This page shows you the latest news items in this category. This is page number 4.
Total 4939 results found since Jan 2013.
Vimentin as antigenic target in autoimmunity: A comprehensive review
Publication date: Available online 17 July 2018Source: Autoimmunity ReviewsAuthor(s): Aram Musaelyan, Sergey Lapin, Vladimir Nazarov, Olga Tkachenko, Boris Gilburd, Alexandra Mazing, Lilia Mikhailova, Yehuda ShoenfeldAbstractVimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lu...
Source: Autoimmunity Reviews - July 18, 2018 Category: Allergy & Immunology Source Type: research
Autoimmune and Paraneoplastic Myelopathies
Semin Neurol 2018; 38: 278-289 DOI: 10.1055/s-0038-1660856Prompt recognition of an inflammatory myelopathy is critical, as a specific diagnosis and management plan allows for optimal patient outcomes. Many treatment options are now available for autoimmune and paraneoplastic myelopathies, but specific management strategies and expected prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information that can help achieve a specific myelopathy diagnosis and treatment plan is essential for all neurologists, given the variety of c...
Source: Seminars in Neurology - July 16, 2018 Category: Neurology Authors: Zalewski, Nicholas L. Flanagan, Eoin P. Tags: Review Article Source Type: research
Peptide receptor radionuclide therapy as a new tool in treatment-refractory sarcoidosis - initial experience in two patients
Conclusion: Peptide receptor radionuclide therapy in sarcoidosis is feasible and might be a new valuable tool in patients with otherwise treatment-refractory disease. Given the long experience with and good tolerability of PRRT, further evaluation of this new treatment option for otherwise treatment-refractory sarcoidosis in larger patient cohorts is warranted.
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Constantin Lapa, Malte Kircher, Heribert H ä nscheid, Andreas Schirbel, G ö tz Ulrich Grigoleit, Erdwine Klinker, Markus B ö ck, Samuel Samnick, Theo Pelzer, Andreas K Buck Tags: Research Paper Source Type: research
Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis
Conditions: Sarcoidosis; Cardiomyopathies Interventions: Diagnostic Test: 18F-FDG-PET/MRI; Diagnostic Test: 18F-GE180-PET/MRI Sponsors: St. Olavs Hospital; Norwegian University of Science and Technology; University Hospital, Essen Not yet recruiting
Source: ClinicalTrials.gov - June 19, 2018 Category: Research Source Type: clinical trials
Sarcoidosis of the central nervous system: clinical features, imaging, and CSF results
ConclusionsThis prospective study of neurosarcoidosis increases our understanding of the pathophysiology of the disease. A reclassification of the clinical and imaging features of the disease allows an understanding of its pathophysiology and correlation with CSF indices allows an early identification of those with a more destructive disease will help to define treatment and may thereby improve outcome.
Source: Journal of Neurology - June 19, 2018 Category: Neurology Source Type: research
Atypical Cutaneous Presentations of Sarcoidosis: Two Case Reports and Review of the Literature
AbstractPurpose of ReviewThe goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin.Recent FindingsWhile the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised distri...
Source: Current Allergy and Asthma Reports - June 14, 2018 Category: Allergy & Immunology Source Type: research
Treatment of Sarcoidosis: Grading the evidence.
Authors: James WE, Baughman R Abstract INTRODUCTION: Treatment of sarcoidosis recommendations are often based on clinical experience and expert opinion. However, there are an increasing number of studies which are providing evidence to support decisions regarding treatment. Areas Covered: Several studies have identified factors associated with increased risk for organ failure or death ("danger"). There have been several studies focused on the role of treatment to improve quality of life for the patient. Sarcoidosis treatment often follows a progression, based on response. Corticosteroids remain the initial treatmen...
