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Total 5084 results found since Jan 2013.

Sarcoidosis presenting as Wallenberg syndrome and panuveitis
We report a case of a patient who presented with the lateral medullary syndrome and panuveitis as her initial manifestation of sarcoidosis. The patient’s course was further complicated by renal involvement. Lacrimal gland and renal biopsies showed noncaseating granulomas without evidence of infection, establishing the diagnosis. Intracranial vertebral artery involvement was confirmed by brain imaging. Bilateral hilar lymphadenopathy with upper lobe predominant nodules on chest imaging was consistent with asymptomatic pulmonary involvement. Systemic steroid therapy is indicated for treatment of ocular sarcoidosis, with st...
Source: Respiratory Medicine Case Reports - July 10, 2018 Category: Respiratory Medicine Source Type: research

Cough in sarcoidosis patients
Publication date: Available online 4 January 2018Source: Respiratory Physiology & NeurobiologyAuthor(s): Eva Kovacova, Tomas Buday, Robert Vysehradsky, Jana PlevkovaAbstractSarcoidosis is a multi-system disease of unknown aetiology characterized by presence of non-caseating granulomatous inflammation. Cough is a common and significant symptom in sarcoidosis, reducing quality of life. Objective 24 h cough monitoring proved that sarcoidosis patients have significantly higher cough frequency compared to controls and their cough has diurnal variation, it is gender-specific and shows racial differences. It correlates with the...
Source: Respiratory Physiology and Neurobiology - July 10, 2018 Category: Respiratory Medicine Source Type: research

Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis
Publication date: April–June 2018Source: Saudi Journal of Ophthalmology, Volume 32, Issue 2Author(s): Daniele Cirone, Luca Cimino, Giovanni SpinucciAbstractSarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging.We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations.A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous ant...
Source: Saudi Journal of Ophthalmology - July 10, 2018 Category: Opthalmology Source Type: research

Tubulointerstitial nephritis and uveitis (TINU) with granulomatosis: a novel report of simultaneous TINU and sarcoidosis in a pediatric patient
We report the case of a 7-year-old girl who presented with bilateral anterior uveitis, acute interstitial nephritis, and asymptomatic pulmonary granulomas and provide novel clinical evidence of an association between tubulointerstitial nephritis and uveitis syndrome and sarcoidosis.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - July 10, 2018 Category: Opthalmology Source Type: research

The fear of lymphadenopathy: A cautionary case of sarcoidosis masquerading as recurrent diffuse large b-cell lymphoma (DLBCL)
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free. The presentation of sarcoidosis masquerading as recurrent DLBCL highlights the importance of tissue samp...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Management of cardiac sarcoidosis – A practical guide
Publication date: April 2018Source: Cor et Vasa, Volume 60, Issue 2Author(s): Petr Kopriva, Martin Griva, Zbynek TüdösAbstractSarcoidosis is a multi-system granulomatous disorder of unclear etiology which can affect any organ of the body including the heart. The heart is involved in up to 25% of sarcoidosis patients. In rare cases, the heart can be the only organ involved.Involvement of the heart, called cardiac sarcoidosis, especially if symptomatic, significantly deteriorates the prognosis for sarcoidosis patients, which is why cardiac sarcoidosis should be not only considered, but also searched for actively. Despite r...
Source: Cor et Vasa - July 10, 2018 Category: Cardiology Source Type: research

Sarcoidosis presenting as Wallenberg syndrome and panuveitis.
We report a case of a patient who presented with the lateral medullary syndrome and panuveitis as her initial manifestation of sarcoidosis. The patient's course was further complicated by renal involvement. Lacrimal gland and renal biopsies showed noncaseating granulomas without evidence of infection, establishing the diagnosis. Intracranial vertebral artery involvement was confirmed by brain imaging. Bilateral hilar lymphadenopathy with upper lobe predominant nodules on chest imaging was consistent with asymptomatic pulmonary involvement. Systemic steroid therapy is indicated for treatment of ocular sarcoidosis, with stan...
Source: Respiratory Care - July 7, 2018 Category: Respiratory Medicine Authors: Oks M, Li A, Makaryus M, Pomeranz HD, Sachdeva M, Pullman J, Schwartz D, Steinberg H Tags: Respir Med Case Rep Source Type: research

