This page shows you the latest news items in this category. This is page number 7.

Total 4716 results found since Jan 2013.

A Contemporary Analysis of Heart Transplantation and Bridge-to-Transplantation Mechanical Circulatory Support Outcomes in Cardiac Sarcoidosis
• Heart transplantation for cardiac sarcoidosis is increasing• Mechanical support as bridge to transplant is an option in cardiac sarcoid• Post-transplant outcomes are favorable in cardiac sarcoid patients
Source: Journal of Cardiac Failure - February 23, 2018 Category: Cardiology Authors: Todd C. Crawford, David R. Okada, J. Trent Magruder, Charles Fraser, Nishant Patel, Brian A. Houston, Glenn J. Whitman, Kaushik Mandal, Kenton J. Zehr, Robert S. Higgins, Edward S. Chen, Hari Tandri, Edward K. Kasper, Ryan J. Tedford, Stuart D. Russell, N Tags: Clinical Investigation Source Type: research

Role of CT Chest and Cytology in Differentiating Tuberculosis from Presumed Sarcoidosis in Uveitis.
CONCLUSIONS: In systemically asymptomatic individuals presenting with uveitis, CT chest helped to establish the diagnosis of TB/sarcoidosis in 71.43% cases (105 out of 147) using only the clinico-radiological criteria, while a confirmed diagnosis of TB/sarcoidosis was possible only in 42 cases (28.57%) by EBUS/TBNA guided cytological examination. PMID: 29420114 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - February 9, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Increased Aqueous Humor CD4+/CD8+ Lymphocyte Ratio in Sarcoid Uveitis.
CONCLUSION: Increased aqueous humor CD4+/CD8+ ratio in sarcoid uveitis. Immunophenotyping of localized lymphocytosis in aqueous humor could be utilized as an additional confirmatory marker for ocular sarcoidosis. PMID: 29420111 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - February 9, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment.
Abstract Sarcoidosis is a systemic disease characterized by noncaseating granulomas and is often a diagnosis of exclusion. The actual prevalence of cardiac sarcoidosis (CS) is unknown, as studies have demonstrated mixed data. CS may be asymptomatic and is likely more frequently encountered than previously thought. Sudden death may often be the presenting feature of CS. Most deaths attributed to CS are caused by arrhythmias or conduction system disease, and congestive heart failure may occur. Current expert consensus on diagnosis of CS continues to rely on endomyocardial biopsy, in the absence of which, histologic ...
Source: The American Journal of the Medical Sciences - February 1, 2018 Category: General Medicine Authors: Yatsynovich Y, Dittoe N, Petrov M, Maroz N Tags: Am J Med Sci Source Type: research

Programmed cell death 1 blockade ‐induced cutaneous sarcoid‐like epithelioid granulomas in advanced melanoma: A case report
This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - January 5, 2018 Category: Dermatology Authors: T. Ogawa, Y. Ishitsuka, K. Iwamoto, H. Koguchi ‐Yoshioka, R. Tanaka, R. Watanabe, Y. Fujisawa, M. Fujimoto Tags: Letter to Editor Source Type: research

Evaluation of QT dispersion and T-peak to T-end interval in patients with early-stage sarcoidosis
Conclusion Our study revealed that QTc dispersion, Tpe and Tpe/QT ratio were greater in sarcoidosis patients compared to the control group. To our knowledge, the present study is the first to use Tpe interval analysis in patients without cardiac involvement in sarcoidosis. Tpe interval and Tpe/QT ratio may be promising markers for cardiovascular morbidity and mortality due to ventricular arrhythmias in patients with and without cardiac involvement in sarcoidosis.
Source: Revista Portuguesa de Cardiologia - January 2, 2018 Category: Cardiology Source Type: research

