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Total 5292 results found since Jan 2013.

Sarcoidosis and chronic hepatitis C: treatment with prednisone and colchicine
In this report a case of sarcoidosis associated with chronic hepatitis C will be described, with subcutaneous lesions, considered rare, and good response to treatment with colchicine and prednisone. The hepatitis C virus was isolated in sarcoid tissue and the association between the two diseases will be discussed.
Source: Anais Brasileiros de Dermatologia - May 13, 2016 Category: Dermatology Source Type: research

Sarcoidosis Presenting Addison's Disease.
Authors: Takahashi K, Kagami S, Kawashima H, Kashiwakuma D, Suzuki Y, Iwamoto I Abstract We herein describe a second Japanese case of sarcoidosis presenting Addison's disease. A 52-year-old man was diagnosed with sarcoidosis based on clinical and laboratory findings, including bilateral hilar lymphadenopathy and elevated levels of serum angiotensin-converting enzyme and lysozyme, as well as the presence of noncaseating epithelioid granulomas. The patient also exhibited general fatigue, pigmentation, weight loss, hypotension and hyponatremia, suggestive of chronic adrenocortical insufficiency. An endocrine examinati...
Source: Internal Medicine - May 8, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research

Renal Angiomyolipoma With Sarcoid Granulomas: Report of a Unique Case
We present the first reported case of sarcoid granulomas in a renal angiomyolipoma, including morphologic and immunohistochemical features.
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: Tarjan, G., Kim, G. J., Haroon Al Rasheed, M. R. Tags: Case Reports Source Type: research

Use of Aqueous Humor and Flow Cytometry in Ocular Sarcoidosis Diagnosis.
CONCLUSIONS: Flow cytometry on aqueous fluid may offer an additional pathway for diagnosing sarcoid anterior uveitis. PMID: 27082232 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - April 16, 2016 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Acute eosinophilic pneumonia as a complication of influenza A (H1N1) pulmonary infection.
We describe the case of influenza A (H1N1) severe pneumonia complicated by an acute eosinophilic pneumonia. Patient presented with respiratory failure and diffuse ground-glass opacities at chest-computed tomography. Clinical suspicion for this complication and bronchoalveolar lavage with cellular count analysis is crucial. PMID: 27055842 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidal granuloma presenting on tattoo: a report of a Japanese female patient and a review of Japanese published work.
CONCLUSIONS: Our results suggest that a tattoo does not have significant impact on the clinical features of sarcoidosis. However, skin lesions on a tattoo can be the first sign of systemic sarcoidosis in any race; therefore, much attention should be paid to skin eruptions on a tattoo for earlier identification of patients who need work-up for systemic illness. PMID: 27055840 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

"The significance of cardiac magnetic resonance imaging in detection and monitoring of the treatment efficacy of heart involvement in eosinophilic granulomatosis with polyangiitis patients".
CONCLUSIONS: CMRI is a sensitive method detecting cardiac lesions in EGPA patients. It helps to detect patients, who need combined therapy and helps evaluate the therapeutic effect. PMID: 27055836 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?
Conclusions MFAP4 is not elevated in sera of patients with pulmonary fibrosis or bleomycin treated mice with pulmonary fibrosis. This may be due to different pathogenic mechanisms of liver and lung fibrogenesis. MFAP4 seems to be useful as serum biomarker for hepatic but not for lung fibrosis. PMID: 27055835 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Validation of transbronchial cryobiopsy in interstitial lung disease - interim analysis of a prospective trial and critical review of the literature.
ConclusionsCryo-TBB may be a reliable diagnostic tool in ILD, dispensing the need for a SLB in most cases. Severe complications may occur less frequently than in SLB. Modifications of the procedure may lead to further risk reduction. PMID: 27055830 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

FDG PET/CT Evidence of Effective Treatment of Cardiac Sarcoidosis With Adalimumab
Abstract: A 53-year-old man with mediastinal lymph node biopsy and cardiac MRI–proven cardiac sarcoidosis (CS) received treatment with pacemaker and steroids. FDG PET/CT showed active CS despite treatment with prednisone and methotrexate. Addition of weekly adalimumab (Humira) injections was introduced for 3 months. Follow-up FDG PET/CT showed complete resolution of CS as well as improvement of other sarcoid lesions in the thoracic lymph nodes.
Source: Clinical Nuclear Medicine - April 7, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

