Evaluating the effect of siRNA on sox2ot expression in the Human Neuron-Committed Teratocarcinoma NT2 Cellline.
Authors: Sadeghi Z, Dodange F, Maleki P, Zarei M, Taheri M, Raheb J Abstract Non-coding RNA elongated (lncRNAs) have recently attracted as molecules that regulate gene expression of the pluripotent properties (pluripotency) of stem cells. Recently our colleagues examined the role of one of these RNAs called SOX2OT in esophageal squamous cell carcinoma, and found a concomitant increase in its expression with some regulatory genes of cell proliferation. In the present study, using the design of suitable primers from SOX2OT gene, we investigated the effect of siRNA on expression of SOX2OT. PMID: 32716352 [PubMed -...
Source: Human Antibodies - July 29, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

CXCL9 chemokine level is associated with spontaneous clearance and sustained virological response in Egyptian Chronic Hepatitis C patients receiving direct acting antivirals.
This study aimed to evaluate the level of chemokine CXCL9 and its correlation with some biochemical parameters in different subjects of HCV patients. MATERIALS AND METHODS: A total of 83 persons participated in this study including healthy subjects without both HCV antibodies and HCV RNA (22.9%), HCV treated responders accomplished SVR post treatment, with HCV antibodies and absence of HCV RNA (24.1%), spontaneous or natural clearance patients, with positive HCV antibodies and negative HCV RNA without treatment (26.5%) and chronic HCV-patients, with both positive HCV antibodies and HCV RNA with no treatment (26.5%). HC...
Source: Human Antibodies - July 19, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

The roles of miRNAs' clinical efficiencies in the colorectal cancer pathobiology: A review article.
Authors: Eshghifar N, Badrlou E, Pouresmaeili F Abstract MiRNAs (microRNAs) are defined as micro directors and regulators of gene expression. Since altered miRNA expression is signified in the pathobiology of diverse cancers such as colorectal cancers (CRCs), these molecules are described as therapeutic targets, either. Manipulation of miRNAs could lead to further therapy for chemo and radio-resistant CRCs. The usage of microRNAs has indicated prominent promise in the prognosis and diagnosis of CRC, because of their unique expression pattern associated with cancer types and malignancies. Nowadays, many researchers ...
Source: Human Antibodies - July 6, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Prognostic impact of ABO Blood group on Type I endometrial cancer in a population of iranian patients.
CONCLUSION: Although there was no significant relationship between the ABO blood group and the patients' clinicopathological characteristics, more studies could provide extensive information about any possible relation between the blood group, especially blood group A, EC, and the grade of the tumor. PMID: 32508322 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - June 10, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Prevalence of calcium and vitamin D deficiency and their association with feto-maternal outcomes in a sample of Iranian pregnant women.
Authors: Amouzegar A, Azizi F, Ashrafivand S, Ahi Z, Saleh M, Mohaghegh S, Gargari SS Abstract BACKGROUND: Calcium and vitamin D deficiency is common among Iranian women of childbearing age and poses adverse effects on pregnancy outcomes. The aim of the current study was to determine the prevalence of vitamin D and calcium in a sample of Iranian pregnant women and to assess its correlation with the feto-maternal outcomes. With this aim. METHODS: In this prospective cross-sectional study, a sample of pregnant women between 15 to 45 years who were in the third trimester were recruited from a number of hospitals i...
Source: Human Antibodies - May 24, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Zero tolerance for complacency by government of West African countries in the face of the COVID-19 pandemic.
Authors: Erhabor O, Erhabor T, Adias TC, Okara GC, Retsky M Abstract A novel Coronavirus (SARS-CoV-2) causing a cluster of respiratory infections (Coronavirus Disease 2019, COVID-19) first discovered in Wuhan, China is responsible for a new illness that has been found to affect the lungs and airways of patients with associated symptoms of fever, cough and shortness of breath. In the light of few cases recorded so far in West Africa there is tendency for complacency. The region needs to make strategic plans based on available evidence to enable them effectively deal with this rapidly evolving pandemic. At this very ...
