This page shows you the latest news items in this category. This is page number 19.

Total 5693 results found since Jan 2013.

Lymphopaenia as a predictor of sarcoidosis in patients with a first episode of uveitis.
CONCLUSION: Lymphopaenia is a non-invasive and useful marker for diagnosing sarcoidosis-associated uveitis. PMID: 30442816 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Authors: Groen-Hakan F, Eurelings L, Rothova A, van Laar J Tags: Br J Ophthalmol Source Type: research

MicroRNA fingerprints in serum and whole blood of sarcoid ‐affected horses as potential non‐invasive diagnostic biomarkers
In this study, we compared equine sarcoid (ES) disease‐specific serum and whole blood miRNA fingerprints and correlated them to miRNA expression in sarcoid tissue. After high throughput sequencing, miRNA differential expression analysis between six ES‐affecte d and five control horses was carried out in serum and whole blood using a DESeq algorithm, accounting for the influence of hemolysis and the white blood cell count. Target gene, pathway prediction and enrichment analyses were conducted using TarBase, mirPath and GeneCodis. After exclusion of four h emolyzed out of a total of 11 serum samples, nine miRNAs were fou...
Source: Veterinary and Comparative Oncology - November 14, 2018 Category: Veterinary Research Authors: Lucia Unger, Vinzenz Gerber, Alicja Pacholewska, Tosso Leeb, Vidhya Jagannathan Tags: ORIGINAL ARTICLE Source Type: research

The prognostic value of quantitating and localizing F-18 FDG uptake in cardiac sarcoidosis
ConclusionsSUV at time of CS diagnosis has significant associations with future cardiac events. Patients with higher SUV, particularly in basal segments, are at increased risk of events. Further studies are needed to identify treatment methods utilizing risk stratification of CS.
Source: Journal of Nuclear Cardiology - November 12, 2018 Category: Nuclear Medicine Source Type: research

Acute kidney injury as a rare manifestation of pediatric sarcoidosis: A case report and systematic literature review
ConclusionsSarcoidosis should be considered in children with acute kidney injury of an unknown etiology. A final diagnosis is established through a combination of the clinical and laboratory characteristics, radiological presentation, and histological features of noncaseating granulomas. A therapeutic schedule should be decided after a systemic assessment.
Source: Clinica Chimica Acta - November 9, 2018 Category: Laboratory Medicine Source Type: research

Myopathies Featuring Non-caseating Granulomas: Sarcoidosis, Inclusion body myositis and an unfolding overlap
Granulomatous myopathy is a clinically and etiologically heterogeneous group of uncommon inflammatory myopathies, pathologically characterized by the presence of granulomas in skeletal muscle. Granulomas may contain necrosis as typically seen in infectious disorders (fungal, tuberculosis, or brucellosis) [1-3] or may occur without necrosis, so-called non-necrotizing or non-caseating granulomas. Various disorders were reported in association with non-caseating granulomatous myopathy, including sarcoidosis and less commonly other autoimmune diseases (Crohn's disease, anti-mitochondrial autoimmunity with or without primary bi...
Source: Neuromuscular Disorders - November 8, 2018 Category: Neurology Authors: Reem M. Alhammad, Teerin Liewluck Source Type: research

Acute kidney injury as a rare manifestation of pediatric sarcoidosis: A case report and systematic literature review.
CONCLUSIONS: Sarcoidosis should be considered in children with acute kidney injury of an unknown etiology. A final diagnosis is established through a combination of the clinical and laboratory characteristics, radiological presentation, and histological features of noncaseating granulomas. A therapeutic schedule should be decided after a systemic assessment. PMID: 30414436 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - November 7, 2018 Category: Chemistry Authors: Wang C, Liu H, Zhang T, Xu H, Shen J, Feng J, Sun L Tags: Clin Chim Acta Source Type: research

Cardiac Sarcoidosis
Clinical and subclinical cardiac sarcoidosis (CS) remain diagnostically challenging as the sensitivity and specificity of the diagnostic modalities are limited. The Japanese Ministry of Health and Welfare criteria and the Heart Rhythm Society expert consensus statement on CS are the most common guidelines used to diagnose CS. However, they are mostly based on expert opinions and lack clinical trial validation. The emergence and increase use of newer imaging modalities such as cardiac magnetic resonance and positron emission tomography may give valuable information for accurate diagnosis and assessment of treatment response in CS patient.
Source: The American Journal of Cardiology - November 5, 2018 Category: Cardiology Authors: Jian Liang Tan, Hee Kong Fong, Edo Y. Birati, Yuchi Han Source Type: research

