodes or heart. Five months later, she presented with acute progressive heart failure that was refractory to convent...
Source: Internal Medicine - November 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Clinical Characteristics and Computed Tomography Findings in Arab Patients Diagnosed with Pulmonary Sarcoidosis
CONCLUSION: At presentation, clinical manifestations of sarcoidosis among this sample of Arab patients were similar to reports from other nations. Further studies are needed to explore the effects of race and ethnicity on disease severity in the Middle East. Ann Saudi Med 2009; 29(6): 454-459PMID: 19847083 DOI: 10.4103/0256-4947.57168
Source: Annals of Saudi Medicine - November 20, 2017 Category: General Medicine Tags: ISSUE 6 Source Type: research

Endpoints in sarcoidosis: More like IPF or asthma?
Sarcoidosis remains an enigmatic disease. Its cause is unknown, the indications for treatment are often unclear, and its natural history is variable. An additional important enigmatic issue that has hampered clinical sarcoidosis research is the failure to develop reliable and universally accepted clinical endpoints.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study
Fatigue is a major and disabling problem in sarcoidosis. Knowledge concerning correlates of the development of fatigue and possible interrelationships is lacking.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Celine Hendriks, Marjolein Drent, Willemien De Kleijn, Marjon Elfferich, Petal Wijnen, Jolanda De Vries Source Type: research

Endpoints in sarcoidosis: More like IPF or asthma?
Sarcoidosis remains an enigmatic disease. Its cause is unknown, the indications for treatment are often unclear, and its natural history is variable. An additional important enigmatic issue that has hampered clinical sarcoidosis research is the failure to develop reliable and universally accepted clinical endpoints.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study
Fatigue is a major and disabling problem in sarcoidosis. Knowledge concerning correlates of the development of fatigue and possible interrelationships is lacking.
Source: Respiratory Medicine - November 20, 2017 Category: Respiratory Medicine Authors: Celine Hendriks, Marjolein Drent, Willemien De Kleijn, Marjon Elfferich, Petal Wijnen, Jolanda De Vries Source Type: research

Oral manifestation of sarcoidosis: A case report and review of the literature
Vladimíra Radochova, Jakub Radocha, Jan Laco, Radovan SlezákJournal of Indian Society of Periodontology 2016 20(6):627-629Sarcoidosis is a common multisystemic granulomatous disease characterized by the formation of nonnecrotizing epithelioid granulomas in various body organs. The most commonly affected organs in the head-and-neck region include salivary glands and cervical lymph nodes. Involvement of the oral mucosa is very rare. The purpose of this report is to present an atypical oral manifestation of sarcoidosis with ulcerations of the buccal mucosa in a 59-year-old female.
Source: Journal of Indian Society of Periodontology - November 17, 2017 Category: Dentistry Authors: Vladim & #237;ra Radochova Jakub Radocha Jan Laco Radovan Slez & #225;k Source Type: research

Soluble Interleukin 2 Receptor IDs Sarcoidosis in Uveitis
sIL - 2R has slightly better diagnostic value than ACE for sarcoidosis in patients with uveitis
Source: Pulmonary Medicine News - Doctors Lounge - November 13, 2017 Category: Respiratory Medicine Tags: Internal Medicine, Emergency Medicine, Ophthalmology, Pathology, Pulmonology, Rheumatology, Journal, Source Type: news

Infliximab for the treatment of CNS sarcoidosis: A multi-institutional series
Conclusions: Most patients with CNS sarcoidosis treated with infliximab exhibit favorable imaging and clinical treatment responses, including some previously refractory to other immunosuppressive treatments. Classification of evidence: This study provides Class IV evidence that for patients with CNS sarcoidosis infliximab is associated with favorable imaging and clinical responses.
Source: Neurology - November 13, 2017 Category: Neurology Authors: Gelfand, J. M., Bradshaw, M. J., Stern, B. J., Clifford, D. B., Wang, Y., Cho, T. A., Koth, L. L., Hauser, S. L., Dierkhising, J., Vu, N., Sriram, S., Moses, H., Bagnato, F., Kaufmann, J. A., Ammah, D. J., Yohannes, T. H., Hamblin, M. J., Venna, N., Green Tags: All Immunology ARTICLE Source Type: research

Cardiac sarcoidosis presenting as arrhythmogenic right ventricular cardiomyopathy/dysplasia with ventricular aneurysms: a case report
A 70-year old Caucasian man with recurrent ventricular tachycardia and progressive biventricular failure attributed to arrhythmogenic right ventricular cardiomyopathy/dysplasia was evaluated for heart transplantation. Cardiac ventriculography revealed an abnormal left ventricle with five saccular aneurysms. Heart transplantation was performed. Pathology of the explanted heart showed multifocal sarcoid granulomas. Replacement fibrosis was widespread in both ventricles and associated with saccular aneurysms.
Source: Cardiovascular Pathology - November 10, 2017 Category: Cardiology Authors: Marija Petrovic, L. Maximilian Buja, Biswajit Kar, Jure Colnaric, Sarita Damaraju, Bihong Zhao, Bindu Akkanti, Milan Radovanovic, Rajko Radovancevic, Pranav Loyalka, Igor D. Gregoric Tags: Clinical Case Report Source Type: research

