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Total 4711 results found since Jan 2013.

Efficacy of a Structured Exercise Program for Improving Functional Capacity and Quality of Life in Patients With Stage 3 and 4 Sarcoidosis: A RANDOMIZED CONTROLLED TRIAL
This study investigated the effects of an exercise program on functional capacity and quality of life in patients with stage 3 and stage 4 sarcoidosis. Methods: Eighteen patients with stage 3 and 4 sarcoidosis were recruited; 9 received 12 wk of supervised exercise training and 9 received usual care. Patients underwent the following evaluations at baseline and follow-up: 6-min walk test, maximal inspiratory and expiratory pressure tests, back and leg dynamometer test, modified Medical Research Council Dyspnea Scale, Fatigue Severity Scale, St George Respiratory Questionnaire, Short Form-36 Quality of Life Questionnaire,...
Source: Journal of Cardiopulmonary Rehabilitation - February 23, 2018 Category: Rehabilitation Tags: Pulmonary Rehabilitation Source Type: research

A Contemporary Analysis of Heart Transplantation and Bridge-to-Transplant Mechanical Circulatory Support Outcomes in Cardiac Sarcoidosis
Sarcoidosis is an immune-mediated disease that may affect any organ in the body, including the heart.1 Cardiac sarcoidosis (CS) manifests as heart failure, ventricular arrhythmias (including sudden cardiac death), and conduction system disease.2 –5 Although only 5% of patients with systemic sarcoidosis display cardiac symptoms, up to 25% of patients with extracardiac sarcoidosis have cardiac involvement at autopsy.6,7 Furthermore, up to 25% of patients with CS have isolated cardiac sarcoidosis (ICS), which may carry a worse prognosis than nonisolated CS, because patients with ICS more frequently present with left ventric...
Source: Journal of Cardiac Failure - February 23, 2018 Category: Cardiology Authors: Todd C. Crawford, David R. Okada, J. Trent Magruder, Charles Fraser, Nishant Patel, Brian A. Houston, Glenn J. Whitman, Kaushik Mandal, Kenton J. Zehr, Robert S. Higgins, Edward S. Chen, Hari Tandri, Edward K. Kasper, Ryan J. Tedford, Stuart D. Russell, N Tags: Clinical Investigation Source Type: research

Correction to: Chronic Granulomatous Disease in a Brazilian Patient Mimetizing Sarcoidosis
AbstractThe original version of abstract PO-162 “Chronic Granulomatous Disease in a Brazilian Patient Mimetizing Sarcoidosis” incorrectly listed the name of the second author as Micheli Barsioti. The correct spelling of the author’s name is Michele Baziotti Man.
Source: Journal of Clinical Immunology - February 22, 2018 Category: Allergy & Immunology Source Type: research

Sarcoidosis mortality in Sweden: a population-based cohort study
We aimed to investigate sarcoidosis mortality in a large, population-based cohort, taking into account disease heterogeneity. Individuals with incident sarcoidosis (n=8207) were identified from the Swedish National Patient Register using International Classification of Disease codes (2003-2013). In a subset, cases receiving treatment ±3 months from diagnosis were identified from the Prescribed Drug Register. Nonsarcoidosis comparators from the general population were matched to cases 10:1 on birth year, sex and county. Individuals were followed for all-cause death in the Cause of Death Register. Adjusted mortal...
Source: European Respiratory Journal - February 21, 2018 Category: Respiratory Medicine Authors: Rossides, M., Kullberg, S., Askling, J., Eklund, A., Grunewald, J., Arkema, E. V. Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung disease Source Type: research

Molecular Imaging of Cardiac Sarcoidosis
AbstractPurpose of ReviewCardiac involvement is increasingly being recognized as a cause of significant morbidity and mortality in patients with sarcoidosis. Unfortunately, imaging cardiac sarcoidosis (CS) remains a challenge and often relies on advanced imaging modalities. The aim of this review is to provide an up-to-date overview of the role of molecular imaging for the diagnosis of cardiac sarcoidosis, with particular emphasis on the use of FDG and non-FDG PET.Recent FindingsIn the last few years, FDG-PET has established itself as an accurate imaging study for the assessment of CS. New diagnostic criteria have recently...
Source: Current Cardiovascular Imaging Reports - February 20, 2018 Category: Radiology Source Type: research

