This page shows you the latest news items in this category. This is page number 10.

Total 4942 results found since Jan 2013.

Transcriptome profiles in sarcoidosis and their potential role in disease prediction
Purpose of review: Sarcoidosis is a systemic disease defined by the presence of nonnecrotizing granuloma in the absence of any known cause. Although the heterogeneity of sarcoidosis is well characterized clinically, the transcriptome of sarcoidosis and underlying molecular mechanisms are not. The signal of all transcripts, small and long noncoding RNAs, can be detected using microarrays or RNA-Sequencing. Analyzing the transcriptome of tissues that are directly affected by granulomas is of great importance to understand biology of the disease and may be predictive of disease and treatment outcome. Recent findings: Multipl...
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Necrotizing sarcoid granulomatosis: a distinctive form of pulmonary granulomatous disease
Conclusion: NGS is a disease often confounded clinically with malignancy or with sarcoidosis even histologically when all criteria are not strictly applied. This review provides NGS' characteristics and discusses its differential diagnosis form sarcoidosis, Wegener granulomatosis and tuberculosis. This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - July 29, 2017 Category: Respiratory Medicine Authors: Georgia Karpathiou, Anna Batistatou, Panagiotis Boglou, Dimitrios Stefanou, Marios E. Froudarakis Tags: Review Article Source Type: research

Sarcoidosis: Drugs under Investigation
Semin Respir Crit Care Med 2017; 38: 532-537 DOI: 10.1055/s-0037-1603768Etiology of sarcoidosis is still elusive, yet there has been considerable progress in various areas of basic and clinical research. In this review, we focus on ongoing or recently completed clinical–pharmacological studies in patients with sarcoidosis. Positive studies were published in well-characterized and homogenous subcohorts of sarcoid patients. Several drugs have shown a positive effect on sarcoidosis-associated fatigue, cutaneous sarcoidosis, and pulmonary hypertension in sarcoid patients. It seems that the recruitment of clinically precisely...
Source: Seminars in Respiratory and Critical Care Medicine - July 27, 2017 Category: Respiratory Medicine Authors: Schupp, Jonas Christian Frye, Bj örn Christian Zissel, Gernot M üller-Quernheim, Joachim Tags: Review Article Source Type: research

Granulomas within renal epithelial neoplasms in patients with sarcoidosis: A causal association?
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Nasma K. Majeed, Andres M. Acosta, Andre Kajdacsy-Balla, Suman Setty, Nathan A. Aardsma Sarcoidosis is a chronic granulomatous disease that can involve virtually every organ system, but most commonly presents as lung, skin, or lymph node disease. Although kidney involvement is usually clinically silent, granulomatous interstitial nephritis − the hallmark of renal sarcoidosis − can lead to functional impairment and organ failure. Also, recent studies have suggested an association between sarcoidosis and an increased risk...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Glucocorticoid sparing effect of zoledronic acid in sarcoid hypercalcemia
ConclusionZoledronic acid should be studied as a potential first-line agent for sarcoid hypercalcemia. Furthermore, disease-modifying effects of zoledronic acid in sarcoidosis should be investigated.
Source: Archives of Orthopaedic and Trauma Surgery - July 19, 2017 Category: Orthopaedics Source Type: research

Non-cardiac sarcoid actually affects the heart by reducing coronary flow reserve
Sarcoidosis is a multisystem granulomatous disease of unclear etiology that is characterized by the formation of non-caseating granuloma in various organs, resulting from an immune-mediated reaction to a yet unknown antigen in genetically predisposed individuals1. The prevalence of sarcoidosis is quite variable and contingent upon ethnicity, gender and regions. For example, the prevalence is 10/100,000 for Caucasians in the USA and Europe, while there is an increased prevalence of sarcoid in African-Americans as compared to Caucasians with a ratio 10 –17:1 [1].
Source: Atherosclerosis - July 6, 2017 Category: Cardiology Authors: Carlos G. Santos-Gallego, Allen J. Weiss, Javier Sanz Tags: Editorial Source Type: research