Coexistence of sarcoidosis and Hashimoto thyroiditis.
Abstract Sarcoidosis is a chronic, inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It can present with bilateral hilar lymphadenopathy, skin lesions, eye involvement and locomotor system findings. Hashimoto thyroiditis is an organ-specific autoimmune disease characterized by increased autoantibody synthesis. Sarcoidosis can involve different endocrine glands. Thyroid gland involvement may lead to increased thyroid function disorders and autoantibodies. Herein, we report an 80-year-old female patient with sarcoidosis and Hashimoto coexistence. PMID: 29976045 [PubMed - in process]
Source: Reumatismo - July 6, 2018 Category: Rheumatology Authors: Semiz H, Yalcin M, Kobak SV Tags: Reumatismo Source Type: research

Sarcoidosis presenting as Wallenberg syndrome and panuveitis
We report a case of a patient who presented with the lateral medullary syndrome and panuveitis as her initial manifestation of sarcoidosis. The patient’s course was further complicated by renal involvement. Lacrimal gland and renal biopsies showed noncaseating granulomas without evidence of infection, establishing the diagnosis. Intracranial vertebral artery involvement was confirmed by brain imaging. Bilateral hilar lymphadenopathy with upper lobe predominant nodules on chest imaging was consistent with asymptomatic pulmonary involvement. Systemic steroid therapy is indicated for treatment of ocular sarcoidosis, with st...
Source: Respiratory Medicine Case Reports - July 5, 2018 Category: Respiratory Medicine Source Type: research

Cough in sarcoidosis patients
Publication date: Available online 4 January 2018Source: Respiratory Physiology & NeurobiologyAuthor(s): Eva Kovacova, Tomas Buday, Robert Vysehradsky, Jana PlevkovaAbstractSarcoidosis is a multi-system disease of unknown aetiology characterized by presence of non-caseating granulomatous inflammation. Cough is a common and significant symptom in sarcoidosis, reducing quality of life. Objective 24 h cough monitoring proved that sarcoidosis patients have significantly higher cough frequency compared to controls and their cough has diurnal variation, it is gender-specific and shows racial differences. It correlates with the...
Source: Respiratory Physiology and Neurobiology - July 5, 2018 Category: Respiratory Medicine Source Type: research

Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis
Publication date: April–June 2018Source: Saudi Journal of Ophthalmology, Volume 32, Issue 2Author(s): Daniele Cirone, Luca Cimino, Giovanni SpinucciAbstractSarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging.We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations.A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous ant...
Source: Saudi Journal of Ophthalmology - July 5, 2018 Category: Opthalmology Source Type: research

Tubulointerstitial nephritis and uveitis (TINU) with granulomatosis: a novel report of simultaneous TINU and sarcoidosis in a pediatric patient
We report the case of a 7-year-old girl who presented with bilateral anterior uveitis, acute interstitial nephritis, and asymptomatic pulmonary granulomas and provide novel clinical evidence of an association between tubulointerstitial nephritis and uveitis syndrome and sarcoidosis.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - July 5, 2018 Category: Opthalmology Source Type: research

The fear of lymphadenopathy: A cautionary case of sarcoidosis masquerading as recurrent diffuse large b-cell lymphoma (DLBCL)
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free. The presentation of sarcoidosis masquerading as recurrent DLBCL highlights the importance of tissue samp...
Source: Leukemia Research Reports - July 5, 2018 Category: Hematology Source Type: research

Management of cardiac sarcoidosis – A practical guide
Publication date: April 2018Source: Cor et Vasa, Volume 60, Issue 2Author(s): Petr Kopriva, Martin Griva, Zbynek TüdösAbstractSarcoidosis is a multi-system granulomatous disorder of unclear etiology which can affect any organ of the body including the heart. The heart is involved in up to 25% of sarcoidosis patients. In rare cases, the heart can be the only organ involved.Involvement of the heart, called cardiac sarcoidosis, especially if symptomatic, significantly deteriorates the prognosis for sarcoidosis patients, which is why cardiac sarcoidosis should be not only considered, but also searched for actively. Despite r...
Source: Cor et Vasa - July 5, 2018 Category: Cardiology Source Type: research

