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Total 5069 results found since Jan 2013.

Cough in sarcoidosis patients
Publication date: Available online 4 January 2018 Source:Respiratory Physiology & Neurobiology Author(s): Eva Kovacova, Tomas Buday, Robert Vysehradsky, Jana Plevkova Sarcoidosis is a multi-system disease of unknown aetiology characterized by presence of non-caseating granulomatous inflammation.Cough is a common and significant symptom in sarcoidosis, reducing quality of life.Objective 24 h cough monitoring proved that sarcoidosis patients have significantly higher cough frequency compared to controls and their cough has diurnal variation, it is gender-specific and shows racial differences. It correlates with th...
Source: Respiratory Physiology and Neurobiology - January 5, 2018 Category: Respiratory Medicine Source Type: research

Th17-lineage cells in pulmonary sarcoidosis and L öfgren's syndrome: Friend or foe?
Th17-lineage cells in pulmonary sarcoidosis and Löfgren's syndrome: Friend or foe? J Autoimmun. 2018 Jan 05;: Authors: Miedema JR, Kaiser Y, Broos CE, Wijsenbeek MS, Grunewald J, Kool M Abstract Sarcoidosis, a multisystem granulomatous disorder, has historically been classified as Th1-driven disease. However, increasing data demonstrate a key role of Th17-cell plasticity in granuloma formation and maintenance. In Löfgren's syndrome (LS), an acute and distinct phenotype of sarcoidosis with a favorable outcome, differences in Th17-lineage cell subsets, cytokine expression and T-cell suppressive mechan...
Source: Journal of Autoimmunity - January 5, 2018 Category: Allergy & Immunology Authors: Miedema JR, Kaiser Y, Broos CE, Wijsenbeek MS, Grunewald J, Kool M Tags: J Autoimmun Source Type: research

Isolated cardiac sarcoidosis - A rare disease entity?
Sarcoidosis is appreciated as a multisystem autoimmune disease with infiltrating non-caseating granuloma that predominantly affects the perihilar-mediastinal lymph nodes and the lungs [1,2]. The prevalence of sarcoidosis is contingent upon ethnicity, gender, and location [2]. Sarcoidosis prevalence may be as variable as from 3 to 10 per 100,000 for Caucasians (highest in Scandinavians), to 35 –80 per 100,000 African American [2]. The prevalence of cardiac sarcoidosis (CS) involvement in systemic disease manifestation in clinic-pathological studies has been reported between 20 and 27% in the United States population and a...
Source: International Journal of Cardiology - January 4, 2018 Category: Cardiology Authors: Thomas H. Schindler, Ines Valenta Tags: Editorial Source Type: research

How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body 18F –fluorodeoxyglucose positron emission tomography
Sarcoidosis is a systemic inflammatory disease which can involve nearly any organ. Clinically manifest cardiac involvement occurs in perhaps 5% of patients with sarcoidosis. The reported prevalence of isolated cardiac sarcoidosis (CS) varies widely with reported rates of 27 –54%. The explanation for this variability is likely multi-factorial but perhaps mostly related to the diagnostic method(s) for assessing extra-cardiac involvement. The primary aim of this study was to assess the rate of isolated CS in a homogeneous, prospectively recruited cohort of patients with clinically manifest CS, using whole body FDG PET-CT im...
Source: International Journal of Cardiology - January 4, 2018 Category: Cardiology Authors: Daniel Juneau, Pablo Nery, Juan Russo, Robert A. de Kemp, Eugene Leung, Rob S.B. Beanlands, David H. Birnie Source Type: research

Pembrolizumab-Related Sarcoid-Like Reaction Presenting as Reactivation of Quiescent Scars.
PMID: 29300520 [PubMed - as supplied by publisher]
Source: JOP - January 4, 2018 Category: Gastroenterology Authors: McKenna MC, Molloy K, Crowther S, Feeney J, Gillis A, Connolly M, Kelleher F Tags: J Oncol Pract Source Type: research

Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis: a case report
Publication date: Available online 4 January 2018 Source:Saudi Journal of Ophthalmology Author(s): Daniele Cirone, Luca Cimino, Giovanni Spinucci Sarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging. We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations. A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous anterior uve...
Source: Saudi Journal of Ophthalmology - January 4, 2018 Category: Opthalmology Source Type: research

Diplopia, Proptosis, and Joint Pain: Possibility of Osseous and Orbital Sarcoidosis.
Authors: Kohli R, Siva C PMID: 29292316 [PubMed - in process]
Source: Journal of Rheumatology - January 3, 2018 Category: Rheumatology Tags: J Rheumatol Source Type: research

Sarcoidosis: a review for the internist
AbstractSarcoidosis is a systemic granulomatous lung disease of unknown origin affecting people of any age, mainly young adults. The disease is extremely heterogeneous with an unpredictable clinical course. Different phenotypes have been identified: an acute syndrome can be distinguished from subacute and chronic variants. About 20% of patients are chronically progressive and may develop lung fibrosis. Sarcoidosis usually involves the lungs and thoracic lymph nodes, although the skin, eyes, bones, liver, spleen, heart, upper respiratory tract and nervous system can also be affected. No reliable indicators of clinical outco...
Source: Internal and Emergency Medicine - January 3, 2018 Category: Emergency Medicine Source Type: research

Rare presentation of sarcoidosis: Multimodal imaging diagnosis of cardiac involvement
We report a case of sarcoidosis with an unusual presentation, initially manifesting as bilateral pulmonary embolism and then as a cardiac form of the disease with an ominous clinical event consisting of sustained ventricular tachycardia. The diagnosis was established by clinical and magnetic resonance criteria despite normal conventional echocardiographic study. Detailed functional assessment provided by tracking techniques (speckle tracking echocardiography and cardiac magnetic resonance tissue tracking) enabled the detection of regional deformation abnormalities, indicating prominent circumferential strain and epicardial...
Source: Revista Portuguesa de Cardiologia - January 2, 2018 Category: Cardiology Source Type: research

Hypercalcemic pancreatitis a rare presentation of sarcoidosis: A case report
We present a case that presented with 1-day history of vomiting, diffuse abdominal pain, and altered mental status.Diagnoses:Initial investigations showed highly elevated calcium levels, acute pancreatitis, and kidney failure. Possible causes entertained were malignancy, hyperparathyroidism, hypervitaminosis D, and granulomatous diseases. Full work-up including a hilar lymph node biopsy revealed noncaseating granuloma. After excluding other diseases capable of producing a similar picture, a diagnosis of sarcoidosis was made.Interventions and outcomes:The patient was started on aggressive intravenous fluid hydration and int...
Source: Medicine - January 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Predictors of Successful Yield of Transbronchial Lung Biopsy in Patients With Sarcoidosis
Conclusions: TBLB is a reasonably safe procedure with a good diagnostic yield. The present study did not identify any predictors associated with successful diagnostic yield of TBLB in sarcoidosis.
Source: Journal of Bronchology and Interventional Pulmonology - January 1, 2018 Category: Respiratory Medicine Tags: Original Investigations Source Type: research

Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis
Conclusions CMR/PET imaging holds major promise for the diagnosis of aCS, providing incremental information about both the pattern of injury and disease activity in a single scan. (In Vivo Molecular Imaging [MRI] of Atherothrombotic Lesions; NCT01418313)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - January 1, 2018 Category: Radiology Authors: Dweck, M. R., Abgral, R., Trivieri, M. G., Robson, P. M., Karakatsanis, N., Mani, V., Palmisano, A., Miller, M. A., Lala, A., Chang, H. L., Sanz, J., Contreras, J., Narula, J., Fuster, V., Padilla, M., Fayad, Z. A., Kovacic, J. C. Tags: Original Research Source Type: research