Physical Activity and Fatigue in Patients with Sarcoidosis
Conclusion: While exercise capacity and quality of life measurements were robust predictors of physical activity in patients with sarcoidosis, associations of objectively measured physical activity with fatigue were surprisingly weak. In sarcoidosis, fatigue might not preclude affected patients from being physically active, although this symptom is subjectively perceived as highly disabling.Respiration
Source: Respiration - November 9, 2017 Category: Respiratory Medicine Source Type: research

Atypical HRCT manifestations of pulmonary sarcoidosis
Conclusions and DiscussionThe atypical pulmonary alterations found in CT examination can be confused with other lung diseases and they are always a challenge even for the most experienced radiologist. In our experience, cases with atypical pulmonary sarcoidosis patterns evaluated in the study are consistent with similar cases described in the literature, both in lymph node and atypical parenchymal involvement. All the atypical characteristics of the work should alert the radiologist to consider sarcoidosis among the possible differential diagnoses, always correlating the results of the computed tomography examination with ...
Source: La Radiologia Medica - November 9, 2017 Category: Radiology Source Type: research

The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis
Conditions:   Sarcoidosis;   Sarcoidosis, Pulmonary;   ILD;   Interstitial Lung Disease Intervention:   Diagnostic Test: Exercise Sponsor:   Kingston University Recruiting
Source: ClinicalTrials.gov - November 8, 2017 Category: Research Source Type: clinical trials

Nail Sarcoidosis Presenting with Longitudinal Erythronychia
A 37-year-old woman presented with progressive longitudinal erythronychia and onychorrhexis of the toenails. She had a history of sarcoidosis of the lung and nose, which was silent without treatment at the time of presentation. Histopathological examination of a nail matrix biopsy revealed granulomas with palisading histiocytes in the connective tissue and a lymphocytic infiltrate in and around the granulomas without necrosis. Based on the clinical presentation, medical history, and histopathological examination, the diagnosis of nail sarcoidosis was made. Treatment with triamcinolone acetonide 40 mg/mL resulted in the dis...
Source: Skin Appendage Disorders - November 8, 2017 Category: Dermatology Source Type: research

Extensively disturbance of regulatory T cells - Th17 cells balance in stage II pulmonary sarcoidosis.
CONCLUSIONS: Disturbance of T memory cells, Th1/Th2, and Tregs/Th17 cells, and activation of PI3K/Akt signaling were seen in newly diagnosed stage II pulmonary sarcoidosis, which can be partly ameliorated by corticosteroids treatment. PMID: 29104468 [PubMed - in process]
Source: International Journal of Medical Sciences - November 8, 2017 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Novel ECG parameters are strongly associated with inflammatory 18F-FDG PET findings in patients with suspected cardiac sarcoidosis
In this study, our aim was to determine whether novel ECG parameters are associated with pathological PET findings in patients with suspected cardiac sarcoidosis.
Source: International Journal of Cardiology - November 6, 2017 Category: Cardiology Authors: Kalle Sipil ä, Heikki Tuominen, Atte Haarala, Antti Tikkakoski, Mika Kähönen, Kjell Nikus Source Type: research

IgG4-related disease in thymus. A very rare case of chronic fibrosis mimicking sarcoidosis.
Authors: Simonetti S, Pérez Muñoz N, López Vivancos J, Sanchez Sitjes L, Herranz Pérez JC, Leal Bohorquez N, Maestre Alcacer JA, de García IK, Carrasco García MÁ Abstract IgG4-related disease (IgG4-RD) is a multi-organ immune-mediated chronic fibroinflammatory condition, with unclear certain etiology. It is morphologically characterized by storiform fibrosis, dense IgG4-positive lymphoplasmacytic infiltrate, and obliterative phlebitis. It was recognized as a systemic condition as recently as 2003. IgG4-RD has been described in virtually every organ, forming sclerosing masses, and often mimicking tumors. Clin...
Source: Tumori - November 5, 2017 Category: Cancer & Oncology Tags: Tumori Source Type: research

Cardiac sarcoidosis: infiltrating under cover
This article describes a case of a heart explanted at transplantation for a clinical diagnosis of dilated cardiomyopathy associated with heart block. Pathological examination of the heart demonstrated non-necrotising granulomas with replacement fibrosis, consistent with sarcoidosis. Cardiac involvement in sarcoidosis may cause chronic cardiac failure, arrhythmia, or sudden cardiac death, and may occur in patients without clinical involvement of other organ systems. Most cases of cardiac sarcoidosis treated by heart transplantation are unsuspected until the explanted heart is examined, with most cases thought to be dilated ...
Source: Diagnostic Histopathology - November 5, 2017 Category: Pathology Authors: Stephen D. Preston Tags: Short case Source Type: research