Efficacy and safety of infliximab biosimilar Inflectra ® in severe sarcoidosis
Infliximab, a monoclonal antibody against tumor necrosis factor alpha (TNF- α) is effective third-line therapy in severe sarcoidosis. The originator product of Infliximab, Remicade®, is expensive, limiting universal access. Recently, a less expensive biosimilar of infliximab, Inflectra®, has become available, but the efficacy and tolerability has not been studied in sarc oidosis.
Source: Respiratory Medicine - February 19, 2018 Category: Respiratory Medicine Authors: Milou C. Schimmelpennink, Adriane D.M. Vorselaars, Frouke T. van Beek, Heleen A. Crommelin, Vera H.M. Deneer, Ruth G.M. Keijsers, Marcel Veltkamp Source Type: research

Orthopaedic Considerations in the Management of Skeletal Sarcoidosis.
Authors: Crawford B, Badlissi F, Lozano Calderón SA Abstract Advanced imaging has demonstrated that musculoskeletal manifestations of systemic sarcoidosis are more common than previously thought. A definitive strategy for the management of osseous sarcoidosis has not been defined. Some lesions resolve spontaneously, and no systemic medication for sarcoidosis consistently resolves lesions. The orthopaedic surgeon treating patients with musculoskeletal sarcoidosis must make an appropriate diagnosis of bony lesions, seek multidisciplinary input from specialists in pulmonology and rheumatology regarding systemic treat...
Source: The Journal of the American Academy of Orthopaedic Surgeons - February 15, 2018 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Ultrasound guided posterior tibial nerve block for the management of chronic peripheral neuropathic foot pain secondary to sarcoidosis
Sarcoidosis is a systemic inflammatory disease of unknown etiology involving multiple organ systems. Sarcoidosis affecting the central and/or peripheral nervous system is called neurosarcoidosis. The case presented focuses on the use of a single interventional therapy for the management of sarcoidosis-induced bilateral lower extremity peripheral neuropathy. A 53 year-old Caucasian male with a 14 year history of steroid-dependent, refractory pulmonary sarcoidosis, and neurosarcoidosis with resulting lower extremity pain secondary to peripheral neuropathy was referred for pain management.
Source: The Journal of Pain - February 14, 2018 Category: Materials Science Authors: N. Prabhu, S. Sharma, S. Kralovic, J. Poli Source Type: research

Clinical Features of Extrapulmonary Sarcoidosis without Lung Involvement.
CONCLUSIONS: Significant demographic and gender differences were observed between pulmonary and non-pulmonary sarcoidosis patients. These differences reflect previous data concerning differences between patients with skin and lung sarcoidosis, as the skin was the major organ involved with NPS. While the lungs are likely the primary site of exposure in pulmonary sarcoidosis, the high prevalence of skin involvement in NPS suggests the skin is the most conducive site of antigen capture outside of the respiratory tract. PMID: 29453944 [PubMed - as supplied by publisher]
Source: Chest - February 14, 2018 Category: Respiratory Medicine Authors: James WE, Koutroumpakis E, Saha B, Nathani A, Saavedra L, Yucel RM, Judson MA Tags: Chest Source Type: research

Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients
ConclusionsThe development of granulomatous/sarcoid-like lesions associated with CPIs is a recognized manifestation with the current class of immune checkpoint therapy that may clinically and radiographically mimic disease recurrence. Awareness of this type of toxicity is important for appropriate management and possible measurement of therapeutic response in a subset of patients who manifest this type of immune-mediated reaction.
Source: Journal for Immunotherapy of Cancer - February 12, 2018 Category: Cancer & Oncology Source Type: research

