This page shows you the latest news items in this category. This is page number 10.

Total 5085 results found since Jan 2013.

CD4/CD8 Ratio in Mediastinal Lymph Nodes Involved by Sarcoidosis: Analysis of Flow Cytometry Data Obtained by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Conclusion: As in BAL fluid, the CD4/CD8 ratio in mediastinal lymph nodes involved by sarcoid granulomas is highly variable and does not reliably confirm or exclude sarcoidosis.
Source: Journal of Bronchology and Interventional Pulmonology - October 1, 2016 Category: Respiratory Medicine Tags: Original Investigations Source Type: research

Intra-cardiac distribution of late gadolinium enhancement in cardiac sarcoidosis and dilated cardiomyopathy.
This article describes the value of LE in patients with CS who have impaired LV systolic function, particularly the diagnostic and clinical significance of LE distribution in comparison with DCM. LE existed at all LV segments and myocardial layers in patients with CS, whereas it was localized predominantly in the midwall of basal to mid septum in those with DCM. Transmural (nodular), circumferential, and subepicardial and subendocardial LE distribution were highly specific in patients with CS, whereas the prevalence of striated midwall LE were high both in patients with CS and with DCM. Since sarcoidosis patients with LE h...
Source: World Journal of Cardiology - September 25, 2016 Category: Cardiology Authors: Sano M, Satoh H, Suwa K, Saotome M, Urushida T, Katoh H, Hayashi H, Saitoh T Tags: World J Cardiol Source Type: research

Skeletal sarcoidosis.
Abstract OBJECTIVE: Presentation of the etiology, pathology, clinical course, radiology and differential diagnostics of skeletal sarcoidosis. PATHOANATOMICAL PRINCIPLES: Noncaseating epithelioid cell granulomas can trigger solitary, multiple or disseminated osteolysis, reactive osteosclerosis and/or granulomatous synovitis. INCIDENCE: The incidence of sarcoidosis is 10-12 per 100,000 inhabitants per year. Skeletal involvement is approximately 14 %. CLINICAL ASPECTS: Skeletal involvement occurs almost exclusively in the stage of lymph node and pulmonary manifestation. Most cases of skeletal involve...
Source: Der Radiologe - September 14, 2016 Category: Radiology Authors: Freyschmidt J, Freyschmidt P Tags: Radiologe Source Type: research

Radiologic Features of World Trade Center–related Sarcoidosis in Exposed NYC Fire Department Rescue Workers
Conclusions: The majority of cases of WTC-related sarcoidosis demonstrated typical radiographic appearances of sarcoidosis, with symmetric hilar and mediastinal lymphadenopathy and mid to upper lung perilymphatic nodules; these findings were consistent with other previously reported cases of sarcoid-like granulomatous disease in association with various alternate underlying etiologies. There was no correlation between disease patterns or extent on CT and pulmonary function testing, likely at least in part due to the overall mild extent of disease in this population.
Source: Journal of Thoracic Imaging - August 26, 2016 Category: Radiology Tags: Original Articles Source Type: research

Hemorrhagic sarcoid pleural effusion: A rare entity
We report a case of active pulmonary sarcoidosis presenting as hemorrhagic pleural effusion requiring tissue diagnosis to rule out malignancy. The rarity of the presentation prompted us to report this case.
Source: Lung India - August 23, 2016 Category: Respiratory Medicine Authors: Onkar Jha Vidya Nair Deepak Talwar Source Type: research