Sudden cardiac death due to sarcoidosis. Case report.
Abstract Sarcoidosis is a systemic granulomatous disease of unknown aetiology, which is characterized by bilateral hilar lymphadenopathy and pulmonary disease. Clinically detected cardiac involvement occurs in 5% of sarcoid patients, although cardiac manifestations are discovered in 25% of the cases at autopsy. Sarcoid heart disease frequently causes atrioventricular block. The authors present the case of a 44-year-old man with bradycardia. On admission, second degree Mobitz II, then third degree atrioventricular block was diagnosed. Coronarography showed normal coronary arteries. 2.5 years following artificial Bi...
Source: Orvosi Hetilap - July 1, 2017 Category: General Medicine Authors: Sejben I, Som Z, Cserni G Tags: Orv Hetil Source Type: research

Chronic pulmonary aspergillosis complicating sarcoidosis
Chronic pulmonary aspergillosis (CPA) complicating sarcoidosis (SA) is associated with high mortality, and there is a lack of clarity regarding the relative contributions of SA or CPA. This was a retrospective single-centre study on CPA-SA. In total, 65 patients (44 men), aged 41.4±13.5 and 48.3±11.9 years at the time of SA and CPA diagnoses, respectively, were included between 1980 and 2015. Of these, 64 had fibrocystic SA, most often advanced, with composite physiological index (CPI) >40 (65% of patients) and pulmonary hypertension (PH) (31%), and 41 patients (63%) were treated for SA (corticosteroi...
Source: European Respiratory Journal - June 15, 2017 Category: Respiratory Medicine Authors: Uzunhan, Y., Nunes, H., Jeny, F., Lacroix, M., Brun, S., Brillet, P.-Y., Martinod, E., Carette, M.-F., Bouvry, D., Charlier, C., Lanternier, F., Planes, C., Tazi, A., Lortholary, O., Baughman, R. P., Valeyre, D. Tags: Interstitial and orphan lung disease, Respiratory infections and tuberculosis Original Articles: Sarcoidosis and aspergillosis Source Type: research

Case of cutaneous sarcoidosis with multiple morphologies and review of the clinical spectrum
We report a case of a 51-year-old white female with sarcoidosis who sequentially exhibited multiple biopsy-proven cutaneous sarcoid morphologies, including subcutaneous nodules, red papules on normal surrounding skin, and papules withi n a preexisting scar.
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research

Impact of a Quantitative Structured Report on the Assessment of Cardiac Involvement in Sarcoidosis using 18F-FDG PET-CT
Conclusion: The use of a quantitative structured report in cardiac PET-CT has the potential to improve diagnostic accuracy and clinician confidence for the detection of cardiac sarcoidosis.
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: De Cecco, C., Gordon, L., James, W., Smith, W., Spicer, K., Nkrumah, Y., Burchett, P., Bradshaw, M. Tags: Cardiovascular Clinical Science Posters Source Type: research

Sarcoidosis Mimicking Malignancy or Infection in the Chest: Importance of Collaborative interpretation of CT and F18 FDG PET/CT
Conclusion: It is imperative for radiologists to be aware of the various imaging appearances of sarcoidosis and understand the added value as well as limitations of FDG PET/CT.
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Chan, C., Lu, T., Son, H. Tags: Educational Exhibits Posters Source Type: research

Quantitative Interpretation of FDG PET for Cardiac Sarcoidosis Reclassifies Visually Interpreted Studies and Potentially Reduces Unnecessary Downstream Interventions
Conclusion: Re-interpretation of FDG PET/CT imaging for cardiac sarcoidosis using quantitative techniques lead to a nearly 1/3 of visually "FDG positive" studies being reclassified as normal (no FDG uptake). In 7/22 patients that were reclassified as normal, initiation or increase of immunosuppression could potentially have been avoided, thus possibly limiting toxicities of these medications. The adverse event rate for arrhythmias and CHF in patients reclassified as normal was low. This suggests quantitative interpretation of FDG PET/CT for CS could reduce unnecessary immunosuppressive treatment in some patients. Research Support: None
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Varghese, M., Miller, E. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