99mTc-anti-TNF-{alpha} antibody for the imaging of disease activity in pulmonary sarcoidosis
In this study we evaluated scintigraphy with technetium-99m (99mTc)-labelled infliximab for the imaging of disease activity in patients with pulmonary sarcoidosis. 10 patients were studied using single photon emission computed tomography/computed tomography (CT) 6 h and 20 h after intravenous administration of 370 MBq of 99mTc-infliximab. Correlation analysis was performed between tissue accumulation of 99mTc-infliximab and laboratory parameters (including soluble interleukin-2 receptor and angiotensin-converting enzyme), lung function parameters (including forced expiratory volume in 1 s and the diffus...
Source: European Respiratory Journal - March 31, 2016 Category: Respiratory Medicine Authors: Vis, R., Malviya, G., Signore, A., Grutters, J. C., Meek, B., van de Garde, E. M. W., Keijsers, R. G. M. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Sarcoidosis: radiographic manifestations in the nails and distal phalanges
We describe a case of sarcoidosis with radiographic findings in the nails and distal phalangeal tufts, which were indicative of nail and osseous sarcoid involvement and strongly supported the presence of chronic systemic disease. Although the nail findings resolved clinically and on radiographs after treatment, the osseous findings showed only minimal improvement. To our knowledge, the radiographic findings of nail sarcoidosis have not been previously addressed in the literature.
Source: Skeletal Radiology - March 19, 2016 Category: Radiology Source Type: research

New Pathogenetic Concepts and Early Pharmacological Studies in Sarcoidosis.
Authors: Schupp JC, Frye BC, Zissel G, Müller-Quernheim J Abstract The etiology of sarcoidosis is still elusive, yet there has been considerable progress in various areas of basic and clinical research. This review focuses on mechanisms of granuloma formation and on new findings in autoimmunity and genetics of sarcoidosis. A new promising concept arose, where serum amyloid A and/or mycobacterial antigens serve as nidus for granuloma formation. Furthermore, autoimmunity in sarcoidosis was neglected for a long time, yet new studies found autoantigens and abnormalities in antigen presentation in sarcoidosis. Last but...
Source: Pneumologie - March 6, 2016 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

Life-Threatening Hypercalcemia Revealing Diffuse and Isolated Acute Sarcoid-Like Myositis: A New Entity? (A Case-Series)
We report on 3 cases of life-threatening hypercalcemia revealing florid and isolated acute sarcoid-like myositis. All patients complained of fatigue, progressive general muscle weakness, and weight loss. Laboratory tests showed a severe life-threatening hypercalcemia (>3.4 mmol/L). Hypercalcemia was associated with increased serum level of 1,25-(OH)2 vitamin D and complicated with acute renal failure. One patient displayed acute pancreatitis due to hypercalcemia. In all cases, PET-scan, performed for malignancy screening, incidentally revealed an intense, diffuse, and isolated muscular fluorodeoxyglucose (FDG) uptake c...
Source: Medicine - March 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Liver Function Testing Is Not Useful in the Diagnosis of Sarcoidosis in Patients Presenting with Uveitis.
CONCLUSIONS: There is no evidence that abnormal liver function tests are an indicator of sarcoidosis in new patients presenting with uveitis. PMID: 26903283 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - February 25, 2016 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Electron microscopy of contact between a monocyte and a multinucleated giant cell in cardiac sarcoidosis
Publication date: Available online 23 February 2016 Source:Canadian Journal of Cardiology Author(s): Yuki Imaizumi, Kazuo Eguchi, Hiroki Imada, Kiyomi Hidano, Satoshi Niijima, Hirotoshi Kawata, Noriyoshi Fukushima, Tsunenori Saito, Michiaki Hiroe, Kazuomi Kario Using electron microscopy, we observed a monocyte contacting a multinucleated giant cell (MGC) via a gap junction in the biopsied myocardium of a cardiac sarcoidosis patient. This is the first report showing in vivo ultrastructural findings of a MGC in sarcoid granulomas. We speculate that communication between monocytes and MGCs, probably leading to cel...
Source: Canadian Journal of Cardiology - February 25, 2016 Category: Cardiology Source Type: research

A rare association of sarcoid-like granuloma with renal cell carcinoma
We describe a rare case of conventional (clear cell) RCC associated with epithelioid granulomas within the tumor parenchyma, in a 42-year-old lady without any evidence of systemic sarcoidosis.
Source: Journal of Cancer Research and Therapeutics - February 15, 2016 Category: Cancer & Oncology Authors: Subhadip KhatuaKousik BoseArghya BandyopadhyayAbhijit Banerjee Source Type: research