Source: Human Antibodies - May 18, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

A case report of haemolytic disease of the foetus and newborn caused by Alloantibody D and Jka in a Rhesus D negative Nigerian woman: Justification for the implementation of universal access to prophylaxis and evidenced-based best practices.
Authors: Osaro E, Azachi WB, Tosan E Abstract A case report of a 38 years old ABO group A and Rhesus D negative multiparous, gravidae 8 and para 2, Nigerian woman who had a case of premarital miscarriage and who was not offered anti-D prophylaxis as part of her management. Lady went on to develop alloantibody D and Jka. Lady has had 7 further pregnancies post the miscarriage. The first child who is B Rhesus D positive is the only surviving child. The surviving child was delivered severely jaundiced and needed management post-delivery for haemolytic disease of the foetus and newborn (HDFN). Lady has had a histo...
Source: Human Antibodies - May 18, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

LINK-A long non-coding RNA and VEGF RNA expression in epithelial ovarian cancer patients.
This study confirms importance of novel lncRNA of LINK-A in Iranian EOC patients. PMID: 32333582 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - April 27, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Prevalence of some hepatitis B virus markers among pregnant women attending antenatal clinic in Specialist Hospital Sokoto Nigeria.
CONCLUSION: The study observed a high prevalence of various hepatitis B viral markers among pregnant women attending antenatal care in Specialist Hospital Sokoto. There is need for routine screening of all pregnant women and infants born to hepatitis B positive mothers. Government and non-governmental organizations should intensify efforts to enlighten the general population on the public health importance of the disease and the importance of hepatitis screening. There is also need for the development of a treatment protocol for the management of pregnant women positive for hepatitis B to prevent mother to child transmissi...
Source: Human Antibodies - April 27, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Study of the application of gold nanoparticles for early detection of prostate cancer.
Authors: Ahmadianpour MV, Mowla J, Sotoodehnejadnematalahi F, Raheb J Abstract Studies on the blood of patients with prostate cancer using Dynamic Light Scattering (DLS) and corona protein size changes have shown that this test is highly specific and sensitive, but this method has not been studied in Iran, and therefore this study intends to perform this procedure using gold nanoparticles in prostate cancer detection. Blood samples of 60 male subjects aged 40-90 years were collected from 20 healthy, 20 benign and 20 prostate cancer patients. Optical scattering changes were measured by the level of gold nanoparticle...
Source: Human Antibodies - April 1, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Identification of HLA-A/B/DRB1 alleles in Iranian patients with Fanconi anemia.
Authors: Sayad A, Dehaghi MO, Taheri M, Fallah H, Arsang-Jang S, Shadnoush M, Ghafouri-Fard S, Hamidieh AA Abstract Fanconi anemia includes a number of clinically and genetically diverse disorders all of them being associated with genomic instability. Some previous studies reported higher frequencies of certain HLA alleles in patients with Fanconi anemia. In the current study, we genotyped HLA-A/B/DRB1 alleles in 40 Iranian patients with Fanconi anemia. We also genotyped these alleles in the same number of Iranian sex-matched healthy individuals. The frequency of DRB1*11 was significantly higher in patients compare...
Source: Human Antibodies - April 1, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Production and Purification of polyclonal antibody against attenuated and wild type leishmania infantum in dogs.
In this study we produced and purified polyclonal antibody against attenuated and wild type leishmania infantum in dogs. Anti-leishmania in dog serums precipitated with ammonium sulphate. The IgG recovered from ammonium sulphate precipitation was subject to ion exchange chromatography (IEC) and the purity of IgG was confirmed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) under reduced condition. The purity of proteins were above 95% and then purified IgG was conjugated with FITC. We determined optimum titer of dog IgG by observation parasites under fluorescent microscope. The optimum dilution of ...
Source: Human Antibodies - March 18, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

MTT assay dataset of Polyethylenimine coated Graphenoxide nanosheets on breast cancer cell lines (MCF7, MDA-MB-231, MDA-MB-468).