Relative value of cardiac MRI and FDG-PET in treatment follow-up for cardiac sarcoidosis.
Conclusion: Myocardial FDG uptake in suspected CS is presumed to represent active inflammation. When treated with oral steroids this improved or resolved on short term follow up. Despite several of the treated cases showing LGE on the initial CMR this was not altered by treatment and there was no change in LV/RV function or volumes. Untreated patients showed no change on follow-up FDG PET or CMR. Although oral steroids modify myocardial disease activity, it remains to be seen whether treatment will alter long term cardiac outcome. (1) Coulden et al. RSNA 2016:archive.rsna.org/2016/16009768.html. (2) Coulden et al. Eur Radi...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Coulden, R., Crean, A., Sonnex, E., Abele, J. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

FDG Uptake Quantification and Right Ventricular Dysfunction in Cardiac Sarcoidosis
Conclusion: These results suggest that several proposed quantitative metrics relating RV or septal FDG uptake correlate with RV function as assessed by TAPSE. RVCMA shows a statistical distinction between normal and abnormal TAPSE patient groups. Interestingly, the second best performing metric, septal cardiac metabolic activity, suggests that increased septal inflammation may be a predictor of poor RV function. Research Support: None
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Bindschadler, M., Petek, B., Elman, S., Cheng, R., Patton, K., Soine, L., Alessio, A. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

Cardiac PET/CT in the Management of Cardiac Sarcoidosis: Association of FDG Uptake with Changes in Symptoms and Medications
Conclusion: While there is an association between worsening symptoms and increased FDG uptake in the myocardium, FDG uptake alone is not a strong predictor of symptom changes (AUC only 0.6). These results may be confounded by numerous factors including many known limitations of myocardial FDG inflammation imaging (e.g., incomplete FDG suppression, spatial resolution, motion) and the unknown impact of the effect of ongoing steroid therapy on baseline FDG trapping. These initial results suggest that patients with similar functional class had reduced FDG uptake if they were on steroids. Further work is needed to assess if ste...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Elman, S., Bindschadler, M., Petek, B., Cheng, R., Patton, K., Soine, L., Alessio, A. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

Prognostic Role of Serial Quantitative Evaluation of 18Fluorodeoxyglucose Uptake by PET/CT in Patients with Cardiac Sarcoidosis Presenting with Ventricular Tachycardia
Conclusion: In patients with CS and VT, temporal reduction of FDG uptake evaluated by a quantitative approach is strongly associated with improvement in systolic function, better arrhythmia free survival, less mortality and less hospitalizations for heart failure
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Castro, S., Muser, D., Santangeli, P., Magnani, S., Werner, T., Garcia, F., Desjardins, B., Marchlinski, F., Alavi, A. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

The Evaluation of Cardiac Sarcoidosis using 18F-FDG PET Scan and the Impact on the Patients Plan of Care.
Conclusion: 18F-FDG PET scan had an impact on the evaluation of cardiac sarcoidosis and the patient’s plan of care. 18F-FDG PET was able to rule out cardiac sarcoidosis in 11/14 or (79%) patients that had suspicious or indeterminate MRI results. 18F-FDG PET imaging was alternatively useful in patients that did not have a prior MRI. 3/8 had positive exams (37%) and were treated steroids. 3/8 had negative (37%) and had pacemaker placement or continued long term steroid therapy, and 2/ 8 had indeterminate (25%) results for cardiac sarcoidosis, both had ICD placement. PET imaging was also significant in evaluating the re...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Alharbi, M. Tags: Technologist Student Papers III Source Type: research

Musculoskeletal manifestations of sarcoidosis.
Abstract Musculoskeletal manifestations in the context of sarcoidosis are frequently observed. The rheumatologist regularly encounters this disease in clinical practice. In the present review, we aim to give a current overview of the manifestations and treatments relevant to the practicing rheumatologist. The most frequently encountered manifestation is Lofgren's syndrome, which is characterized by bilateral ankle periarthritis, bilateral hilar lymphadenopathy, and erythema nodosum and has an excellent prognosis. Chronic arthropathy most commonly manifests as oligoarthritis, which sometimes hampers its differenti...
Source: Zeitschrift fur Rheumatologie - May 9, 2017 Category: Rheumatology Authors: Korsten P, Chehab G Tags: Z Rheumatol Source Type: research