Clinical features and prognostic significance of splenic involvement in sarcoidosis.
Authors: Tetikkurt C, Yanardag H, Pehlivan M, Bilir M Abstract Sarcoidosis is a systemic disease characterized by noncasefied granulomas in various organs. Incidence of splenic disease is variable and is reported to occur in 6.7 to 77 percent of the patients. Firm data establishing the clinical features and the association of splenic involvement with prognosis in sarcoidosis is scant. The aim of our study was to investigate the clinical features and the consequence of splenic involvement on the prognostic outcome of sarcoidosis patients. We evaluated the clinical and laboratory findings in 82 sarcoidosis patients. ...
Source: Monaldi Archives for Chest Disease - February 10, 2018 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Association of HLA antigens with the clinical course of sarcoidosis and familial disease.
Authors: Yanardag H, Tetikkurt C, Bilir M, Yılmaz E Abstract Patients with sarcoidosis usually have a benign course and a favourable prognosis. Although spontaneous remission is common, a progressive disease with a severe prognosis occurs in a small but significant number of patients. The aim of this study was to evaluate the potential significance of HLA antigens as a clinical marker on the outcome of sarcoidosis patients. We conducted a retrospective cohort study for HLA class I and II allels in 74 sarcoidosis patients and 72 healthy transplant donors. Bronchoscopy and bronchial biopsies were performed in each p...
Source: Monaldi Archives for Chest Disease - February 10, 2018 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Association of genetic variants in RAB23 and ANXA11 with uveitis in sarcoidosis.
Conclusions: Genetic variants in RAB23 and ANXA11 genes were associated with an increased risk of sarcoidosis-associated uveitis. These loci have previously been associated with overall sarcoidosis risk. PMID: 29416296 [PubMed - in process]
Source: Molecular Vision - February 10, 2018 Category: Molecular Biology Tags: Mol Vis Source Type: research

A case of longitudinal care of a patient with cardiac sarcoidosis
We present the case of a 36-year-old man known to have sarcoidosis in which a variety of imaging modalities not only assisted in the diagnosis of cardiac sarcoidosis, but also played a key role in the monitoring of disease activity and response to therapy.
Source: Journal of Nuclear Cardiology - February 8, 2018 Category: Nuclear Medicine Source Type: research

Prognostic Impact of Extent, Severity, and Heterogeneity of Abnormalities on 18F-FDG PET Scans for Suspected Cardiac Sarcoidosis
Conclusions Quantitative measures of extent and severity of perfusion–metabolism mismatch and coefficient of variation of FDG uptake provide an incremental prognostic advantage in patients undergoing FDG-PET for CS. These results support the use of a more detailed analysis of imaging findings, as is conventional in coronary artery disease.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 5, 2018 Category: Radiology Authors: Sperry, B. W., Tamarappoo, B. K., Oldan, J. D., Javed, O., Culver, D. A., Brunken, R., Cerqueira, M. D., Hachamovitch, R. Tags: Original Research Source Type: research

Pleuroparenchymal sarcoidosis - A recognised but rare manifestation of disease
Publication date: 2018 Source:Respiratory Medicine Case Reports, Volume 23 Author(s): S. Walker, H. Adamali, N. Bhatt, N. Maskell, S.L. Barratt Pleural involvement is rare in sarcoidosis. The presence of a large symptomatic effusion in a patient with sarcoidosis should therefore prompt further investigation for an alternate aetiology. Here we present a case of confirmed pleuro-parenchymal sarcoidosis. We discuss the important differential diagnoses and review the current literature.
Source: Respiratory Medicine Case Reports - February 3, 2018 Category: Respiratory Medicine Source Type: research

Efficacy of a Structured Exercise Program for Improving Functional Capacity and Quality of Life in Patients With Stage 3 and 4 Sarcoidosis: A RANDOMIZED CONTROLLED TRIAL.
CONCLUSIONS: Exercise training improves functional capacity, muscle strength, dyspnea, quality of life, anxiety, fatigue, and oxygenation in patients with stage 3 and stage 4 sarcoidosis. Standard treatment of patients with late-stage sarcoidosis should integrate exercise training and pulmonary rehabilitation. PMID: 29401114 [PubMed - as supplied by publisher]
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - February 2, 2018 Category: Rehabilitation Authors: Naz I, Ozalevli S, Ozkan S, Sahin H Tags: J Cardiopulm Rehabil Prev Source Type: research

A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance
Abstract A 52‐year‐old male visited our hospital with abnormal electrocardiogram and exertional fatigue. The electrocardiogram showed first‐degree atrioventricular block, complete right bundle branch block, and inverted T waves in Leads II, III, aVF, V3, and V4. Echocardiography showed biventricular wall thickening involving granular sparkling of the interventricular septum. Late gadolinium enhancement on cardiovascular magnetic resonance (CMR) was found at the circumferential right ventricular wall and patchy regions of the left ventricle. Although these findings strongly suggested cardiac amyloidosis, he was finall...
Source: ESC Heart Failure - February 1, 2018 Category: Cardiology Authors: Kazunori Takemura, Ryuta Nakamura, Kazuhito Shimazu, Youichiro Sugimoto, Tetsuro Takase, Minamimoto Ryogo, Michiaki Hiroe Tags: Case Report Source Type: research