Repositioning 'old' drugs to treat rare diseases: arguing from the mechanism of action.
Authors: Drent M, Bast A, Bootsma HP, Deneer V PMID: 27537726 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Successful management of acute respiratory failure in an Idiopathic Pulmonary Fibrosis patient using an extracorporeal carbon dioxide removal system.
Authors: Vianello A, Arcaro G, Paladini L, Iovino S Abstract Patients with Idiopathic Pulmonary Fibrosis (IPF) requiring Invasive Mechanical Ventilation (IMV) following unsuccessful treatment with Non-Invasive Ventilation (NIV) have a high mortality rate. IMV is, moreover, an independent predictor of poor outcome during the post-transplantation period in patients on waiting lists for Lung Transplantation (LT). Here we describe the successful management of an IPF patient with acute respiratory failure (ARF) using a pump-assisted veno-venous system for extracorporeal CO2 removal (ECCO2R) (ProLUNG® system) as an alte...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Polishing surgical metal pieces, granulomatosis and mineralogical analysis.
This study suggests that mineralogical analysis combined with a questionnaire on dust exposure could help redirect the diagnosis of a dust-related disease. PMID: 27537720 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Exercise related ventilation dynamics and clinical correlates in patients with fibrotic idiopathic interstitial pneumonias.
Authors: De Martino M, Cobuccio R, Bruzzese D, Rea G, Meoli I, Stefanelli F, Canora A, Capaccio A, Sanduzzi A, Matarese A, Bocchino M Abstract Assessment of exercise performance is a key component in the management of interstitial lung diseases, as its limitation may occur very early. Aim of the present study was to assess ventilation dynamics in combination with pulse-oximetry changes in 54 clinically stable patients affected by idiopathic pulmonary fibrosis or idiopathic fibrotic nonspecific interstitial pneumonia. Testing was successfully performed with the Spiropalm 6-MWT Hand-held spirometer by the majority of...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Platelet aggregability in patients with interstitial pneumonias.
CONCLUSIONS: Serum coagulation and fibrinolysis markers significantly increased in IIPs and CTD-IPs. In contrast, platelet aggregability was only weakly enhanced in CTDs, but not in IIPs. PMID: 27537717 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

High-resolution CT predictors of hypersensitivity pneumonitis.
CONCLUSION: Our results provide evidence that HRCT can accurately distinguish HP from other DPLDs. PMID: 27537713 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Multisystemic Sarcoidosis Presenting as Pretibial Leg Ulcers
We report the case of a 45-year-old female patient with chronic multisystemic sarcoidosis presenting with pretibial leg ulcers. Other etiology could be excluded. Histology revealed nonspecific findings. Therefore, the diagnosis of nonspecific leg ulcers in sarcoidosis was confirmed. Treatment consisted of oral prednisolone and good ulcer care. Complete healing was achieved within 6 months. Sarcoidosis is a rare cause of leg ulcers and usually sarcoid granulomas can be found. Our patient illustrates that even in the absence of sarcoid granulomas, leg ulcers can be due to sarcoidosis.
Source: The International Journal of Lower Extremity Wounds - August 9, 2016 Category: Surgery Authors: Wollina, U., Baunacke, A., Hansel, G. Tags: Case Reports Source Type: research

Expanded lung T-bet+ROR{gamma}T+ CD4+ T-cells in sarcoidosis patients with a favourable disease phenotype
Disease phenotypes of pulmonary sarcoidosis are distinguished by clinical rather than immunological criteria. We aimed to characterise patterns of CD4+ T-cell lineage plasticity underlying the differences in clinical presentation and disease course between the acute form, Löfgren's syndrome, and the heterogeneous, potentially progressive "non-Löfgren" form. 33 pulmonary sarcoidosis patients and nine controls underwent bronchoscopy with bronchoalveolar lavage. CD4+ T-cell transcription factor, chemokine receptor and T-cell receptor expression, proliferation and cytokine production were assessed in the lavage...
Source: European Respiratory Journal - July 30, 2016 Category: Respiratory Medicine Authors: Kaiser, Y., Lepzien, R., Kullberg, S., Eklund, A., Smed-Sörensen, A., Grunewald, J. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Innate immunity in sarcoidosis pathobiology
Purpose of review: The immunopathogenesis of sarcoidosis is considered to involve contributions from both adaptive and innate immune responses. Although the identification of adaptive responses to candidate pathogenic antigens will elucidate mechanisms that regulate inflammation in sarcoidosis, innate mechanisms likely represent the ‘missing link’ to the initiation, maintenance, and resolution of noncaseating granulomatous inflammation, the hallmark feature of sarcoidosis. Furthermore, environments that expose patients to candidate pathogenic antigens for sarcoidosis also provide opportunities for engagement with innat...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