Sarcoidosis-Lymphoma Syndrome Associated with Folliculotropic Peripheral T Cell Lymphoma Not Otherwise Specified
In this report, we describe a case of sarcoidosis-lymphoma syndrome associated with folliculotropic peripheral T cell lymphoma not otherwise specified, which caused dense infiltration of CD30+ CD163+ tumor-associated macrophages (TAMs) only in the lesional skin. Our present case might suggest the significance of TAMs in developing sarcoid-lymphoma syndrome.Case Rep Oncol 2017;10:372 –376
Source: Case Reports in Oncology - April 24, 2017 Category: Cancer & Oncology Source Type: research

A Case of Subcutaneous Sarcoidosis Occurring along the Superficial Veins of the Forearms: A Distinctive Cutaneous Manifestation Masquerading Venous Tropic Action in the Underlying Systemic Disease?
Sarcoidosis is a multisystem disease of unknown etiology, developing granulomas in any tissues and organs. Approximately 25% of sarcoidosis patients have cutaneous involvement with various clinical manifestations, which are categorized into specific or nonspecific diseases based on the histopathology; the former represents the typical sarcoid granulomas. Subcutaneous sarcoidosis is one of the specific skin lesions and often affects extremities, to a much lesser extent with other anatomical sites. Herein, we report the case of an 82-year-old Japanese man with subcutaneous sarcoidosis whose skin nodules exclusively overlay t...
Source: Case Reports in Dermatology - April 11, 2017 Category: Dermatology Source Type: research

Sarcoidosis associated with infliximab therapy in ulcerative colitis: A case report
We report the case of a 30-year-old male patient, with no personal or familial history of lung disease, with a personal history of ulcerative colitis (UC), under clinical remission following infliximab therapy in maintenance dose, who was admitted for treatment administration, but also for dyspnea, nocturnal sweating, and nonproductive cough. Diagnoses: Based on clinical manifestations, biological landmarks excluding various infections, CT scan, fibrobronchoscopy with bronchoalveolar lavage for culture and immunohistochemical examination, followed by mediastinoscopy with sampling of paratracheal lymph node, which underwen...
Source: Medicine - March 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Risk of cardiovascular disease among patients with sarcoidosis: a population-based retrospective cohort study, 1976-2013
In this study, 345 patients with incident sarcoidosis in Olmsted County (Minnesota, USA) during 1976–2013 were identified based on comprehensive medical record review. 345 sex- and age-matched comparators were also identified from the same underlying population. Medical records were individually reviewed for CVD, including coronary artery disease, congestive heart failure, atrial fibrillation, cerebrovascular accident, transient ischaemic attack, peripheral arterial disease and abdominal aortic aneurysm. Cox proportional hazards models with adjustment for age, sex, calendar year and cardiovascular risk factors were u...
Source: European Respiratory Journal - February 22, 2017 Category: Respiratory Medicine Authors: Ungprasert, P., Crowson, C. S., Matteson, E. L. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Coexistent Sarcoidosis and Tuberculosis: A Case Report
We report a case of bilateral tuberculous pleurisy in a 45-year-old male native of a North-African region with an atypical severe multisystem disease characterized by a fever resistant to anti-TB therapy and respondent to corticosteroid treatment. The choice to continue both steroid and anti-TB therapy proved to be correct for the late evidence of TB mycobacterial growth only on pleural specimens. The case described is suggestive of a coexistent systemic sarcoid manifestation and low-antigen TB, which is an underrecognized entity in the medical literature.Respiration
Source: Respiration - February 8, 2017 Category: Respiratory Medicine Source Type: research

