This page shows you the latest news items in this category. This is page number 12.

Total 4716 results found since Jan 2013.

A case of disseminated nontuberculous mycobacteriosis and cerebellar toxoplasmosis with autoantibody to interferon-γ.
We report the case of a 64-year-old Japanese woman who suffered from concomitant or sequential infections of the skin, lungs, bronchi, uterus, andbladder with nontuberculous mycobacteriosis, cerebellar toxoplasmosis, measles,herpes zoster, and vulvar herpes. Blood mononuclear cells from the patient displayed intact cytokine production in response to various stimuli and interferon-γ. High-titer anti-interferon-γ autoantibodies were detected in her serum. The atypical pathology hampered early diagnosis, but indeterminate results of an interferon-γ release assay could offer a simple clue suggesting the presence of autoanti...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Systemic glucocorticoid and anti-tuberculosis therapy in a patient with coexisting tuberculosis and anthracosis.
Conclusions: Glucocorticoid therapy may raise some concerns in patients with TB. Here, we present a case with anthracosis and coexistent TB, who responded very well to simultaneous anti-TB and glucocorticoid therapy. PMID: 24351622 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

YKL-40 and matrix metalloproteinases as potential biomarkers of inflammation and fibrosis in the development of bronchiolitis obliterans syndrome.
CONCLUSIONS: From the moment of transplantation onwards, patients who eventually developed BOS had significantly increased MMP-9 serum levels in comparison with patients who did not develop BOS. Therefore, increased MMP-9 serum levels might be useful as risk factor for BOS. PMID: 24003532 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Clinical profiles of 12 Chinese patients with diffuse panbronchiolitis.
Conclusions:More DPB cases need to be analyzed from Chinese population due to different presentations compared to Japanese population. This experience should help other clinicians in the investigation and management of DPB in non-Japanese patients. PMID: 24351621 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Whole-lung volume and density in spirometrically-gated inspiratory and expiratory CT in systemic sclerosis: correlation with static volumes at pulmonary function tests.
CONCLUSIONS: In restrictive lung disease due to SSc there is poor agreement between static lung volumes measured using LDCT and PFT and the relationship between volume and density values on CT is altered. PMID: 24003531 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Surgical lung biopsy for the diagnosis of interstitial lung disease: a review of the literature and recommendations for optimizing safety and efficacy.
Authors: Nguyen W, Meyer KC Abstract Making an accurate diagnosis of a specific type of interstitial lung disease (ILD) requires a structured and comprehensive approach that includes a complete patient history, careful physical examination, appropriate laboratory testing, and thoracic imaging. If invasive procedures are required, bronchoscopy with bronchoalveolar lavage (BAL) and/or endoscopic lung biopsy (ELB) can frequently establish a confident diagnosis. However, surgical lung biopsy (SLB) may be required to make a confident diagnosis. Because SLB may be associated with a significant risk of morbidity and morta...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Prevention of Pulmonary Fibrosis via Trichostatin A (TSA) in Bleomycin Induced Rats.
CONCLUSION: Non selective histone deacetylase inhibitors of Trichostatin A (TSA) can reduce the bleomycin induced pulmonary fibrosis in rats. TSA attenuates pulmonary fibrosis and it can inhibit HDAC2 expression at the gene and protein level. Bleomycin induced fibrosis has the relationship with p-SMAD2 in gene and protein levels, but TSA inhibit bleomycin-induced lung fibrosis effect with no relation with SMAD2 phosphorylation pathways. PMID: 25363222 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Stem cells, aging and pulmonary vascular remodelling.
Authors: Ferlosio A, Orlandi A PMID: 23461081 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Review of IPF diagnosis and management recommendations in Europe.
Authors: Xaubet A, Behr J, Bendstrup E, Cottin V, Hirani N, Kähler C, Sköld M Abstract Increased knowledge of Idiopathic Pulmonary Fibrosis (IPF) led to the development of evidence-based diagnosis and treatment guidelines. A 2011 update of the American Thoracic Society and the European Respiratory Society, together with the Japanese Respiratory Society ( JRS) and Latin AmericanThoracic Association (ALAT) provided new guidance on the diagnosis and treatment of IPF. Although the 2011 statement was a major advance, the application of guideline recommendations has identified limitations.The guidelines focus primarily...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Embryonic stem cells for lung fibrosis Is it the Prometheus myth or the Pandora's Box?
Authors: Tzouvelekis A, Bouros D Abstract Three thousand years ago the Greek epic narrativepoet Hesiod introduced to humanity his earliestwork called "Theogony" where he narrates the mythof "Prometheus" who provoked Zeus' wrath by stealingfire from the Gods and delivering it to humans. ... PMID: 24351615 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Analysis of lung function and survival in RECAP: An open-label extension study of pirfenidone in patients with idiopathic pulmonary fibrosis.
