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Total 5297 results found since Jan 2013.

Sarcoid-like granulomatosis in cancer patients treated with immune checkpoints inhibitors.
CONCLUSIONS: Knowledge of this toxicity is crucial as the clinical signs and radiological patterns may suggest tumour progression. PMID: 30220489 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Cardiac sarcoidosis: Diagnosis confirmation by bronchoalveolar lavage and lung biopsy
The diagnosis of cardiac sarcoidosis (CS) is difficult to ascertain due to the insensitivity of endomyocardial biopsy. Current diagnostic criteria require a positive endomyocardial biopsy or extra-cardiac biopsy with clinical features suggestive of CS. Common tests for diagnosis of pulmonary sarcoidosis include bronchoalveolar lavage (BAL), lung and mediastinal lymph node (MLN) biopsies. Our objective was to determine the diagnostic utility of these tests in patients with suspected CS and without prior history of pulmonary involvement.
Source: Respiratory Medicine - September 16, 2018 Category: Respiratory Medicine Authors: Bradley J. Petek, David G. Rosenthal, Kristen K. Patton, Sanaz Behnia, Jonathan M. Keller, Bridget F. Collins, Richard K. Cheng, Lawrence A. Ho, Paco E. Bravo, Carmen Mikacenic, Ganesh Raghu Source Type: research

Pulmonary Multiloculated 'Lotus Torus-like' Sarcoidosis Mimicking Lung Adenocarcinoma.
Authors: Kanaji N, Nakashima N, Inoue T, Ibuki E, Murota M, Kadowaki N Abstract A 34-year-old Japanese woman exhibited a 35×25-mm solitary multiloculated mass shadow in the left lower lobe mimicking lung adenocarcinoma. On computed tomography, the mass resembled a lotus torus. A transbronchial lung biopsy and mediastinal lymph node biopsy led to the diagnosis of sarcoidosis. This lotus torus-like mass regressed spontaneously. This is the second reported case of pulmonary cavitary sarcoidosis with a 'lotus torus-like' appearance. We propose several findings regarding the lotus torus-like appearance by comparing the...
Source: Internal Medicine - September 15, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Significant elevation of the levels of B-cell activating factor (BAFF) in patients with sarcoidosis
This study demonstrated that the BAFF levels in both the serum and BALF were positively correlated with the disease activity markers and disease severity. BAFF may be useful as an indicator of both the disease activity and severity.
Source: Clinical Rheumatology - September 12, 2018 Category: Rheumatology Source Type: research

Endobronchial Ultrasound Elastography Helps Identify Fibrotic Lymph Nodes in Sarcoidosis.
PMID: 30207738 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 12, 2018 Category: Respiratory Medicine Authors: Livi V, Cancellieri A, Pirina P, Fois A, van der Heijden EHFM, Trisolini R Tags: Am J Respir Crit Care Med Source Type: research