Pulmonary Microscopic Polyangiitis Presenting as Acute Respiratory Failure from Diffuse Alveolar Hemorrhage.
We present two cases of rapid onset respiratory failure secondary to diffuse alveolar hemorrhage in young active duty military personnel. After serological testing and surgical lung biopsy, both patients were diagnosed with microscopic polyangiitis with isolated pulmonary involvement. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 372-377). PMID: 26847106 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

IgG4-related lung disease: a case series of 6 patients and review of the literature.
In this report, we describe the clinical and pathologic features of six patients with IgG4-related disease of the lung. Patients were followed 1 - 5 years following their diagnosis. We describe unique features of IgG4- related lung disease, including one patient who presented with alveolar hemorrhage and a positive anti-neutrophil cytoplasmic antibody and two patients whose disease improved after treatment with mycophenylate mofetil. Two patients presented with pulmonary pseudotumor. We conclude that the clinical presentation of IgG4-related lung disease varies widely, and histopathology remains the key to diagnosis. ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Prognostic value of the initial chest high-resolution CT pattern in idiopathic pulmonary fibrosis.
CONCLUSION: There were no significant difference in survival between the three patient groups categorized by their initial chest HRCT pattern. PMID: 26847103 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Characterization of F-18 Fluorodeoxyglucose PET/CT in Granulomatosis with Polyangiitis.
CONCLUSIONS: FDG-PET/CT cannot differentiate between malignant and inflammatory lesions in GPA. However, occult sites of disease activity may be identified and provide a better assessment of the extent of disease activity and a more accurate assessment of treatment response. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 342-352). PMID: 26847102 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The Value of T-SPOT.TB in Early Diagnosis of Tracheobronchial Tuberculosis.
CONCLUSION: T-SPOT.TB can provide important basis for the diagnosis of tracheobronchial tuberculosis.It is the fastest and most accu-rate method in the diagnosis of tracheobronchial tuberculosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 336-341). PMID: 26847101 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Rituximab for the treatment of connective tissue disease-associated interstitial lung disease.
CONCLUSION: In this small, retrospective study of chronic CTD-ILD, RTX was not associated with changes in FVC% or corticosteroid-sparing effects. Controlled, prospective studies are needed to more confidently define the effects of RTX in CTD-ILD. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 296-304). PMID: 26847096 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - February 9, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Intravitreal aflibercept for choroidal neovascularization in ocular sarcoidosis.
CONCLUSIONS: We report a case of CNV in a patient with ocular sarcoidosis treated with intravitreal aflibercept. In our experience, intravitreal aflibercept injection achieved morphologic resolution for sarcoid-related peripapillary CNV. PMID: 26868005 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - February 5, 2016 Category: Opthalmology Authors: Querques L, Querques G, Miserocchi E, Modorati G, Bandello F Tags: Eur J Ophthalmol Source Type: research

Retinal Detachment and Symptomatic Hypercalcemia in a Patient with Sarcoidosis: Unusual Presentation of a Granulomatous Disease.
We describe herein a unique presentation of sarcoidosis with retinal detachment and symptomatic hypercalcemia as its first manifestation. Prompt therapy with steroids is indicated in these cases, and an immediate ophthalmology referral cannot be overemphasized. PMID: 26882785 [PubMed - in process]
Source: Connecticut Medicine - January 1, 2016 Category: Journals (General) Authors: Khurana A, Cherian S, Majumder S, Nakrani R, Kowlgi GN, Dasanu CA Tags: Conn Med Source Type: research

Pulmonary sarcoidosis is associated with high‐level inducible co‐stimulator (ICOS) expression on lung regulatory T cells – possible implications for the ICOS/ICOS‐ligand axis in disease course and resolution
Summary Sarcoidosis is a granulomatous inflammatory disorder of unknown aetiology. The increased frequency of activated lung CD4+ T cells with a T helper type 1 (Th1) cytokine profile in sarcoidosis patients is accompanied by a reduced proportion and/or impaired function of regulatory T cells (Tregs). Here we evaluated the expression of the inducible co‐stimulator (ICOS) on lung and blood CD4+ T cell subsets in sarcoidosis patients with different prognosis, by flow cytometry. Samples from the deep airways were obtained by bronchoalveolar lavage (BAL). We show that Tregs from the inflamed lung of sarcoidosis patients were...
Source: Clinical and Experimental Immunology - November 24, 2015 Category: Allergy & Immunology Authors: P. Sakthivel, J. Grunewald, A. Eklund, D. Bruder, J. Wahlström Tags: Original Article Source Type: research