Source: Expert Review of Clinical Pharmacology - June 9, 2018 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis
Condition: Cardiac Sarcoidosis Interventions: Drug: 68Ga-DOTATATE PET/CT; Drug: 18FDG PET/CT scan; Drug: 13NH3 PET/CT scan Sponsor: Mayo Clinic Not yet recruiting
Source: ClinicalTrials.gov - June 8, 2018 Category: Research Source Type: clinical trials
Respiratory muscle involvement in sarcoidosis.
Authors: Schreiber T, Windisch W Abstract INTRODUCTION: In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced inspiratory muscle strength and/or a reduced diaphragm function may contribute to exertional dyspnea, fatigue and reduced health-related quality of life. Previous studies using volitional and non-volitional tests demonstrated a reduced inspiratory muscle strength in sarcoidosis compared to control subjects, and also showed that respiratory muscle function may even...
Source: Expert Review of Respiratory Medicine - June 1, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Robotic-Assisted Splenectomy for Massive Splenomegaly Secondary to Sarcoidosis.
PMID: 29981591 [PubMed - in process]
Source: The American Surgeon - June 1, 2018 Category: Surgery Authors: Parsi S, Siripurapu V Tags: Am Surg Source Type: research
Importance of Early Diagnosis of Cardiac Sarcoidosis in Patients with Complete Atrioventricular Block.
Authors: Kaida T, Inomata T, Minami Y, Yazaki M, Fujita T, Iida Y, Ikeda Y, Nabeta T, Ishii S, Naruke T, Maekawa E, Koitabashi T, Ako J Abstract Our aim is to clarify the factors for early diagnosis of cardiac sarcoidosis (CS) in patients with complete atrioventricular block (CAVB) and its impact on cardiac function after corticosteroid therapy.A total of 15 CS patients with CAVB who underwent corticosteroid therapy were retrospectively analyzed. Patients were divided into two groups according to the time from the first CAVB onset to the diagnosis of CS. Clinical characteristics and outcomes were compared between t...
Source: International Heart Journal - May 30, 2018 Category: Cardiology Tags: Int Heart J Source Type: research
A Sarcoidosis Clinician's Perspective of MHC Functional Elements Outside the Antigen Binding Site.
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. This manuscript provides a brief clinical description of sarcoidosis, and a clinician's perspective of the immunopathogenesis of sarcoidosis in terms of the MHC binding site, MHC functional elements beyond the binding site, and other possible alternative mechanisms. Input from cl...
Source: Human Immunology - May 30, 2018 Category: Allergy & Immunology Authors: Judson MA Tags: Hum Immunol Source Type: research
Prognostic significance of ventricular late potentials in patients with pulmonary sarcoidosis
Early detection of cardiac involvement in sarcoidosis is difficult but essential to achieve optimal treatment. Signal-averaged electrocardiography (SAECG) can detect subtle cardiac electrical abnormalities termed late potentials (LPs) and would be useful for the early diagnosis of cardiac involvement.
Source: Heart Rhythm - May 29, 2018 Category: Cardiology Authors: Kenji Yodogawa, Yoshihiko Seino, Toshihiko Ohara, Yu-ki Iwasaki, Meiso Hayashi, Yasushi Miyauchi, Arata Azuma, Wataru Shimizu Tags: Featured Article Source Type: research
Three Cases of Scalp Sarcoidosis with Alopecia.
PMID: 29857946 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - May 29, 2018 Category: Dermatology Authors: Ishikawa M, Ohtsuka M, Yamamoto T Tags: Actas Dermosifiliogr Source Type: research
Unusual presentation of a skull base mass lesion in sarcoidosis mimicking malignant neoplasm: a case report
Sarcoidosis is a multi-organ disease of unknown etiology characterised by the presence of epithelioid granulomas, without caseous necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis i...