YKL-40 and matrix metalloproteinases as potential biomarkers of inflammation and fibrosis in the development of bronchiolitis obliterans syndrome.
CONCLUSIONS: From the moment of transplantation onwards, patients who eventually developed BOS had significantly increased MMP-9 serum levels in comparison with patients who did not develop BOS. Therefore, increased MMP-9 serum levels might be useful as risk factor for BOS. PMID: 24003532 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Whole-lung volume and density in spirometrically-gated inspiratory and expiratory CT in systemic sclerosis: correlation with static volumes at pulmonary function tests.
CONCLUSIONS: In restrictive lung disease due to SSc there is poor agreement between static lung volumes measured using LDCT and PFT and the relationship between volume and density values on CT is altered. PMID: 24003531 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Surgical lung biopsy for the diagnosis of interstitial lung disease: a review of the literature and recommendations for optimizing safety and efficacy.
Authors: Nguyen W, Meyer KC Abstract Making an accurate diagnosis of a specific type of interstitial lung disease (ILD) requires a structured and comprehensive approach that includes a complete patient history, careful physical examination, appropriate laboratory testing, and thoracic imaging. If invasive procedures are required, bronchoscopy with bronchoalveolar lavage (BAL) and/or endoscopic lung biopsy (ELB) can frequently establish a confident diagnosis. However, surgical lung biopsy (SLB) may be required to make a confident diagnosis. Because SLB may be associated with a significant risk of morbidity and morta...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Stem cells, aging and pulmonary vascular remodelling.
Authors: Ferlosio A, Orlandi A PMID: 23461081 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Chest wall shrapnel-induced beryllium-sensitization and associated pulmonary disease.
Authors: Fireman E, Shai AB, Lerman Y, Topilsky M, Blanc PD, Maier L, Li L, Chandra S, Abraham JM, Fomin I, Aviram G, Abraham JL Abstract Chronic beryllium disease (CBD) is an exposure-related granulomatous disease mimicking sarcoidosis. Beryllium exposure-associated disease occurs mainly via inhalation, but skin may also be a source of sensitization. A 65-year-old male with a history of war-related shrapnel wounds was initially diagnosed with pulmonary sarcoidosis. Twenty years later, the possibility of a metal-related etiology for the lung disease was raised. A beryllium lymphocyte proliferation test, elemental a...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A prospective clinical multicentre study on adult pulmonary Langerhans' cell histiocytosis.
CONCLUSION: The data underline the key role of smoking as the sole known risk factor. A significant effect of smoking cessation on the course could not be confirmed. The overall prognosis was good in this series as compared to previous reports. PMID: 23461076 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Are clinical features in Löfgren's syndrome-related erythema nodosum different from idiopathic erythema nodosum?
CONCLUSIONS: Apart from BHL, arthritis and/or arthralgia especially periarticular ankle inflammation is the feature which could be used to differentiate LS related EN from IEN. There is more need for steroids in LS patients and the symptoms quickly resolve with steroids. PMID: 23461075 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Health-related quality of life does not predict mortality in idiopathic pulmonary fibrosis.
CONCLUSIONS: There was no significant relationship between HRQL evaluated with the SGRQ and the subsequent mortality in IPF. The present negative result might suggest that HRQL is measuring an aspect other than one from physiological and functional impairment or disability. PMID: 23461073 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Six-minute stepper test to assess effort intolerance in interstitial lung diseases.
Authors: Delourme J, Stervinou-Wemeau L, Salleron J, Grosbois JM, Wallaert B Abstract The six-minute stepper test (6MST) is a new test for evaluating exercise tolerance. Unlike the six-minute walk test (6MWT) it can be carried out in a limited space. The aim of this study was to compare the 6MST and the 6MWT in patients with various diffuse interstitial lung disease (ILD). 6MWT and 6MST were performed the same day in 84 patients with various ILD. The covered distance during 6MWT was compared to the number of steps during the 6MST. We also compared heart rate, oxygen saturation, dyspnoea and leg tiredness on a Borg ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Clinical characteristics classified by the serum KL-6 level in patients with organizing pneumonia.
CONCLUSIONS: Patients with normal KL-6 levels showed lower CXR and CT scores. The serum KL-6 level on admission is a useful marker to judge the need for corticosteroid treatment in OP patients. PMID: 24003534 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis
Sarcoidosis is characterised by non-caseating granulomas that secrete pro-inflammatory cytokines, including interleukin (IL)-12, IL-23, and tumour necrosis factor (TNF)-α. Ustekinumab and golimumab are monoclonal antibodies that specifically inhibit IL-12/IL-23 and TNF-α, respectively. Patients with chronic pulmonary sarcoidosis (lung group) and/or skin sarcoidosis (skin group) received either 180 mg ustekinumab at week 0 followed by 90 mg every 8 weeks, 200 mg golimumab at week 0 followed by 100 mg every 4 weeks, or placebo. Patients underwent corticosteroid tapering between weeks 16 and 28. The primary end-po...
Source: European Respiratory Journal - October 31, 2014 Category: Respiratory Medicine Authors: Judson, M. A., Baughman, R. P., Costabel, U., Drent, M., Gibson, K. F., Raghu, G., Shigemitsu, H., Barney, J. B., Culver, D. A., Hamzeh, N. Y., Wijsenbeek, M. S., Albera, C., Huizar, I., Agarwal, P., Brodmerkel, C., Watt, R., Barnathan, E. S. Tags: Original Articles: Sarcoidosis Source Type: research