Treatment of intramural ventricular tachycardia in cardiac sarcoidosis with transcoronary ethanol ablation
A 67-year-old man with sarcoidosis presented with recurrent ventricular tachycardia (VT) despite treatment with amiodarone. Cardiac magnetic resonance imaging demonstrated delayed enhancement of the mid-myocardium in the inferolateral wall and septum (Figure, upper panel) and cardiac positron emission tomography –computed tomography (PET-CT) showed a perfusion defect with increased uptake of 18F-fluorodeoxyglucose in the same region. Two inducible VTs were both mapped to the cardiac crux along the inferior interventricular septum (RBBB, superior axis and LBBB, superior axis, respectively). Prior attempts at radiofrequenc...
Source: Europace - November 4, 2017 Category: Cardiology Source Type: research

Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013
To evaluate the risk and pattern of multimorbidity in patients with sarcoidosis.
Source: Mayo Clinic Proceedings - November 3, 2017 Category: Internal Medicine Authors: Patompong Ungprasert, Eric L. Matteson, Cynthia S. Crowson Tags: Original article Source Type: research

Right ventricular scar ‐related ventricular tachycardia in nonischemic cardiomyopathy: Electrophysiological characteristics, mapping, and ablation of underlying heart disease
ConclusionsUp to one‐third of patients with RV scar‐related VT are not classifiable as ARVC/D or CS. These patients had a somewhat better prognosis than ARVC/D or sarcoid and did not develop evidence of these diseases during the initial 2 years of follow‐up. The extent to which this population comprises mild ARVC/D, CS, or other diseases is not clear.
Source: Journal of Cardiovascular Electrophysiology - November 3, 2017 Category: Cardiology Authors: Saurabh Kumar, Samuel H. Baldinger, Sunil Kapur, Jorge Romero, Nishaki K. Mehta, Saagar Mahida, Akira Fujii, Usha B. Tedrow, William G. Stevenson Tags: ORIGINAL ARTICLE Source Type: research

Patient page-sarcoidosis imaging
AbstractOptimizing our imaging capabilities for patients with cardiac sarcoidosis is critical as it has diagnostic, prognostic, and therapeutic implications.18FDG PET/CT has the highest sensitivity for the detection of CS but requires specific dietary preparation that is difficult for patients to follow which may lead to ineffective suppression of physiologic18FDG uptake. This may result in inconclusive scan results in up to 30% of patients undergoing18FDG PET/CT imaging for CS. Therefore, it is imperative that we relay to our patients the importance of dietary preparation for CS PET imaging and then provide simple, easy t...
Source: Journal of Nuclear Cardiology - November 1, 2017 Category: Nuclear Medicine Source Type: research

No evidence found for an association between prednisone dose and FVC change in newly-treated pulmonary sarcoidosis
Prednisone is used as first-line therapy for pulmonary sarcoidosis. What dosing strategy has the best balance between effect and side-effects is largely unknown. We analyzed change in forced vital capacity (FVC) and weight during different prednisone doses used in daily practice for treatment na ïve pulmonary sarcoidosis patients.
Source: Respiratory Medicine - October 31, 2017 Category: Respiratory Medicine Authors: Caroline E. Broos, Linda H.C. Poell, Caspar W.N. Looman, Johannes C.C.M. In ’t Veen, Marco J.J.H. Grootenboers, Roxane Heller, Leon M. van den Toorn, Monique Wapenaar, Henk C. Hoogsteden, Mirjam Kool, Marlies S. Wijsenbeek, Bernt van den Blink Tags: Clinical Trial Paper Source Type: research

Physical Functioning and Symptoms of Chronic Fatigue in Sarcoidosis Patients.
Authors: Pilzak K, Żebrowska A, Sikora M, Hall B, Łakomy O, Kostorz S, Ziora D, Jastrzębski D Abstract Scientific reports underscore the importance of measuring the health-related quality of life in sarcoidosis patients. The present study seeks to define how sarcoidosis patients' quality of life, daily physical activity, and physical performance are related to each other. Seventeen patients (mean age 46.8 ± 8.8 years) suffering from sarcoidosis completed the following questionnaires: the fatigue assessment scale (FAS), the quality of life scale (SF-36 questionnaire), and the Borg dyspnea scale. Physical activi...
Source: Advances in Experimental Medicine and Biology - October 28, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

A Study to Estimate the Effect Sizes of HRCT Endpoints in Response to Glucocorticoid Induction Therapy in Subjects With Pulmonary Sarcoidosis
Condition:   Sarcoidosis, Pulmonary Intervention:   Drug: Glucocorticoid (prednisone or prednisolone) Sponsor:   Celgene Not yet recruiting
Source: ClinicalTrials.gov - October 27, 2017 Category: Research Source Type: clinical trials