This page shows you the latest news items in this category. This is page number 20.

Total 4711 results found since Jan 2013.

Pirfenidone for Progressive Fibrotic Sarcoidosis
Condition:   Sarcoidosis, Pulmonary Interventions:   Drug: Pirfenidone;   Drug: Placebos Sponsors:   University of Cincinnati;   Royal Brompton & Harefield NHS Foundation Trust Not yet recruiting - verified August 2017
Source: ClinicalTrials.gov - August 22, 2017 Category: Research Source Type: clinical trials

Vitamin D, Cathelicidin, Prolactin, Autoantibodies, and Cytokines in Different Forms of Pulmonary Tuberculosis versus Sarcoidosis.
CONCLUSIONS: We demonstrated the role of vitamin D deficiency in poor cathelicidin response in  tuberculosis and sarcoidosis. Both diseases are accompanied by significant changes in the autoimmune profile, probably related to the status of vitamin D and cytokine regulation. PMID: 28825769 [PubMed - in process]
Source: The Israel Medical Association Journal - August 22, 2017 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Gammaglobulins Level is Predictive Factor of Evolution in Sarcoidosis
Condition:   Sarcoidosis Intervention:   Biological: Analysis of gamma globulin Sponsor:   Rennes University Hospital Recruiting - verified August 2017
Source: ClinicalTrials.gov - August 21, 2017 Category: Research Source Type: clinical trials

Shared αβ TCR Usage in Lungs of Sarcoidosis Patients with Löfgren's Syndrome.
This study aimed to identify expanded αβTCR pairs expressed on CD4(+) T cells derived from the BAL of DR3(+) LS patients. Using a deep-sequencing approach, we determined TCRα- and TCRβ-chain usage, as well as αβTCR pairs expressed on BAL CD4(+) T cells from LS patients. TRAV12-1 and TRBV2 (formerly BV22) were the most expanded V region gene segments in DR3(+) LS patients relative to control subjects, and TRAV12-1 and TRBV2 CDR3 motifs were shared among multiple DR3(+) LS patients. When assessing αβTCR pairing, TRAV12-1 preferentially paired with TRBV2, and these TRAV12-1/TRBV2 TCRs displayed CDR3 homology. These fi...
Source: Journal of Immunology - August 21, 2017 Category: Allergy & Immunology Authors: Mitchell AM, Kaiser Y, Falta MT, Munson DJ, Landry LG, Eklund A, Nakayama M, Slansky JE, Grunewald J, Fontenot AP Tags: J Immunol Source Type: research

Semi-quantitative metabolic values on FDG PET/CT including extracardiac sites of disease as a predictor of treatment course in patients with cardiac sarcoidosis
ConclusionsMaximum SUV across all involved organ-systems of the chest and upper abdomen, not that of the heart alone, could be a predictor of treatment course of steroid therapy at 6  months in patients with active cardiac sarcoidosis.
Source: EJNMMI Research - August 18, 2017 Category: Radiology Source Type: research

Sarcoidosis Granuloma Crystals
A 59-year-old man presented with several weeks of left upper eyelid fullness/ptosis (Fig 1A). Vision was 20/20 and ocular examination was otherwise normal. Orbital ultrasonography identified superior rectus and levator complex thickening (8.7 vs 5.1 mm in the right eye). Magnetic resonance imaging showed muscle and extraconal fat infiltration. Orbital biopsy revealed non-caseating granulomas (Fig 1B) with birefringent crystals (Fig 1C). Chest computed tomography disclosed bilateral hilar/mediastinal adenopathy, and diagnosis of sarcoidosis was made.
Source: Ophthalmology - August 17, 2017 Category: Opthalmology Authors: Anton M. Kolomeyer, Vivian Lee Tags: Pictures & Perspectives Source Type: research

Appendectomy, tonsillectomy, and risk for sarcoidosis – A hospital-based case-control study in Japan
Conclusions Appendix and tonsil removal was associated with sarcoidosis onset, suggesting their potential protective role against sarcoidosis development. Further studies are needed to minimize possible confounding factors.
Source: Respiratory Investigation - August 17, 2017 Category: Respiratory Medicine Source Type: research