Source: BMC Neurology - May 29, 2018 Category: Neurology Authors: Katsunori Shijo, Nobuhiro Moro, Mari Sasano, Mitsuru Watanabe, Hiroshi Yagasaki, Shori Takahashi, Taku Homma and Atsuo Yoshino Tags: Case report Source Type: research
IJERPH, Vol. 15, Pages 1077: Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis
This study aimed to determine if short-term exposure to particulate matter (PM2.5) and ozone (O3) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM2.5 and O3 estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline &gt; 10%) and questionnaire outcomes (Leicester cough quest...
Source: International Journal of Environmental Research and Public Health - May 26, 2018 Category: Environmental Health Authors: Cheryl S. Pirozzi Daniel L. Mendoza Yizhe Xu Yue Zhang Mary Beth Scholand Robert P. Baughman Tags: Article Source Type: research
Importance of differential diagnosis post-treatment of adenocarcinoma of the uterine cervix: a case report of sarcoidosis.
This study shows the importance of differential diagnosis during the oncologic monitoring of cervical cancer patients to avoid unnecessary treatments at the expense of better therapeutic options. PMID: 29787017 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea.
Conclusions: In patients with biopsy-proven pulmonary sarcoidosis, the presence of ocular involvement and uveitis as a first sign could be significant factors associated with higher systemic treatment rate, especially with immunosuppressive agents. Biopsy site determined by location and size had no influence on clinical features. PMID: 29785303 [PubMed]
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research
Quantification of global FDG uptake as a novel imaging modality to assess Sarcoidosis in the diseased organs and the entire body
Conclusions: Currently, FDG-PET is not used as a first-line imaging modality in sarcoidosis, as it is considered to be of value for advanced and relapsing stages of the disease. However, having a score that allows assessment of global disease activity in the body will provide potential for expanding the clinical utility of FDG-PET to evaluate disease behavior, treatment response and disease relapse at any stage of this common inflammatory disorder.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Al-zaghal, A., Jahangiri, P., Pournazari, K., Khosravi, M., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research
Novel approach of FDG PET for diagnosing of cardiac sarcoidosis -application possibility of the texture analysis-
Conclusions: Our findings revealed that the texture analysis could apply for the diagnosis of CS with high inter-operator and inter-scan reproducibility. Reference: Ref1 Manabe O, Kroenke M, Aikawa T, Murayama A, Naya M, Masuda A, Oyama-Manabe N, Hirata K, Watanabe S, Shiga T, Katoh C, Tamaki N. J Nucl Cardiol. 2017 Dec 14. doi: 10.1007/s12350-017-1122-6. Ref2 Orlhac F, Soussan M, Maisonobe JA, Garcia CA, Vanderlinden B, Buvat I. Tumor texture analysis in 18F-FDG PET: relationships between texture parameters, histogram indices, standardized uptake values, metabolic volumes, and total lesion glycolysis. J Nucl Med 2014;55:414-22.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Manabe, O., Hirata, K., Ohira, H., Tsujino, I., Naya, M., Aikawa, T., Oyama-Manabe, N., Tamaki, N. Tags: Cardiovascular Basic Science Poster Session Source Type: research
18F-FDG PET-CT in the clinical management of cardiac sarcoidosis: A regional academic referral center experience.