T-cell immunology in sarcoidosis: Disruption of a delicate balance between helper and regulatory T-cells
Purpose of review: Although the aetiology of sarcoidosis is not yet completely understood, immunological changes within the T-cell compartment are characteristic for an exaggerated antigen-driven immune response. In this review, we describe the most recent findings on T-cell subset responses and regulation in sarcoidosis. We discuss how future immunological research can advance the field to unravel pathobiological mechanisms of this intriguingly complex disease. Recent findings: Research into the field of T-cell plasticity has recently challenged the long-held T helper type 1 (Th1) paradigm in sarcoidosis and striking par...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

From granuloma to fibrosis: sarcoidosis associated pulmonary fibrosis
Purpose of review: Up to twenty percent of patients with sarcoidosis develop pulmonary fibrosis, transforming an often benign disease into a highly morbid and potentially fatal one. We highlight the fibrotic pulmonary sarcoidosis phenotype as an area of intense clinical and translational investigation, review recent developments in treatment, and provide a roadmap for future research in sarcoidosis associated pulmonary fibrosis. Recent findings: Granulomatous inflammation in a lymphatic distribution is the hallmark finding of pulmonary sarcoidosis and the nidus for fibrosis. Recent research demonstrates that fibrotic sarc...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

Experimental models of sarcoidosis
Purpose of review: Sarcoidosis is a disease caused by a complex combination of genetic susceptibility, immune networks and infectious and/or environmental agents. The onset and phenotypic variability of sarcoidosis remain poorly elucidated, not only due to the lack of clearly identified causes, but also because it is widely considered that no reliable model of this disease is available. In this review, we discuss the various models of granulomatous diseases in order to challenge this assertion. Recent findings: A large number of models of granulomatous diseases are available, both cellular models used to study the natural...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

Biomarkers in sarcoidosis: the contribution of system biology
Purpose of review: System biology is an interdisciplinary approach with the purpose to evaluate the experimental results of ‘-omics’ sciences as a whole. The ‘-omics’ sciences do not start generally from a-priori assumptions and are aimed to study the constituents of a specific biological domain (genome, transcriptome, proteome and metabolome) in a given state, using different high-throughput technologies (as polymerase chain reaction, arrays, liquid chromatography, mass spectrometry, etc.) and allowing a hermeneutical integration and recomposition of the experimental information. The aim of the present review is t...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

New molecular targets for the treatment of sarcoidosis
Purpose of review: Sarcoidosis is a chronic granulomatous disease typically affecting the lung, lymph nodes, and other organ systems. Evidence suggests that the morbidity and mortality rates for sarcoidosis in the USA are rising, despite widespread use of anti-inflammatory therapies. In this review, we survey new therapies that target specific inflammatory pathways in other diseases (such as rheumatoid arthritis, Crohn's disease, and psoriasis) that are similar to pathways relevant to sarcoidosis immunopathogenesis, and therefore, represent potentially new sarcoidosis therapies. Recent findings: Immunopathogenesis of sarc...
Source: Current Opinion in Pulmonary Medicine - July 29, 2016 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Daniel A. Culver and Dominique Valeyre Source Type: research

GSE75023 Transcriptional profle of bronchoalveolar cells in sarcoidosis
Conclusions: BAL cells in sarcoidosis are characterized by enrichment of distinct transcriptional networks involved in immuno-inflammatory and proteasomal processes. Our findings add to the growing evidence implicating airspace resident cells in the pathogenesis of sarcoidoisis and identify specific pathways whose activation may modulate disease progression.
Source: GEO: Gene Expression Omnibus - July 22, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Sarcoid Pericarditis and Large Vessel Vasculitis Detected on FDG PET/CT
Abstract: A 65-year-old woman with history of sarcoidosis, hypertension, and peripheral vascular disease presented with lower extremity claudication and low left ventricular ejection fraction of 45% on echocardiogram. Further FDG PET/CT revealed hypermetabolic bilateral chest lymphadenopathy and pulmonary nodules in a butterfly-shaped distribution pattern, which was typically seen in patients with sarcoidosis. In addition, abnormal increased radiotracer uptake was present in pericardium, and along the walls of inferior vena cava, aorta, and pulmonary artery, which correlated with delayed enhancement on further cardiac MRI....
Source: Clinical Nuclear Medicine - July 9, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