CONCLUSION: FVC and survival outcomes in IPF patients newly treated with pirfenidone in RECAP were similar to those in the CAPACITY pirfenidone group. These data provide further evidence to support the use of pirfenidone in patients with IPF. PMID: 25363219 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Chest wall shrapnel-induced beryllium-sensitization and associated pulmonary disease.
Authors: Fireman E, Shai AB, Lerman Y, Topilsky M, Blanc PD, Maier L, Li L, Chandra S, Abraham JM, Fomin I, Aviram G, Abraham JL Abstract Chronic beryllium disease (CBD) is an exposure-related granulomatous disease mimicking sarcoidosis. Beryllium exposure-associated disease occurs mainly via inhalation, but skin may also be a source of sensitization. A 65-year-old male with a history of war-related shrapnel wounds was initially diagnosed with pulmonary sarcoidosis. Twenty years later, the possibility of a metal-related etiology for the lung disease was raised. A beryllium lymphocyte proliferation test, elemental a...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Idiopathic Pulmonary Fibrosis (IPF) incidence and prevalence in Italy.
CONCLUSION: The data provide a first estimate of IPF incidence in Italy and indicate that incidence and prevalence in southern European regions may be similar to those observed in northern Europe and North America. PMID: 25363218 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A prospective clinical multicentre study on adult pulmonary Langerhans' cell histiocytosis.
CONCLUSION: The data underline the key role of smoking as the sole known risk factor. A significant effect of smoking cessation on the course could not be confirmed. The overall prognosis was good in this series as compared to previous reports. PMID: 23461076 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Chronic bronchiolitis in ankylosing spondylitis.
We report two cases of severe chronic bronchiolitis in ankylosing spondylitis patients. Their clinical and radiological presentation were similar, characterized by progressive deterioration of stage III-IV dyspnea, non-reversible obstructive ventilatory defect, and CT scan showing air trapping with mosaic attenuation and ground-glass opacity in expiration. Lung biopsies confirmed the diagnosis of severe follicular bronchiolitis in one patient and constrictive bronchiolitis is suspected in the other. Only the patient with follicular bronchiolitis responded positively to treatment with low doses of macrolides. PMID: 242...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Transbronchial cryobiopsy in diffuse parenchymal lung disease. A new star in the horizon.
Authors: Poletti V, Benzaquen S Abstract IntroductionSurgical lung biopsy is still considered the gold standard to obtain enough lung tissue in the clinical context of diffuse parenchymal lung disease... PMID: 25363216 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Are clinical features in Löfgren's syndrome-related erythema nodosum different from idiopathic erythema nodosum?
CONCLUSIONS: Apart from BHL, arthritis and/or arthralgia especially periarticular ankle inflammation is the feature which could be used to differentiate LS related EN from IEN. There is more need for steroids in LS patients and the symptoms quickly resolve with steroids. PMID: 23461075 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A Novel Missense Mutation of DKC1 In Dyskeratosis Congenita With Pulmonary Fibrosis.
Authors: Hisata S, Sakaguchi H, Kanegane H, Hidaka T, Ichinose M, Kojima S, Nukiwa T, Ebina M Abstract Dyskeratosiscongenita (DC) is a rare inherited multisystem disorder causedby mutations in seven genes involved in telomere biology, with approximately 20% of cases having pulmonarycomplications. DKC1 mutations exhibita severe disease phenotype of DC that develops in early childhood. Here, wereport a unique case of DC with pulmonaryfibrosis diagnosed at the ageof 46. A novel missense mutation(p.Arg65Lys) of DKC1 was detected, andpredicted to show a weak mutagenic effect. In spite of the steroid andimmunosuppressive...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Metformin/glibenclamide-related interstitial lung disease: a case report.
Authors: Zuccarini G, Bocchino M, Assante LR, Rea G, Sanduzzi A Abstract Interstitial lung disease (ILD) may be caused by a wide panel of recognized drugs. Despite the increasing number of reports in the literature, high-lightings of ILD related to oral hypoglycemic drugs are very infrequent.  Herein, we describe the case of a 78-yr-old Caucasian diabetic woman who developed mild dyspnoea at rest, asthenia and fever while on treatment with oral metformin (2000 mg/day) and glibenclamide (12.5 mg/day). On hospital admission, pulmonary function testing (PFT), chest x-ray and thorax high resolution computed tomography...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Health-related quality of life does not predict mortality in idiopathic pulmonary fibrosis.
CONCLUSIONS: There was no significant relationship between HRQL evaluated with the SGRQ and the subsequent mortality in IPF. The present negative result might suggest that HRQL is measuring an aspect other than one from physiological and functional impairment or disability. PMID: 23461073 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Hermansky Pudlak Syndrome and Pulmonary Alveolar Proteinosis at the same patient: first case report in the world literature.
We report the first case of PAP in a patient with HPS. PMID: 24284295 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Six-minute stepper test to assess effort intolerance in interstitial lung diseases.