Biomarkers in Sarcoidosis: Can microRNAs Fill the Gap?
PMID: 29286860 [PubMed - in process]
Source: American Journal of Respiratory Cell and Molecular Biology - December 30, 2017 Category: Molecular Biology Authors: Bonham CA Tags: Am J Respir Cell Mol Biol Source Type: research

Primary cavitary sarcoidosis: A case report, systematic review, and proposal of new diagnostic criteria
In this report, we present a case of a 47-year-old male patient with PCS who was initially treated as pulmonary tuberculosis. We also systematically review the literature on PCS and propose a new classification for this entity.
Source: Lung India - December 29, 2017 Category: Respiratory Medicine Authors: Ajay Handa Sahajal Dhooria Inderpaul Singh Sehgal Ritesh Agarwal Source Type: research

Sarcoidosis post-anti-PD-1 therapy, mimicking relapse of metastatic melanoma in a patient undergoing complete remission.
We report a patient developing pulmonary and cutaneous sarcoidosis after pembrolizumab therapy while complete regression of stage IV melanoma was perceived. Coincident development of sarcoidosis and metastatic melanoma as illustrated by this case report poses a diagnostic challenge because, in contrast to other irAEs, both diseases share common features such as pulmonary lesions, hilar adenopathies and skin nodules. Considering sarcoidosis as a potential side-effect of pembrolizumab treatment is crucial to avoid misdiagnosis with malignant lesions, hence careful description and reporting of such cases is primordial for pat...
Source: Revue de Medecine Interne - December 28, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Primary Cavitary Sarcoidosis: A Diagnostic Challenge for the Clinician.
PMID: 29290456 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - December 28, 2017 Category: Respiratory Medicine Authors: Sajawal Ali M, Ciftci Olsen F, Franco R Tags: Arch Bronconeumol Source Type: research

Predictors of Successful Yield of Transbronchial Lung Biopsy in Patients With Sarcoidosis
Conclusions: TBLB is a reasonably safe procedure with a good diagnostic yield. The present study did not identify any predictors associated with successful diagnostic yield of TBLB in sarcoidosis.
Source: Journal of Bronchology and Interventional Pulmonology - December 26, 2017 Category: Respiratory Medicine Tags: Original Investigations Source Type: research

Splenic sarcoidosis diagnosed by US-guided biopsy: About a case.
CONCLUSION: Diagnosis of splenic nodular sarcoidosis can be challenging without any other localization. Splenic biopsy achieved diagnosis. This procedure is associated with a low risk of complications - in particular hemorragic ones. Diagnostic splenectomy should be an exceptional intervention. PMID: 29274795 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - December 25, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Sarcoidosis presenting with acute dacryoadenitis.
We report a case of the disease that presented with acute dacryoadenitis followed by acute parotitis. PMID: 29257721 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - December 20, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Pulmonary Sarcoidosis in a patient with Multiple Sclerosis on Daclizumab monotherapy
Publication date: Available online 18 December 2017 Source:Multiple Sclerosis and Related Disorders Author(s): Elijah Edward Rhone, Peter Siu Pan Cho, Surinder S. Birring, James Galloway, Eli Silber As new immunomodulatory therapies continue to be licensed for use in Multiple Sclerosis, it is important to remain vigilant for new, unexpected associations relating to these medications. We highlight this by reporting on a case of a 45-year-old man who developed systemic, non-specific symptoms following long term use of daclizumab and was subsequently diagnosed with sarcoidosis. We go on to briefly discuss the action of dacli...
Source: Multiple Sclerosis and Related Disorders - December 18, 2017 Category: Neurology Source Type: research