A dual tracer 68 Ga-DOTANOC PET/CT and 18 F-FDG PET/CT pilot study for detection of cardiac sarcoidosis
Conclusions Despite prolonged pre-scan fasting, a large proportion of 18F-FDG PET/CT images were rated as inconclusive, resulting in low agreement among reviewers and correspondingly poor diagnostic accuracy. By contrast, 68Ga-DOTANOC PET/CT had excellent diagnostic accuracy with the caveat that inter-observer variability was still significant. Nevertheless, 68Ga-DOTANOC PET/CT looks very promising as an alternative CS PET tracer. Trial registration Current Controlled Trials NCT01729169.
Source: EJNMMI Research - June 16, 2016 Category: Radiology Source Type: research

Pulmonary sarcoid-like granulomatosis induced by nivolumab.
This article is protected by copyright. All rights reserved. PMID: 27291635 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - June 12, 2016 Category: Dermatology Authors: Montaudié H, Pradelli J, Passeron T, Lacour JP, Leroy S Tags: Br J Dermatol Source Type: research

Bidirectional ventricular tachycardia in cardiac sarcoidosis
Publication date: Available online 4 June 2016 Source:Journal of Arrhythmia Author(s): Mina M. Benjamin, Kevin Hayes, Michael E. Field, Melvin M. Scheinman, Kurt S. Hoffmayer A 73-year-old man with history of pulmonary sarcoidosis was found to have runs of non-sustained bidirectional ventricular tachycardia (BVT) with two different QRS morphologies on a Holter monitor. Cardiac magnetic resonance delayed gadolinium imaging revealed a region of patchy mid-myocardial enhancement within the left ventricular basal inferolateral myocardium. An 18-fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased u...
Source: Journal of Arrhythmia - June 3, 2016 Category: Cardiology Source Type: research

Beryllium disease and sarcoidosis: still besties after all these years?
Toxic pulmonary disease from beryllium exposure first came to light in the 1930s, soon after the emergence of industrial uses of beryllium alloys. An early manufacturing application for beryllium compounds, as phosphors in fluorescent tubes, was the cause of some of the first known cases of chronic beryllium disease (CBD) (first termed "pulmonary granulomatosis of beryllium workers"). However, the association between beryllium and granulomatous inflammation was controversial at the outset, leading to the moniker "Salem sarcoid" to describe the outbreak of "sarcoidosis" among fluorescent bulb workers at a manufacturing plan...
Source: European Respiratory Journal - May 30, 2016 Category: Respiratory Medicine Authors: Culver, D. A. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Usefulness of combined FDG-PET/MR to diagnose active cardiac sarcoidosis.
Conclusions These preliminary results of our prospective study show the usefulness of combined FDG-PET/MR in the diagnosis of CS using TNRmax measurements. Further inclusions of patients are needed to validate an optimal threshold of TNRmax and verify the clinical utility of combined FDG-PET/MR. This series also confirms the ability of PET/MR imaging to evaluate extra-cardiac involvement of sarcoidosis and in assessing alternative myocardial pathologies.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Abgral, R., Dweck, M., Robson, P., Trivieri, M., Karakatsanis, N., Sanz, J., Contreras, J., Fuster, V., Padilla, M., Kovacic, J., Fayad, Z. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research

The relation of myocardial and extra-myocardial inflammation in patients with cardiac sarcoidosis (CS). Evaluation by whole body 18F FDG-PET
Conclusions The extra-myocardial inflammation was frequently observed in whole-body FDG and linked to myocardial active inflammation in CS. However, active inflammation was no longer observed in advanced LV dysfunction. Active systemic sarcoidosis with cardiac involvement needs to be considered as early stage of CS which can be salvaged by anti-inflammatory therapy. $$graphic_FBC6DAA5-224E-4ACB-9906-2573C4BF2033$$
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Fukushima, K., Momose, M., Serizawa, N., Suzuki, A., Abe, K., Hagiwara, N., Sakai, S. Tags: Cardiovascular Clinical Science: Myocardial Amyloidosis and Sarcoidosis Source Type: research