Authors: Maleki P, Sadeghi Z, Shahryar Rahpeyma S, Taheri M, Raheb J Abstract Graphen oxide has emerged as a promising tool in medical biotechnology due to its outstanding properties applicable in several fields as well as cell imaging, drug and gene delivery. Monolayer structure and high surface area of Graphen benefits elevated loading capacity of drugs rather than other nanomaterials. However Graphen oxide in physiological solutions has unfavourable reactions which confine it's application in biomedical field without additional surface functionalization. Coating of graphenoxide by polyethylenimine is an approach...
Source: Human Antibodies - March 18, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Fine-tuning ofroutine combined first- trimester screening: The ratio of serum-free- beta-human chorionic gonadotropin (f β-hCG) to pregnancy-associated plasma protein-A (PAPP-A) could improve performance of Down syndrome screening program, a retrospective cohort study in Iran.
CONCLUSION: Compared with the current policy, our novel proposed approach had better performance and could be applied by the Iran National Health Service to improve the screening program guideline. PMID: 32176639 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - March 18, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Effect of hypocomplementemia on perinatal outcomes of pregnancies with autoimmune disorders.
CONCLUSION: Low complement levels in pregnant women with autoimmune disorders may be associated with gestational problems and poor obstetric history. Immunomodulatory treatment modalities such as ours may be beneficial for improving the obstetric and neonatal outcomes. PMID: 32116241 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - March 4, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Screening for scFv-fragments that are stable and active in the cytosol.
In this study, we evaluated fast and simple screening methods to identify scFv fragments that are stable and functional in the cytosol. We analyzed various phage display derived human scFv antibodies recognizing extracellular signal-regulated kinase 2 (Erk2) for stability and antigen binding under reducing and non-reducing conditions. Further, we developed an assay allowing to measure the interaction of the scFv intrabodies with their antigen in the cytosol of in living cells, by using a Split-Luciferase (Split-Luc) assay. ScFv fragments showing antigen binding in the cytosol could successfully be identified. PMID: 321...
Source: Human Antibodies - March 4, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Surface modification of superparamagnetic iron oxide (SPION) and comparison of cytotoxicity effect of mPEG2000-PEI-SPION and mPEG750-PEI-SPION on the human embryonic carcinoma stem cell, NTERA2 cell line.
Authors: Sadeghi Z, Maleki P, Shahabi F, Bondarkhilli SAM, Masoumi M, Taheri M, Mohammadi M, Raheb J Abstract Non-viral carriers based on nanoparticles are promising vectors for drug and gene delivery into the target cells. The data provided in this article are related to research entitled "Efficiency of surface modified SPION". In this article the surface of superparamagnetic iron oxide (SPION) (core) coated with poly (ethylene glycol)-grafted polyethylenimine (mPEG-co-PEI) shell. PEI was used to increase gene transfection efficiency and poly (ethylene glycol) methyl ether was applied to reduce cytotoxic...
Source: Human Antibodies - March 4, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Construction and development of FimH lectin domain for rising immune response after injection by uropathogenic E. coli.
Authors: Zandi M, Fallah Mehrabadi J, Mahdavi M, Irani S Abstract Uropathogenic E. coli is one of the major agents of urinary tract infection. Today, no effective treatment or vaccine against this infection is exist. Accordingly, in the present study, a genetic constrruct for inducing of cellular immune system was designed. At first, fimH gene from E. coli 35218 was amplified using PCR. PCR product inserted into pET23a expression vector and the recombinant vector was analysed by sequencing. The vector was transformed to E. coli strain Origami and the protein was expressed under the 1 mM IPTG. FimH was purified...
Source: Human Antibodies - March 4, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Assessment of anti-cancer effects of koenimbine on colon cancer cells.
CONCLUSION: The current in vitro study showed the cytotoxic effects of koenimbin on two colon cancer cell lines and the effects of this substance on expression of selected genes from Wnt-β catenin pathway. Future in vivo studies are needed before suggestion of this substance as an anti-cancer drug. PMID: 32116245 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - March 4, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Association between HLA alleles and risk of celiac disease in Iranian patients.