Somatostatin Receptor Scintigraphy Patterns in Patients With Sarcoidosis
Conclusions: Somatostatin receptor scintigraphy enhances the yield of investigations in sarcoidosis patients and therefore provides a useful and sensitive imaging technique to monitor organ involvement and therapeutic efficacy in patients with sarcoidosis.
Source: Clinical Nuclear Medicine - November 7, 2015 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Atopy in sarcoidosis a good prognostic sign?
Conclusions: Identifying atopy in sarcoidosis may be useful in predicting the need for treatment and prognosis.References: Hajdarbegovic E et al. Prevalence of atopic diseases in patients with sarcoidosis. Allergy Asthma Proc. 2014 Jul; 35 (4):57-61.Cushin B et al. The Th2-mediated Lymphocyte Response in Sarcoidosis. Ir J Med Sci. 2013 182 (Suppl 10): S427-S486 Nov; 8.1.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Minnis, P., Riddel, P., O'Dwyer, D., Byrne, P., Donnelly, S. C. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Serum and bronchoalveolar exosomal miRNAs in pulmonary sarcoidosis
Conclusion: We showed three exosomal miRNAs (miR-340, miR-212 and miR-21) to be deregulated in sarcoidosis course. Grant support:CZ.1.07/2.3.00/30.0004,LO1304,IGA UP: LF_2015_020.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Navratilova, Z., Novosadova, E., Smitalova, D., Kishore, A., Kolek, V., Petrek, M. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Leptin, inflammatory biomarkers and body composition in patients with sarcoidosis
Conclusions: our findings could support the role of CRP as a biomarker among sarcoid patients but does not support correlation between sL and TNF-α, IL-5 and 6 in the studied group. All these findings need to be verified with large-scale studies.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Puscinska, E., Bednarek, M., Goljan-Geremek, A., Chorostowska-Wynimko, J., Rozy, A., Jagus, P., Sliwinski, P., Gorecka, D. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

The value of cardiopulmonary exercise testing in sarcoidosis
Normal pulmonary function tests (PTFs) do not always predict functional limitations during exercise in sarcoidosis. Cardiopulmonary exercise testing (CPET) may facilitate in recognition of exercise intolerance in these patients. A relevant data in sarcoid patients are limited, including spirometry, DLCO and lung volumes and CPET using standard protocol, 83 sarcoid patients consecutively referred for evaluation of exertional dyspnea over a 3-year period. Patients were grouped according to their radiologiacal stages as Stage I: 43, Stages II-III: 31 and Stage IV: 9. VO2 peak was decreased (<84% predicted) in 53% of patien...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Fouka, E., Zarogoulidis, P., Kioumis, I., Pitsiou, G., Zarogoulidis, K., Kallianos, A., Rapti, A., Trakada, G. Tags: 4.1 Clinical respiratory physiology, exercise and functional imaging Source Type: research

Vitamin D concentration and patient reported outcomes in sarcoidosis
Sarcoidosis patients frequently have low inactive Vitamin D form levels accompanied with the increased levels of the active form due to its autonomic conversion in sarcoid granulomas. The aim of our study was to evaluate the influence of lower serum Vitamin D3 concentration on subjective disease outcomes – fatigue and depression.In the cross-sectional study the degree of fatigue and depression was measured in 400 (27.3% males) patients with pulmonary sarcoidosis. Fatigue was measured by standardized Fatigue Assessment Scale (FAS). Depression was assessed by CES-D instrument.Mean age of patients was 50.5±11 yea...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Gvozdenovic, B. S., Vucinic, V., Vukovic, M., Stjepanovic, M. Tags: 1.13 Clinical Problems - Other Source Type: research

Are there any predictors of MTX response in progressive pulmonary sarcoidosis?
Conclusion: Defining initial inflammatory status of potential candidates for therapy might be helpful in further therapeutic decisions and enhance prognostication. Goljan Geremek A. et al. Methotrexate as a single agent for treating pulmonary sarcoidosis: a single centre real-life prospective study Pneumonol Alergol Pol, 2014, 82, 518-33.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Goljan Geremek, A., Bednarek, M., Demkow, U., Puscinska, E., Nowinski, A., Gorecka, D. Tags: 1.13 Clinical Problems - Other Source Type: research

