Circulating macrophage inflammatory protein-1 β/IL-12p40 ratio predicts sofosbuvir-based treatment outcome in HCV- genotype 4 patients
This study aimed to evaluate the prognostic value of baseline macrophage inflammatory protein (MIP)-1β/IL12p40 ratio for antiviral treatment outcome in HCV genotype 4 patients.METHODS: Sera of 450 treatment-naïve chronic HCV patients and 50 healthy individuals were collected. Liver transaminases, total bilirubin and albumin were biochemically tested, viral RNA was quantified, and circulating MIP-1β and IL-12p40 were estimated using human anti-MIP-1β and IL-12p40 antibodies in Sandwich ELISA.RESULTS: No difference was observed in the baseline chemokines levels between responders and relapsers, but the la...
Source: Human Antibodies - September 13, 2021 Category: Biochemistry Authors: Heba Shawky Reem El-Shenawy Naiera M Helmy Source Type: research