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Total 4720 results found since Jan 2013.

Intravitreal aflibercept for choroidal neovascularization in ocular sarcoidosis.
CONCLUSIONS: We report a case of CNV in a patient with ocular sarcoidosis treated with intravitreal aflibercept. In our experience, intravitreal aflibercept injection achieved morphologic resolution for sarcoid-related peripapillary CNV. PMID: 26868005 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - February 5, 2016 Category: Opthalmology Authors: Querques L, Querques G, Miserocchi E, Modorati G, Bandello F Tags: Eur J Ophthalmol Source Type: research

Retinal Detachment and Symptomatic Hypercalcemia in a Patient with Sarcoidosis: Unusual Presentation of a Granulomatous Disease.
We describe herein a unique presentation of sarcoidosis with retinal detachment and symptomatic hypercalcemia as its first manifestation. Prompt therapy with steroids is indicated in these cases, and an immediate ophthalmology referral cannot be overemphasized. PMID: 26882785 [PubMed - in process]
Source: Connecticut Medicine - January 1, 2016 Category: Journals (General) Authors: Khurana A, Cherian S, Majumder S, Nakrani R, Kowlgi GN, Dasanu CA Tags: Conn Med Source Type: research

Pulmonary sarcoidosis is associated with high‐level inducible co‐stimulator (ICOS) expression on lung regulatory T cells – possible implications for the ICOS/ICOS‐ligand axis in disease course and resolution
Summary Sarcoidosis is a granulomatous inflammatory disorder of unknown aetiology. The increased frequency of activated lung CD4+ T cells with a T helper type 1 (Th1) cytokine profile in sarcoidosis patients is accompanied by a reduced proportion and/or impaired function of regulatory T cells (Tregs). Here we evaluated the expression of the inducible co‐stimulator (ICOS) on lung and blood CD4+ T cell subsets in sarcoidosis patients with different prognosis, by flow cytometry. Samples from the deep airways were obtained by bronchoalveolar lavage (BAL). We show that Tregs from the inflamed lung of sarcoidosis patients were...
Source: Clinical and Experimental Immunology - November 24, 2015 Category: Allergy & Immunology Authors: P. Sakthivel, J. Grunewald, A. Eklund, D. Bruder, J. Wahlström Tags: Original Article Source Type: research

Somatostatin Receptor Scintigraphy Patterns in Patients With Sarcoidosis
Conclusions: Somatostatin receptor scintigraphy enhances the yield of investigations in sarcoidosis patients and therefore provides a useful and sensitive imaging technique to monitor organ involvement and therapeutic efficacy in patients with sarcoidosis.
Source: Clinical Nuclear Medicine - November 7, 2015 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Atopy in sarcoidosis a good prognostic sign?
Conclusions: Identifying atopy in sarcoidosis may be useful in predicting the need for treatment and prognosis.References: Hajdarbegovic E et al. Prevalence of atopic diseases in patients with sarcoidosis. Allergy Asthma Proc. 2014 Jul; 35 (4):57-61.Cushin B et al. The Th2-mediated Lymphocyte Response in Sarcoidosis. Ir J Med Sci. 2013 182 (Suppl 10): S427-S486 Nov; 8.1.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Minnis, P., Riddel, P., O'Dwyer, D., Byrne, P., Donnelly, S. C. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Serum and bronchoalveolar exosomal miRNAs in pulmonary sarcoidosis
Conclusion: We showed three exosomal miRNAs (miR-340, miR-212 and miR-21) to be deregulated in sarcoidosis course. Grant support:CZ.1.07/2.3.00/30.0004,LO1304,IGA UP: LF_2015_020.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Navratilova, Z., Novosadova, E., Smitalova, D., Kishore, A., Kolek, V., Petrek, M. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Leptin, inflammatory biomarkers and body composition in patients with sarcoidosis
Conclusions: our findings could support the role of CRP as a biomarker among sarcoid patients but does not support correlation between sL and TNF-α, IL-5 and 6 in the studied group. All these findings need to be verified with large-scale studies.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Puscinska, E., Bednarek, M., Goljan-Geremek, A., Chorostowska-Wynimko, J., Rozy, A., Jagus, P., Sliwinski, P., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