Sarcoid-Associated Uveitis and Cardiac Disease
This case series explores the potential importance of distinguishing sarcoidosis-associated uveitis from idiopathic uveitis.
Source: JAMA Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

What Is Sarcoidosis?
Authors: PMID: 29388823 [PubMed - in process]
Source: Am J Respir Crit Car... - February 1, 2018 Category: Intensive Care Tags: Am J Respir Crit Care Med Source Type: research

A case of refractory acute sarcoid myopathy successfully treated with intravenous immunoglobulin.
PMID: 29376470 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - January 29, 2018 Category: Rheumatology Authors: Kono M, Kono M, Jodo S Tags: Scand J Rheumatol Source Type: research

Psoriasiform sarcoidosis: an unusual variety.
Authors: Mazzeo M, DI Raimondo C, Vaccarini S, Ferlosio A, Orlandi A, Cantonetti M, Bianchi L PMID: 29368850 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - January 27, 2018 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

Phenotypes of organ involvement in sarcoidosis
Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype–Phenotype Relationship in Sarcoidosis) project represents a European multicentre study to investigate the influence of genotype on disease phenotypes in sarcoidosis. The baseline phenotype module of GenPhenReSa comprised 2163 Caucasian patients with sarcoidosis who were phenotyped at 31 study centres according to a standardised protocol. From this module, we found that patients with acute onset were mainly female, young and of Scadding type I or II. Female patients showed a significantly higher fr...
Source: European Respiratory Journal - January 25, 2018 Category: Respiratory Medicine Authors: Schupp, J. C., Freitag-Wolf, S., Bargagli, E., Mihailovic-Vucinic, V., Rottoli, P., Grubanovic, A., Müller, A., Jochens, A., Tittmann, L., Schnerch, J., Olivieri, C., Fischer, A., Jovanovic, D., Filipovic, S., Videnovic-Ivanovic, J., Bresser, P., Tags: Original Articles: Interstitial lung diseases Source Type: research

It's time to evolve from Scadding: phenotyping sarcoidosis
Sarcoidosis is complex and highly variable, with protean clinical manifestations and a wide array of consequences for patients. The course is likewise unpredictable, leading to the moniker "sarcoidoses" to connote that sarcoidosis may be a syndrome rather than a single disease [1]. Delineating distinct subgroups, "phenotypes", has been an attempt to simplify prediction about individual patients and to homogenise groups for research purposes. Sarcoidosis phenotypes have been used most often to predict prognosis or to cluster patients with similar outcomes [2–5]. But phenotyping could also be used primarily to stratify...
Source: European Respiratory Journal - January 25, 2018 Category: Respiratory Medicine Authors: Culver, D. A., Baughman, R. P. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Muscular sarcoidosis involving the chest and abdominal walls: case report with MR imaging
AbstractSarcoidosis is an inflammatory disorder that is characterized by the presence of noncaseating granulomas in tissues, involving many organs and tissues. Extra-pulmonary, especially muscular sarcoidosis is a rare condition. The most common location of the muscular sarcoidosis is known to be the proximal muscles of the extremities; however, there have been no cases of diffuse involvement of the chest and abdominal wall muscles. Here, we report a rare muscular sarcoidosis with infiltrative pattern in the chest and abdominal wall muscles and describe the MR imaging findings that were mistaken as lymphoma at initial diag...
Source: Skeletal Radiology - January 24, 2018 Category: Radiology Source Type: research

Uveitis May Signal Cardiac Sarcoidosis in Some Patients Uveitis May Signal Cardiac Sarcoidosis in Some Patients
Some older patients with apparently idiopathic uveitis may in fact have sarcoidosis-associated disease, which can have cardiac consequences, according to a retrospective case series.Reuters Health Information
Source: Medscape Medical News Headlines - January 19, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Cardiac Manifestations of Sarcoidosis Cardiac Manifestations of Sarcoidosis
Review the diagnosis and management of cardiac sarcoidosis, which effects up to five percent of patients with sarcoidosis, and may even be the first manifestation of sarcoidosis in any organ.European Heart Journal
Source: Medscape Today Headlines - January 18, 2018 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Daily home spirometry to detect early steroid treatment effects in newly treated pulmonary sarcoidosis
Prednisone is the mainstay of sarcoidosis treatment. However, prednisone treatment optimisation is warranted, since prolonged high-dose prednisone therapy is associated with burdensome and harmful side-effects [1, 2]. Early prednisone dose tapering has the potential to reduce side-effects. Gaining insight in the early treatment response can help to determine when tapering could be initiated. To date, there are no prospective studies that look at early treatment response to prednisone in sarcoidosis by monitoring clinical symptoms and daily patient-administered lung function. Therefore, we initiated a multicentre, prospecti...
Source: European Respiratory Journal - January 18, 2018 Category: Respiratory Medicine Authors: Broos, C. E., Wapenaar, M., Looman, C. W. N., in t Veen, J. C. C. M., van den Toorn, L. M., Overbeek, M. J., Grootenboers, M. J. J. H., Heller, R., Mostard, R. L., Poell, L. H. C., Hoogsteden, H. C., Kool, M., Wijsenbeek, M. S., van den Blink, B. Tags: Interstitial and orphan lung disease Original Articles: Research letters Source Type: research