Recalcitrant Diffuse Cutaneous Sarcoidosis With Perianal Involvement Responding to Adalimumab.
Authors: Cohen GF, Wolfe CM Abstract <p>Recalcitrant cutaneous sarcoidosis with perianal involvement is rare. To our knowledge we present the first documented case of cutaneous sarcoidosis with perianal involvement successfully treated with adalimumab.</p> <p><em>J Drugs Dermatol. 2017;16(12):1305-1306.</em></p>. PMID: 29240869 [PubMed - in process]
Source: Journal of Drugs in Dermatology - December 15, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis.
Authors: Hawkins C, Shaginurova G, Shelton DA, Herazo-Maya JD, Oswald-Richter KA, Rotsinger JE, Young A, Celada LJ, Kaminski N, Sevin C, Drake WP Abstract Investigation of the Th1 immune response in sarcoidosis CD4+ T cells has revealed reduced proliferative capacity and cytokine expression upon TCR stimulation. In other disease models, such cellular dysfunction has been associated with a step-wise, progressive loss of T cell function that results from chronic antigenic stimulation. T cell exhaustion is defined by decreased cytokine production upon TCR activation, decreased proliferation, increased expression of in...
Source: Journal of Immunology Research - December 15, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Light and Laser Modalities in the Treatment of Cutaneous Sarcoidosis: A Systematic Review.
PMID: 29242948 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - December 15, 2017 Category: Dermatology Authors: Lima AL, Goetze S, Illing T, Elsner P Tags: Acta Derm Venereol Source Type: research

Steroids for sarcoidosis: How much and for how long?
Most clinicians agree that corticosteroids are the first choice for treatment for symptomatic pulmonary sarcoidosis [1,2]. Prednisone is one of the most commonly used corticosteroids, with the usual initial dose being 20 –40 mg daily [3,4]. However, the specific dose and rationale for such a dose is unclear. Early studies of corticosteroids were associated with quite variable doses and duration of therapy. In some studies, 60 mg for one month and then slowly tapered for more than a year [5] while others gave 15 mg for three months total [6].
Source: Respiratory Medicine - December 15, 2017 Category: Respiratory Medicine Authors: Robert P. Baughman, Elyse E. Lower Tags: Editorial Source Type: research

To progress understanding of disease triggers and modifiers in sarcoidosis, stratification is the key
The vast majority of sarcoidosis literature starts with something similar to the following sentence "Sarcoidosis is a multi-system granulomatous disease of unknown aetiology predominantly affecting the lung". The unknown cause continues to inspire researchers to search for a possible trigger, especially if new and high-throughput methods are at their disposal. The histological hallmark of sarcoidosis is epithelioid cell granuloma. Formation of granuloma is a common reaction towards, for example, bacterial agents. Evidence for bacterial involvement in sarcoidosis consist of presence of bacterial peptides inside lung granulo...
Source: European Respiratory Journal - December 14, 2017 Category: Respiratory Medicine Authors: van Moorsel, C. H. M. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Isolated Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Ventricular Cardiomyopathy.
Authors: Waki H, Eguchi K, Toriumi S, Ikemoto T, Suzuki T, Fukushima N, Kario K Abstract The diagnosis of cardiac sarcoidosis (CS) has become easier due to advances in imaging modalities, but we sometimes encounter difficult-to-diagnose patients. We herein report the case of a 60-year-old Japanese woman who was diagnosed with isolated CS, although she also met the diagnostic criteria of arrhythmogenic right ventricular cardiomyopathy (ARVC). A histological examination by an endomyocardial biopsy of the right ventricle revealed the typical findings of granulomatous change for CS. Although she did not show any charac...
Source: Internal Medicine - December 13, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Dilemma of diagnosing thoracic sarcoidosis in tuberculosis endemic regions: An imaging-based approach. Part 1
Ashu S Bhalla, A Das, P Naranje, A Goyal, R Guleria, Gopi C KhilnaniIndian Journal of Radiology and Imaging 2017 27(4):369-379 Sarcoidosis is a multi-systemic disorder of unknown etiology, although commonly believed to be immune-mediated. Histologically, it is characterized by noncaseating granuloma which contrasts against the caseating granuloma seen in tuberculosis (TB), an infectious disease that closely mimics sarcoidosis, both clinically as well as radiologically. In TB-endemic regions, the overlapping clinico-radiological manifestations create significant diagnostic dilemma, especially since the management options a...
Source: Indian Journal of Radiology and Imaging - December 13, 2017 Category: Radiology Authors: Ashu S Bhalla A Das P Naranje A Goyal R Guleria Gopi C Khilnani Source Type: research