Papulo-Nodular Reactions in Black Tattoos as Markers of Sarcoidosis: Study of 92 Tattoo Reactions from a Hospital Material
Conclusion: Black tattoos with papulo-nodular reactions should be seen as markers of sarcoidosis. Papulo-nodular reactions may, as triggers, induce widespread reactions in other black tattoos - a “rush phenomenon” - depending on individual predisposition. Sarcoidosis is estimated to be 500-fold increased in papulo-nodular reactions compared to the prevalence in the general population, and the association with black tattoos is strong.Dermatology
Source: Dermatology - February 6, 2017 Category: Dermatology Source Type: research

Myocardial Blood Flow and Inflammatory Cardiac Sarcoidosis
Conclusions Sarcoid-mediated myocardial inflammation is associated with a regional impairment of coronary circulatory function. The association between immune-suppressive treatment-related alterations in myocardial inflammation and changes in coronary vasodilator capacity suggests direct adverse effect of inflammation on coronary circulatory function in cardiac sarcoidosis.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 5, 2017 Category: Radiology Authors: Kruse, M. J., Kovell, L., Kasper, E. K., Pomper, M. G., Moller, D. R., Solnes, L., Chen, E. S., Schindler, T. H. Tags: Original Research Source Type: research

Adalimumab-induced pulmonary sarcoidosis not progressing upon treatment with etanercept.
Abstract Tumor necrosis factor alpha (TNF-α) inhibitors effectively treat sarcoidosis, but can, paradoxically, induce sarcoidosis. The TNF-α inhibitor etanercept is most commonly associated with paradoxical sarcoidosis, which has previously been reported to be resolved by adalimumab. However, we describe the case of a patient with ankylosing spondylitis and adalimumab-induced sarcoidosis not aggravated by switching to etanercept, thus indicating that etanercept could be a treatment option for patients who develop paradoxical sarcoid-like reactions after treatment with other TNF-α inhibitors. PMID: 281247...
Source: Zeitschrift fur Rheumatologie - January 25, 2017 Category: Rheumatology Authors: Jung JH, Kim JH, Song GG Tags: Z Rheumatol Source Type: research

Annular lesions of cutaneous sarcoidosis with granulomatous vasculitis
ABSTRACT Sarcoidosis is known to be involved in diseases with vasculitis as sarcoid vasculitis. However, vasculitis in cutaneous sarcoidal lesions is extremely rare. Here we describe a case of sarcoidosis with multiple annular skin lesions with granulomatous vasculitis. A 62‐year‐old female was diagnosed with sarcoidosis by chest‐abdominal CT examination and laboratory tests. The skin lesions had appeared on her lower limbs 2 years before. Physical examination showed multiple infiltrated annular eruptions on the lower extremities. A skin biopsy of an area of erythema showed multiple non‐caseating epithelioid cell g...
Source: Journal of Cutaneous Pathology - January 24, 2017 Category: Pathology Authors: Kana Mizuno, Nguyen Thi Hong Chuyen, Ikuko Ueda ‐Hayakawa, Hiroyuki Okamoto Tags: CASE REPORT Source Type: research

Time-course of Serum Pro-inflammatory Cytokines and Chemokines Levels Observed in Granulomatosis with Polyangiitis: A Case Report.
Authors: Kozu Y, Gon Y, Takano Y, Noguchi T, Hayashi S, Kumasawa F, Mizumura K, Maruoka S, Hashimoto S Abstract A 77-year-old man visited our hospital with chief complaints of difficulty in hearing, nasal discharge and fever. The patients was diagnosed with otitis media, and his fever continued at approximately 38°C despite the administration of clarithromycin. After that, dyspnea on exertion developed and chest X-ray examination indicated multiple infiltrative shadows. PR3-ANCA levels were high (238-fold of the normal levels), and granulomatosis with polyangiitis (GPA) was diagnosed on the basis of clinical sympt...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Solely lung-involved IgG4-related disease : a case report and review of the literature.
Authors: Zhang XQ, Chen GP, Wu SC, Yu S, Wang H, Chen XY, Ren ZC Abstract By analyzing the clinical data of 1 case of IgG4-related lung disease(IgG4-RLD) and the review of literature, the author investigated the clinical characteristics of IgG4-RLD. IgG4-RLD is a rare disease characterized by significant elevation of serum IgG4 and infiltration of a large number of IgG4+ plasma cells. The clinical manifestations of the disease were nonspecific, and the imaging features were mixed with several types. The disease can only be involved in the lung, but also multiple organ involvement. Solely lung-involved IgG4-RD is no...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Corticosteroid and cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: a single center experience and literature review.
In conclusion, combined intravenous pulse doses of high-dose corticosteroid and cyclophosphamide could be a reasonable add-on therapy for AEx-IPF, considering the few side effects and safe profile. A complete and rapid diagnostic work-up associated to the proper management (e.g. support of respiratory failure with non-invasive ventilation) in the right setting, may also have a positive effect on patients' outcome. PMID: 28079851 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