Atopobium and Fusobacterium as novel candidates for sarcoidosis-associated microbiota
Sarcoidosis is a granulomatous disease that mainly affects the lung. A role of microbial factors in disease pathogenesis is assumed, but has not been investigated systematically in a large cohort. This cross-sectional study compared the lung microbiota of 71 patients with sarcoidosis, 15 patients with idiopathic pulmonary fibrosis (non-infectious controls) and 10 healthy controls (HCs). Next-generation sequencing of 16S DNA was used on bronchoalveolar lavage samples to characterise the microbial composition, which was analysed for diversity and indicator species. Host genotypes for 13 known sarcoidosis risk variants were d...
Source: European Respiratory Journal - December 14, 2017 Category: Respiratory Medicine Authors: Zimmermann, A., Knecht, H., Häsler, R., Zissel, G., Gaede, K. I., Hofmann, S., Nebel, A., Müller-Quernheim, J., Schreiber, S., Fischer, A. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Detrended Fluctuation Analysis independently predicts all-cause mortality of patients with Sarcoidosis
Conclusion: The DFA α1 is a strong and independent predictor of mortality in Sarcoidosis. This study highlights the importance of the non-linear dynamic indices in prognosis in Sarcoid population.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Gialafos, E., Kouranos, V., Papaioannou, T., Manali, E., Kolilekas, L., Tsougkos, E., Gaga, M., Rapti, A., Koulouris, N., Papiris, S., Filippatos, G. Tags: Diffuse Parenchymal Lung Disease Source Type: research

The role of vitamin D receptor BsmI polymorphism in the course of sarcoidosis
Conclusion: Our results showed that the VDR Bsm I B allele might be a protective against sarcoidosis in Serbian patients, while in patients with diagnosed sarcoidosis b allele was related with a mild course of the disease.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Radjenovic Petkovic, T., Pejcic, T., Marinkovic, M., Nastasijevic, D., Stankovic, I., Vrbic, B. Tags: Molecular Pathology and Functional Genomics Source Type: research

Cardiovascular magnetic resonance imaging and clinical performance of somatostatin receptor positron emission tomography in cardiac sarcoidosis
ConclusionsWithin follow‐up, CS persisted in barely half the patients, and the patients were not afflicted with cardiac death. Additional 68Ga‐DOTATOC PET/CT allowed for visualization of acute myocardial inflammation.
Source: ESC Heart Failure - November 1, 2017 Category: Cardiology Authors: Carmen Pizarro, Folke Kluenker, Darius Dabir, Daniel Thomas, Florian C. Gaertner, Markus Essler, Christian Groh é, Georg Nickenig, Dirk Skowasch Tags: Original Research Article Source Type: research

Clinical Course of Sarcoidosis in World Trade Center Exposed Firefighters.
CONCLUSIONS: Extrathoracic disease was more prevalent in WTC-related sarcoidosis than reported for sarcoidosis patients without WTC-exposure or for other exposure-related granulomatous diseases (beryllium disease and hypersensitivity pneumonitis). Cardiac involvement would have been missed if evaluation stopped after electrocardiogram, 48-hour recordings and echocardiogram. Our results also support the need for advanced cardiac screening in asymptomatic patients with strenuous, stressful, public safety occupations, given the potential fatality of a missed diagnosis. PMID: 29066387 [PubMed - as supplied by publisher]
Source: Chest - October 21, 2017 Category: Respiratory Medicine Authors: Hena KM, Yip J, Jaber N, Goldfarb D, Fullam K, Cleven K, Moir W, Zeig-Owens R, Webber MP, Spevack DM, Judson MA, Maier L, Krumerman A, Aizer A, Spivack SD, Berman J, Aldrich TK, Prezant DJ, FDNY Sarcoidosis Clinical Research Group, Christodoulou V, Hena Z Tags: Chest Source Type: research