The relation of myocardial fatty acid metabolism dysfunction, inflammation, and fibrosis in patients with cardiac sarcoidosis (CS): A regional and correlative analysis.
Conclusions Fatty acid metabolism dysfunction was observed in CS, and related to cardiac myocardial fibrosis. Impaired fatty acid metabolism in comparable fibrosis indicated the presence of ongoing damage due to persistent inflammation in advanced heart failure, and may have benefit from anti-inflammatory therapy.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Umiko, I., Fukushima, K., Yamamoto, A., Momose, M., Serizawa, N., Suzuki, A., Abe, K., Nekolla, S., Hagiwara, N., Sakai, S. Tags: Cardiovascular Clinical Science: Myocardial Amyloidosis and Sarcoidosis Source Type: research

The regional evaluation of cardiac sympathetic nervous system dysfunction and inflammatory lesion for sarcoidosis patients
Conclusions CS patients showed higher FDG uptake and lower RI than non-CS patients. The regional analysis demonstrated the significant correlation between FDG uptake and SNS dysfunction. The FDG uptake region was larger than SNS dysfunction region in the patients without a history of steroid therapy. SNS dysfunction may persist even the FDG uptake was decreased after steroid therapy. $$graphic_688B7EA9-8D3C-4175-A919-8B09C8328477$$ $$graphic_45523217-7CD7-486C-990B-B1B4CFABCC3A$$
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Manabe, O., Yoshinaga, K., Ohira, H., Tsujino, I., Oyama-Manabe, N., Nishimura, M., Tamaki, N. Tags: Cardiovascular Clinical Science: Myocardial Amyloidosis and Sarcoidosis Source Type: research

Pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with Propionibacterium acnes.
Authors: Jiang D, Huang X, Geng J, Dong R, Li S, Liu Z, Wang C, Dai H Abstract Pulmonary fibrosis (PF) associated with chronic sarcoidosis remains poorly understood, and no experimental model is currently available for this condition. Previous studies have shown that Propionibacterium acnes (PA) was associated with sarcoidosis and induced granuloma formation in mice. Here, we investigated whether repeated challenge with PA induces persistent inflammation leading to sarcoidosis followed by PF in mice. Specifically, C57BL/6 mice were inoculated intraperitoneally and subjected to intratracheal challenge with PA, and t...
Source: Oncotarget - May 21, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Clinical Features of Ocular Sarcoidosis in Patients with Biopsy-proven Pulmonary Sarcoidosis in Serbia.
CONCLUSIONS: Patients in Serbia demonstrated ocular sarcoidosis as the first most common site of extrapulmonary sarcoid manifestations, with more often neuro-ophthalmologic lesions than in other European populations. PMID: 27191355 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - May 19, 2016 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Sarcoidosis and chronic hepatitis C: treatment with prednisone and colchicine
In this report a case of sarcoidosis associated with chronic hepatitis C will be described, with subcutaneous lesions, considered rare, and good response to treatment with colchicine and prednisone. The hepatitis C virus was isolated in sarcoid tissue and the association between the two diseases will be discussed.
Source: Anais Brasileiros de Dermatologia - May 13, 2016 Category: Dermatology Source Type: research

Sarcoidosis Presenting Addison's Disease.
Authors: Takahashi K, Kagami S, Kawashima H, Kashiwakuma D, Suzuki Y, Iwamoto I Abstract We herein describe a second Japanese case of sarcoidosis presenting Addison's disease. A 52-year-old man was diagnosed with sarcoidosis based on clinical and laboratory findings, including bilateral hilar lymphadenopathy and elevated levels of serum angiotensin-converting enzyme and lysozyme, as well as the presence of noncaseating epithelioid granulomas. The patient also exhibited general fatigue, pigmentation, weight loss, hypotension and hyponatremia, suggestive of chronic adrenocortical insufficiency. An endocrine examinati...
Source: Internal Medicine - May 8, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research

Renal Angiomyolipoma With Sarcoid Granulomas: Report of a Unique Case
We present the first reported case of sarcoid granulomas in a renal angiomyolipoma, including morphologic and immunohistochemical features.
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: Tarjan, G., Kim, G. J., Haroon Al Rasheed, M. R. Tags: Case Reports Source Type: research

