This page shows you the latest news items in this category. This is page number 15.

Total 4943 results found since Jan 2013.

Quantification of global FDG uptake as a novel imaging modality to assess Sarcoidosis in the diseased organs and the entire body
Conclusions: Currently, FDG-PET is not used as a first-line imaging modality in sarcoidosis, as it is considered to be of value for advanced and relapsing stages of the disease. However, having a score that allows assessment of global disease activity in the body will provide potential for expanding the clinical utility of FDG-PET to evaluate disease behavior, treatment response and disease relapse at any stage of this common inflammatory disorder.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Al-zaghal, A., Jahangiri, P., Pournazari, K., Khosravi, M., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research

Novel approach of FDG PET for diagnosing of cardiac sarcoidosis -application possibility of the texture analysis-
Conclusions: Our findings revealed that the texture analysis could apply for the diagnosis of CS with high inter-operator and inter-scan reproducibility. Reference: Ref1 Manabe O, Kroenke M, Aikawa T, Murayama A, Naya M, Masuda A, Oyama-Manabe N, Hirata K, Watanabe S, Shiga T, Katoh C, Tamaki N. J Nucl Cardiol. 2017 Dec 14. doi: 10.1007/s12350-017-1122-6. Ref2 Orlhac F, Soussan M, Maisonobe JA, Garcia CA, Vanderlinden B, Buvat I. Tumor texture analysis in 18F-FDG PET: relationships between texture parameters, histogram indices, standardized uptake values, metabolic volumes, and total lesion glycolysis. J Nucl Med 2014;55:414-22.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Manabe, O., Hirata, K., Ohira, H., Tsujino, I., Naya, M., Aikawa, T., Oyama-Manabe, N., Tamaki, N. Tags: Cardiovascular Basic Science Poster Session Source Type: research

18F-FDG PET-CT in the clinical management of cardiac sarcoidosis: A regional academic referral center experience.
Conclusion 18F-FDG PET-CT is an effective tool in the clinical management of CS, including its initial diagnosis and assessment following therapy. Although not statistically significant, patients treated for a longer duration were more likely to respond to the therapy. Additionally, dual immunomodulator therapy with prednisone and methotrexate may improve therapeutic response in CS. Figure 1. F-18 FDG PET-CT MIP and axial fused PET-CT images showing (A) focal on diffuse hypermetabolic activity in the left ventricular myocardium consistent with cardiac sarcoidosis, and (B) resolution of the myocardial activity following imm...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Rieter, W., Burchett, P., De Cecco, C., James, W., Hargrave, P., Nance, J., Gordon, L. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

Exploring the optimal reference to estimate the effect of anti-inflammatory therapy for the cardiac sarcoidosis -metabolic volume assessment of FDG PET-
Conclusions: We measured the FDG uptake in the liver and blood pool before and during steroid therapy. Steroid therapy might be increase the liver FDG uptake because of its effect on glyceroneogenesis in the liver and adipose tissue. However, the blood pool uptake didn’t show significant differences. Our findings revealed that the DA is suitable threshold rather than liver uptake to evaluate the therapy effect using volume-based analysis of cardiac FDG PET.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Furuya, S., Hirata, K., Manabe, O., Hiroshi, O., Naya, M., Aikawa, T., Koyanagawa, K., Tsujino, I., Shiga, T., Kudo, K. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

Low downstream event rate in patients without clinical cardiac sarcoidosis referred for cardiac FDG-PET imaging
Conclusion: In patients not meeting clinical criteria for CS and without extra-cardiac sarcoidosis, the overall event rate was similar between patients with and without abnormal FDG uptake. The overall low event rate suggests a potential lack of clinical utility in obtaining FDG PET imaging for all patients with non-ischemic cardiomyopathy to evaluate for CS. Future investigations are needed to determine if FDG PET imaging may be better targeted to certain subgroups of patients with non-ischemic cardiomyopathy.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Varghese, M., Miller, E. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

FDG-PET/CT performances to detect systemic sarcoidosis in patients from a general hospital in Europe
Conclusions: Our retrospective study shows that FDG PET/CT examination is a reliable method to detect systemic sarcoidosis (high sensibility, specificity, PPV, NPV and accuracy). However further evaluation of cost effectiveness of this examination, and a more comprehensive understanding on which patients would benefit from this intervention are warranted.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Trabelsi, K., Muteganya, R., Garcia, C. Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research