Serial FDG-PET/CT Imaging in the Management of Cardiac Sarcoidosis
A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. Myocardial perfusion scan demonstrated a moderate sized, fixed perfusion defect along the mid to proximal anteroseptal wall of the left ventricle, with better perfusion on stress images. FDG-PET/CT demonstrated corresponding focal FDG avidity of the mid to proximal anteroseptal wall, suggestive of active cardiac sarcoidosis. Because of severe side effects, mycophenolate mofetil was discontinued, and the patient received low-dose steroid therapy. A...
Source: Clinical Nuclear Medicine - January 17, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Two successive opportunistic infections associated with severe CD4 lymphocytopenia revealing systemic sarcoidosis.
PMID: 29373277 [PubMed - as supplied by publisher]
Source: Presse Medicale - January 17, 2018 Category: General Medicine Authors: Didier K, Servettaz A, Tabary T, Nguyen Y, Bani-Sadr F Tags: Presse Med Source Type: research

Complementary Value of Cardiac Magnetic Resonance Imaging and Positron Emission Tomography/Computed Tomography in the Assessment of Cardiac Sarcoidosis Cardiomyopathies
Conclusions— Among patients with suspected CS, combining CMR and PET provides complementary value for estimating the likelihood of CS and guiding patient management.
Source: Circulation: Cardiovascular Imaging - January 15, 2018 Category: Radiology Authors: Vita, T., Okada, D. R., Veillet-Chowdhury, M., Bravo, P. E., Mullins, E., Hulten, E., Agrawal, M., Madan, R., Taqueti, V. R., Steigner, M., Skali, H., Kwong, R. Y., Stewart, G. C., Dorbala, S., Di Carli, M. F., Blankstein, R. Tags: Inflammation, Cardiomyopathy, Inflammatory Heart Disease, Magnetic Resonance Imaging (MRI), Nuclear Cardiology and PET Cardiomyopathies Source Type: research

Necrotizing Sarcoid Granulomatosis with Natural Resolution after a Surgical Lung Biopsy.
Authors: Shibata T, Takahashi K, Uchida M, Yamasaki F, Kawashima M, Sueoka-Aragane N Abstract Necrotizing sarcoid granulomatosis (NSG) is a rare disease that is diagnosed based on pathological findings. We herein report the case of a 27-year-old man who had multiple nodular shadows in bilateral lung fields on chest radiography and elevated levels of C-reactive protein (CRP). The pathological evaluation of a lung biopsy specimen showed the infiltration of lymphocytes, granulomas with necrosis and granulomatous angiitis. He was therefore diagnosed with NSG. He has been followed without treatment, as his fever and CRP...
Source: Internal Medicine - January 13, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Cardiac Sarcoidosis Concomitant with Large-vessel Aortitis Detected by 18F-fluorodeoxyglucose Positron Emission Tomography.
Authors: Higuchi Y, Kimoto Y, Tanoue R, Tokunou T, Tomonari K, Maeda T, Horiuchi T Abstract We herein report a case of concurrent cardiac sarcoidosis and large-vessel aortitis detected by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and followed up during immunosuppressive therapy. After high-dose prednisolone administration (1 mg/kg), serial FDG-PET showed that almost all of the abnormal FDG uptake in the heart and extracardiac region, including the abdominal to bilateral iliac arteries, had been disappeared. During the tapering of prednisolone, additive methotrexate therapy was needed to treat th...
Source: Internal Medicine - January 13, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Granulomatous intersticial nephritis secondary to sarcoidosis.
CONCLUSION: The objective of the article was to describe a case of NIG and to alert to the importance of its clinical investigation. In this case, renal biopsy, associated with systemic clinical manifestations, contributed to the diagnosis of sarcoidosis. PMID: 29319778 [PubMed - in process]
Source: Jornal Brasileiro de Nefrologia - January 11, 2018 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Neutrophil gelatinase-associated lipocalin in patients with sarcoidosis
This study aimed to examine the expression of NGAL in patients with sarcoidosis. In addition, we examined whether NGAL could serve as a marker of disease activity and prognosis.
Source: Respiratory Medicine - January 11, 2018 Category: Respiratory Medicine Authors: Shinpei Kato, Naoki Inui, Hironao Hozumi, Yusuke Inoue, Hideki Yasui, Masato Karayama, Masato Kono, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe, Takafumi Suda Source Type: research