Role of infliximab in managing resistant ventricular arrhythmias in sarcoidosis
We present a case of a 56 year old lady with multi-system sarcoid and resistant VT.Case: The patient was known to have pulmonary and ocular sarcoid with the diagnosis confirmed on a transbronchial biopsy. She developed VT in 2008. Cardiac MRI showed patchy epicardial-mid wall delayed gadolinium enhancement suggestive of cardiac sarcoid. The patient was cardioverted and started on prednisolone. An ICD was implanted after a second admission with VT in 2010. She started mycophenolate, which was changed to Azathioprine due to side effects. Radiofrequency ablation was performed in 2012, with reduction in the burden of VT. The p...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Konda, S., Chua, F., Saba, M., Pagonda, R., Aul, R. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Inhibited IL-17A ameliorates sarcoid-like granulomatosis in mice
Conclusions: These results suggest IL-17A plays central role in granuloma formation and inhibiting IL-17A may be potential treatment in sarcoidosis.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Jiang, D., Geng, J., Liu, Z., Zhu, M., Zheng, X., Dai, H. Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research

Sarcoidosis as unusual cause of massive pleural effusion
Publication date: Available online 13 October 2015 Source:Respiratory Medicine Case Reports Author(s): Sharad Joshi, Pallavi Periwal, Vikas Dogra, Deepak Talwar Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Pleural involvement is relatively rare. Development of pleural effusion in sarcoidosis needs to be evaluated for other causes, especially tuberculosis in endemic countries. Sarcoid pleural effusion responds to systemic corticosteroids. We are presenting case of 42 year old male patient of sarcoidosis who developed massive pleural effusion while on treatment with steroids, which was attrib...
Source: Respiratory Medicine Case Reports - October 25, 2015 Category: Respiratory Medicine Source Type: research

The influence of comorbidities on mortality in sarcoidosis: A observational prospective cohort study
Conclusion: The comorbidity burden has strong impact on mortality in sarcoidosis. Thyroid diseases are more frequent in sarcoidosis than in non sarcoid controls. This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - October 16, 2015 Category: Respiratory Medicine Authors: A. Nowiński, E. Puścińska, A. Goljan, J. Peradzynska, M. Bednarek, D. Korzybski, D. Kamiński, A. Stokłosa, M. Czystowska, P. Śliwiński, D Górecka Tags: Original Article Source Type: research

Sarcoidosis in Patients Treated with Vemurafenib for Metastatic Melanoma: A Paradoxical Autoimmune Activation
Conclusion: BRAF inhibitors probably have immune system-enhancing effects and should therefore be recognized as potential inducers of sarcoidosis.Dermatology
Source: Dermatology - October 10, 2015 Category: Dermatology Source Type: research