Atypical CT findings of pulmonary sarcoidosis: A case report
Rationale: Pulmonary involvement occurs in about 90% of patients with sarcoidosis. However, delayed diagnosis sometimes occurs due to atypical thoracic imaging findings. Patient concerns: A 52-year-old woman presented with recurrent uveitis and fever of unknown origin. She had been admitted to the hospital due to fever, but its cause was not determined. Diagnoses: Chest computed tomography (CT) revealed a solitary pulmonary nodule and an enlarged right axillary lymph node. The nodule had showed an interval growth from 0.7 cm to 1.1 cm over 18 months, when compared to the previous chest CT. Mosaic attenuation wa...
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Focal Myocardial Damage in Cardiac Sarcoidosis Characterized by Strain Analysis on Magnetic Resonance Tagged Imaging in Comparison with Fluorodeoxyglucose Positron Emission Tomography Accumulation and Magnetic Resonance Late Gadolinium Enhancement
Objective The aims of this study were to characterize focal myocardial damage of cardiac sarcoidosis by strain analysis and to compare it with late gadolinium enhancement (LGE) and fluorodeoxyglucose (FDG) positron emission tomography. Methods We reviewed 208 segments from 13 cardiac sarcoidosis patients and measured the circumferential strain (Ecc) and the strain change per second (Ecc rate). The mean Ecc and Ecc rate values were compared between the FDG(+) and FDG(−), and the LGE(+) and LGE(−) segments using Welch's t test. Results The peak and max Ecc rates were better in the LGE(−) segments than in the LG...
Source: Journal of Computer Assisted Tomography - July 1, 2018 Category: Radiology Tags: Cardiothoracic Imaging Source Type: research

Sarcoidosis with multiple organ involvement associated with necrotizing crescentic glomerulonephritis.
We report a case of a young Saudi male who presented with generalized body weakness and easy fatigability associated with fever, night sweating, loss of weight and appetite, and renal impairment. He was diagnosed as a case of sarcoidosis, and renal biopsy report was consistent with necrotizing crescentic glomerulonephritis (GN). Immunosuppressive medication was started to help halting the progression to renal failure and stabilize renal function. To the best of our knowledge, the association between sarcoidosis and crescentic GN has been reported in only few cases in literature. PMID: 30152439 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - July 1, 2018 Category: Urology & Nephrology Authors: Al-Hwiesh AK, Abdul-Rahman IS, Alhwiesh A, Al-Oudah N, Alratroo JA, Al-Oudah N, Al-Muhanna FA, Alsharani H, Ibrahim EF, Al-Durayash I, Al-Mubark AJ Tags: Saudi J Kidney Dis Transpl Source Type: research

Sarcoidosis in Patients with Antisynthetase Syndrome: Presentation and Outcome.
CONCLUSION: Sarcoidosis may be underdiagnosed in patients with AS. PMID: 29961694 [PubMed - as supplied by publisher]
Source: J Rheumatol - July 1, 2018 Category: Rheumatology Authors: Couture P, Brillet PY, Varin S, Le Goff B, Meyer A, Sibilia J, Jouneau S, Valeyre D, Hervier B, Uzunhan Y Tags: J Rheumatol Source Type: research

Effect of Needle Size in Diagnostic Yield of EBUS-TBNA in Sarcoidosis and Lymphoma
Conditions:   Sarcoidosis;   Lymphoma;   Adenopathy Hilar Interventions:   Device: ViziShot FLEX 19G needle;   Device: Vizishot 22G needle (standard) Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM) Not yet recruiting
Source: ClinicalTrials.gov - June 29, 2018 Category: Research Source Type: clinical trials