The value of cardiopulmonary exercise testing in sarcoidosis
Normal pulmonary function tests (PTFs) do not always predict functional limitations during exercise in sarcoidosis. Cardiopulmonary exercise testing (CPET) may facilitate in recognition of exercise intolerance in these patients. A relevant data in sarcoid patients are limited, including spirometry, DLCO and lung volumes and CPET using standard protocol, 83 sarcoid patients consecutively referred for evaluation of exertional dyspnea over a 3-year period. Patients were grouped according to their radiologiacal stages as Stage I: 43, Stages II-III: 31 and Stage IV: 9. VO2 peak was decreased (<84% predicted) in 53% of patien...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Fouka, E., Zarogoulidis, P., Kioumis, I., Pitsiou, G., Zarogoulidis, K., Kallianos, A., Rapti, A., Trakada, G. Tags: 4.1 Clinical respiratory physiology, exercise and functional imaging Source Type: research

Vitamin D concentration and patient reported outcomes in sarcoidosis
Sarcoidosis patients frequently have low inactive Vitamin D form levels accompanied with the increased levels of the active form due to its autonomic conversion in sarcoid granulomas. The aim of our study was to evaluate the influence of lower serum Vitamin D3 concentration on subjective disease outcomes – fatigue and depression.In the cross-sectional study the degree of fatigue and depression was measured in 400 (27.3% males) patients with pulmonary sarcoidosis. Fatigue was measured by standardized Fatigue Assessment Scale (FAS). Depression was assessed by CES-D instrument.Mean age of patients was 50.5±11 yea...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Gvozdenovic, B. S., Vucinic, V., Vukovic, M., Stjepanovic, M. Tags: 1.13 Clinical Problems - Other Source Type: research

Are there any predictors of MTX response in progressive pulmonary sarcoidosis?
Conclusion: Defining initial inflammatory status of potential candidates for therapy might be helpful in further therapeutic decisions and enhance prognostication. Goljan Geremek A. et al. Methotrexate as a single agent for treating pulmonary sarcoidosis: a single centre real-life prospective study Pneumonol Alergol Pol, 2014, 82, 518-33.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Goljan Geremek, A., Bednarek, M., Demkow, U., Puscinska, E., Nowinski, A., Gorecka, D. Tags: 1.13 Clinical Problems - Other Source Type: research

Role of infliximab in managing resistant ventricular arrhythmias in sarcoidosis
We present a case of a 56 year old lady with multi-system sarcoid and resistant VT.Case: The patient was known to have pulmonary and ocular sarcoid with the diagnosis confirmed on a transbronchial biopsy. She developed VT in 2008. Cardiac MRI showed patchy epicardial-mid wall delayed gadolinium enhancement suggestive of cardiac sarcoid. The patient was cardioverted and started on prednisolone. An ICD was implanted after a second admission with VT in 2010. She started mycophenolate, which was changed to Azathioprine due to side effects. Radiofrequency ablation was performed in 2012, with reduction in the burden of VT. The p...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Konda, S., Chua, F., Saba, M., Pagonda, R., Aul, R. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Inhibited IL-17A ameliorates sarcoid-like granulomatosis in mice
Conclusions: These results suggest IL-17A plays central role in granuloma formation and inhibiting IL-17A may be potential treatment in sarcoidosis.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Jiang, D., Geng, J., Liu, Z., Zhu, M., Zheng, X., Dai, H. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Sarcoidosis as unusual cause of massive pleural effusion
Publication date: Available online 13 October 2015 Source:Respiratory Medicine Case Reports Author(s): Sharad Joshi, Pallavi Periwal, Vikas Dogra, Deepak Talwar Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Pleural involvement is relatively rare. Development of pleural effusion in sarcoidosis needs to be evaluated for other causes, especially tuberculosis in endemic countries. Sarcoid pleural effusion responds to systemic corticosteroids. We are presenting case of 42 year old male patient of sarcoidosis who developed massive pleural effusion while on treatment with steroids, which was attrib...
Source: Respiratory Medicine Case Reports - October 25, 2015 Category: Respiratory Medicine Source Type: research

The influence of comorbidities on mortality in sarcoidosis: A observational prospective cohort study
Conclusion: The comorbidity burden has strong impact on mortality in sarcoidosis. Thyroid diseases are more frequent in sarcoidosis than in non sarcoid controls. This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - October 16, 2015 Category: Respiratory Medicine Authors: A. Nowiński, E. Puścińska, A. Goljan, J. Peradzynska, M. Bednarek, D. Korzybski, D. Kamiński, A. Stokłosa, M. Czystowska, P. Śliwiński, D Górecka Tags: Original Article Source Type: research