Dilemma of diagnosing thoracic sarcoidosis in tuberculosis-endemic regions: An imaging-based approach. Part 2
Ashu S Bhalla, A Das, P Naranje, A Goyal, R Guleria, Gopi C KhilnaniIndian Journal of Radiology and Imaging 2017 27(4):380-388 The second part of the review discusses the role of different existing imaging modalities in the evaluation of thoracic sarcoidosis, including chest radiograph, computed tomography, magnetic resonance imaging, endobronchial ultrasound, and positron emission tomography. While summarizing the advantages and pitfalls of each imaging modality, the authors propose imaging recommendations and an algorithm to be followed in the evaluation of clinically suspected case of sarcoidosis in tuberculosis-endemic regions.
Source: Indian Journal of Radiology and Imaging - December 13, 2017 Category: Radiology Authors: Ashu S Bhalla A Das P Naranje A Goyal R Guleria Gopi C Khilnani Source Type: research

The Burden of Comorbidity and Complexity in Sarcoidosis: Impact of Associated Chronic Diseases
ConclusionWe found higher rates of comorbidity and complexity in patients with sarcoidosis compared with a control group. Liver, pulmonary, autoimmune and neoplastic diseases were the main comorbidities found in patients with sarcoidosis.
Source: Lung - December 11, 2017 Category: Respiratory Medicine Source Type: research

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis
ConclusionThis study identifies defective TLR3 function as a previously unidentified factor in persistent clinical disease in pulmonary sarcoidosis and revealsTLR3 L412F as a candidate biomarker.
Source: QJM - December 11, 2017 Category: Internal Medicine Source Type: research

The pathogenesis of pulmonary sarcoidosis and implications for treatment.
Abstract Thoracic sarcoidosis is the most common form of sarcoidosis, encompassing a heterogeneous group of patients with a wide range of clinical features and associated outcomes. The distinction between isolated thoracic lymphadenopathy and pulmonary involvement matters. Morbidity is often higher, and long-term outcomes are worse for the latter. While inflammatory infiltrates in pulmonary sarcoidosis may resolve, persistent disease activity is common and can result in lung fibrosis. Given the distinct clinical features and natural history of pulmonary sarcoidosis, its pathogenesis may differ in important ways fr...
Source: Chest - December 7, 2017 Category: Respiratory Medicine Authors: Patterson KC, Chen ES Tags: Chest Source Type: research

Insights from RNA-sequencing of bronchoalveolar lavage cells in a large sarcoidosis cohort
Conclusion: RNA-sequencing of BAL in sarcoidosis patients identified novel genes associated with features of disease. Preliminary analysis suggests the presence of molecular disease endotypes.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Vukmirovic, M., Yan, X., Gibson, K. F., Gulati, M., DeIuliis, G., Woolard, T., Adams, T., Hu, B., Zang, W., Mihaljinec, A., Luijk, H. D., Aurelien, N., O'Neal, S. M., Becich, M. J., Hochheiser, H., Herzog, E. L., Senior, R. M., Chen, E. S., Morris, A. M., Tags: Molecular Pathology and Functional Genomics Source Type: research

Muscle strength training; does number of repetitions affect fatigue in sarcoidosis patients?
Conclusion: Many repetitions increase fatigue significantly from baseline to end exercise and remains after 24 hours. However, muscle strength training in patients with sarcoidosis induce only a slight change in fatigue, both after 5RM and 25RM.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Grongstad, A., Kopke Vollestad, N., Oldervoll, L., Spruit, M., Edvardsen, A. Tags: Physiotherapists Source Type: research

Severe sarcoidosis: a comparative study
Conclusion: Severe forms of sarcoidosis must be recognized because of their unfavorable outcome.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Fessi, R., Zaibi, H., Ben Amar, J., Maazaoui, S., Ali Baccar, M., Azzabi, S., Ourari, B., Aouina, H. Tags: Clinical Problems Others Source Type: research