Clinical features of sarcoid myelopathy focusing on age, distribution, and concomitant spinal disease
Background: Myelopathy is a relatively rare manifestation of sarcoidosis. Although spinal cord compression related to spinal cord swelling was reported in sarcoid myelopathy, the relationship between sarcoid myelopathy and mechanical compression due to orthopedic disorders has not been fully evaluated. We aimed to reveal clinical and radiological features of sarcoid myelopathy that demarcate the disease from other inflammatory myelopathy (OIM), especially focusing on age, distribution of spinal cord lesion (SCL), and concomitant orthopedical spinal diseases.
Source: Journal of Neuroimmunology - October 15, 2014 Category: Allergy & Immunology Authors: , Kazuo Fujihara, Yasuto Itoyama, Masashi Aoki Tags: 388 Source Type: research

The Two Extremes of Cardiac Sarcoidosis and the Effect of Prednisone Therapy
Described herein are clinical and morphologic findings in 2 patients who underwent heart transplantation because of severe heart failure resulting from cardiac sarcoidosis. Although the explanted hearts in each patient had characteristic gross changes of cardiac sarcoidosis, one patient who had been treated with prednisone, had no residual sarcoid granulomas in the myocardium, whereas the other patient, in whom diagnosis was not made until heart transplantation, had innumerable sarcoid granulomas in her heart.
Source: The American Journal of Cardiology - October 13, 2014 Category: Cardiology Authors: Danielle Armstrong, Gonzalo V. Gonzalez-Stawinski, Jong Mi Ko, Shelley A. Hall, William C. Roberts Tags: Case Report Source Type: research

The Two Extremes of Cardiac Sarcoidosis and the Effect of Prednisone Therapy
Described herein are clinical and morphologic findings in 2 patients who underwent heart transplantation because of severe heart failure resulting from cardiac sarcoidosis. Although the explanted hearts in each patient had characteristic gross changes of cardiac sarcoidosis, one patient who had been treated with prednisone, had no residual sarcoid granulomas in the myocardium, whereas the other patient, in whom diagnosis was not made until heart transplantation, had innumerable sarcoid granulomas in her heart.
Source: The American Journal of Cardiology - October 13, 2014 Category: Cardiology Authors: Danielle Armstrong, Gonzalo V. Gonzalez-Stawinski, Jong Mi Ko, Shelley A. Hall, William C. Roberts Source Type: research

The Clinical Features of Sarcoidosis: A Comprehensive Review
Abstract Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoidosis. These manifestations are presented organ by organ, although additional sections describe systemic and multiorgan presentations of sarcoidosis. The lung is the organ most commonly involved with sarcoidosis with at least 90 % of sarcoidosis patients demonstrating lung involvement in mos...
Source: Clinical Reviews in Allergy and Immunology - October 2, 2014 Category: Allergy & Immunology Source Type: research

A cytomorphometric analysis of pulmonary and mediastinal granulomas: Differentiating histoplasmosis from sarcoidosis by fine‐needle aspiration
CONCLUSIONSDifferentiation between histoplasmosis and sarcoidosis is possible in the majority of cases. Histoplasmosis usually exhibits few angular, ragged granulomas (<2 granulomas per slide) in a background of bland necrosis. Yeasts are identified on special stains performed in aspirate smears. Sarcoidosis typically contains many more granulomas (often >10 per slide) than histoplasmosis and has a rounded morphology with crisp and sharp borders. Typically, there is no necrosis or acute inflammation, and giant cell infiltrates are frequent. Cancer (Cancer Cytopathol) 2014. © 2014 American Cancer Society.
Source: Cancer Cytopathology - October 1, 2014 Category: Pathology Authors: Michael P. Gailey, Matthew E. Keeney, Chris S. Jensen Tags: Original Article Source Type: research

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes
Previously, we demonstrated concordance in differentially expressed genes in sarcoidosis blood and lung, implicating shared dysfunction of specific immune pathways. In the present study, we hypothesised that expression levels of candidate genes in sarcoidosis blood could predict and track with disease outcomes longitudinally. We applied Ingenuity Pathway Analysis to a cross-sectional derivation microarray dataset (n=38) to identify canonical pathways and candidate genes associated with sarcoidosis. In a separate longitudinal sarcoidosis cohort (n=103), we serially measured 48 candidate gene transcripts, and assessed their ...
Source: European Respiratory Journal - September 30, 2014 Category: Respiratory Medicine Authors: Su, R., Li, M. M., Bhakta, N. R., Solberg, O. D., Darnell, E. P. B., Ramstein, J., Garudadri, S., Ho, M., Woodruff, P. G., Koth, L. L. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