High-resolution computed tomography to differentiate chronic diffuse infiltrative lung diseases with chronic multifocal consolidation patterns using logical analysis of data.
CONCLUSION: LAD provides relevant models that can be used as a diagnosis support for the radiologist. It highlights the need to add clinical data in the analysis due to frequent overlap between diseases at HRCT. PMID: 28079848 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Relationship Between Abnormalities on High-Resolution Computerized Tomography, Pulmonary Function, and Bronchoalveolar Lavage in Progressive Systemic Sclerosis.
CONCLUSION: This study showed a strong correlation between the extent of x-ray abnormalities and FVC, RV, and DLCO, as well as an increase in the percentage of BAL fluid neutrophils in patients with SSc-PI. PMID: 28079847 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Serum interleukin-6 in systemic sclerosis and its correlation with disease parameters and cardiopulmonary involvement.
CONCLUSION: IL-6 level is increased in patients with SSc and significantly correlates with EUSTAR score, IRS, DLCO, 6MWD, HRCT scores, and echocardiographic abnormalities of the right side of the heart. These results support the role of IL-6 in the disease activity and in the development of cardiopulmonary manifestations in SSc patients. PMID: 28079844 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Increased erythrocyte aggregation and oxidative stress in patients with idiopathic interstitial pneumonia.
CONCLUSIONS: Increment of oxidative stress in IIP seems to depend on enhancement of oxidants, rather than alteration of antioxidants. The issue that, elevated erythrocyte aggregation may further impair tissue oxygenation by disturbing microcirculation in IIP, may be considered in the follow up and development of new treatment protocols for this disease. PMID: 28079842 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 14, 2017 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pathology of the Lung in Sarcoidosis: A Review
Abstract: Sarcoidosis is a multisystem disease of unknown etiology, often affecting the respiratory tract. The diagnosis depends on a compatible clinical and radiological presentation, the finding of nonnecrotizing epithelioid granulomas by biopsy, and exclusion of other possible causes of granulomas. The granulomas are distributed in a lymphangitic pattern in lung; interstitial pneumonitis is sparse and can be the only finding in early stages. Up to 40% of granulomas show small central foci of necrosis. Granulomatous vasculitis can be found in 42% to 69% of cases and likely is due to intrusion of perivascular granulomas o...
Source: Pathology Case Reviews - December 31, 2016 Category: Pathology Tags: Reviews Source Type: research

Mechanism of granuloma formation in sarcoidosis
Purpose of review: The formation of noncaseating granuloma is a hallmark of pulmonary sarcoidosis. This review summarizes recent progress made to explain the cellular dynamics within the granuloma structure that may considerably differ between the two clinically distinct variants, that is, acute and chronic sarcoidosis. Recent findings: Compelling evidence exists that in acute but not chronic sarcoidosis CD4+ T lymphocytes specifically recognizing the auto-antigen vimentin on human leukocyte antigen-DR3 molecules accumulate in sarcoid granuloma. These so-called TH17.1 cells produce high amounts of the TH17-related cytokin...
Source: Current Opinion in Hematology - December 29, 2016 Category: Hematology Tags: MYELOID BIOLOGY: Edited by David C. Dale Source Type: research