A Circulating Micro-RNA Signature Serves as a Diagnostic and Prognostic Indicator in Sarcoidosis.
Abstract Micro-RNAs (miRNAs) act as post-transcriptional regulators of gene expression. In sarcoidosis, aberrant miRNA expression may enhance immune responses mounted against an unknown antigenic agent. We tested whether a distinct miRNA signature functions as a diagnostic biomarker and explored its role as an immune modulator in sarcoidosis. Expression of miRNAs from peripheral blood mononuclear cells from subjects that met clinical and histopathologic criteria for sarcoidosis were compared to those from matched controls in the ACCESS study. Signature miRNAs were determined by miRNA microarray analysis and valida...
Source: Am J Respir Cell Mol... - August 16, 2017 Category: Respiratory Medicine Authors: Ascoli C, Huang Y, Schott C, Turturice BA, Metwally A, Perkins DL, Finn PW, ACCESS Research Group Tags: Am J Respir Cell Mol Biol Source Type: research

Predominance of Comorbidities in the Detriment of Daily Activity in Sarcoidosis Patients.
Authors: Kostorz S, Jastrzębski D, Sikora M, Zebrowska A, Margas A, Stepanik D, Swinder H, Ziora D Abstract Sarcoidosis may affect lung function, working ability, overall mobility, and daily activity. In the present study we performed an analysis of clinical settings in patients with sarcoidosis to disentangle its influence on daily physical activity (PA). PA assessment (number of steps per day, daily energy expenditure) was performed by accelerometry during consecutive 7 days after discharge from hospital. Thirty patients with sarcoidosis, aged 46.4 ± 10.5, were enrolled in the study. Clinical data (age, gend...
Source: Advances in Experimental Medicine and Biology - August 15, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Acquired anhidrosis associated with systemic sarcoidosis: Quantification of nerve fibers around eccrine glands by confocal microscopy.
This article is protected by copyright. All rights reserved. PMID: 28796884 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - August 10, 2017 Category: Dermatology Authors: Nishida M, Namiki T, Sone Y, Hashimoto T, Tokoro S, Hanafusa T, Yokozeki H Tags: Br J Dermatol Source Type: research

Acquired anhidrosis associated with systemic sarcoidosis: Quantification of nerve fibers around eccrine glands by confocal microscopy
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - August 10, 2017 Category: Dermatology Authors: M. Nishida, T. Namiki, Y. Sone, T. Hashimoto, S. Tokoro, T. Hanafusa, H. Yokozeki Tags: Research Letter Source Type: research

Increased Risk of Atherosclerosis in Patients with Sarcoidosis
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Recent studies demonstrated that its pathogenesis is related with enhanced oxidative stress (protein carbonylation and lipid peroxidation) and alterations in the circulating lipid profile. Alterations of lipid metabolism (including the reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1 concentrations) induce plasma membrane, bronchial and lung capillary endothelial cell damage in sarcoidosis patients. Dyslipidemia is associated with increased oxidative stress, diminished overall antioxidative protection and increased risk for a...
Source: Pathobiology - August 9, 2017 Category: Pathology Source Type: research

Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmüller and Alberto Cavazza
Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub l...
Source: European Respiratory Review - August 9, 2017 Category: Respiratory Medicine Authors: Ohshimo, S., Guzman, J., Costabel, U., Bonella, F. Tags: Respiratory clinical practice Pathology for the Clinician Source Type: research

Systemic Sarcoidosis with Thyroid Involvement.
Authors: Okuma H, Hashimoto K, Wang X, Ohkiba N, Murooka N, Akizuki N, Inazawa T, Ogawa Y Abstract A 66-year-old woman, who was diagnosed with iritis, visited our hospital due to general malaise. A blood analysis revealed hypercalcemia. Computed tomography revealed mediastinal and hilar lymph node hyperplasia. Moreover, (67)Gallium scintigraphy demonstrated strong accumulation in the lesions, suggesting sarcoidosis. A core needle biopsy (CNB) of the hypoechoic areas of the thyroid was performed because the patient refused to undergo a bronchoscopic examination. The scattering of slightly acidophilic epithelioid cel...
Source: Internal Medicine - August 8, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Sarcoidosis with Takayasu arteritis: a model of overlapping granulomatosis. A report of seven cases and literature review
ConclusionsTA stands as pathology associated with sarcoidosis. TA occurred in three cases among 50. When sarcoidosis preceded TA, a recovery of sarcoidosis was achieved mostly without treatment. TA is a prognostic and therapeutic factor. Immunosuppressive treatment, including steroids, led to a good prognosis for TA as well as for sarcoidosis.
Source: APLAR Journal of Rheumatology - August 8, 2017 Category: Rheumatology Authors: Catherine Chapelon ‐Abric, David Saadoun, Isabelle Marie, Cloé Comarmond, Anne Claire Desbois, Fanny Domont, Léa Savey, Patrice Cacoub Tags: Original Article Source Type: research