A challenging case: spinal cord sarcoidosis
A 54-year old man with severe ankylosing spondylitis presented with rapidly progressing bilateral lower limb weakness and altered sensation, associated with urinary retention. Examination showed flaccid paraparesis with lower limb areflexia and a sensory level to T10. His upper limbs were normal. MR scan of whole spine showed marked ankylosing spondylitis changes, including canal narrowing, and extensive, discontinuous signal change within the spinal cord at C7–T1, T3–T4 and T7–T11. There was no leptomeningeal enhancement. Severe ankylosing spondylitis meant we were unable to obtain CSF, MR scan of head o...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Wynford-Thomas, R., Smith, P. Tags: Abstracts Source Type: research

Sarcoidosis of the Head and Neck
This article seeks to provide a comprehensive review of head and neck sarcoidosis, as this fascinating disorder often poses a diagnostic and therapeutic challenge. A brief discussion of surgical treatment for pituitary lesions is also provided. Articles from 1997 to 2013 were selected and reviewed by three researchers utilizing the most recent literature regarding sarcoidosis in the head and neck. PubMed searches were conducted using search terms such as “sarcoidosis”, “neurosarcoid”, and “extra-pulmonary sarcoid”, among many others. A large collection of articles was generated and reviewed by the team of autho...
Source: Head and Neck Pathology - September 3, 2014 Category: Pathology Source Type: research

Esophageal cancer associated with bilateral hilar lymphadenopathy caused by sarcoid-like reactions: a report of two cases
We report two patients with esophageal cancer accompanied by bilateral hilar lymphadenopathy or accumulation on [18F]-fluorodeoxyglucose positron emission tomography–computed tomography. The first patient underwent surgery because the enlarged bilateral hilar lymph nodes were considered to be nonmalignant lesions owing to superficial carcinoma and symmetric distribution of the hilar lymph nodes. The second patient received chemotherapy, which caused the main tumor to shrink and decreased [18F]-fluorodeoxyglucose uptake. However, chemotherapy did not affect the hilar lymphadenopathy, which suggests that it was caused by r...
Source: Esophagus - September 2, 2014 Category: Gastroenterology Source Type: research

Application of medical thoracoscopy in diagnosis of sarcoidosis‐related pleural effusion
Abstract Pleural effusion caused by sarcoidosis is unusual. Medical thoracoscopy could help clinicians detect associated pleural disease, yet studies on thoracoscopic observations in sarcoidosis pleural involvement are rare. In this article, we report the utility of medical thoracoscopy in diagnosing sarcoid‐related pleural disease for three patients. Pleural nodularity was common with solitary and multiple nodules evident; biopsies confirmed the presence of diagnostic noncaseating granulomas. Medical thoracoscopy showed that sarcoidosis pleural involvement was variable from multiple nodules to subtle change in the pleura.
Source: Respirology Case Reports - July 2, 2014 Category: Respiratory Medicine Authors: Feng Wang, Zhaohui Tong, Zhen Wang, Xiaojuan Wang, Xi Zhan, Huanzhong Shi Tags: Case Report Source Type: research

Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis
Abstract: A 52-year-old Japanese woman complaining of horizontal double vision for 10days was admitted to our hospital. Neurological examination revealed left abducent nerve palsy and muscle swelling in her thighs. Brain MRI showed obstruction in the spinal fluid space of the left Dorello's canal, which transmits a portion of the abducent nerve. In Ga-67-enhanced citrate scintigraphy, wide accumulation was seen in her bilateral thighs, lower legs, and gluteus muscles. Muscular MRI showed a star-shaped central structure on short tau inversion recovery (STIR) images, and the three stripes sign on T2-weighted images. These MR...
Source: Journal of the Neurological Sciences - June 2, 2014 Category: Neurology Authors: Ayako Shioya, Hiroshi Takuma, Masanari Shiigai, Akiko Ishii, Akira Tamaoka Tags: Short Communications Source Type: research