In this study, 40 patients of CD and 40 healthy control samples were genotyped for HLA-DQB1 and 14 patients of CD and 14 healthy control samples were genotyped for HLA-DQA1genes using the SSP-PCR technique and a commercial kit.The DQA1*05 allele had the highest frequency among the patient group (42.86%). The frequency of this allele was 28.57% in healthy controls, and there was no statistically significant difference in this case (p= 0.771).The DQB1*02 allele was the most common in patients (33.75%) followed by the DQB1*03 allele (31.25%).The difference in frequency of the HLA-DQB1*02 allele in the patient and control grou...
Source: Human Antibodies - October 30, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Optimized protocol for soluble prokaryotic expression, purification and refolding of the human inhibin α subunit, a cysteine rich peptide chain.
Optimized protocol for soluble prokaryotic expression, purification and refolding of the human inhibin α subunit, a cysteine rich peptide chain. Hum Antibodies. 2019 Oct 18;: Authors: Kolivand S, Nazari M, Modarressi MH, Najafabadi MRH, Hemati A, Ghafouri-Fard S, Motevaseli E Abstract BACKGROUND: Inhibin A, a member of TGF-β superfamily, consists of α and β subunits. These subunits contain several cysteine residues in amino acid sequence that forms inter- and intra-subunits disulfide bonds. Due to the reducing environment of the bacterial cytoplasm, disulfide bonds formation in E....
Source: Human Antibodies - October 30, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

The modified vaccination technique designed to prevent and cure acute and chronic disorders.
Authors: Barabas AZ, Cole CD, Kovacs ZB, Kovacs EI, Lafreniere R, Weir DM Abstract In spite of enormous efforts there have been no solutions to date for preventing/terminating certain acute and chronic disorders of humans by vaccination or drugs. Yet it is well understood that if the target antigen (ag) could be presented appropriately to the cells of the immune system then solutions could be found. Recently, the Barabas research group has introduced and described the third vaccination method - called modified vaccination technique (MVT) - which has the ability to provide a corrective immune response in experimenta...
Source: Human Antibodies - October 10, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Association between tumor necrosis factor-alpha gene rs1800629 (-308G/A) and rs361525 (-238G > A) polymorphisms and prostate cancer risk in an Iranian cohort.
CONCLUSIONS: Although, the achieved results of this investigation demonstrated that the two examined genetic variants do not seem to be suitable markers for early diagnosis of prostate cancer in this pilot study; however increased risk for the disease is shown in GA heterozygotes and smokers which is indicative of some epigenetic factors influence on prostate cancer etiology. PMID: 31594215 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - October 10, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Assessment the genes and molecular mechanisms of B cells activation through systems biology approaches.
In conclusion, we explored holistic methods for molecular assay of difference between B cell activation mechanisms with Th1 and Th2. PMID: 31524152 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - September 18, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

The relationship between health literacy and quality of life among hemodialysis patients: An integrative review.
CONCLUSION: There is a relationship between health literacy and quality of life among patients receiving hemodialysis. Conclusively, addressing health literacy may improve the quality of life among patients receiving hemodialysis. PMID: 31524153 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - September 18, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

The nine lives of epitope-based antibody patents.
This article strives to give an overview about the as is situation both in Europe and the United States. PMID: 31524154 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - September 18, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Former antiplatelet drug administration and consequences of intravenous thrombolysis in acute ischemic stroke.
CONCLUSION: Based on the results of this study, patients with acute ischemic stroke and history of taking antiplatelet drugs have poor outcome following administration of standard dose of tPA. PMID: 31356199 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - July 31, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Cellular immune responses against cancer-germline genes in cancers.
CONCLUSION: Cellular immune responses against cancer-germline genes are indicative of appropriateness of these genes as therapeutic targets. PMID: 31356200 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - July 31, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Nanobodies: The "magic bullets" in therapeutics, drug delivery and diagnostics.