Sarcoidosis in Patients Treated with Vemurafenib for Metastatic Melanoma: A Paradoxical Autoimmune Activation
Conclusion: BRAF inhibitors probably have immune system-enhancing effects and should therefore be recognized as potential inducers of sarcoidosis.Dermatology
Source: Dermatology - October 10, 2015 Category: Dermatology Source Type: research

Pulmonary manifestations revealing Rosai-Dorfman disease.
We present the case of a patient with a pulmonary form of Rosai-Dorfman disease without peripheral or intra-thoracic lymph nodes, characterized by the presence of pulmonary nodules and cysts associated with bilateral pleural effusions. PMID: 26422575 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Early detection of colon cancer by increased serum level of Krebs von den Lungen-6 in a patient with dermatomyositis-associated interstitial pneumonia.
Authors: Fukuhara N, Tanino Y, Sato S, Fukuhara A, Uematsu M, Nikaido T, Misa K, Sato Y, Saito J, Wang X, Munakata M Abstract Krebs von den Lungen-6 (KL-6) is a high-molecular-weight glycoprotein which is elevated in serum of patients with interstitial pneumonia (IP).  Serum KL-6 level is clinically used for the diagnosis of IP as well as the evaluation of its disease activity.  KL-6 is originally identified when exploring novel soluble antigens in patients with lung cancer, and is known to be elevated in patients with several malignant tumors.  The risk of malignant tumors is high in IP patients with polymyosit...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Long-term stable lung function and second uncomplicated pregnancy on sirolimus in lymphangioleiomyomatosis (LAM).
In conclusion, the second pregnancy on uninterrupted sirolimus was uncomplicated both with respect to mother and child suggesting that sirolimus at the dose used may be safe in pregnant patients with LAM. During pregnancy, blood levels of sirolimus declined spontaneously indicating a faster metabolism of the drug. However, even at sirolimus levels considered subtherapeutic in the MILES trial, lung function was preserved during pregnancy in this patient. Since the vast majority of LAM patients are young women with a much improved outcome on sirolimus, a significant number may wish to become pregnant. However, in LAM trials,...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Efficacy and safety of surgical lung biopsy for interstitial disease. Experience of 161 consecutive patients from a single institution in Italy.
CONCLUSIONS: Lung biopsy was performed mostly by VATS, with limited morbidity, and was effective in yielding a specific histologic diagnosis in the vast majority of undefined ILD cases. To optimize the outcome of surgical biopsy for specific diagnosis of ILD, this procedure should be performed only exceptionally in patients with critical respiratory illness as postoperative mortality risk in these subjects is exceedingly high. PMID: 26422571 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Fibrosing interstitial lung diseases involve different pathogenic pathways with similar outcomes.
Authors: Vasakova M, Poletti V Abstract Fibrosing interstitial lung diseases (ILDs) are a large group of diseases triggered by external or internal stimuli that can have similar outcomes, i.e. lung fibrosis. Some ILDs are primarily fibro-proliferative disorders in which alveolar loss and epithelial/fibroblastic proliferation and dysplasia lead to lung fibrosis and architectural derangement, while other ILDs are considered inflammatory disorders in which specific underlying conditions (with either an external or an internal origin) can shift the pathogenic process to the fibro-proliferative pathway. The treatment of...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Biomarkers to identify ILD and predict lung function decline in scleroderma lung disease or idiopathic pulmonary fibrosis.
CONCLUSIONS: Combining KL-6 with MMP7 may be a useful screening tool for patients at risk of ILD. SP-D may predict short-term decline in lung function. PMID: 26422568 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Efficacy and Safety of Rituximab in Connective Tissue Disease related Interstitial Lung Disease.
CONCLUSIONS: Treatment with RTX resulted in an objective, measurable improvement in pulmonary function and/or radiological severity for the majority of patients included in the series. This was statistically significant despite the small numbers included. These results indicate a positive response to RTX with few complications of treatment.  . PMID: 26422566 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pulmonary sarcoidosis is associated with high‐level ICOS expression on lung regulatory T cells ‐ possible implications for the ICOS/ICOS‐L axis in disease course and resolution
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - September 29, 2015 Category: Allergy & Immunology Authors: Priya Sakthivel, Johan Grunewald, Anders Eklund, Dunja Bruder, Jan Wahlström Tags: Original Article Source Type: research

Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and resolution.
This article is protected by copyright. All rights reserved. PMID: 26415669 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - September 28, 2015 Category: Allergy & Immunology Authors: Sakthivel P, Grunewald J, Eklund A, Bruder D, Wahlström J Tags: Clin Exp Immunol Source Type: research