Sarcoidosis in the setting of combination ipilimumab and nivolumab immunotherapy: a case report & amp; review of the literature
ConclusionsTissue biopsy for evaluation of new lesions on immunotherapy is an important step to help guide decision making, as non-melanoma lesions can mimic disease progression.
Source: Journal for Immunotherapy of Cancer - December 19, 2016 Category: Cancer & Oncology Source Type: research

Anti ‐TNF‐α for necrotizing sarcoid granulomatosis of the liver
This article is protected by copyright. All rights reserved.
Source: Hepatology - December 15, 2016 Category: Internal Medicine Authors: Marcial Sebode, S ören Weidemann, Malte Wehmeyer, Ansgar W. Lohse, Christoph Schramm Tags: Clinical Observations in Hepatology Source Type: research

Diagnostic Categorization According to the First International Workshop on Ocular Sarcoidosis (FIWOS) Criteria in a Series of 11 Patients
Conclusions Ocular sarcoidosis was diagnosed in more than half of the patients who had no confirmatory biopsy. Bilateral panuveitis and chronic anterior uveitis were the patterns most frequently observed.
Source: Reumatologia Clinica - December 4, 2016 Category: Rheumatology Source Type: research

Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden
This study represents the largest epidemiological investigation of sarcoidosis using population-based individual-level data. Age at diagnosis in men was 10 years younger than in women and geographical variation was observed.
Source: European Respiratory Journal - November 29, 2016 Category: Respiratory Medicine Authors: Arkema, E. V., Grunewald, J., Kullberg, S., Eklund, A., Askling, J. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis
We evaluated mortality rates and underlying causes of death among French decedents with sarcoidosis from 2002 to 2011. We used data from the French Epidemiological Centre for the Medical Causes of Death to 1) calculate sarcoidosis-related mortality rates, 2) examine differences by age and gender, 3) determine underlying and nonunderlying causes of death, 4) compare with the general population (observed/expected ratios), and 5) analyse regional differences. 1662 death certificates mentioning sarcoidosis were recorded. The age-standardised mortality rate was 3.6 per million population and significantly increased over the stu...
Source: European Respiratory Journal - November 29, 2016 Category: Respiratory Medicine Authors: Jamilloux, Y., Maucort-Boulch, D., Kerever, S., Gerfaud-Valentin, M., Broussolle, C., Eb, M., Valeyre, D., Seve, P. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Solitary tentorial sarcoid granuloma associated with Propionibacterium acnes infection: case report.
Abstract Sarcoidosis is a systemic granulomatous disease with unknown cause, which very rarely occurs exclusively in the central nervous system. The authors performed biopsy sampling of a mass that developed in the left tentorium cerebelli that appeared to be a malignant tumor. The mass was diagnosed as a sarcoid granuloma, which was confirmed with the onset of antibody reaction product against Propionibacterium acnes. Findings suggesting sarcoidosis to be an immune response to P. acnes infection have recently been reported, and they give insight for diagnosis and treatment of this disease. The authors report the ...
Source: Journal of Neurosurgery - November 24, 2016 Category: Neurosurgery Authors: Akimoto J, Nagai K, Ogasawara D, Tanaka Y, Izawa H, Kohno M, Uchida K, Eishi Y Tags: J Neurosurg Source Type: research

The clinical characteristics of sarcoid arthropathy based on a prospective cohort study
Conclusions: Inflammatory arthritis occurs in a majority of patients with sarcoidosis. Acute arthritis with bilateral ankle involvement is the most common pattern of sarcoid arthropathy. Sarcoidosis can mimic many primary rheumatic diseases or may coexist with them. Sarcoidosis should be considered not only as a mimicker but also as a Th1-mediated primary rheumatologic pathology.
Source: Therapeutic Advances in Musculoskeletal Disease - November 20, 2016 Category: Orthopaedics Authors: Kobak, S., Sever, F., Usluer, O., Goksel, T., Orman, M. Tags: Original Research Source Type: research