Cardiac sarcoidosis presenting as constrictive pericarditis.
We report the case of a 57-year-old man who presented with clinical and hemodynamic features of constrictive pericarditis, of unclear cause. He was admitted for treatment of recurrent pleural effusion. After a complicated hospital course, he underwent pericardiectomy. His clinical and hemodynamic conditions improved substantially, and he was discharged from the hospital in good condition. The pathologic findings, the patient's clinical course, and his response to pericardiectomy led to our diagnosis of cardiac sarcoidosis presenting as constrictive pericarditis. In addition to the patient's case, we discuss the nature and ...
Source: Texas Heart Institute Journal - June 1, 2014 Category: Cardiology Authors: Darda S, Zughaib ME, Alexander PB, Machado CE, David SW, Saba S Tags: Tex Heart Inst J Source Type: research

Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis.
Abstract Sarcoidosis is an immune-mediated multisystem disease characterized by the formation of non-caseating granulomas. The pathogenesis of sarcoidosis is unclear, with proposed infectious or environmental antigens triggering an aberrant immune response in susceptible hosts. Multiple pro-inflammatory signaling pathways have been implicated in mediating macrophage activation and granuloma formation in sarcoidosis, including IFN-γ/STAT-1, IL-6/STAT-3, and NF-κB. It is difficult to distinguish sarcoidosis from other granulomatous diseases or assess disease severity and treatment response with histopathology alon...
Source: Experimental and Molecular Pathology - April 21, 2014 Category: Pathology Authors: Christophi GP, Caza T, Curtiss C, Gumber D, Massa PT, Landas SK Tags: Exp Mol Pathol Source Type: research

Sarcoidosis and uveitis.
Abstract Uveitis is a frequent (20-50%) and early feature of sarcoidosis. Typical sarcoid uveitis presents with mutton-fat keratic precipitates, iris nodules, and anterior and posterior synechiae. Posterior involvement includes vitreitis, vasculitis, and choroidal lesions. Cystoid macular edema is the most important and sight-threatening consequence. Histologic proof from a biopsy is the gold standard for the diagnosis of ocular sarcoidosis An international workshop has recently established diagnostic criteria for sarcoidosis uveitis when biopsy is unavailable or negative: these are based on a combination of ophth...
Source: Autoimmunity Reviews - April 3, 2014 Category: Allergy & Immunology Authors: Jamilloux Y, Kodjikian L, Broussolle C, Sève P Tags: Autoimmun Rev Source Type: research

Cardiac Sarcoid: A Chameleon Masquerading as Hypertrophic Cardiomyopathy and Dilated Cardiomyopathy in the Same Patient
We describe a case of cardiac sarcoid in a young patient wherein a distinctive appearance of the cardiac sarcoid spectrum from “hypertrophic” stage to thinned/scarred stage, masquerading as hypertrophic cardiomyopathy followed by dilated cardiomyopathy, is demonstrated.
Source: Echocardiography - February 8, 2014 Category: Cardiology Authors: Anushree Agarwal, Nasir Z. Sulemanjee, Omar Cheema, Francis X. Downey, A. Jamil Tajik Tags: Case Report Source Type: research

Necrotizing sarcoid granulomatosis with an uncommon manifestation: clinicopathological features and review of literature.
We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-year-old non smoker male. The patient was admitted to the hospital for sudden back pain. Chest X-ray revealed areas of parenchymal consolidation and high resolution computed tomography demonstrated a pulmonary nodular pattern without any lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a lung surgical biopsy and by excluding other cau...
Source: Respiratory Care - December 10, 2013 Category: Respiratory Medicine Authors: Giraudo C, Nannini N, Balestro E, Meneghin A, Lunardi F, Polverosi R, Calabrese F Tags: Respir Care Source Type: research

Morphologic Features of Cardiac Sarcoidosis in Native Hearts of Patients Having Cardiac Transplantation
Described herein are 10 patients who underwent cardiac transplantation (CT) for severe chronic systolic heart failure resulting from cardiac sarcoidosis. None had the diagnosis of sarcoidosis established before CT except for the 3 patients who earlier had had a portion of left ventricular wall excised for insertion of a left ventricular assist device and non-caseating granulomas were present in the removed myocardium. Although none of the 10 patients had significant narrowing of any of the epicardial coronary arteries, all had focal scarring of the walls of the left and right ventricles and ventricular septum and all had d...
Source: The American Journal of Cardiology - November 25, 2013 Category: Cardiology Authors: William C. Roberts, Monica S. Chung, Jong Mi Ko, John E. Capehart, Shelley A. Hall Tags: Cardiomyopathy Source Type: research