Tuberculosis and Sarcoidosis Imaging in 18F-FDG-PET/CT: Consistencies and Inconsistencies
Conclusions: Apart from the common capability of showing anatomic spread of disease in the whole body in one single examination for both TB and SC, in TB 18F-FDG seems to be a good predictor for the extent of disease by assessment of the highest SUV seen in any pathological lesion and for therapy control, too, as indicated in earlier work. In SC, FDG-uptake markedly focuses on lymph nodes, consistent with the natural history of the disease. However, we see uptake behavior clearly different from TB in respect of the prediction of disease extent and some other features. Evaluation of the relevance of these facts for initial ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Huber, H., Lang, D., Fellner, F., Lamprecht, B., Gabriel, M. Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research

Use of deep convolutional neural network-based features for detection of cardiac sarcoidosis from polar map
Conclusions: The classification performance of DCNN-based features outperformed the CoV-based classification performance. Experimental results suggested that DCNN-based high-dimensional features have a potential of semi-automated diagnosis of CS.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Togo, R., Hirata, K., Manabe, O., Ohira, H., Tsujino, I., Ogawa, T., Haseyama, M., Shiga, T. Tags: Deep Learning In Molecular Imaging Studies Source Type: research

Sarcoidosis
Source: eMedicineHealth.com - May 22, 2018 Category: General Medicine Source Type: news

Sarcoidosis-Like Granulomatous Reaction Associated With Pembrolizumab Immunotherapy.
PMID: 29801680 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - May 22, 2018 Category: Respiratory Medicine Authors: Gayá García-Manso I, García Ródenas MDM, Barroso Medel ME, Illán Gambín FJ Tags: Arch Bronconeumol Source Type: research

Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses.
CONCLUSION: Our results suggest that sarcoidosis is a new subset in the spectrum of paraneoplastic syndrome. We propose that lymphoproliferative disorders should be considered in patients with cutaneous sarcoidosis who have a poor response to conventional therapy or whose skin biopsy shows a significant number of mitoses. PMID: 29779211 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - May 20, 2018 Category: Cancer & Oncology Authors: El-Khalawany M, Mosbeh A, Aboeldahab S, Ali S Tags: Clin Exp Dermatol Source Type: research

Plasmapheresis in a Patient with Sarcoidosis Who Developed Multiple Myeloma and Massive Free Kappa Light Chains Nephropathy.
Authors: Markel A, Habashe N, Aviv A, Monich O, Elmalah I, Marei N, Tovbin D PMID: 29761682 [PubMed - in process]
Source: The Israel Medical Association Journal - May 19, 2018 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

A Clinical Study of Tranilast in the Treatment of Sarcoidosis
Condition:   Sarcoidosis Intervention:   Drug: Tranilast Sponsor:   The First Affiliated Hospital with Nanjing Medical University Not yet recruiting
Source: ClinicalTrials.gov - May 17, 2018 Category: Research Source Type: clinical trials

Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis
Abstract: A 52-year-old Japanese woman complaining of horizontal double vision for 10days was admitted to our hospital. Neurological examination revealed left abducent nerve palsy and muscle swelling in her thighs. Brain MRI showed obstruction in the spinal fluid space of the left Dorello's canal, which transmits a portion of the abducent nerve. In Ga-67-enhanced citrate scintigraphy, wide accumulation was seen in her bilateral thighs, lower legs, and gluteus muscles. Muscular MRI showed a star-shaped central structure on short tau inversion recovery (STIR) images, and the three stripes sign on T2-weighted images. These MR...
Source: Journal of the Neurological Sciences - June 2, 2014 Category: Neurology Authors: Ayako Shioya, Hiroshi Takuma, Masanari Shiigai, Akiko Ishii, Akira Tamaoka Tags: Short Communications Source Type: research

Cardiac sarcoidosis presenting as constrictive pericarditis.
We report the case of a 57-year-old man who presented with clinical and hemodynamic features of constrictive pericarditis, of unclear cause. He was admitted for treatment of recurrent pleural effusion. After a complicated hospital course, he underwent pericardiectomy. His clinical and hemodynamic conditions improved substantially, and he was discharged from the hospital in good condition. The pathologic findings, the patient's clinical course, and his response to pericardiectomy led to our diagnosis of cardiac sarcoidosis presenting as constrictive pericarditis. In addition to the patient's case, we discuss the nature and ...
Source: Texas Heart Institute Journal - June 1, 2014 Category: Cardiology Authors: Darda S, Zughaib ME, Alexander PB, Machado CE, David SW, Saba S Tags: Tex Heart Inst J Source Type: research

Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis.
Abstract Sarcoidosis is an immune-mediated multisystem disease characterized by the formation of non-caseating granulomas. The pathogenesis of sarcoidosis is unclear, with proposed infectious or environmental antigens triggering an aberrant immune response in susceptible hosts. Multiple pro-inflammatory signaling pathways have been implicated in mediating macrophage activation and granuloma formation in sarcoidosis, including IFN-γ/STAT-1, IL-6/STAT-3, and NF-κB. It is difficult to distinguish sarcoidosis from other granulomatous diseases or assess disease severity and treatment response with histopathology alon...
Source: Experimental and Molecular Pathology - April 21, 2014 Category: Pathology Authors: Christophi GP, Caza T, Curtiss C, Gumber D, Massa PT, Landas SK Tags: Exp Mol Pathol Source Type: research

Sarcoidosis and uveitis.
Abstract Uveitis is a frequent (20-50%) and early feature of sarcoidosis. Typical sarcoid uveitis presents with mutton-fat keratic precipitates, iris nodules, and anterior and posterior synechiae. Posterior involvement includes vitreitis, vasculitis, and choroidal lesions. Cystoid macular edema is the most important and sight-threatening consequence. Histologic proof from a biopsy is the gold standard for the diagnosis of ocular sarcoidosis An international workshop has recently established diagnostic criteria for sarcoidosis uveitis when biopsy is unavailable or negative: these are based on a combination of ophth...
Source: Autoimmunity Reviews - April 3, 2014 Category: Allergy & Immunology Authors: Jamilloux Y, Kodjikian L, Broussolle C, Sève P Tags: Autoimmun Rev Source Type: research

Cardiac Sarcoid: A Chameleon Masquerading as Hypertrophic Cardiomyopathy and Dilated Cardiomyopathy in the Same Patient
We describe a case of cardiac sarcoid in a young patient wherein a distinctive appearance of the cardiac sarcoid spectrum from “hypertrophic” stage to thinned/scarred stage, masquerading as hypertrophic cardiomyopathy followed by dilated cardiomyopathy, is demonstrated.
Source: Echocardiography - February 8, 2014 Category: Cardiology Authors: Anushree Agarwal, Nasir Z. Sulemanjee, Omar Cheema, Francis X. Downey, A. Jamil Tajik Tags: Case Report Source Type: research

Necrotizing sarcoid granulomatosis with an uncommon manifestation: clinicopathological features and review of literature.
We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-year-old non smoker male. The patient was admitted to the hospital for sudden back pain. Chest X-ray revealed areas of parenchymal consolidation and high resolution computed tomography demonstrated a pulmonary nodular pattern without any lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a lung surgical biopsy and by excluding other cau...
Source: Respiratory Care - December 10, 2013 Category: Respiratory Medicine Authors: Giraudo C, Nannini N, Balestro E, Meneghin A, Lunardi F, Polverosi R, Calabrese F Tags: Respir Care Source Type: research

Morphologic Features of Cardiac Sarcoidosis in Native Hearts of Patients Having Cardiac Transplantation
Described herein are 10 patients who underwent cardiac transplantation (CT) for severe chronic systolic heart failure resulting from cardiac sarcoidosis. None had the diagnosis of sarcoidosis established before CT except for the 3 patients who earlier had had a portion of left ventricular wall excised for insertion of a left ventricular assist device and non-caseating granulomas were present in the removed myocardium. Although none of the 10 patients had significant narrowing of any of the epicardial coronary arteries, all had focal scarring of the walls of the left and right ventricles and ventricular septum and all had d...
Source: The American Journal of Cardiology - November 25, 2013 Category: Cardiology Authors: William C. Roberts, Monica S. Chung, Jong Mi Ko, John E. Capehart, Shelley A. Hall Tags: Cardiomyopathy Source Type: research