Comprehensive Cardiovascular Magnetic Resonance Assessment in Patients With Sarcoidosis and Preserved Left Ventricular Ejection Fraction Cardiomyopathies
Conclusions— Patients with sarcoidosis demonstrate higher T1, extracellular volume, and T2 values compared with healthy controls, with most significant differences for native T1 and T2. While promising, the clinical significance of the newer mapping techniques with respect to early diagnosis and therapy of CS will have to be determined in future studies.
Source: Circulation: Cardiovascular Imaging - November 7, 2016 Category: Radiology Authors: Greulich, S., Kitterer, D., Latus, J., Aguor, E., Steubing, H., Kaesemann, P., Patrascu, A., Greiser, A., Groeninger, S., Mayr, A., Braun, N., Alscher, M. D., Sechtem, U., Mahrholdt, H. Tags: Fibrosis, Cardiomyopathy, Inflammatory Heart Disease, Magnetic Resonance Imaging (MRI) Cardiomyopathies Source Type: research

Long-term results obtained by cardiovascular magnetic resonance imaging and somatostatin receptor PET in cardiac sarcoidosis
Cardiac affection constitutes a major limiting condition in systemic sarcoidosis.We performed cardiovascular magnetic resonance (CMR) imaging and somatostatin receptor scintigraphy to define the course in cardiac sarcoidosis (CS).In a pilot study, we identified cardiac involvement – diagnosed by CMR imaging – to be present in 29 of 188 patients (15.4%) with histologically proven, extracardiac sarcoidosis. Out of these initial 29 CS-positive patients, 27 patients (49.9 ± 11.8 years, 59.3% male) were presently re-examined and underwent a second CMR-study. 68Ga-DOTATOC PET/CT was performed when clinically i...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Pizarro, C., Kluenker, F., Dabir, D., Gärtner, F., Grohe, C., Nickenig, G., Skowasch, D. Tags: 1.3 Imaging Source Type: research

MR imaging of lung parenchymal changes in sarcoidosis
CONCLUSION: There is substantial correlation and agreement between MRI and CT in the scoring of pulmonary sarcoidosis especially using T2w sequences. However, improvement in detection of small pulmonary nodules seems warrant.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Ley, S., Schenk, H., Karl, M., Pforte, A. Tags: 1.3 Imaging Source Type: research

Incidence and prognostic factors for airflow obstruction in sarcoidosis
Conclusion: AO is frequent (36%) in sarcoid patients requiring treatment for disease deterioration. Several prognostic factors were disclosed, however randomised study is necessary to evaluate AO nature in sarcoid patients.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Bednarek, M., Goljan-Geremek, A., Puscinska, E., Nowinski, A., Korzybski, D., Sliwinski, P. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Prevalence of smoking among Polish sarcoid patients
Conclusions: Results from the present study showed a fairly high smoking prevalence among our sarcoid pts and draws attention to relationship between parental smoking and the risk of smoking initiation.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Puscinska, E., Goljan Geremek, A., Radzikowska, E., Wyrostkiewicz, D., Soszka, A., Nowinski, A., Bednarek, M., Sliwinski, P. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Prevalence of ocular sarcoidosis in patients with intra thoracic sarcoidosis
Discussion: 76.6.% had histological diagnosis. 23 out of 36 had bronchoscopy/EBUS..Study revealed fairly high prevalence of ocular symptoms amongest sarcoid patients (51%) & 37% of them had abnormal eye examination finding. Non of our patient had conjunctival biopsy. literature review indicate that conjunctival biopsy is positive in up to 66% of cases with conjunctival follicles & up to 31% without it. conjunctival biopsy in presence of pulmonary infiltrate is reported to be positive in 51.6% patients.Considering our study finding we may conclude that requesting conjuntival biopsy will reduced our need of transbron...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Hussain, M., Mahdi, H., Hassan, M. Tags: 1.13 Clinical Problems - Other Source Type: research

The predictors of mortality in IPF - Does emphysema change the prognosis?
CONCLUSION: In present study, IPF with emphysema was more common in male smokers. When emphysema accompanies IPF, life expectancy is remarkably worse, but not independently so. PMID: 27758993 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 21, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research