Sarcoidosis mortality in Sweden: a population-based cohort study
Conclusions: Compared to the general population, individuals with sarcoidosis have a greater risk for death and are more likely to die prematurely. This shows sarcoidosis is not always a self-resolving disease and may cause severe long-term consequences.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Rossides, M., Kullberg, S., Askling, J., Eklund, A., Grunewald, J., Arkema, E. Tags: Epidemiology Source Type: research

First steps at implementing value based healthcare internationally in sarcoidosis: comparing outcomes
Conclusions: Collecting outcomes in pulmonary sarcoidosis internationally is feasible. The use of a standardized outcome indicator set will enable international comparison. Differences in outcomes could facilitate improvements in quality of care for pulmonary sarcoidosis.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kampstra, N., van der Wees, P. J., Van der Nat, P. B., van Beek, F., van Moorsel, C. H., Baughman, R. P., Culver, D. C., Renzoni, E. A., Kouranos, V., Wuyts, W., Wijsenbeek, M. S., Zanen, P., Grutters, J. C. Tags: Epidemiology Source Type: research

Comparing outcomes internationally in pulmonary sarcoidosis: PFT change by scadding stage
Conclusions: In our multicenter cohort we detected differences in baseline FVC %predicted between Scadding stages. Remarkably, both FVC, FEV1 and DLCOc improvement was established in all stages.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kampstra, N., van der Wees, P. J., van der Nat, P. B., van Beek, F., van Moorsel, C. H., Baughman, R. P., Culver, D. C., Renzoni, E. A., Kouranos, V., Wuyts, W., Wijsenbeek, M. S., Zanen, P., Grutters, J. C. Tags: Epidemiology Source Type: research

Sarcoidosis in Israel: Clinical outcome status, organ involvement and long term follow up
This study reviewed the clinical outcome status (COS) and organ involvement of Israeli sarcoidosis patients during a five year period. Then, we compared our results to the WASOG COS and the ACCESS instruments in order to evaluate their relevance to the Israeli population.Methods: The retrospective study group consisted of 166 patients from 2010 to 2015. All patients with clinical presentation of sarcoidosis were included. Data on demographic characteristics, presenting symptoms, co-morbidities, disease duration, lung function tests, treatment program, chest X-ray and chest high resolution computed tomography (HRCT) were co...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Markavych, N., Epstein Shochet, G., Shitrit, D., Israeli-Shani, L. Tags: Epidemiology Source Type: research

Sarcoidosis in South Croatia, 30-year follow up
Conclusion: The incidence in the wider district of Split-Dalmatian county is low (3.1-3.4), the most common form is the stage II endothoracal sarcoidosis. Patients live a number of years without any significant complications. Mortality is low, 1.56%, which is directly associated with S.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Skopljanac, I., Mise, K., Segrt, I., Ilak, D. Tags: Epidemiology Source Type: research

A genetic landscape of familial predisposition to sarcoidosis identified by whole exome sequencing
Conclusion: This extensive WES analysis of SARC families suggests combined and synergistic mechanisms acting for granuloma formation and SARC occurrence.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Calender, A., Pacheco, Y., Rollat Farnier, P., Bardel, C., Seve, P., Devouassoux, G., Cottin, V., Bentaher, A., Bernaudin, J., Bouvry, D., Israel Biet, D., Nunes, H., Valeyre, D., Nathan, N. Tags: Diffuse Parenchymal Lung Disease Source Type: research