Balloon pulmonary angioplasty in sarcoid-related pulmonary hypertension
A 43-year-old, never-smoking, African-American female was referred to our outpatient clinic for progressive dyspnoea. She had a medical history of sarcoidosis with lymph-node, pulmonary, skin and ocular involvement. Diagnosis was based on a previously conducted chest high-resolution computed tomography (CT) that showed bilateral hilar and mediastinal lymphadenopathy containing calcifications and multiple small lung nodules with peri-lymphatic distribution along the pleura and fissures A histological analysis of biopsy specimens from a lymph node located in the left side of the neck revealed large granulomas with multinucle...
Source: European Respiratory Journal - January 11, 2018 Category: Respiratory Medicine Authors: Tramper, J., Nossent, E. J., Lely, R. J., Krouwels, F. H., Meijboom, L. J., Vonk Noordegraaf, A. Tags: Interstitial and orphan lung disease Original Articles: Correspondence Source Type: research

How Many Passes Are Needed for Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Sarcoidosis? A Prospective Multicenter Study
Conclusions: If rapid on-site cytological evaluation is not available, we recommend at least 4 passes per patient for either single or multiple lesions with EBUS-TBNA for pathological diagnosis of stage I/II sarcoidosis.Respiration
Source: Respiration - January 10, 2018 Category: Respiratory Medicine Source Type: research

Serial FDG-PET/CT Imaging in the Management of Cardiac Sarcoidosis
A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. Myocardial perfusion scan demonstrated a moderate sized, fixed perfusion defect along the mid to proximal anteroseptal wall of the left ventricle, with better perfusion on stress images. FDG-PET/CT demonstrated corresponding focal FDG avidity of the mid to proximal anteroseptal wall, suggestive of active cardiac sarcoidosis. Because of severe side effects, mycophenolate mofetil was discontinued, and the patient received low-dose steroid therapy. A...
Source: Clinical Nuclear Medicine - January 5, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Cough in sarcoidosis patients
Publication date: Available online 4 January 2018 Source:Respiratory Physiology & Neurobiology Author(s): Eva Kovacova, Tomas Buday, Robert Vysehradsky, Jana Plevkova Sarcoidosis is a multi-system disease of unknown aetiology characterized by presence of non-caseating granulomatous inflammation.Cough is a common and significant symptom in sarcoidosis, reducing quality of life.Objective 24 h cough monitoring proved that sarcoidosis patients have significantly higher cough frequency compared to controls and their cough has diurnal variation, it is gender-specific and shows racial differences. It correlates with th...
Source: Respiratory Physiology and Neurobiology - January 5, 2018 Category: Respiratory Medicine Source Type: research

Th17-lineage cells in pulmonary sarcoidosis and L öfgren's syndrome: Friend or foe?
Th17-lineage cells in pulmonary sarcoidosis and Löfgren's syndrome: Friend or foe? J Autoimmun. 2018 Jan 05;: Authors: Miedema JR, Kaiser Y, Broos CE, Wijsenbeek MS, Grunewald J, Kool M Abstract Sarcoidosis, a multisystem granulomatous disorder, has historically been classified as Th1-driven disease. However, increasing data demonstrate a key role of Th17-cell plasticity in granuloma formation and maintenance. In Löfgren's syndrome (LS), an acute and distinct phenotype of sarcoidosis with a favorable outcome, differences in Th17-lineage cell subsets, cytokine expression and T-cell suppressive mechan...
Source: Journal of Autoimmunity - January 5, 2018 Category: Allergy & Immunology Authors: Miedema JR, Kaiser Y, Broos CE, Wijsenbeek MS, Grunewald J, Kool M Tags: J Autoimmun Source Type: research