Authors: Delourme J, Stervinou-Wemeau L, Salleron J, Grosbois JM, Wallaert B Abstract The six-minute stepper test (6MST) is a new test for evaluating exercise tolerance. Unlike the six-minute walk test (6MWT) it can be carried out in a limited space. The aim of this study was to compare the 6MST and the 6MWT in patients with various diffuse interstitial lung disease (ILD). 6MWT and 6MST were performed the same day in 84 patients with various ILD. The covered distance during 6MWT was compared to the number of steps during the 6MST. We also compared heart rate, oxygen saturation, dyspnoea and leg tiredness on a Borg ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Clinical course and characterisation of lymphangioleiomyomatosis in a Brazilian reference centre.
CONCLUSIONS: Clinical and functional features of the LAM patients from our centre are similar to those from other countries. Our sample showed preserved exercise capacity, with desaturation in the 6MWT, and impaired quality of life. Survival was similar, whereas the annual rate of decline of FEV1 was slightly lower than in recent studies. PMID: 25078640 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Human embryonic stem cells recover in vivo acute lung inflammation bleomycin-induced.
Authors: Sangiuolo F, Spitalieri P, Quitadamo MC, Orlandi A, Puxeddu E, Curradi G, Sangiuolo F Abstract Idiopathic pulmonary fibrosis (IPF)  is characterized by alveolar epithelial cell injury, type II cell activation, apoptosis and bronchiolar epithelial cell proliferation, accumulation of extracellular matrix and fibroblasts. No current animal model recapitulates all of these cardinal manifestation of the human disease. However, bleomycin instillation in mice lung by intranasal way (ITN) represents the best experimental model of pulmonary fibrosis in which alveolar pneumocytes type II (ATII) are usually depleted...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Leflunomide-induced interstitial lung disease (a systematic review).
Conclusions: Leflunomide can cause ILD. Most of these patients present within three months of starting leflunomide with acute symptoms for a week or less. Bilateral ground glass opacities and diffuse alveolar damage are the most common radiologic and histopathologic findings, respectively. Patients with pre-existing ILD are particularly at risk for this complication, and leflunomide should be avoided in this population. Activated charcoal and cholestyramine significantly decrease the half-life of the drug because of its enterohepatic circulation and should be considered in cases with acute toxicity. PMID: 24284289 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Neurosarcoidosis presenting as trigeminal nevralgia: a case report and review of the literature.
Authors: Braksick S, Shah-Haque S, El-Haddad Et Al B Abstract Sarcoidosis is a granulomatous disease that can present systemically, but primarily has pulmonary manifestations. It is reported across all races, but has a higher incidence among African Americans. Neurological involvement in sarcoidosis is rare, with cranial nerve seven being the most commonly reported neurological finding. Trigeminal neuralgia, as presented in this case, is very rare. A 38-year-old African American female, with history of refractory trigeminal neuralgia, cutaneous sarcoidosis, and an extensive psychiatric history, presented to the hos...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The clinical and integrated management of COPD.
This article is being simultaneusly published in Multidisciplinary Respiratory Medicine 2014; 9:25(Sarcoidosis Vasc Diffuse Lung Dis 2014; 31 Suppl 1: 3-21). PMID: 24820963 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Outcome of patients with interstitial lung disease admitted to the intensive care unit.
Conclusion: This study, while confirming the poor prognosis of FIIP patients in ICU, highlights the better prognosis of DI-ILD and M-ILD even though severity criteria on admission are similar in these 3 groups. These data impact on the management of these patients in ICU in whom a proper diagnostic of the underlying condition is crucial. PMID: 24071885 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Decreased sputum caveolin-1 is associated with systemic sclerosis related lung disease.
CONCLUSION:    These results suggest that decreased sputum Cav-1 levels is associated with SSc related-ILD and may be used as a marker for the detection of SSc-ILD.   PMID: 24751454 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The effect of anticoagulant therapy for idiopathic pulmonary fibrosis in real life practice.
Conclusion: In this retrospective study patients treated with anticoagulants had a worse survival and a shorter interval to disease progression. This support the recent finding that warfarin worsen the respiratory status and survival of IPF patients. PMID: 24071883 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Clinical course and outcome of rheumatoid arthritis-related usual interstitial pneumonia.
Conclusions: In spite of variable clinical course of RA-UIP, overall prognosis of RA-UIP was significantly better compared to IPF. Our data supported the treatment of the patients with significant functional impairments or progression. PMID: 24071881 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Features and outcome of familial idiopathic pulmonary fibrosis.
Conclusion:familial IPF seems indistinguishable from sporadic IPF with respectto most clinical and physiologic findings; however the age of onsetwas slightly lower among the familial cases than in the sporadiccases of IPF and the phenomenon of anticipation could be observed. PMID: 24751451 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