Multiorgan Involvement of Chemotherapy-Induced Sarcoidosis Mimicking Progression of Lymphoma on FDG PET/CT
Abstract: A 35-year-old woman with biopsy-proven recurrent Hodgkin lymphoma in the neck lymph nodes received salvage chemotherapy of brentuximab/insulin growth factor-methotrexate. Although the patient continued doing well clinically with no constitutional symptoms or significant laboratory abnormalities following the second recurrence, subsequent FDG PET CT examinations over the next 2 years revealed multiple new FDG-avid foci including lymph nodes above/below the diaphragm, liver, spleen, lungs, and bone. An alternate diagnosis of chemotherapy-induced sarcoidosis was suggested and confirmed on both bone marrow and right ...
Source: Clinical Nuclear Medicine - August 7, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Nivolumab-Induced Development of Pulmonary Sarcoidosis in Renal Cell Carcinoma
Abstract: A 64-year-old woman with metastatic clear cell renal carcinoma who had been on nivolumab immunotherapy for 10 months was referred for a FDG PET scan to monitor disease progress. New bilateral mediastinal and hilar FDG-avid lymphadenopathy was noted. Pathology on subsequent mediastinal nodal biopsy showed well-formed epithelioid granulomas with no evidence of malignancy consistent with sarcoidosis. This case illustrates that pulmonary sarcoidosis can be induced by immunotherapy in the treatment of renal cell carcinoma.
Source: Clinical Nuclear Medicine - August 7, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Sarcoidosis onset after breast cancer; a potential association.
PMID: 28797536 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - August 7, 2017 Category: Internal Medicine Authors: Schweitzer MD, Salamo O, Holt G, Donna E, Mirsaeidi M Tags: Eur J Intern Med Source Type: research

Paraneoplastic Sarcoidosis in Multiple Myeloma.
Authors: Kusaba K, Kojima K, Naito S, Taba M, Kai K, Ureshino H, Nishida Y, Kimura S Abstract Sarcoidosis predominantly affects the lungs, intrathoracic lymph nodes, and eyes; it less frequently affects the musculoskeletal system. We herein report a case of paraneoplastic sarcoidosis in a patient presenting with multiple myeloma. The patient developed ocular sarcoidosis and showed an increased (18)F-fluorodeoxyglucose uptake in the mediastinal lymph nodes and vertebral column. A lymph node specimen showed the histological features of sarcoidosis, while an examination of the vertebral tumor revealed myeloma. Althoug...
Source: Internal Medicine - August 6, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Clinical Features of Pulmonary Sarcoidosis Complicated by Lung Cancer.
Conclusion In patients with lung cancer complicated by sarcoidosis, the clinical assessment of the state of lymphadenopathy is difficult to make. However, as many of them tend to be benign, we suggest that surgical resection should be considered for a complete cure in the absence of any remote metastasis. PMID: 28768963 [PubMed - in process]
Source: Internal Medicine - August 6, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Untreated cardiac sarcoidosis with active inflammation: Severe left ventricular dysfunction and ventricular wall thinning in three years
Publication date: Available online 5 August 2017 Source:Journal of Cardiology Cases Author(s): Ryota Kakizaki, Toshimi Koitabashi, Yoshiyasu Minami, Takeru Nabeta, Toyoji Kaida, Shunsuke Ishii, Emi Maekawa, Takayuki Inomata, Junya Ako A 74-year-old female was admitted for the treatment of complete atrioventricular block. Echocardiography showed thickening of interventricular septum and a slight thinning in the basal region with normal left ventricular (LV) function. She was clinically diagnosed with cardiac sarcoidosis accompanied by active inflammation from the findings of blood test, nuclear scanning, and magnetic reson...
Source: Journal of Cardiology Cases - August 6, 2017 Category: Cardiology Source Type: research

The complimentary role of transbronchial lung cryobiopsy and endobronchial ultrasound fine needle aspiration in the diagnosis of sarcoidosis
Transbronchial lung cryobiopsy (TBLC) is a novel technique that has proved to be useful in diagnosing various interstitial lung diseases (ILD). The use of TBLC to diagnose sarcoidosis in an unselected patient population is unknown, and could be complimentary to endobronchial ultrasound fine needle aspiration (EBUS-FNA).
Source: Respiratory Medicine - August 4, 2017 Category: Respiratory Medicine Authors: Alejandro Adolfo Aragaki-Nakahodo, Robert P. Baughman, Ralph T. Shipley, Sadia Benzaquen Source Type: research