The evaluation of serum biomarkers in patients with sarcoidosis: Can visfatin be a new biomarker for sarcoidosis?
There is no known biomarker for follow-up of patients with sarcoidosis. Visfatin is a proinflammatory adipokine which has been studied for several inflammatory diseases such as diabetes mellitus, obesity and metabolic syndrome. Our aim was to evaluate visfatin together with inflammatory biomarkers like serum ACE, sedimentation and CRP.59 patients with sarcoidosis were included in our study. Serum concentrations of visfatin were analyzed by ELISA. Patients were divided into those with and without parenchymal involvement. Serum ACE levels and ESR were significantly higher in patients with pulmonary involvement. There was no ...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Tanrıverdi, E., Iliaz, S., Cörtük, M., Turan, D., Ugur Chousein, E. G., Gül, S., Özgül, M. A., Cetinkaya, E. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Does endurance exercise intensity affect fatigue in sarcoidosis patients?
Conclusion: Both high and moderate exercise intensity induced only a slight increase in fatigue. A significantly increased fatigue was only seen at high intensity 24 hours post exercise.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Grongstad, A., Kopke Vollestad, N., Spruit, M., Edvardsen, A., Oldervoll, L. Tags: Physiotherapists Source Type: research

Physical activity in patients with sarcoidosis
Conclusion: While exercise capacity and quality of life measurements were robust predictors of physical activity in patients with sarcoidosis, associations of objectively measured physical activity with fatigue were surprisingly weak. In sarcoidosis, fatigue might not preclude affected patients from being physically active, although this symptom is subjectively perceived as highly disabling.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Bahmer, T., Watz, H., Develaska, M., Waschki, B., Rabe, K. F., Magnussen, H., Kirsten, D., Kirsten, A.-M. Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Late Breaking Abstract - Promising results of the infliximab biosimilar Inflectra(R) in severe sarcoidosis patients
Conclusion: The infliximab biosimilar Inflectra® seems well tolerated and effective in the treatment of refractory sarcoidosis.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Schimmelpennink, M. C., Vorselaars, A. D. M., Van Beek, F. T., Crommelin, H. C., Keijsers, R. G. M., Veltkamp, M. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Safety of corticosteroid therapy in patients with pulmonary sarcoidosis
Conclusion: The need of alternative immunosuppressive therapy in sarcoidosis patients with lung parenchymal lesions is about 32,4 %. The study data indicate the necessity of development of new effective and safe immunosuppressive therapy in pulmonary sarcoidosis patients.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Merenkova, I., Dziublyk, Y. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Malondialdehyde and nitrotyrosine as markers of peroxynitrite activity in sarcoidosis
Sarcoidosis (SA) is granulomatous disease with unknown etiology. Infectious factors, genetics and autoimmunity are considered in the etiopathogenesis of SA. In contrast to tuberculosis (TB), we evidenced decreased clearance of immune complexes with mycobacterial heat shock proteins by resistant to apoptosis monocytes with diminished serum microbicidal/degradable nitrate/nitrite and increased concentration of peroxynitrite (ONOO-) in SA. ONOO- reacts with a variety of lipids and proteins initiating peroxidation process with subsequent oxidative tissue injury. Malondialdehyde (MDA) and nitrotyrosine (NT) are the final produc...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Dubaniewicz, A., Skotarczak, M., Romanowicz, G., Słominski, J. M., Kalinowski, L. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Timing of cardiac sarcoidosis in patients with sarcoidosis>
Conclusion: Our pilot study suggests that cardiac involvement in sarcoidosis usually occurs in the early phase of disease and the risk decreases over time. Therefore, we recommend that screening for cardiac sarcoidosis should be a part of the initial evaluation of every patient with sarcoidosis.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Schweitzer, M., Salamo, O., Pardinas Gutierrez, M., Asharhan, L., Campos, M., Mirsaeidi, M., Calderon-Candelario, R. Tags: Clinical Problems Others Source Type: research

Increased risk of sarcoidosis among breast cancer patients; Breast cancer - sarcoidosis syndrome
Conclusion: Our pilot study suggests that sarcoidosis may occur after recent cancer episode, particularly breast cancer. Our finding should be validated in a large dataset.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Schweitzer, M., Salamo, O., Mirsaeidi, M., Holt, G., Donna, E., Pardinas Gutierrez, M., Asharhan, L. Tags: Clinical Problems Others Source Type: research