23-year-old female with dyspnea, hematuria, and seizure progressing to respiratory failure.
We report a 23-year old female who presented with fever, shortness of breath and abdominal pain. Shortly thereafter the patient developed hematuria, hemoptysis and seizure progressing to respiratory failure. She was found to have aortitis and alveolar hemorrhage. We discuss the clinical manifestations and the diagnostic work up of Takayasu arteritis. The patient's response to therapy and a discussion on treatment modalities of the disease are also included in the report. PMID: 24003540 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Multi-dimensional indices to stage idiopathic pulmonary fibrosis: a systematic review.
Authors: Rozanski C, Mura M Abstract Idiopathic pulmonary fibrosis (IPF) has the highest mortality rate among all interstitial lung diseases, with a mean survival time of 2 to 3 years from the time of diagnosis. Prognosis is difficult to determine, due to the recognized heterogeneous progression of the disease, as well as lack of a well recognized staging system. This in turn raises challenges when considering therapeutic options for IPF patients, such as lung transplantation, versus a more conservative approach.  Multiple independent factors have been identified as prognostic indicators in IPF, and a number of st...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Familial interstitial pneumonia in an adolescent boy with surfactant protein C gene (Y104H) mutation.
We report here a case of familial interstitial pneumonia in an adolescent boy whose paternal grandfather and father suffered from idiopathic interstitial pneumonia (IIP). The patient was asymptomatic but showed an abnormal shadow in the chest at his medical check-up. The surgical biopsy of the patient revealed non-specific interstitial pneumonia and showed pathological findings similar to those in his father's autopsy. Genomic DNA from blood leucocytes of the patient was sequenced for the Thy104His (Y104H) SFTPC mutation. Based on these results, he was diagnosed with SFTPC mutation-associated familial interstitial pneumoni...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Transthoracic lung ultrasonography in pulmonary alveolar proteinosis - case report.
We present a patient in whom repeated transthoracic lung ultrasonography (TLUS) brought parallel to HRCT data in assessing PAP extent. It may indicate that TLUS might be potentially a relevant tool in monitoring of PAP. PMID: 24351624 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Clinical characteristics classified by the serum KL-6 level in patients with organizing pneumonia.
CONCLUSIONS: Patients with normal KL-6 levels showed lower CXR and CT scores. The serum KL-6 level on admission is a useful marker to judge the need for corticosteroid treatment in OP patients. PMID: 24003534 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis
Sarcoidosis is characterised by non-caseating granulomas that secrete pro-inflammatory cytokines, including interleukin (IL)-12, IL-23, and tumour necrosis factor (TNF)-α. Ustekinumab and golimumab are monoclonal antibodies that specifically inhibit IL-12/IL-23 and TNF-α, respectively. Patients with chronic pulmonary sarcoidosis (lung group) and/or skin sarcoidosis (skin group) received either 180 mg ustekinumab at week 0 followed by 90 mg every 8 weeks, 200 mg golimumab at week 0 followed by 100 mg every 4 weeks, or placebo. Patients underwent corticosteroid tapering between weeks 16 and 28. The primary end-po...
Source: European Respiratory Journal - October 31, 2014 Category: Respiratory Medicine Authors: Judson, M. A., Baughman, R. P., Costabel, U., Drent, M., Gibson, K. F., Raghu, G., Shigemitsu, H., Barney, J. B., Culver, D. A., Hamzeh, N. Y., Wijsenbeek, M. S., Albera, C., Huizar, I., Agarwal, P., Brodmerkel, C., Watt, R., Barnathan, E. S. Tags: Original Articles: Sarcoidosis Source Type: research