Nanobodies: The "magic bullets" in therapeutics, drug delivery and diagnostics. Hum Antibodies. 2019 Jul 12;: Authors: Mir MA, Mehraj U, Sheikh BA, Hamdani SS Abstract Antibodies represent a well-established class of clinical diagnostics for medical applications as well as essential research and biotechnological tools. Although both polyclonal and monoclonal antibodies are indispensable reagents in basic research and diagnostics but both of them have their limitations. Hence, there is urgent need to develop strategies aimed at production of alternative scaffolds and recombinant antibodies of ...
Source: Human Antibodies - July 21, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

The association between diet quality and obesity-related metabolic risks.
CONCLUSIONS: High diet quality incorporating more anti-inflammatory diet may have a potential benefit in reducing obesity-related metabolic risks. PMID: 31282409 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - July 11, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Anaemia and thrombocytopenia among pregnant women attending Aminu Kano Teaching Hospital, Kano State, North Western Nigeria.
CONCLUSION: The values obtained from this research showed an increase in prevalence of anaemia and thrombocytopenia among pregnant women compared to the non-pregnant controls. It is vital to routinely monitor the indices of anaemia and thrombocytopenia among pregnant women to reduce the incidence of these diseases and of their complications. PMID: 31282410 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - July 11, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Effects of malaria parasitaemia on some haemostatic parameters among pregnant women of African descent in Specialist Hospital Sokoto, Nigeria.
CONCLUSION: This study has shown that malaria in pregnancy causes a significant decrease in the platelet count and prolongation in the prothrombin (PT) and the activated partial thromboplastin time (APTT). There is need for the malaria and haemostatic parameters to be assayed routinely on pregnant women particularly those presenting to antenatal clinic with febrile illness. PMID: 31282411 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - July 11, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Assessment of SGO1 and SGO1-AS1 contribution in breast cancer.
Authors: Nasim N, Ghafouri-Fard S, Soleimani S, Esfandi F, Shirkhoda M, Safaei M, Oskooei VK, Taheri M, Raheb J Abstract Shugoshin-like protein 1 (SGO1) participated in the proper progression of mitosis. This fundamental role has indicated the importance of this gene in the pathogenesis of cancer as a disorder of mitotic cell division. A previous high throughput study of long non-coding RNAs (lncRNAs) expression in lung cancer has identified aberrant expression of SGO1-antisense 1 (SGO1-AS1) in these specimens. In the current study, we quantified expression of SGO1 and SGO1-AS1 in 39 breast cancer tissues and their...
Source: Human Antibodies - June 4, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Comparison between the effect of regular human insulin and NPH with novo-rapid and levemir insulin in glycemic control in gestational diabetes.
CONCLUSION: Altogether, The Novo-rapid and Levemir Insulin in comparing with the Regular and NPH Insulin were practically advantageous due to the simple using method and short hospitalization period of the patient. Thus, we prefer and suggest this beneficial method (using Novo-rapid and Levemir Insulin) to reach therapeutic goals. PMID: 31156155 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - June 4, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Menstrual cycle-associated effects on some acute phase reactants parameters of students in Usmanu Danfodiyo University Sokoto, North Western Nigeria.
CONCLUSIONS: There is need to generate data on menstrual disorders and their impact on women's health status, quality of life and social integration. It is vital that evaluation and treatment of menstrual complaints should be given a higher priority in primary care programs. There is need to invest in public enlightenment program to increase awareness in secondary schools to increase the level of awareness among adolescents as well as young females. PMID: 31156156 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - June 4, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Effects of resveratrol supplementation in male Wistar rats undergoing an endurance exercise and acute exercise training.
CONCLUSION: This study provides further evidence of the antioxidant effects of RES after exercise. However, several factors such as type and duration of exercise, the type of model, the amount of RES supplementation and the time-course consideration can affect the quality of the results. For this reason, further studies in this field are required. PMID: 31127758 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - May 29, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Serum inducible protein-10 chemokine as a biomarker for clearance of HCV with and without treatment in Egyptian patients.