Clinical Characteristics of Sarcoid Arthropathy: A Population‐Based Study
Conclusion: Inflammatory arthritis occurs in a minority of patients with sarcoidosis. Acute oligoarthritis with bilateral ankles involvement was the most common pattern of sarcoid arthropathy. It should be noted that the generalizability of the results may be limited as the cohort was predominantly Caucasian. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - September 28, 2015 Category: Rheumatology Authors: Patompong Ungprasert, Cynthia S. Crowson, Eric L. Matteson Tags: Original Article Source Type: research

Clinical features and diagnostic evaluation of 83 biopsy-proven sarcoid uveitis cases
Conclusions In this largest European series of biopsy-proven sarcoidosis to date, the outstanding diagnostic ability of enzyme test plus imaging test couple suggests that the recourse to invasive procedures should be limited to patients with ocular involvement that would justify systemic treatments.
Source: British Journal of Ophthalmology - September 22, 2015 Category: Opthalmology Authors: Febvay, C., Kodjikian, L., Maucort-Boulch, D., Perard, L., Iwaz, J., Jamilloux, Y., Broussolle, C., Burillon, C., Seve, P. Tags: Original articles - Clinical science Source Type: research

Sarcoidosis: a rheumatologist's perspective
Sarcoidosis is a systemic disorder of unknown etiology, which may involve various tissues and organs and is characterized by a noncaseating granuloma reaction. While pathogenesis is not yet clear, cellular immune system activation and nonspecific inflammatory response occur secondarily to several genetic and environmental factors. T helper 1-cells and macrophage-derived pro-inflammatory cytokines stimulate the inflammatory cascade and formation of granuloma occurs as a result of tissue permeability, cell influx, and local cell proliferation. The different prevalence, clinical results, and disease course observed in differe...
Source: Therapeutic Advances in Musculoskeletal Disease - September 15, 2015 Category: Orthopaedics Authors: Kobak, S. Tags: Reviews Source Type: research

A case of chronic sarcoid myopathy with IBM like distal muscle involvement
Sarcoidosis is a multisystemic inflammatory granulomatous disease of unknown etiology that involves nearly any organ system, including muscle. Asymptomatic involvement of muscle occurs frequently in sarcoidosis but symptomatic sarcoid myopathy is an extremely rare condition. Herein we report a case of chronic sarcoid myopathy presenting with proximal and distal muscle involvement mimicking IBM. A 56-year-old woman complaining of muscle weakness was admitted to our hospital with suspected inclusion body myositis.
Source: Neuromuscular Disorders - September 11, 2015 Category: Neurology Authors: H. Karasoy, M. Eroglu, F. Gokcay, M. Argin, O. Ekmekci, A. Yuceyar Source Type: research

Sarcoid tenosynovitis, rare presentation of a common disease. Case report and literature review
We describe an unusual case of sarcoidosis presenting with granulomatous tenosynovitis as the only manifestation of the disease, illustrating the radiological findings on different modalities followed by a review of the literature. Radiologists and clinicians should be aware of tenosynovitis as a manifestation of sarcoidosis as early and therefore appropriate treatment significantly alters patient's outcome and prognosis.
Source: Journal of Radiology Case Reports - August 31, 2015 Category: Radiology Source Type: research