Advanced cardiovascular imaging for the evaluation of cardiac sarcoidosis
AbstractCardiac sarcoidosis (CS) remains an intriguing infiltrating disorder and one of the most important forms of inflammatory cardiomyopathy. Identification of patients with CS is of extreme importance because they are at higher risk of sudden death, and heart-failure progression. And while it remains a diagnostic conundrum, a great amount of experience has been accumulated over the last decade with the advent of fluorine-18 fluorodeoxyglucose positron emission tomography and cardiac magnetic resonance with late gadolinium enhancement imaging. They have both proven to be advanced imaging techniques that provide importan...
Source: Journal of Nuclear Cardiology - November 2, 2018 Category: Nuclear Medicine Source Type: research

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis
Conditions:   Pulmonary Hypertension;   Pulmonary Fibrosis;   Sarcoidosis, Pulmonary Intervention:   Combination Product: iNO Sponsor:   Bellerophon Not yet recruiting
Source: ClinicalTrials.gov - November 1, 2018 Category: Research Source Type: clinical trials

Life-threatening hypercalcemia and acute kidney injury induced by etanercept.
We report a case of sarcoid-like granulomatosis manifesting as life-threatening hypercalcemia and acute kidney injury in a woman treated with etanercept for a rheumatoid arthritis. Seven days after admission, she developed hypoxemic interstitial pneumonia with negative mycobacterial and fungal analysis. This picture suggested sarcoid-like disease induced by tumor necrosis factor blockers and prompted etanercept cessation. Kidney biopsy performed 30 days after admission revealed significant acute interstitial nephritis and intratubular calcium crystals. Staining for acid-fast bacilli and fungi was negative. Clinical pictur...
Source: Nephrologie and Therapeutique - November 1, 2018 Category: Urology & Nephrology Authors: Tsevi YM, Aydin S, Durez P, Labriola L Tags: Nephrol Ther Source Type: research

Pulmonary Sarcoidosis Considerations in Primary Care
The current literature shows that pharmacologic treatment of pulmonary sarcoidosis should depend on patient-specific symptomology and be individually customized. Approaching this multifaceted disease process that has poorly understood etiology and disease predictability is further complicated by a lack of standardized guidelines for this condition, specifically detailing the appropriateness of observation for possible spontaneous resolution and when to initiate pharmacotherapy in the primary care setting.
Source: The Journal for Nurse Practitioners - November 1, 2018 Category: Nursing Authors: Kaitlin Denson, Melissa Herbein, Felicia Stewart Tags: Feature Article Source Type: research

Cardiac Sarcoidosis Mimicking Septal Tumor with Intermittent Complete Atrioventricular Block.
Authors: Fujimoto R, Asano T, Maezawa H, Shimojima H, Tsujiuchi M, Hori Y, Ebato M, Suzuki H Abstract A 52-year-old woman with intermittent complete atrioventricular (AV) block detected on exercise was admitted to the hospital. Echocardiography revealed lesions on the right ventricular side of the interventricular septum and free wall of the basal inferolateral area. Gadolinium-enhanced cardiovascular magnetic resonance (CMR) imaging revealed the mass and wall thickening at the same locations with late gadolinium enhancement (LGE). Focal uptake at the septal lesion was detected using 67Ga scintigraphy. Focal on dif...
Source: International Heart Journal - October 31, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Management and outcomes of cardiac sarcoidosis: a 20 ‐year experience in two tertiary care centres
ConclusionIn a large series of CS subjects, rates of ventricular arrhythmia and heart failure events remain high with no treatment regimen clearly associated with better outcome. Patients with cardiomyopathy at diagnosis were more likely to reach the composite endpoint.
Source: European Journal of Heart Failure - October 31, 2018 Category: Cardiology Authors: Lynn A. Fussner, Erin Karlstedt, David O. Hodge, Nowell M. Fine, Sanjay Kalra, Eva M. Carmona, James P. Utz, Debra L. Isaac, Leslie T. Cooper Tags: Research Article Source Type: research

Cardiac sarcoidosis with complete metabolic response and resolution of left ventricular dysfunction complicated by subsequent VT storm
We present a case of cardiac sarcoidosis with significantly impaired ejection fraction that was diagnosed late in the course of disease with complete metabolic response to therapy and an improvement of LV function, but with a subsequent complication of ventricular tachycardia storm.
Source: Journal of Nuclear Cardiology - October 30, 2018 Category: Nuclear Medicine Source Type: research

Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis
Publication date: Available online 26 October 2018Source: MitochondrionAuthor(s): Zoe Daniil, Ourania S. Kotsiou, Alexandros Grammatikopoulos, Sotiria Peletidou, Helen Gkika, Foteini Malli, Katerina Antoniou, Eirini Vasarmidi, Zissis Mamuris, Konstantinos Gourgoulianis, Emily ZifaAbstractMitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of 22 mt-tRNA genes and parts of their flanking genes revealed 32 and 45 mutations in 38/40 IPF and 69/85 sarcoidosis patie...
Source: Mitochondrion - October 27, 2018 Category: Biochemistry Source Type: research