Pulmonary manifestations revealing Rosai-Dorfman disease.
We present the case of a patient with a pulmonary form of Rosai-Dorfman disease without peripheral or intra-thoracic lymph nodes, characterized by the presence of pulmonary nodules and cysts associated with bilateral pleural effusions. PMID: 26422575 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Early detection of colon cancer by increased serum level of Krebs von den Lungen-6 in a patient with dermatomyositis-associated interstitial pneumonia.
Authors: Fukuhara N, Tanino Y, Sato S, Fukuhara A, Uematsu M, Nikaido T, Misa K, Sato Y, Saito J, Wang X, Munakata M Abstract Krebs von den Lungen-6 (KL-6) is a high-molecular-weight glycoprotein which is elevated in serum of patients with interstitial pneumonia (IP).  Serum KL-6 level is clinically used for the diagnosis of IP as well as the evaluation of its disease activity.  KL-6 is originally identified when exploring novel soluble antigens in patients with lung cancer, and is known to be elevated in patients with several malignant tumors.  The risk of malignant tumors is high in IP patients with polymyosit...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Long-term stable lung function and second uncomplicated pregnancy on sirolimus in lymphangioleiomyomatosis (LAM).
In conclusion, the second pregnancy on uninterrupted sirolimus was uncomplicated both with respect to mother and child suggesting that sirolimus at the dose used may be safe in pregnant patients with LAM. During pregnancy, blood levels of sirolimus declined spontaneously indicating a faster metabolism of the drug. However, even at sirolimus levels considered subtherapeutic in the MILES trial, lung function was preserved during pregnancy in this patient. Since the vast majority of LAM patients are young women with a much improved outcome on sirolimus, a significant number may wish to become pregnant. However, in LAM trials,...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Efficacy and safety of surgical lung biopsy for interstitial disease. Experience of 161 consecutive patients from a single institution in Italy.
CONCLUSIONS: Lung biopsy was performed mostly by VATS, with limited morbidity, and was effective in yielding a specific histologic diagnosis in the vast majority of undefined ILD cases. To optimize the outcome of surgical biopsy for specific diagnosis of ILD, this procedure should be performed only exceptionally in patients with critical respiratory illness as postoperative mortality risk in these subjects is exceedingly high. PMID: 26422571 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Fibrosing interstitial lung diseases involve different pathogenic pathways with similar outcomes.
Authors: Vasakova M, Poletti V Abstract Fibrosing interstitial lung diseases (ILDs) are a large group of diseases triggered by external or internal stimuli that can have similar outcomes, i.e. lung fibrosis. Some ILDs are primarily fibro-proliferative disorders in which alveolar loss and epithelial/fibroblastic proliferation and dysplasia lead to lung fibrosis and architectural derangement, while other ILDs are considered inflammatory disorders in which specific underlying conditions (with either an external or an internal origin) can shift the pathogenic process to the fibro-proliferative pathway. The treatment of...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Biomarkers to identify ILD and predict lung function decline in scleroderma lung disease or idiopathic pulmonary fibrosis.
CONCLUSIONS: Combining KL-6 with MMP7 may be a useful screening tool for patients at risk of ILD. SP-D may predict short-term decline in lung function. PMID: 26422568 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Efficacy and Safety of Rituximab in Connective Tissue Disease related Interstitial Lung Disease.
CONCLUSIONS: Treatment with RTX resulted in an objective, measurable improvement in pulmonary function and/or radiological severity for the majority of patients included in the series. This was statistically significant despite the small numbers included. These results indicate a positive response to RTX with few complications of treatment.  . PMID: 26422566 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - October 3, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pulmonary sarcoidosis is associated with high‐level ICOS expression on lung regulatory T cells ‐ possible implications for the ICOS/ICOS‐L axis in disease course and resolution
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - September 29, 2015 Category: Allergy & Immunology Authors: Priya Sakthivel, Johan Grunewald, Anders Eklund, Dunja Bruder, Jan Wahlström Tags: Original Article Source Type: research

Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and resolution.
This article is protected by copyright. All rights reserved. PMID: 26415669 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - September 28, 2015 Category: Allergy & Immunology Authors: Sakthivel P, Grunewald J, Eklund A, Bruder D, Wahlström J Tags: Clin Exp Immunol Source Type: research

Clinical Characteristics of Sarcoid Arthropathy: A Population‐Based Study
Conclusion: Inflammatory arthritis occurs in a minority of patients with sarcoidosis. Acute oligoarthritis with bilateral ankles involvement was the most common pattern of sarcoid arthropathy. It should be noted that the generalizability of the results may be limited as the cohort was predominantly Caucasian. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - September 28, 2015 Category: Rheumatology Authors: Patompong Ungprasert, Cynthia S. Crowson, Eric L. Matteson Tags: Original Article Source Type: research

Clinical features and diagnostic evaluation of 83 biopsy-proven sarcoid uveitis cases
Conclusions In this largest European series of biopsy-proven sarcoidosis to date, the outstanding diagnostic ability of enzyme test plus imaging test couple suggests that the recourse to invasive procedures should be limited to patients with ocular involvement that would justify systemic treatments.
Source: British Journal of Ophthalmology - September 22, 2015 Category: Opthalmology Authors: Febvay, C., Kodjikian, L., Maucort-Boulch, D., Perard, L., Iwaz, J., Jamilloux, Y., Broussolle, C., Burillon, C., Seve, P. Tags: Original articles - Clinical science Source Type: research

Sarcoidosis: a rheumatologist's perspective
Sarcoidosis is a systemic disorder of unknown etiology, which may involve various tissues and organs and is characterized by a noncaseating granuloma reaction. While pathogenesis is not yet clear, cellular immune system activation and nonspecific inflammatory response occur secondarily to several genetic and environmental factors. T helper 1-cells and macrophage-derived pro-inflammatory cytokines stimulate the inflammatory cascade and formation of granuloma occurs as a result of tissue permeability, cell influx, and local cell proliferation. The different prevalence, clinical results, and disease course observed in differe...
Source: Therapeutic Advances in Musculoskeletal Disease - September 15, 2015 Category: Orthopaedics Authors: Kobak, S. Tags: Reviews Source Type: research