Foreign Body Granulomatous Reaction to Silica, Silicone, and Hyaluronic Acid in a Patient With Interferon-Induced Sarcoidosis.
We report the case of a patient who developed sarcoid granulomas 11 months after starting treatment with pegylated interferon alfa and ribavirin for chronic hepatitis C. The sites of the lesions were related to 3 different foreign bodies: silica in old scars on the skin, hyaluronic acid that had been injected into facial tissues, and silicone in an axillary lymph node draining the area of a breast implant. Systemic sarcoidosis was diagnosed on the basis of a history of dry cough and fever and blood tests that revealed elevated angiotensin converting enzyme and liver enzymes. Interruption of the antiviral therapy led to nor...
Source: Actas Dermo-Sifiliograficas - November 13, 2013 Category: Dermatology Authors: Novoa R, Barnadas MA, Torras X, Curell R, Alomar A Tags: Actas Dermosifiliogr Source Type: research

Fatal clinical outcome in a patient with sarcoidosis-lymphoma syndrome.
Abstract A 62-year-old female suspected of malignant disease underwent a splenectomy that revealed noncaseating granulomas in the histological specimen. Chest X-ray (CXR) and lung CT scans suggested sarcoidosis stage II. TBLB showed noncaseating granulomas. A diagnosis of sarcoidosis was made. Initially no treatment was needed as partial remission on CXR and normal lung function were observed. During the follow up she underwent open lung biopsy and axillary lymph node biopsy because of radiological progression with presence of CXR opacities imitating metastases and recurrent lymphadenopathy. No malignant cells wer...
Source: Pneumonologia i Alergologia Polska - October 25, 2013 Category: Respiratory Medicine Authors: Goljan-Geremek A, Puścińska E, Bednarek M, Nowiński A, Kamiński D, Ptak J, Bestry I, Langfort R, Staszewska M, Gorecka D Tags: Pneumonol Alergol Pol Source Type: research

ICAM-1 Deficiency Exacerbates Sarcoid-Like Granulomatosis Induced by Propionibacterium acnes through Impaired IL-10 Production by Regulatory T Cells.
Abstract Propionibacterium acnes has been implicated as one of the suggested causative antigens for sarcoidosis, a systemic granulomatous disease. By injecting heat-killed P. acnes into the dorsal skin of C57BL/6J mice on days 1, 3, 5, and 14, sarcoid-like granulomatosis was induced in skin and lungs of these mice on day 28. To clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we induced sarcoid-like granulomatosis in mice deficient of intercellular adhesion molecule (ICAM)-1, L-selectin, P-selectin, or E-selectin via repeated P. acnes injection. Histopathologic analysis revealed that granuloma...
Source: The American Journal of Pathology - October 5, 2013 Category: Pathology Authors: Kamata M, Tada Y, Mitsui A, Shibata S, Miyagaki T, Asano Y, Sugaya M, Kadono T, Sato S Tags: Am J Pathol Source Type: research

Atypical radiological manifestations of thoracic sarcoidosis: A review and pictorial essay
We present a review of literature and illustrate the review with unpublished data, intended to provide a more recent single comprehensive reference to assist with the diagnosis when atypical radiographic findings of thoracic sarcoidosis are encountered. Thoracic involvement accounts for most of morbidity and mortality associated with sarcoidosis. An accurate timely identification is required to minimize morbidity and mortality. It is essential to recognize atypical imaging findings and relate these to clinical manifestations and histology.
Source: Annals of Thoracic Medicine - September 20, 2013 Category: Respiratory Medicine Authors: Hamdan Al-JahdaliPrabhakar RajiahShyam Sunder KoteyarCarolyn AllenAli Nawaz Khan Source Type: research

Microbial and human heat shock proteins as 'danger signals' in sarcoidosis.
Abstract In the light of the Matzinger's model of immune response, human heat shock proteins (HSPs) as main 'danger signals' (tissue damage-associated molecular patterns-DAMPs) or/and microbial HSPs as pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors (PRR), may induce sarcoid granuloma by both infectious and non-infectious factors in genetically different predisposed host. Regarding infectious causes of sarcoid models, low-virulence strains of, e.g. mycobacteria and propionibacteria recognized through changed PRR and persisting in altered host phagocytes, generate increase...
Source: Human Immunology - August 27, 2013 Category: Allergy & Immunology Authors: Dubaniewicz A Tags: Hum Immunol Source Type: research

Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition.
We present a patient with sarcoidosis who developed acute kidney injury (AKI). He had a high 1,25-OH vitamin D level and hypercalciuria. As his renal function declined he developed hypercalcemia. A kidney biopsy showed acute tubular necrosis (ATN) with giant cell formation around calcium phosphate crystals. Calcium phosphate deposition is uncommon in sarcoid. We speculate that early interstitial calcium phosphate deposition may in time lead to the development of Randall's plaques and to the more typical calcium oxalate nephrolithiasis seen in sarcoidosis. PMID: 23845267 [PubMed - in process]
Source: Clinical Nephrology - July 16, 2013 Category: Urology & Nephrology Authors: Manjunath V, Moeckel G, Dahl NK Tags: Clin Nephrol Source Type: research

Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes.
Abstract Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. Many P. acnes have been detected in sarcoid lymph nodes using quantitative PCR and in sarcoid granulomas by in situ hybridization. P. acnes trigger factor protein causes a cellular immune response only in sarcoid patients and induces pulmonary granulomas in mice sensitized with the protein and adjuvant, but only those with latent P. acnes infection in their lungs. Eradication of P. acnes by antibiotics prevents the development of granulomas in ...
Source: Biomed Res - July 16, 2013 Category: Research Authors: Eishi Y Tags: Biomed Res Int Source Type: research

Heart Transplantation for End-Stage Heart Failure Due to Cardiac Sarcoidosis
Conclusions: Patients with cardiac sarcoidosis undergoing heart transplantation have acceptable long-term outcomes without evidence of recurrence of sarcoidosis in the allograft when maintained on low-dose corticosteroids. Progression of extracardiac sarcoid was uncommon, possibly related to immunosuppression. In patients with cardiac sarcoidosis, heart transplantation is a viable treatment modality.
Source: Transplantation Proceedings - July 1, 2013 Category: Transplant Surgery Authors: D. Perkel, L.S.C. Czer, R.P. Morrissey, A. Ruzza, M. Rafiei, M. Awad, J. Patel, J.A. Kobashigawa Tags: Thoracic Transplantation Source Type: research

Sarcoidosis Lung Nodules in Colorectal Cancer Follow-Up: Sarcoidosis or Not?
Conclusion: Our cases focused on the usefulness of histologic proof in patients with cancer with sarcoidosis.
Source: The American Journal of Medicine - June 20, 2013 Category: Journals (General) Authors: Marie Lequoy, Romain Coriat, Alexandre Rouquette, Olivier Mir, Géraldine Perkins, Jean-François Regnard, Catherine Brezault, Stanislas Chaussade Tags: Brief observation Source Type: research

Sarcoidosis Manifesting as a Pseudotumorous Renal Mass
A 53 year-old African American woman with a three-year history of pulmonary sarcoidosis had a follow-up computed tomographic scan to evaluate the status of her disease and response to treatment. On the scan, an abnormal, hypodense mass on the left renal superior pole, which was not present on previous scans, was incidentally discovered. The initial concern was of carcinoma, despite her lack of any urinary symptoms. She underwent further evaluation with magnetic resonance, and the enhancement pattern and the shape of the mass were more suggestive of lymphoma or infarction than a carcinoma. A review of literature revealed sp...
Source: Journal of Radiology Case Reports - June 3, 2013 Category: Radiology Source Type: research

Correlation of late gadolinium enhancement MRI and quantitative T2 measurement in cardiac sarcoidosis
ConclusionLGE‐MRI can identify cardiac involvement in systemic sarcoidosis. MCLE might be more sensitive at detecting subtle myocardial lesion. The decreased T2 observed in cardiac sarcoid may reflect its inactive phase, thus might provide a noninvasive method for monitoring disease activity or therapy.J. Magn. Reson. Imaging 2013;00:000–000. © 2013 Wiley Periodicals, Inc.
Source: Journal of Magnetic Resonance Imaging - May 29, 2013 Category: Radiology Authors: Yuesong Yang, Katherine Safka, John J. Graham, Idan Roifman, Mohammad I. Zia, Graham A. Wright, Meyer Balter, Alexander J. Dick, Kim A. Connelly Tags: Original Research Source Type: research