Use of Aqueous Humor and Flow Cytometry in Ocular Sarcoidosis Diagnosis.
CONCLUSIONS: Flow cytometry on aqueous fluid may offer an additional pathway for diagnosing sarcoid anterior uveitis. PMID: 27082232 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - April 16, 2016 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Acute eosinophilic pneumonia as a complication of influenza A (H1N1) pulmonary infection.
We describe the case of influenza A (H1N1) severe pneumonia complicated by an acute eosinophilic pneumonia. Patient presented with respiratory failure and diffuse ground-glass opacities at chest-computed tomography. Clinical suspicion for this complication and bronchoalveolar lavage with cellular count analysis is crucial. PMID: 27055842 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidal granuloma presenting on tattoo: a report of a Japanese female patient and a review of Japanese published work.
CONCLUSIONS: Our results suggest that a tattoo does not have significant impact on the clinical features of sarcoidosis. However, skin lesions on a tattoo can be the first sign of systemic sarcoidosis in any race; therefore, much attention should be paid to skin eruptions on a tattoo for earlier identification of patients who need work-up for systemic illness. PMID: 27055840 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

"The significance of cardiac magnetic resonance imaging in detection and monitoring of the treatment efficacy of heart involvement in eosinophilic granulomatosis with polyangiitis patients".
CONCLUSIONS: CMRI is a sensitive method detecting cardiac lesions in EGPA patients. It helps to detect patients, who need combined therapy and helps evaluate the therapeutic effect. PMID: 27055836 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?
Conclusions MFAP4 is not elevated in sera of patients with pulmonary fibrosis or bleomycin treated mice with pulmonary fibrosis. This may be due to different pathogenic mechanisms of liver and lung fibrogenesis. MFAP4 seems to be useful as serum biomarker for hepatic but not for lung fibrosis. PMID: 27055835 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Validation of transbronchial cryobiopsy in interstitial lung disease - interim analysis of a prospective trial and critical review of the literature.
ConclusionsCryo-TBB may be a reliable diagnostic tool in ILD, dispensing the need for a SLB in most cases. Severe complications may occur less frequently than in SLB. Modifications of the procedure may lead to further risk reduction. PMID: 27055830 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

FDG PET/CT Evidence of Effective Treatment of Cardiac Sarcoidosis With Adalimumab
Abstract: A 53-year-old man with mediastinal lymph node biopsy and cardiac MRI–proven cardiac sarcoidosis (CS) received treatment with pacemaker and steroids. FDG PET/CT showed active CS despite treatment with prednisone and methotrexate. Addition of weekly adalimumab (Humira) injections was introduced for 3 months. Follow-up FDG PET/CT showed complete resolution of CS as well as improvement of other sarcoid lesions in the thoracic lymph nodes.
Source: Clinical Nuclear Medicine - April 7, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

99mTc-anti-TNF-{alpha} antibody for the imaging of disease activity in pulmonary sarcoidosis
In this study we evaluated scintigraphy with technetium-99m (99mTc)-labelled infliximab for the imaging of disease activity in patients with pulmonary sarcoidosis. 10 patients were studied using single photon emission computed tomography/computed tomography (CT) 6 h and 20 h after intravenous administration of 370 MBq of 99mTc-infliximab. Correlation analysis was performed between tissue accumulation of 99mTc-infliximab and laboratory parameters (including soluble interleukin-2 receptor and angiotensin-converting enzyme), lung function parameters (including forced expiratory volume in 1 s and the diffus...
Source: European Respiratory Journal - March 31, 2016 Category: Respiratory Medicine Authors: Vis, R., Malviya, G., Signore, A., Grutters, J. C., Meek, B., van de Garde, E. M. W., Keijsers, R. G. M. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Sarcoidosis: radiographic manifestations in the nails and distal phalanges
We describe a case of sarcoidosis with radiographic findings in the nails and distal phalangeal tufts, which were indicative of nail and osseous sarcoid involvement and strongly supported the presence of chronic systemic disease. Although the nail findings resolved clinically and on radiographs after treatment, the osseous findings showed only minimal improvement. To our knowledge, the radiographic findings of nail sarcoidosis have not been previously addressed in the literature.
Source: Skeletal Radiology - March 19, 2016 Category: Radiology Source Type: research