Foreign Body Granulomatous Reaction to Silica, Silicone, and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis.
We report the case of a patient who developed sarcoid granulomas 11 months after starting treatment with pegylated interferon alfa and ribavirin for chronic hepatitis C. The sites of the lesions were related to 3 different foreign bodies: silica in old scars on the skin, hyaluronic acid that had been injected into facial tissues, and silicone in an axillary lymph node draining the area of a breast implant. Systemic sarcoidosis was diagnosed on the basis of a history of dry cough and fever and blood tests that revealed elevated angiotensin converting enzyme and liver enzymes. Interruption of the antiviral therapy led to nor...
Source: Actas Dermo-Sifiliograficas - November 13, 2013 Category: Dermatology Authors: Novoa R, Barnadas MA, Torras X, Curell R, Alomar A Tags: Actas Dermosifiliogr Source Type: research

Fatal clinical outcome in a patient with sarcoidosis-lymphoma syndrome.
Abstract A 62-year-old female suspected of malignant disease underwent a splenectomy that revealed noncaseating granulomas in the histological specimen. Chest X-ray (CXR) and lung CT scans suggested sarcoidosis stage II. TBLB showed noncaseating granulomas. A diagnosis of sarcoidosis was made. Initially no treatment was needed as partial remission on CXR and normal lung function were observed. During the follow up she underwent open lung biopsy and axillary lymph node biopsy because of radiological progression with presence of CXR opacities imitating metastases and recurrent lymphadenopathy. No malignant cells wer...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Goljan-Geremek A, Puścińska E, Bednarek M, Nowiński A, Kamiński D, Ptak J, Bestry I, Langfort R, Staszewska M, Gorecka D Tags: Pneumonol Alergol Pol Source Type: research

ICAM-1 Deficiency Exacerbates Sarcoid-Like Granulomatosis Induced by Propionibacterium acnes through Impaired IL-10 Production by Regulatory T Cells.
Abstract Propionibacterium acnes has been implicated as one of the suggested causative antigens for sarcoidosis, a systemic granulomatous disease. By injecting heat-killed P. acnes into the dorsal skin of C57BL/6J mice on days 1, 3, 5, and 14, sarcoid-like granulomatosis was induced in skin and lungs of these mice on day 28. To clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we induced sarcoid-like granulomatosis in mice deficient of intercellular adhesion molecule (ICAM)-1, L-selectin, P-selectin, or E-selectin via repeated P. acnes injection. Histopathologic analysis revealed that granuloma...
Source: The American Journal of Pathology - October 5, 2013 Category: Pathology Authors: Kamata M, Tada Y, Mitsui A, Shibata S, Miyagaki T, Asano Y, Sugaya M, Kadono T, Sato S Tags: Am J Pathol Source Type: research

Atypical radiological manifestations of thoracic sarcoidosis: A review and pictorial essay
We present a review of literature and illustrate the review with unpublished data, intended to provide a more recent single comprehensive reference to assist with the diagnosis when atypical radiographic findings of thoracic sarcoidosis are encountered. Thoracic involvement accounts for most of morbidity and mortality associated with sarcoidosis. An accurate timely identification is required to minimize morbidity and mortality. It is essential to recognize atypical imaging findings and relate these to clinical manifestations and histology.
Source: Annals of Thoracic Medicine - September 20, 2013 Category: Respiratory Medicine Authors: Hamdan Al-JahdaliPrabhakar RajiahShyam Sunder KoteyarCarolyn AllenAli Nawaz Khan Source Type: research

Microbial and human heat shock proteins as 'danger signals' in sarcoidosis.
Abstract In the light of the Matzinger's model of immune response, human heat shock proteins (HSPs) as main 'danger signals' (tissue damage-associated molecular patterns-DAMPs) or/and microbial HSPs as pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors (PRR), may induce sarcoid granuloma by both infectious and non-infectious factors in genetically different predisposed host. Regarding infectious causes of sarcoid models, low-virulence strains of, e.g. mycobacteria and propionibacteria recognized through changed PRR and persisting in altered host phagocytes, generate increase...
Source: Human Immunology - August 27, 2013 Category: Allergy & Immunology Authors: Dubaniewicz A Tags: Hum Immunol Source Type: research

Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition.
We present a patient with sarcoidosis who developed acute kidney injury (AKI). He had a high 1,25-OH vitamin D level and hypercalciuria. As his renal function declined he developed hypercalcemia. A kidney biopsy showed acute tubular necrosis (ATN) with giant cell formation around calcium phosphate crystals. Calcium phosphate deposition is uncommon in sarcoid. We speculate that early interstitial calcium phosphate deposition may in time lead to the development of Randall's plaques and to the more typical calcium oxalate nephrolithiasis seen in sarcoidosis. PMID: 23845267 [PubMed - in process]
Source: Clinical Nephrology - July 16, 2013 Category: Urology & Nephrology Authors: Manjunath V, Moeckel G, Dahl NK Tags: Clin Nephrol Source Type: research

Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes.
Abstract Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. Many P. acnes have been detected in sarcoid lymph nodes using quantitative PCR and in sarcoid granulomas by in situ hybridization. P. acnes trigger factor protein causes a cellular immune response only in sarcoid patients and induces pulmonary granulomas in mice sensitized with the protein and adjuvant, but only those with latent P. acnes infection in their lungs. Eradication of P. acnes by antibiotics prevents the development of granulomas in ...
Source: Biomed Res - July 16, 2013 Category: Research Authors: Eishi Y Tags: Biomed Res Int Source Type: research

Heart Transplantation for End-Stage Heart Failure Due to Cardiac Sarcoidosis
Conclusions: Patients with cardiac sarcoidosis undergoing heart transplantation have acceptable long-term outcomes without evidence of recurrence of sarcoidosis in the allograft when maintained on low-dose corticosteroids. Progression of extracardiac sarcoid was uncommon, possibly related to immunosuppression. In patients with cardiac sarcoidosis, heart transplantation is a viable treatment modality.
Source: Transplantation Proceedings - July 1, 2013 Category: Transplant Surgery Authors: D. Perkel, L.S.C. Czer, R.P. Morrissey, A. Ruzza, M. Rafiei, M. Awad, J. Patel, J.A. Kobashigawa Tags: Thoracic Transplantation Source Type: research

Sarcoidosis Lung Nodules in Colorectal Cancer Follow-Up: Sarcoidosis or Not?
Conclusion: Our cases focused on the usefulness of histologic proof in patients with cancer with sarcoidosis.
Source: The American Journal of Medicine - June 20, 2013 Category: Journals (General) Authors: Marie Lequoy, Romain Coriat, Alexandre Rouquette, Olivier Mir, Géraldine Perkins, Jean-François Regnard, Catherine Brezault, Stanislas Chaussade Tags: Brief observation Source Type: research

Sarcoidosis Manifesting as a Pseudotumorous Renal Mass
A 53 year-old African American woman with a three-year history of pulmonary sarcoidosis had a follow-up computed tomographic scan to evaluate the status of her disease and response to treatment. On the scan, an abnormal, hypodense mass on the left renal superior pole, which was not present on previous scans, was incidentally discovered. The initial concern was of carcinoma, despite her lack of any urinary symptoms. She underwent further evaluation with magnetic resonance, and the enhancement pattern and the shape of the mass were more suggestive of lymphoma or infarction than a carcinoma. A review of literature revealed sp...
Source: Journal of Radiology Case Reports - June 3, 2013 Category: Radiology Source Type: research

Correlation of late gadolinium enhancement MRI and quantitative T2 measurement in cardiac sarcoidosis
ConclusionLGE‐MRI can identify cardiac involvement in systemic sarcoidosis. MCLE might be more sensitive at detecting subtle myocardial lesion. The decreased T2 observed in cardiac sarcoid may reflect its inactive phase, thus might provide a noninvasive method for monitoring disease activity or therapy.J. Magn. Reson. Imaging 2013;00:000–000. © 2013 Wiley Periodicals, Inc.
Source: Journal of Magnetic Resonance Imaging - May 29, 2013 Category: Radiology Authors: Yuesong Yang, Katherine Safka, John J. Graham, Idan Roifman, Mohammad I. Zia, Graham A. Wright, Meyer Balter, Alexander J. Dick, Kim A. Connelly Tags: Original Research Source Type: research