The frequency of granulomatous lacrimal gland inflammation as a cause of lacrimal gland enlargement in patients without a diagnosis of systemic sarcoidosis.
Discussion: In patients with clinical lacrimal gland enlargement, incisional biopsy led to a diagnosis of sarcoidosis in 20% of patients. An elevated ACE level may help predict which patients have a greater diagnostic yield with biopsy. PMID: 23480843 [PubMed - in process]
Source: Orbit - May 26, 2013 Category: Opthalmology Authors: Rabinowitz MP, Halfpenny CP, Bedrossian EH Tags: Orbit Source Type: research

Coexistence of sarcoidosis with seminoma - a case report.
Abstract A 30-year-old patient, with diagnosis of seminoma (T1 Nx Mx) was treated radically with orchidectomy. In chest CT performed postoperatively numerous diffuse nodules were revealed in both lungs. Lesions were situated particularly in the upper and middle pulmonary zones. In order to verify the nature of pulmonary abnormalities videothoracoscopy of the right pleural cavity was performed with specimen collection. Histopathological examination excluded the possibility of cancer metastases to pulmonary parenchyma and revealed the presence of sarcoid-like granulomas. Coexistence of seminoma and diffuse sarcoid-l...
Source: Pneumonologia i Alergologia Polska - February 22, 2013 Category: Respiratory Medicine Authors: Kita-Milczarska K, Górska L, Kuziemski K, Sejda A, Jassem E, Biernat W Tags: Pneumonol Alergol Pol Source Type: research

Preliminary characterizations of a serum biomarker for sarcoidosis by comparative proteomic approach with tandem-mass spectrometry in ethnic Han Chinese patients
Background: The diagnosis of sarcoidosis is still a significant challenge in China because of the need to exclude other diseases including granulomatous infections and malignancies that may be clinically and radiographically similar. The specific aim of the study is to search for serum protein biomarkers of sarcoidosis and to validate their clinical usefulness in differential diagnosis. Methods: Serum samples were collected from patients with sarcoidosis (n = 37), and compared to those from patients with tuberculosis (n = 20), other pulmonary diseases (n = 20), and healthy volunteers (n = 20) for determination of sarcoidos...
Source: Respiratory Research - February 11, 2013 Category: Respiratory Medicine Authors: Yuan ZhangXianqiu ChenYang HuShanshan DuLi ShenYifan HeYuxuan ZhangXia ZhangHuiping LiRex Yung Source Type: research

Splenic sarcoidosis mimicking neoplastic disease
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause that commonly involves the spleen. Sarcoid can produce either homogeneous splenomegaly or multiple splenic nodules. Although other organ system involvement usually occurs, this is not invariable. Herein, we report on the clinical, histological, and radiological features—including sonography and MRI—of an isolated splenic sarcoidosis that mimicked neoplastic disease in a 37‐year‐old female. Knowledge of this atypical sonographic presentation may prevent unnecessary splenectomy. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013
Source: Journal of Clinical Ultrasound - January 1, 2013 Category: Radiology Authors: Salem Bauones, Thomas Le Corroller, Olivier Durieux, Daphné Guenoun, Jean Del Grande, Nicolas Pirro, Pierre Champsaur Tags: Case Report Source Type: research

Sarcoid-like granulomatosis induced by Propionibacterium acnes in mice; role of ICAM-1 in prevention of granuloma formation
Sarcoidosis is a systemic granulomatous disease which is characterized by a variable clinical presentation and course. The etiology of the disease has remained unknown. Propionibacterium acnes (P. acnes), an anaerobic nonspore-forming gram-positive rod bacterium, has been implicated as one of the suggested causative antigens of sarcoidosis since this bacterium has been isolated from sarcoid lesions. In order to clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we first established an in vivo model of sarcoid-like skin granulomatosis by injecting heat-killed P. acnes into the back of C57BL/6J mice. These...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Masahiro Kamata, Yayoi Tada, Yoshihide Asano, Makoto Sugaya, Takafumi Kadono, Shinichi Sato Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Primary Sarcoid of the Breast with Incidental Malignancy
We report a very unusual case of primary breast sarcoidosis with incidentally discovered breast carcinoma. The roles of mammography, ultrasound, and MRI in the diagnosis as well as other potential differential diagnosis are discussed.
Source: Journal of Clinical Imaging Science - July 28, 2012 Category: Radiology Authors: Laura M IsleyAbbie R CluverRebecca J LeddyMegan K Baker Source Type: research