Authors: Tabll A, El Shenawy R, Elsharkawy H, Mohamed FZ Abstract BACKGROUND AND AIMS: Assessment the potential predictive value of serum inducible protein-10 chemokine (IP-10) in the clearance of HCV in Egyptian patients with and without treatment. MATERIALS AND METHODS: Ninety Egyptian individuals were involved in the current study where, 20 patients (23%) were chronic HCV (positive HCV antibodies and positive HCV RNA without treatment, 20 (22%) were healthy individuals (negative for both HCV antibodies and HCV RNA, 20 (22%) were natural clearance (positive HCV antibodies and negative for HCV RNA without trea...
Source: Human Antibodies - May 29, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Leydig cells express the FABP9 in human testis.
CONCLUSION: The expression of FABP9 in a different cell type rather than spermatogenic cells in other mammals, reports of a plausible different function for the gene product like its involvement in fertility potential in homo sapiens. PMID: 31127760 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - May 29, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Perceptions of leadership, motivation, structure, and assurance for implementation of emergency medical services in Ethiopia: Perspectives of emergency medical services case teams based on focus group discussions.
Authors: Gebru AA, Mosadeghrad AM, Sari AA Abstract BACKGROUND: The research was assessed the Ethiopian Emergency Medical Services Case teams' and officers views on Emergency Medical services in Ethiopia. The aim of study was to present the point of views, prospect and priorities of Emergency medical services case teams and its coordinator along some main dimensions of emergency medical services, such as Leadership, Motivation, Structure, and Assurance for implementation. METHODS: Six focus group discussion were facilitated with EMS case teams, focal persons and FMoH emergency medical services case teams from D...
Source: Human Antibodies - May 29, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Some haematological parameters among pregnant women of African descent attending antenatal clinic in Sokoto North Western Nigeria.
Authors: Polycarp II, Osaro E, Kester D Abstract Pregnancy is the fertilization and development of one or more offspring, known as an embryo or foetus in a woman's uterus. Pregnancy is a critical stage of development during which maternal nutrition can strongly influence obstetric and neonatal outcomes. The aim of this study was to determine the effect of pregnancy on the full blood count parameters of pregnant women of African descent residing in Sokoto, North Western Nigeria. This case-control study investigated 74 pregnant subjects and 22 non-pregnant controls. The mean age and income of the subjects w...
Source: Human Antibodies - May 4, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Estimating the household drought driven food insecurity using system dynamics model: The case of afar national regional state of Ethiopia.
Authors: Belay GD, Ostadtaghizadeh A, Khoei EM, Ardalan A, Hosseinzadeh-Attar MJ, Assen M Abstract BACKGROUND: Building resilient communities has emerged as a dominant schema in the policy arena and in academia in the wake of recent disasters. Food insecurity is a complex and multidimensional phenomenon that is not appropriately captured by conventional proxy indicators currently used to assess the problem in developing countries. Ethiopia like many countries in sub-Saharan Africa, continues to experience high levels of drought driven food insecurity despite decades of implementing poverty alleviation and preventio...
Source: Human Antibodies - April 24, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Humoral immune responses against cancer-testis antigens in human malignancies.
CONCLUSION: Humoral immune responses against CTAs are putative biomarkers for cancer detection and follow-up. PMID: 31006681 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - April 24, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Client satisfaction on Emergency department services and quality of emergency medical care in Ethiopia: A systematic review.
CONCLUSION: This study finding shown that there was the variety of client perception on the emergency department and its quality care. Therefore, Emergency outpatient department should be raised progressively further by health care managers, governmental executives, EMS directorate, and other to address the efficient attribute of deprived value of health care and continuity of care delivery system but also it should be tied with new policy in Ethiopia. PMID: 30958338 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - April 9, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Emergency medical services in Ethiopia: Drivers, challenges and opportunities.