Isolated cardiac sarcoidosis - A rare disease entity?
Sarcoidosis is appreciated as a multisystem autoimmune disease with infiltrating non-caseating granuloma that predominantly affects the perihilar-mediastinal lymph nodes and the lungs [1,2]. The prevalence of sarcoidosis is contingent upon ethnicity, gender, and location [2]. Sarcoidosis prevalence may be as variable as from 3 to 10 per 100,000 for Caucasians (highest in Scandinavians), to 35 –80 per 100,000 African American [2]. The prevalence of cardiac sarcoidosis (CS) involvement in systemic disease manifestation in clinic-pathological studies has been reported between 20 and 27% in the United States population and a...
Source: International Journal of Cardiology - January 4, 2018 Category: Cardiology Authors: Thomas H. Schindler, Ines Valenta Tags: Editorial Source Type: research

How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body 18F –fluorodeoxyglucose positron emission tomography
Sarcoidosis is a systemic inflammatory disease which can involve nearly any organ. Clinically manifest cardiac involvement occurs in perhaps 5% of patients with sarcoidosis. The reported prevalence of isolated cardiac sarcoidosis (CS) varies widely with reported rates of 27 –54%. The explanation for this variability is likely multi-factorial but perhaps mostly related to the diagnostic method(s) for assessing extra-cardiac involvement. The primary aim of this study was to assess the rate of isolated CS in a homogeneous, prospectively recruited cohort of patients with clinically manifest CS, using whole body FDG PET-CT im...
Source: International Journal of Cardiology - January 4, 2018 Category: Cardiology Authors: Daniel Juneau, Pablo Nery, Juan Russo, Robert A. de Kemp, Eugene Leung, Rob S.B. Beanlands, David H. Birnie Source Type: research

Pembrolizumab-Related Sarcoid-Like Reaction Presenting as Reactivation of Quiescent Scars.
PMID: 29300520 [PubMed - as supplied by publisher]
Source: JOP - January 4, 2018 Category: Gastroenterology Authors: McKenna MC, Molloy K, Crowther S, Feeney J, Gillis A, Connolly M, Kelleher F Tags: J Oncol Pract Source Type: research

Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis: a case report
Publication date: Available online 4 January 2018 Source:Saudi Journal of Ophthalmology Author(s): Daniele Cirone, Luca Cimino, Giovanni Spinucci Sarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging. We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations. A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous anterior uve...
Source: Saudi Journal of Ophthalmology - January 4, 2018 Category: Opthalmology Source Type: research

Diplopia, Proptosis, and Joint Pain: Possibility of Osseous and Orbital Sarcoidosis.
Authors: Kohli R, Siva C PMID: 29292316 [PubMed - in process]
Source: Journal of Rheumatology - January 3, 2018 Category: Rheumatology Tags: J Rheumatol Source Type: research

Sarcoidosis: a review for the internist
AbstractSarcoidosis is a systemic granulomatous lung disease of unknown origin affecting people of any age, mainly young adults. The disease is extremely heterogeneous with an unpredictable clinical course. Different phenotypes have been identified: an acute syndrome can be distinguished from subacute and chronic variants. About 20% of patients are chronically progressive and may develop lung fibrosis. Sarcoidosis usually involves the lungs and thoracic lymph nodes, although the skin, eyes, bones, liver, spleen, heart, upper respiratory tract and nervous system can also be affected. No reliable indicators of clinical outco...
Source: Internal and Emergency Medicine - January 3, 2018 Category: Emergency Medicine Source Type: research

Rare presentation of sarcoidosis: Multimodal imaging diagnosis of cardiac involvement
We report a case of sarcoidosis with an unusual presentation, initially manifesting as bilateral pulmonary embolism and then as a cardiac form of the disease with an ominous clinical event consisting of sustained ventricular tachycardia. The diagnosis was established by clinical and magnetic resonance criteria despite normal conventional echocardiographic study. Detailed functional assessment provided by tracking techniques (speckle tracking echocardiography and cardiac magnetic resonance tissue tracking) enabled the detection of regional deformation abnormalities, indicating prominent circumferential strain and epicardial...
Source: Revista Portuguesa de Cardiologia - January 2, 2018 Category: Cardiology Source Type: research