Sarcoidosis update: approaching the disease from multiple directions
No abstract available
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Many faces of neurosarcoidosis: from chronic meningitis to myelopathy
Purpose of review: Neurosarcoidosis occurs in 5% of patients with sarcoidosis and can be difficult to diagnose. In this review we discuss the most recent advances in our understanding of the disease, describing clinical characteristics, diagnostic process, treatment, and prognosis. Recent findings: Clinical presentation is heterogeneous with most patients presenting with cranial nerve palsy, headache, or sensory abnormalities. Patients are classified according to probability of the diagnosis with the Zajicek criteria. In these criteria, histopathological confirmation of noncaseating granulomas in affected tissue outside t...
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Development of Hodgkin lymphoma in a patient with sarcoidosis.
Abstract Sarcoidosis is a chronic granulomatous disease of unknown etiology characterized by non-caseified granulomas in many different organs and systems. The disease most frequently manifests with bilateral hilar lymphadenopathy and infiltrations in the lungs and skin, as well as with eye lesions. It may mimic a number of systemic diseases and/or accompany them. The development of lymphoma in patients with sarcoidosis or the co-occurrence of both diseases is rarely reported in the literature. In this paper we report a female patient followed up with sarcoidosis for three years who developed Hodgkin lymphoma, acc...
Source: Reumatismo - August 3, 2017 Category: Rheumatology Authors: Gediz F, Yilmaz AF, Payzin B, Yuksel T, Calli AO, Kobak S Tags: Reumatismo Source Type: research

Scar Sarcoidosis Developed after Blepharoplasty in Acute Lymphoblastic Leukemia Patient.
Authors: Kim SJ, Kim JY, Im M, Seo YJ, Lee JH, Lee Y PMID: 28761310 [PubMed]
Source: Annals of Dermatology - August 2, 2017 Category: Dermatology Tags: Ann Dermatol Source Type: research

Right ventricular involvement and the extent of left ventricular enhancement with magnetic resonance predict adverse outcome in pulmonary sarcoidosis
ConclusionsBiventricular LGE at presentation is the strongest, independent predictor of adverse outcome during long‐term follow‐up. Asymptomatic myocardial scar <8% of LV mass carried a favourable long‐term outcome.
Source: ESC Heart Failure - August 1, 2017 Category: Cardiology Authors: Jan ‐Peter Smedema, Robert‐Jan Geuns, Joris Ector, Hein Heidbuchel, Gillian Ainslie, Harry J.G.M. Crijns Tags: Original Research Article Source Type: research

Inter- and Intraobserver Agreement of 18F-FDG PET/CT Image Interpretation in Patients Referred for Assessment of Cardiac Sarcoidosis
Conclusion: The interobserver agreement of cardiac 18F-FDG uptake image patterns was moderate. However, agreement was better regarding overall interpretation of CS. Detailed prescan dietary preparation seemed to improve interobserver agreement.
Source: Journal of Nuclear Medicine - August 1, 2017 Category: Nuclear Medicine Authors: Ohira, H., Ardle, B. M., deKemp, R. A., Nery, P., Juneau, D., Renaud, J. M., Klein, R., Clarkin, O., MacDonald, K., Leung, E., Nair, G., Beanlands, R., Birnie, D. Tags: Clinical Source Type: research

Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway?
Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our know...
Source: BMC Pulmonary Medicine - July 28, 2017 Category: Respiratory Medicine Authors: Fabiano Di Marco, Giuseppina Palumbo, Silvia Terraneo, Gianluca Imeri, Elena Lesma, Nicola Sverzellati, Angela Peron, Lorenzo Gualandri, Maria Paola Canevini and Stefano Centanni Tags: Case report Source Type: research

Cardiac sarcoidosis diagnosed by multimodality imaging
A 66‐year‐old woman presented with frequent premature ventricular contractions (PVC) and akinesis of the basal septum on echocardiography. Coronary angiography was normal. Cardiac magnetic resonance showed mid‐wall enhancement. Positron emission tomography showed a perfusion defect at the same location using 13N‐ammonia, but increased 18‐fluorodeoxyglucose uptake. These findings supported the diagnosis of cardiac sarcoidosis. High‐dose steroids initially reduced frequency of PVCs but had to be withdrawn due to severe side effects. An ICD was implanted. Our case demonstrates the utility of multimodality imaging ...
Source: Echocardiography - July 28, 2017 Category: Cardiology Authors: Kana Fujikura, Mario J. Garcia Tags: ECHO ROUNDS Source Type: research