The importance of histopathology in the diagnosis of isolated renal sarcoidosis: a case report.
CONCLUSIONS: The use of histopathology together with clinical and laboratory data to diagnose isolated renal sarcoidosis, rule out other etiologies and introduce early treatment is of paramount importance. PMID: 29944158 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - June 29, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Propionibacterium acnes Septic Pericarditis in a Patient With Sarcoidosis and Acne
We present the first case of infective pericarditis caused by P. acnes in a man with acne and severe sarcoidosis. This case emphasizes the importance of considering this microorganism as a causative agent of pericarditis in this setting.
Source: Infectious Diseases in Clinical Practice - June 28, 2018 Category: Infectious Diseases Tags: Case Reports Source Type: research

Common symptoms for a rare disease in a girl with sarcoidosis: a case report
Sarcoidosis in pediatric age is uncommon and challenging diagnosis, because manifestations can be significantly variable and non-specific since it is a multisystem disease, and virtually any organ system may b...
Source: Italian Journal of Pediatrics - June 28, 2018 Category: Pediatrics Authors: Mattia Giovannini, Michele Luzzati, Giovanna Ferrara, Anna Maria Buccoliero, Gabriele Simonini, Maurizio de Martino, Rolando Cimaz and Teresa Giani Tags: Case report Source Type: research

Sarcoidosis onset simulating a unique hepatic metastasis.
We present a clinical case of a female diagnosed with an isolated hepatic sarcoidosis that simulated a unique hepatic metastatic lesion. The hepatic biopsy was diagnostic. PMID: 29931995 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - June 23, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Granulomatous Tumoral Melanosis Associated With Pembrolizumab Therapy: A Mimicker of Disease Progression in Metastatic Melanoma
We report a case of sarcoid-like granulomatous tumoral melanosis in a patient on the programmed cell death-1 (PD-1) receptor inhibitor pembrolizumab for metastatic melanoma. This is, to our knowledge, the first reported case of a sarcoidal form of tumoral melanosis in a patient on anti-PD-1 therapy. We postulate that this reflects tumor regression in response to pembrolizumab-induced immune activation, with concomitant therapy–triggered induction of a sarcoid-like reaction. These findings and the literature review presented herein should alert clinicians and pathologists to the possibility of regressed lesions with sarco...
Source: The American Journal of Dermatopathology - June 21, 2018 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Clinical characteristics associated with pacing-induced cardiac dysfunction: a high incidence of undiagnosed cardiac sarcoidosis before permanent pacemaker implantation
AbstractPrevious studies suggested that right ventricular pacing was associated with pacing-induced cardiac dysfunction (PICD). The purpose of this study was to investigate the clinical characteristics including the incidence of undiagnosed cardiac sarcoidosis (CS) in patients with atrioventricular block (AVB) who manifest PICD. We retrospectively investigated consecutive patients with permanent pacemaker (PPM) undergoing a first-generator replacement surgery with a new PPM or an upgrade procedure to a cardiac resynchronization therapy (CRT) device between December 1, 2011 and June 30, 2017. Patients with AVB showing norma...
Source: Heart and Vessels - June 21, 2018 Category: Cardiology Source Type: research

Peptide receptor radionuclide therapy as a new tool in treatment-refractory sarcoidosis - initial experience in two patients
Conclusion: Peptide receptor radionuclide therapy in sarcoidosis is feasible and might be a new valuable tool in patients with otherwise treatment-refractory disease. Given the long experience with and good tolerability of PRRT, further evaluation of this new treatment option for otherwise treatment-refractory sarcoidosis in larger patient cohorts is warranted.
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Constantin Lapa, Malte Kircher, Heribert H ä nscheid, Andreas Schirbel, G ö tz Ulrich Grigoleit, Erdwine Klinker, Markus B ö ck, Samuel Samnick, Theo Pelzer, Andreas K Buck Tags: Research Paper Source Type: research

Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis
Conditions:   Sarcoidosis;   Cardiomyopathies Interventions:   Diagnostic Test: 18F-FDG-PET/MRI;   Diagnostic Test: 18F-GE180-PET/MRI Sponsors:   St. Olavs Hospital;   Norwegian University of Science and Technology;   University Hospital, Essen Not yet recruiting
Source: ClinicalTrials.gov - June 19, 2018 Category: Research Source Type: clinical trials