Increased liver stiffness in idiopathic pulmonary fibrosis: a pilot study.
CONCLUSIONS: To our knowledge, this is the first report suggesting that liver stiffness is increased in more than one-third of IPF patients. Application of novel methodologies should be encouraged for investigating further IPF. PMID: 26278699 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Acute eosinophilic pneumonia associated with glyphosate-surfactant exposure.
We report a case of a female patient who developed acute eosinophilic pneumonia (AEP) after recent onset of smoking and exposure to glyphosate-surfactant.The additional exposure associated with the recent start of smoking may have contributed to the development and/or severity of AEP.A clinical relapse after re-challenge four years later both with smoking and glyphosate-surfactant made the association highly likely.Respiratory distress is a factor of poor outcome and mortality after ingestion of glyphosate-surfactant.This case highlights the importance of a thorough exposure history e.g., possible occupational and environm...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Near fatal desquamative interstitial pneumonia with bilateral recurrent tension pneumothorax.
We report a rare case of near fatal DIP with recurrent bilateral tension pneumothorax despite of corticosteroid maintenance therapy. Clinical and radiological findings improved with surgical intervention in addition to combination therapy with prednisolone and clarithromycin. The patient has remained in an improved state and has been receiving prednisolone and clarithromycin for 9 months. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 167-171). PMID: 26278697 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Significance of granulomatous inflammation in usual interstitial pneumonia.
In conclusion, we present two patients in whom a diagnosis of sarcoidosis preceded the diagnosis of UIP by 20 years or more. The subsequent course of disease in both patients was consistent with Idiopathic Pulmonary Fibrosis (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 160-166). PMID: 26278696 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Bone mineral density in patients with interstitial lung disease.
CONCLUSIONS: We observed a high prevalence of osteoporosis and osteopenia among newly diagnosed ILD patients. Our findings suggest that there is a substantially increased risk of osteoporosis and that early screening and aggressive treatment with various anti-bone resorptive therapies are necessary in ILD patients. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 151-159). PMID: 26278695 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Comparison of clinical characteristics and outcomes between combined pulmonary fibrosis and emphysema associated with usual interstitial pneumonia pattern and non-usual interstitial pneumonia.
CONCLUSIONS: This study demonstrated that the presence of UIP pattern and high-CPI in CPFE patients were associated with poorer mortality. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 129-137). PMID: 26278692 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A score for estimating survival in idiopathic pulmonary fibrosis with rest SpO2>88.
A score for estimating survival in idiopathic pulmonary fibrosis with rest SpO2>88. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32(2):121-8 Authors: Soares MR, Pereira C, Ferreira R, Nei Aparecida Martins Coletta E, Silva Lima M, Muller Storrer K Abstract BACKGROUND: Prediction models for survival at baseline evaluation have been proposed in IPF but some are difficult to use. The aim of present study was to develop a new mortality risk scoring system for patients with IPF at initial evaluation. METHODS: One hundred twenty with definitive IPF were selected through a review of standardized medical rec...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Practical management of Idiopathic Pulmonary Fibrosis.
Authors: Kishaba T Abstract  Idiopathic Pulmonary Fibrosis (IPF) is relentless progressive interstitial lung disease (ILD) of unknown etiology. Main pathogenesis is aberrant recovery of epithelial injury and collagen deposition. Majority of IPF patients have been elderly men with smokers. However, there are important differential diagnosis such as fibrotic non-specific interstitial pneumonia (NSIP), Connective Tissue Disease (CTD) associated ILD, chronic hypersensitivity pneumonia (CHP). Clinical point of view, non-productive cough and progressive exertional dyspnea are main symptoms. In addition, scalene muscle h...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

IPF, comorbidities and management implications.
Authors: Vancheri C, Cottin V, Kreuter M, Hilberg O Abstract Idiopathic pulmonary fibrosis (IPF) is a complex disease that is associated with various respiratory and non-respiratory comorbidities. The most common comorbidity is cardiovascular disease (CVD), which increases in incidence with increasing duration of IPF and is associated with a higher risk of mortality. The direction of causality between CVD and IPF is unclear. There is evidence that IPF is associated with a prothrombotic state; however, warfarin is not beneficial in IPF patients. Lung cancer is another common comorbidity, being present in more than 5...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Challenges in the classification of fibrotic ILD: Patient case 2.
Authors: Wijsenbeek M Abstract Patient presentation and diagnostic work-upThe patient is a 72-year-old man presenting with dyspnoea on exertion. He is a former heavy smoker (40 pack-years) and his father, now deceased, had rheumatoid arthritis (RA). On physical examination he had mild bi-basilar crackles but no finger clubbing. Autoimmune serology was positive for rheumatoid factor (RF: 25 IU/ml). Lung function tests showed normal FVC, a FEV1/FVC ratio of 72% and a TLCO of 49% predicted. Lung CT showed centrilobular and paraseptal emphysema, subpleural fine reticulation and traction bronchiolectasis, with no clear ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Challenges in the classification of fibrotic ILD: Patient case 1.
Authors: Manali ED Abstract Patient presentation and clinical historyThe patient is a 43-year-old male non-smoker who works as a farmer and cheese-maker. He complained of a dry cough for 6-12 months without fever or other clinical signs. His medical history was unremarkable with no use of drugs or alcohol and no signs of Raynaud's syndrome. In his family history he had two first-degree relatives with pulmonary fibrosis, one of whom also had rheumatoid arthritis.[...]. PMID: 26237437 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Challenges in the classification of fibrotic ILD.
Authors: Bendstrup E, Maher TM, Manali ED, Wijsenbeek M Abstract According to current international guidelines the idiopathic interstitial pneumonias (IIPs) are grouped into three categories; major, rare, and unclassifiable. Idiopathic pulmonary fibrosis (IPF) is one of the major IIPs and has been recognised as a distinct clinical entity since 2001. This has led to significant advances in our understanding and treatment of the disease and to the identification of new therapeutic targets. While multidisciplinary team assessment yields a definite diagnosis in many cases of interstitial lung disease (ILD), 15-25% of p...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Autologous cytokine-induced killer (CIK) immunotherapy in a case of disseminated tuberculosis.
In conclusion, adjuvant autologous CIK immunotherapy is an effective approach for disseminated tuberculosis. PMID: 26237360 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Primary dural lymphoma: Complete remission after treatment with radiation therapy.
We present a case where a PDL was diagnosed after CNS symptoms failed to resolve after steroid therapy for presumed neurosarcoidosis. PMID: 26237359 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Inhaled Interferon and Diffusion Capacity in Idiopathic Pulmonary Fibrosis (IPF).
CONCLUSIONS: DLCO was significantly improved following inhaled (IFN-γ) as treatment for IPF. Our data suggest that previous studies utilizing parenteral IFN-γ may have failed because of the mode of delivery. Future randomized, controlled, phase 3 trials, comparing the difference in PFT behavior (specifically DLCO) longitudinally may be more sensitive to drug effect and serve as a valuable clinical endpoint. PMID: 26237354 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