Clinical features of sarcoid myelopathy focusing on age, distribution, and concomitant spinal disease
Background: Myelopathy is a relatively rare manifestation of sarcoidosis. Although spinal cord compression related to spinal cord swelling was reported in sarcoid myelopathy, the relationship between sarcoid myelopathy and mechanical compression due to orthopedic disorders has not been fully evaluated. We aimed to reveal clinical and radiological features of sarcoid myelopathy that demarcate the disease from other inflammatory myelopathy (OIM), especially focusing on age, distribution of spinal cord lesion (SCL), and concomitant orthopedical spinal diseases.
Source: Journal of Neuroimmunology - October 15, 2014 Category: Allergy & Immunology Authors: , Kazuo Fujihara, Yasuto Itoyama, Masashi Aoki Tags: 388 Source Type: research

The Two Extremes of Cardiac Sarcoidosis and the Effect of Prednisone Therapy
Described herein are clinical and morphologic findings in 2 patients who underwent heart transplantation because of severe heart failure resulting from cardiac sarcoidosis. Although the explanted hearts in each patient had characteristic gross changes of cardiac sarcoidosis, one patient who had been treated with prednisone, had no residual sarcoid granulomas in the myocardium, whereas the other patient, in whom diagnosis was not made until heart transplantation, had innumerable sarcoid granulomas in her heart.
Source: The American Journal of Cardiology - October 13, 2014 Category: Cardiology Authors: Danielle Armstrong, Gonzalo V. Gonzalez-Stawinski, Jong Mi Ko, Shelley A. Hall, William C. Roberts Tags: Case Report Source Type: research