Conclusion 18F-FDG PET-CT is an effective tool in the clinical management of CS, including its initial diagnosis and assessment following therapy. Although not statistically significant, patients treated for a longer duration were more likely to respond to the therapy. Additionally, dual immunomodulator therapy with prednisone and methotrexate may improve therapeutic response in CS. Figure 1. F-18 FDG PET-CT MIP and axial fused PET-CT images showing (A) focal on diffuse hypermetabolic activity in the left ventricular myocardium consistent with cardiac sarcoidosis, and (B) resolution of the myocardial activity following imm...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Rieter, W., Burchett, P., De Cecco, C., James, W., Hargrave, P., Nance, J., Gordon, L. Tags: Cardiovascular Clinical Science Poster Session Source Type: research
Exploring the optimal reference to estimate the effect of anti-inflammatory therapy for the cardiac sarcoidosis -metabolic volume assessment of FDG PET-
Conclusions: We measured the FDG uptake in the liver and blood pool before and during steroid therapy. Steroid therapy might be increase the liver FDG uptake because of its effect on glyceroneogenesis in the liver and adipose tissue. However, the blood pool uptake didn’t show significant differences. Our findings revealed that the DA is suitable threshold rather than liver uptake to evaluate the therapy effect using volume-based analysis of cardiac FDG PET.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Furuya, S., Hirata, K., Manabe, O., Hiroshi, O., Naya, M., Aikawa, T., Koyanagawa, K., Tsujino, I., Shiga, T., Kudo, K. Tags: Cardiovascular Clinical Science Poster Session Source Type: research
Low downstream event rate in patients without clinical cardiac sarcoidosis referred for cardiac FDG-PET imaging
Conclusion: In patients not meeting clinical criteria for CS and without extra-cardiac sarcoidosis, the overall event rate was similar between patients with and without abnormal FDG uptake. The overall low event rate suggests a potential lack of clinical utility in obtaining FDG PET imaging for all patients with non-ischemic cardiomyopathy to evaluate for CS. Future investigations are needed to determine if FDG PET imaging may be better targeted to certain subgroups of patients with non-ischemic cardiomyopathy.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Varghese, M., Miller, E. Tags: Cardiovascular Clinical Science Poster Session Source Type: research
FDG-PET/CT performances to detect systemic sarcoidosis in patients from a general hospital in Europe
Conclusions: Our retrospective study shows that FDG PET/CT examination is a reliable method to detect systemic sarcoidosis (high sensibility, specificity, PPV, NPV and accuracy). However further evaluation of cost effectiveness of this examination, and a more comprehensive understanding on which patients would benefit from this intervention are warranted.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Trabelsi, K., Muteganya, R., Garcia, C. Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research
Tuberculosis and Sarcoidosis Imaging in 18F-FDG-PET/CT: Consistencies and Inconsistencies
Conclusions: Apart from the common capability of showing anatomic spread of disease in the whole body in one single examination for both TB and SC, in TB 18F-FDG seems to be a good predictor for the extent of disease by assessment of the highest SUV seen in any pathological lesion and for therapy control, too, as indicated in earlier work. In SC, FDG-uptake markedly focuses on lymph nodes, consistent with the natural history of the disease. However, we see uptake behavior clearly different from TB in respect of the prediction of disease extent and some other features. Evaluation of the relevance of these facts for initial ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Huber, H., Lang, D., Fellner, F., Lamprecht, B., Gabriel, M. Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research
Use of deep convolutional neural network-based features for detection of cardiac sarcoidosis from polar map
Conclusions: The classification performance of DCNN-based features outperformed the CoV-based classification performance. Experimental results suggested that DCNN-based high-dimensional features have a potential of semi-automated diagnosis of CS.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Togo, R., Hirata, K., Manabe, O., Ohira, H., Tsujino, I., Ogawa, T., Haseyama, M., Shiga, T. Tags: Deep Learning In Molecular Imaging Studies Source Type: research
Sarcoidosis-Like Granulomatous Reaction Associated With Pembrolizumab Immunotherapy.
PMID: 29801680 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - May 22, 2018 Category: Respiratory Medicine Authors: Gayá García-Manso I, García Ródenas MDM, Barroso Medel ME, Illán Gambín FJ Tags: Arch Bronconeumol Source Type: research
Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses.
CONCLUSION: Our results suggest that sarcoidosis is a new subset in the spectrum of paraneoplastic syndrome. We propose that lymphoproliferative disorders should be considered in patients with cutaneous sarcoidosis who have a poor response to conventional therapy or whose skin biopsy shows a significant number of mitoses. PMID: 29779211 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - May 20, 2018 Category: Cancer & Oncology Authors: El-Khalawany M, Mosbeh A, Aboeldahab S, Ali S Tags: Clin Exp Dermatol Source Type: research