CONCLUSION: A long-term discussion is needed to further services system in various health care facilities. An Emergency Medical services policy making and analysis framework is needed to make quality emergency medical care at Emergency department in hospitals and outside the hospitals. PMID: 30958339 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - April 9, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Impact of food insecurity and malnutrition on the burden of Non-communicable diseases and death in Ethiopia: A situational analysis.
CONCLUSION: The SDGs are a target to call for comprehensive and it should have participatory approaches worldwide. Therefore, Ethiopian government and all policy-makers should be given great attention in order to improve the overall problems in the country. Especially, it requires the knowledge, commitment and responsibilities of politicians, researchers, health professionals and all stakeholders in the country. PMID: 30958340 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - April 9, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Establishment of serum derived infectivity coculture model for enhancement of hepatitis C virus replication in vitro.
CONCLUSIONS: Viral replication capacity was increased 3-5 folds in the coculture condition compared to the individual cell lines, which indicates an improvement to viral infectivity in vitro. SIGNIFICANCE STATEMENT: This novel coculture system represents a new in vitro model that will help study the underlying mechanisms of HCV pathogenicity. PMID: 30958341 [PubMed - as supplied by publisher] (Source: Human Antibodies)
Source: Human Antibodies - April 9, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Assessment of malnutrition and its anthropometric measurement among 0-59 month children aged at Amibara and Awash Fentale districts, afar national regional state of Ethiopia.
Authors: Hosseinzadeh Attar MJ, Belay GD, Ardalan A, Assen M, Khoei EM, Ostadtaghizadeh A Abstract PURPOSE: Famines and food shortages are one of the most common long time histories of Ethiopia. Hence, malnutrition has been persisted at alarming raters in the country. Moreover, it is a major cause of morbidity and mortality in Afar specifically, Amibara and Awash Fentale districts. The anthropometric data were presented on height, weight, MUAC, weight/height/Age and derived measure of Body Mass Index (BMI) of under-five aged children's. METHODS: A cross-sectional descriptive survey was conducted from March 01, ...
Source: Human Antibodies - April 9, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Circulating innate and adaptive immunity against anti-Haemophilus influenzae type b.
Authors: Zarei AE, Linjawi MH, Redwan EM Abstract Haemophilus influenzae type b (Hib) are one of most dangerous microbes that occupies the paediatric nasopharyngeal as a commensal opportunistic bacterium, which may lead to meningitis in uncontrolled infection. Colonisation of pharyngeal tissues is the starting point for most H. influenzae infections, which may develop into invasive diseases, such meningitis. The vaccination against Hib in specific, as well as against most of vaccines preventable diseases; in general, play a major role in reducing children (
Source: Human Antibodies - April 9, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Short note: Infliximab recovery in a simulated intestinal fluid of the upper intestine tract.
Authors: Volpatti D, Gulisano E, Spanghero M Abstract BACKGROUND: The oral administration of Infliximab (IFX) antibody would ensure a direct action on inflammatory intestinal tissues without side effects. Thus, investigations about its resilience within the intestinal environment are required. OBJECTIVE: Quantify the IFX recovery in a simulated upper intestinal environment. METHODS: IFX was incubated for different times until 120 min in simulated intestinal fluids (SIF) which differed (i) for pH (7.2 vs 6.8, Exp 1), (ii) for addition or not with pancreatin (Exp 2) and (iii) for addition or not with bov...
Source: Human Antibodies - April 9, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Some haematological parameters, copper and selenium level among children of African descent with sickle cell disease in specialist hospital Sokoto, Nigeria.
Authors: Erhabor O, Ogar K, Tosan E, Dangana A Abstract BACKGROUND: Sickle cell disease is a genetic disorder of haemoglobin causing myriad of pathology including anaemia. OBJECTIVES: The aim of this study was to evaluate some haematological parameters and trace elements of total of forty-five (45) children with Sickle cell disease attending Specialist Hospital Sokoto. METHOD: Twenty-five (25) apparently healthy children which were assessed as controls. The haematological parameters were determined using automated method and trace elements (copper and selenium) were determined using colorimetric and atomic ...
Source: Human Antibodies - March 26, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research