The Two Extremes of Cardiac Sarcoidosis and the Effect of Prednisone Therapy
Described herein are clinical and morphologic findings in 2 patients who underwent heart transplantation because of severe heart failure resulting from cardiac sarcoidosis. Although the explanted hearts in each patient had characteristic gross changes of cardiac sarcoidosis, one patient who had been treated with prednisone, had no residual sarcoid granulomas in the myocardium, whereas the other patient, in whom diagnosis was not made until heart transplantation, had innumerable sarcoid granulomas in her heart.
Source: The American Journal of Cardiology - October 13, 2014 Category: Cardiology Authors: Danielle Armstrong, Gonzalo V. Gonzalez-Stawinski, Jong Mi Ko, Shelley A. Hall, William C. Roberts Source Type: research

The Clinical Features of Sarcoidosis: A Comprehensive Review
Abstract Sarcoidosis has innumerable clinical manifestations, as the disease may affect every body organ. Furthermore, the severity of sarcoidosis involvement may range from an asymptomatic state to a life-threatening condition. This manuscript reviews a wide variety of common and less common clinical characteristics of sarcoidosis. These manifestations are presented organ by organ, although additional sections describe systemic and multiorgan presentations of sarcoidosis. The lung is the organ most commonly involved with sarcoidosis with at least 90 % of sarcoidosis patients demonstrating lung involvement in mos...
Source: Clinical Reviews in Allergy and Immunology - October 2, 2014 Category: Allergy & Immunology Source Type: research

A cytomorphometric analysis of pulmonary and mediastinal granulomas: Differentiating histoplasmosis from sarcoidosis by fine‐needle aspiration
CONCLUSIONSDifferentiation between histoplasmosis and sarcoidosis is possible in the majority of cases. Histoplasmosis usually exhibits few angular, ragged granulomas (<2 granulomas per slide) in a background of bland necrosis. Yeasts are identified on special stains performed in aspirate smears. Sarcoidosis typically contains many more granulomas (often >10 per slide) than histoplasmosis and has a rounded morphology with crisp and sharp borders. Typically, there is no necrosis or acute inflammation, and giant cell infiltrates are frequent. Cancer (Cancer Cytopathol) 2014. © 2014 American Cancer Society.
Source: Cancer Cytopathology - October 1, 2014 Category: Pathology Authors: Michael P. Gailey, Matthew E. Keeney, Chris S. Jensen Tags: Original Article Source Type: research

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes
Previously, we demonstrated concordance in differentially expressed genes in sarcoidosis blood and lung, implicating shared dysfunction of specific immune pathways. In the present study, we hypothesised that expression levels of candidate genes in sarcoidosis blood could predict and track with disease outcomes longitudinally. We applied Ingenuity Pathway Analysis to a cross-sectional derivation microarray dataset (n=38) to identify canonical pathways and candidate genes associated with sarcoidosis. In a separate longitudinal sarcoidosis cohort (n=103), we serially measured 48 candidate gene transcripts, and assessed their ...
Source: European Respiratory Journal - September 30, 2014 Category: Respiratory Medicine Authors: Su, R., Li, M. M., Bhakta, N. R., Solberg, O. D., Darnell, E. P. B., Ramstein, J., Garudadri, S., Ho, M., Woodruff, P. G., Koth, L. L. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

A challenging case: spinal cord sarcoidosis
A 54-year old man with severe ankylosing spondylitis presented with rapidly progressing bilateral lower limb weakness and altered sensation, associated with urinary retention. Examination showed flaccid paraparesis with lower limb areflexia and a sensory level to T10. His upper limbs were normal. MR scan of whole spine showed marked ankylosing spondylitis changes, including canal narrowing, and extensive, discontinuous signal change within the spinal cord at C7–T1, T3–T4 and T7–T11. There was no leptomeningeal enhancement. Severe ankylosing spondylitis meant we were unable to obtain CSF, MR scan of head o...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Wynford-Thomas, R., Smith, P. Tags: Abstracts Source Type: research