The frequency of granulomatous lacrimal gland inflammation as a cause of lacrimal gland enlargement in patients without a diagnosis of systemic sarcoidosis.
Discussion: In patients with clinical lacrimal gland enlargement, incisional biopsy led to a diagnosis of sarcoidosis in 20% of patients. An elevated ACE level may help predict which patients have a greater diagnostic yield with biopsy. PMID: 23480843 [PubMed - in process]
Source: Orbit - May 26, 2013 Category: Opthalmology Authors: Rabinowitz MP, Halfpenny CP, Bedrossian EH Tags: Orbit Source Type: research

Coexistence of sarcoidosis with seminoma - a case report.
Abstract A 30-year-old patient, with diagnosis of seminoma (T1 Nx Mx) was treated radically with orchidectomy. In chest CT performed postoperatively numerous diffuse nodules were revealed in both lungs. Lesions were situated particularly in the upper and middle pulmonary zones. In order to verify the nature of pulmonary abnormalities videothoracoscopy of the right pleural cavity was performed with specimen collection. Histopathological examination excluded the possibility of cancer metastases to pulmonary parenchyma and revealed the presence of sarcoid-like granulomas. Coexistence of seminoma and diffuse sarcoid-l...
Source: Pneumonologia i Alergologia Polska - February 22, 2013 Category: Respiratory Medicine Authors: Kita-Milczarska K, Górska L, Kuziemski K, Sejda A, Jassem E, Biernat W Tags: Pneumonol Alergol Pol Source Type: research

Preliminary characterizations of a serum biomarker for sarcoidosis by comparative proteomic approach with tandem-mass spectrometry in ethnic Han Chinese patients
Background: The diagnosis of sarcoidosis is still a significant challenge in China because of the need to exclude other diseases including granulomatous infections and malignancies that may be clinically and radiographically similar. The specific aim of the study is to search for serum protein biomarkers of sarcoidosis and to validate their clinical usefulness in differential diagnosis. Methods: Serum samples were collected from patients with sarcoidosis (n = 37), and compared to those from patients with tuberculosis (n = 20), other pulmonary diseases (n = 20), and healthy volunteers (n = 20) for determination of sarcoidos...
Source: Respiratory Research - February 11, 2013 Category: Respiratory Medicine Authors: Yuan ZhangXianqiu ChenYang HuShanshan DuLi ShenYifan HeYuxuan ZhangXia ZhangHuiping LiRex Yung Source Type: research

Splenic sarcoidosis mimicking neoplastic disease
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause that commonly involves the spleen. Sarcoid can produce either homogeneous splenomegaly or multiple splenic nodules. Although other organ system involvement usually occurs, this is not invariable. Herein, we report on the clinical, histological, and radiological features—including sonography and MRI—of an isolated splenic sarcoidosis that mimicked neoplastic disease in a 37‐year‐old female. Knowledge of this atypical sonographic presentation may prevent unnecessary splenectomy. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013
Source: Journal of Clinical Ultrasound - January 1, 2013 Category: Radiology Authors: Salem Bauones, Thomas Le Corroller, Olivier Durieux, Daphné Guenoun, Jean Del Grande, Nicolas Pirro, Pierre Champsaur Tags: Case Report Source Type: research

Sarcoid-like granulomatosis induced by Propionibacterium acnes in mice; role of ICAM-1 in prevention of granuloma formation
Sarcoidosis is a systemic granulomatous disease which is characterized by a variable clinical presentation and course. The etiology of the disease has remained unknown. Propionibacterium acnes (P. acnes), an anaerobic nonspore-forming gram-positive rod bacterium, has been implicated as one of the suggested causative antigens of sarcoidosis since this bacterium has been isolated from sarcoid lesions. In order to clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we first established an in vivo model of sarcoid-like skin granulomatosis by injecting heat-killed P. acnes into the back of C57BL/6J mice. These...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Masahiro Kamata, Yayoi Tada, Yoshihide Asano, Makoto Sugaya, Takafumi Kadono, Shinichi Sato Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Primary Sarcoid of the Breast with Incidental Malignancy
We report a very unusual case of primary breast sarcoidosis with incidentally discovered breast carcinoma. The roles of mammography, ultrasound, and MRI in the diagnosis as well as other potential differential diagnosis are discussed.
Source: Journal of Clinical Imaging Science - July 28, 2012 Category: Radiology Authors: Laura M IsleyAbbie R CluverRebecca J LeddyMegan K Baker Source Type: research