New Pathogenetic Concepts and Early Pharmacological Studies in Sarcoidosis.
Authors: Schupp JC, Frye BC, Zissel G, Müller-Quernheim J Abstract The etiology of sarcoidosis is still elusive, yet there has been considerable progress in various areas of basic and clinical research. This review focuses on mechanisms of granuloma formation and on new findings in autoimmunity and genetics of sarcoidosis. A new promising concept arose, where serum amyloid A and/or mycobacterial antigens serve as nidus for granuloma formation. Furthermore, autoimmunity in sarcoidosis was neglected for a long time, yet new studies found autoantigens and abnormalities in antigen presentation in sarcoidosis. Last but...
Source: Pneumologie - March 6, 2016 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

Life-Threatening Hypercalcemia Revealing Diffuse and Isolated Acute Sarcoid-Like Myositis: A New Entity? (A Case-Series)
We report on 3 cases of life-threatening hypercalcemia revealing florid and isolated acute sarcoid-like myositis. All patients complained of fatigue, progressive general muscle weakness, and weight loss. Laboratory tests showed a severe life-threatening hypercalcemia (>3.4 mmol/L). Hypercalcemia was associated with increased serum level of 1,25-(OH)2 vitamin D and complicated with acute renal failure. One patient displayed acute pancreatitis due to hypercalcemia. In all cases, PET-scan, performed for malignancy screening, incidentally revealed an intense, diffuse, and isolated muscular fluorodeoxyglucose (FDG) uptake c...
Source: Medicine - March 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Liver Function Testing Is Not Useful in the Diagnosis of Sarcoidosis in Patients Presenting with Uveitis.
CONCLUSIONS: There is no evidence that abnormal liver function tests are an indicator of sarcoidosis in new patients presenting with uveitis. PMID: 26903283 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - February 25, 2016 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Electron microscopy of contact between a monocyte and a multinucleated giant cell in cardiac sarcoidosis
Publication date: Available online 23 February 2016 Source:Canadian Journal of Cardiology Author(s): Yuki Imaizumi, Kazuo Eguchi, Hiroki Imada, Kiyomi Hidano, Satoshi Niijima, Hirotoshi Kawata, Noriyoshi Fukushima, Tsunenori Saito, Michiaki Hiroe, Kazuomi Kario Using electron microscopy, we observed a monocyte contacting a multinucleated giant cell (MGC) via a gap junction in the biopsied myocardium of a cardiac sarcoidosis patient. This is the first report showing in vivo ultrastructural findings of a MGC in sarcoid granulomas. We speculate that communication between monocytes and MGCs, probably leading to cel...
Source: Canadian Journal of Cardiology - February 25, 2016 Category: Cardiology Source Type: research

A rare association of sarcoid-like granuloma with renal cell carcinoma
We describe a rare case of conventional (clear cell) RCC associated with epithelioid granulomas within the tumor parenchyma, in a 42-year-old lady without any evidence of systemic sarcoidosis.
Source: Journal of Cancer Research and Therapeutics - February 15, 2016 Category: Cancer & Oncology Authors: Subhadip KhatuaKousik BoseArghya BandyopadhyayAbhijit Banerjee Source Type: research

Pulmonary Microscopic Polyangiitis Presenting as Acute Respiratory Failure from Diffuse Alveolar Hemorrhage.
We present two cases of rapid onset respiratory failure secondary to diffuse alveolar hemorrhage in young active duty military personnel. After serological testing and surgical lung biopsy, both patients were diagnosed with microscopic polyangiitis with isolated pulmonary involvement. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 372-377). PMID: 26847106 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

IgG4-related lung disease: a case series of 6 patients and review of the literature.
In this report, we describe the clinical and pathologic features of six patients with IgG4-related disease of the lung. Patients were followed 1 - 5 years following their diagnosis. We describe unique features of IgG4- related lung disease, including one patient who presented with alveolar hemorrhage and a positive anti-neutrophil cytoplasmic antibody and two patients whose disease improved after treatment with mycophenylate mofetil. Two patients presented with pulmonary pseudotumor. We conclude that the clinical presentation of IgG4-related lung disease varies widely, and histopathology remains the key to diagnosis. ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research