AIR 2014 - The Year in IPF.
Authors: Bendstrup E, Wells AU PMID: 26237445 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Challenges in IPF diagnosis, current management and future perspectives: Patient case 2.
Authors: Margaritopoulos G Abstract Patient presentation and diagnosisThe patient is a 73-year-old male retired house painter and ex-smoker who was admitted to the respiratory medicine department of a district hospital in Greece due to the presence of streaks of blood in his sputum. His past medical history included coronary artery disease, arterial hypertension and supraventricular tachycardia (SVT). A high resolution computed tomography (HRCT) was performed which showed enlarged mediastinal lymph nodes with evidence of fibrosis.[...]. PMID: 26237444 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Challenges in IPF diagnosis, current management and future perspectives: Patient case 1.
Authors: Egan J Abstract Patient presentation and diagnosisA 78-year-old female was referred to our department in April 2011 with shortness of breath. Clinical examination revealed bilateral limited crackles but no signs of finger clubbing. Lung function evaluation showed a percent predicted FVC of 78 and DLco of 67. The patient underwent HRCT imaging which showed cardinal features of a UIP pattern enabling a rapid diagnosis of IPF without the need for surgical lung biopsy.[...]. PMID: 26237443 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Challenges in IPF diagnosis, current management and future perspectives.
Authors: Wells AU, Costabel U, Poletti V, Crestani B, Egan J, Margaritopoulos G, Antoniou K Abstract Recent developments have clarified our understanding of IPF and improved outcomes with two viable new therapeutic options, pirfenidone and nintedanib. In spite of these advances, questions and challenges concerning IPF still remain. Here we will focus on some of these unresolved areas: the diagnosis of IPF is hindered by limitations in current practice guidelines, surgical lung biopsy is contraindicated in many patients, the accuracy of prognostic evaluation needs to be increased and tolerability factors can jeopard...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

IPF, comorbidities and management implications: Patient case 2.
Authors: Hilberg O Abstract Patient presentation and diagnosisThe patient is a 50-year-old woman who was referred to a tertiary centre with an HRCT showing definite UIP and a 6-minute walking distance of 145 metres. She was severely ill at presentation with a diffusion capacity of just 20%.The patient had a history of peripheral arterial disease and had undergone both aortofemoral and femoro-femoral bypass due to arteriosclerosis and gluteal ischaemia. She also was suffering from renal impairment and had recently quit smoking.[...]. PMID: 26237441 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

IPF, comorbidities and management implications: Patient case 1.
Authors: Kreuter M Abstract Patient presentation and follow-upThe patient was a 54-year-old man who presented with mild dyspnoea, a persistent cough and "velcro" crackles. He worked as a carpenter and smoked (10 pack-years) until 14 years ago. He had arterial hypertension and suffered a deep vein thrombosis 2 years ago. His lung function was impaired with an FVC of 70% and DLCO of 43%.[...]. PMID: 26237440 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research