Sarcoidosis of the Head and Neck
This article seeks to provide a comprehensive review of head and neck sarcoidosis, as this fascinating disorder often poses a diagnostic and therapeutic challenge. A brief discussion of surgical treatment for pituitary lesions is also provided. Articles from 1997 to 2013 were selected and reviewed by three researchers utilizing the most recent literature regarding sarcoidosis in the head and neck. PubMed searches were conducted using search terms such as “sarcoidosis”, “neurosarcoid”, and “extra-pulmonary sarcoid”, among many others. A large collection of articles was generated and reviewed by the team of autho...
Source: Head and Neck Pathology - September 3, 2014 Category: Pathology Source Type: research

Esophageal cancer associated with bilateral hilar lymphadenopathy caused by sarcoid-like reactions: a report of two cases
We report two patients with esophageal cancer accompanied by bilateral hilar lymphadenopathy or accumulation on [18F]-fluorodeoxyglucose positron emission tomography–computed tomography. The first patient underwent surgery because the enlarged bilateral hilar lymph nodes were considered to be nonmalignant lesions owing to superficial carcinoma and symmetric distribution of the hilar lymph nodes. The second patient received chemotherapy, which caused the main tumor to shrink and decreased [18F]-fluorodeoxyglucose uptake. However, chemotherapy did not affect the hilar lymphadenopathy, which suggests that it was caused by r...
Source: Esophagus - September 2, 2014 Category: Gastroenterology Source Type: research

Application of medical thoracoscopy in diagnosis of sarcoidosis‐related pleural effusion
Abstract Pleural effusion caused by sarcoidosis is unusual. Medical thoracoscopy could help clinicians detect associated pleural disease, yet studies on thoracoscopic observations in sarcoidosis pleural involvement are rare. In this article, we report the utility of medical thoracoscopy in diagnosing sarcoid‐related pleural disease for three patients. Pleural nodularity was common with solitary and multiple nodules evident; biopsies confirmed the presence of diagnostic noncaseating granulomas. Medical thoracoscopy showed that sarcoidosis pleural involvement was variable from multiple nodules to subtle change in the pleura.
Source: Respirology Case Reports - July 2, 2014 Category: Respiratory Medicine Authors: Feng Wang, Zhaohui Tong, Zhen Wang, Xiaojuan Wang, Xi Zhan, Huanzhong Shi Tags: Case Report Source Type: research

Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis
Abstract: A 52-year-old Japanese woman complaining of horizontal double vision for 10days was admitted to our hospital. Neurological examination revealed left abducent nerve palsy and muscle swelling in her thighs. Brain MRI showed obstruction in the spinal fluid space of the left Dorello's canal, which transmits a portion of the abducent nerve. In Ga-67-enhanced citrate scintigraphy, wide accumulation was seen in her bilateral thighs, lower legs, and gluteus muscles. Muscular MRI showed a star-shaped central structure on short tau inversion recovery (STIR) images, and the three stripes sign on T2-weighted images. These MR...
Source: Journal of the Neurological Sciences - June 2, 2014 Category: Neurology Authors: Ayako Shioya, Hiroshi Takuma, Masanari Shiigai, Akiko Ishii, Akira Tamaoka Tags: Short Communications Source Type: research

Cardiac sarcoidosis presenting as constrictive pericarditis.
We report the case of a 57-year-old man who presented with clinical and hemodynamic features of constrictive pericarditis, of unclear cause. He was admitted for treatment of recurrent pleural effusion. After a complicated hospital course, he underwent pericardiectomy. His clinical and hemodynamic conditions improved substantially, and he was discharged from the hospital in good condition. The pathologic findings, the patient's clinical course, and his response to pericardiectomy led to our diagnosis of cardiac sarcoidosis presenting as constrictive pericarditis. In addition to the patient's case, we discuss the nature and ...
Source: Texas Heart Institute Journal - June 1, 2014 Category: Cardiology Authors: Darda S, Zughaib ME, Alexander PB, Machado CE, David SW, Saba S Tags: Tex Heart Inst J Source Type: research