Response to Letter to Editor regarding "Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?"
We thank Drs. Valentin, Hyde, Gomez and Patel for commenting on our recently published article “Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?” [1]. Indeed, one of our objectives in reporting our observations was to provoke further interest in the scientific community regarding such patients and conduct of clinical studies in such cohorts.
Source: Respiratory Medicine - October 26, 2018 Category: Respiratory Medicine Authors: Bridget F. Collins, Ganesh Raghu Tags: Correspondence Source Type: research

Evaluation of FDG PET combined with cardiac MRI for the diagnosis and therapeutic monitoring of cardiac sarcoidosis
To compare combined 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron-emission tomography (PET) and cardiac magnetic resonance imaging (CMR) for the diagnosis and therapy monitoring of cardiac sarcoidosis (CS).
Source: Clinical Radiology - October 25, 2018 Category: Radiology Authors: B. Sgard, P.-Y. Brillet, D. Bouvry, S. Djelbani, H. Nunes, C. Meune, D. Valeyre, M. Soussan Source Type: research

Bosentan for patients with steroid-resistant pulmonary sarcoidosis: a randomised controlled trial.
CONCLUSIONS: There is no evidence to support efficacy of bosentan as an antifibrotic treatment for patients with steroid-resistant pulmonary sarcoidosis. Bosentan was well tolerated and no drug-related adverse effects were observed within the study population. TRIAL REGISTRATION: ISRCTN registry, ISRCTN73579020. PMID: 30378090 [PubMed - in process]
Source: Swiss Medical Weekly - October 22, 2018 Category: General Medicine Authors: Hostettler K, Baty F, Kleiner R, Junker L, Tamm M, Brutsche M Tags: Swiss Med Wkly Source Type: research

Pulmonary follicular lymphoma showing diffuse micronodules mimicking sarcoidosis.
Authors: Takuma K, Eri H, Satoshi I, Takashi O PMID: 30333400 [PubMed - as supplied by publisher]
Source: Internal Medicine - October 20, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Effect of Cardiac Resynchronization Therapy on Left Ventricular Remodeling in Patients with Cardiac Sarcoidosis
Cardiac resynchronization therapy (CRT) has been shown to be beneficial in patients with medically refractory heart failure. While it has been found to be effective in a wide range of etiologies for non-ischemic cardiomyopathy, its role in improving remodeling and survival of patients with cardiac sarcoidosis (CS) remains undefined. We performed a retrospective review of all patients at our institution with CS who underwent implantation of a CRT device between 2007 and 2017. The outcomes of this population were compared to the outcomes of a cohort of patients with non-ischemic cardiomyopathy with an etiology other than sarcoidosis.
Source: The American Journal of Cardiology - October 20, 2018 Category: Cardiology Authors: Divyang Patel, Kevin M. Trulock, Saleem Toro, Adam Grimaldi, Matthew Gonzalez, Laurie Ann Moennich, Eiran Z. Gorodeski, Emer Joyce, Mark Niebauer, Bruce L. Wilkoff, Niraj Varma, John W. Rickard Source Type: research

Efficacy of Remission-induction Regimen With Infliximab for Severe Extrathoracic Sarcoidosis (EFIRTES)
Condition:   Extrathoracic Sarcoidosis Interventions:   Drug: Infliximab;   Drug: Placebo Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials

PET/MR Imaging In Patients With Cardiac Sarcoidosis
Condition:   Cardiac Sarcoidosis Interventions:   Other: 18F-FDG;   Drug: Prednisolone Sponsor:   University of Edinburgh Recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials

Efficacy of Remission-induction Regimen With Infliximab for Severe Extrathoracic Sarcoidosis (EFIRTES)
Condition:   Extrathoracic Sarcoidosis Interventions:   Drug: Infliximab;   Drug: Placebo Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials

PET/MR Imaging In Patients With Cardiac Sarcoidosis
Condition:   Cardiac Sarcoidosis Interventions:   Other: 18F-FDG;   Drug: Prednisolone Sponsor:   University of Edinburgh Recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials

Efficacy of Remission-induction Regimen With Infliximab for Severe Extrathoracic Sarcoidosis (EFIRTES)
Condition:   Extrathoracic Sarcoidosis Interventions:   Drug: Infliximab;   Drug: Placebo Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials

PET/MR Imaging In Patients With Cardiac Sarcoidosis
Condition:   Cardiac Sarcoidosis Interventions:   Other: 18F-FDG;   Drug: Prednisolone Sponsor:   University of Edinburgh Recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials

Efficacy of Remission-induction Regimen With Infliximab for Severe Extrathoracic Sarcoidosis (EFIRTES)
Condition:   Extrathoracic Sarcoidosis Interventions:   Drug: Infliximab;   Drug: Placebo Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials

PET/MR Imaging In Patients With Cardiac Sarcoidosis
Condition:   Cardiac Sarcoidosis Interventions:   Other: 18F-FDG;   Drug: Prednisolone Sponsor:   University of Edinburgh Recruiting
Source: ClinicalTrials.gov - October 15, 2018 Category: Research Source Type: clinical trials