Ocular sarcoidosis: What the internist should know?
Authors: Sève P, Kodjikian L, Jamilloux Y Abstract Sarcoidosis is one of the leading causes of inflammatory eye disease. Any part of the eye and its adnexal tissues can be involved. Uveitis and optic neuropathy are the main manifestations, which the internists face. This review reports the state of knowledge for these two ocular involvements and proposes an assessment-algorithm for sarcoidosis in patients with suspected sarcoid uveitis. Two groups of patients with sarcoid uveitis can be distinguished: one young and multiethnic group in which ophthalmological findings are various and another group of elderly Caucas...
Source: Revue de Medecine Interne - October 19, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Management and long-term outcomes of sarcoidosis-associated pulmonary hypertension
Studies reporting the effects of modern strategies with pulmonary arterial hypertension (PAH)-targeted therapies in sarcoidosis-associated pulmonary hypertension (S-APH) are limited. Clinical and haemodynamic data from newly diagnosed patients with severe S-APH (mean pulmonary artery pressure (mPAP) >35 mmHg or mPAP 25–35 mmHg with cardiac index <2.5 L·min–1·m–2) were collected from the French Pulmonary Hypertension Registry between 2004 and 2015. Data from 126 patients with severe S-APH were analysed (mean±sd age 57.5±11.6 years, 74% radiological stag...
Source: European Respiratory Journal - October 19, 2017 Category: Respiratory Medicine Authors: Boucly, A., Cottin, V., Nunes, H., Jaïs, X., Tazi, A., Prevot, G., Reynaud-Gaubert, M., Dromer, C., Viacroze, C., Horeau-Langlard, D., Pison, C., Bergot, E., Traclet, J., Weatherald, J., Simonneau, G., Valeyre, D., Montani, D., Humbert, M., Sitbon Tags: Interstitial and orphan lung disease, Pulmonary vascular disease Original Articles: Pulmonary vascular diseases and sarcoidosis Source Type: research

Sarcoid-like granulomatosis associated with eosinophilic fasciitis.
DISCUSSION: Association of EF and granulomatous disease is uncommon. Our case highlights the possible association of EF with sarcoidosis-like reactions. PMID: 28967434 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - September 26, 2017 Category: Dermatology Authors: Zuelgaray E, Sallé de Chou C, Vignon-Pennamen MD, Battistella M, Leonard-Louis S, Hefez L, Guibal F, Bagot M, Bouaziz JD Tags: Ann Dermatol Venereol Source Type: research

Distinguishing Features of Ocular Sarcoidosis in an International Cohort of Uveitis Patients
To determine which clinical features distinguish ocular sarcoidosis from other forms of uveitis in an international population and to estimate the sensitivity and specificity of the International Workshop on Ocular Sarcoidosis (IWOS) clinical signs and laboratory tests.
Source: Ophthalmology - August 16, 2017 Category: Opthalmology Authors: Nisha R. Acharya, Erica N. Browne, Narsing Rao, Manabu Mochizuki, International Ocular Sarcoidosis Working Group ∗ Source Type: research

Bronchoscopic modalities to diagnose sarcoidosis
Purpose of review: Several studies have investigated different bronchoscopic techniques to obtain tissue diagnosis in patients with suspected sarcoidosis when the diagnosis cannot be based on clinicoradiographic findings alone. In this review, we will describe the most recent and relevant evidence from different bronchoscopic modalities to diagnose sarcoidosis. Recent findings: Despite multiple available bronchoscopic modalities to procure tissue samples to diagnose sarcoidosis, the vast majority of evidence favors endobronchial ultrasound transbronchial needle aspiration to diagnose Scadding stages 1 and 2 sarcoidosis. T...
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Ocular sarcoidosis: new diagnostic modalities and treatment
Purpose of review: Ocular involvement in sarcoidosis is present in up to 80% of patients and is frequently manifested before diagnosis of the underlying systemic disease. Considering the therapeutic consequences, early diagnosis of the underlying disease is advantageous in patients presenting with ocular inflammation. There are several ocular findings suggestive of underlying sarcoidosis, such as granulomatous keratic precipitates, iris nodules, cells in the vitreous humor known as snowballs and snowbanks, and retinal periphlebitis. High suspicion is crucial for the diagnosis of sarcoidosis. This review on ocular sarcoidos...
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Current concepts regarding calcium metabolism and bone health in sarcoidosis
Purpose of review: Vitamin D supplementation is widespread used in the general population. In sarcoidosis, up to 50% of patients, especially postmenopausal women and those taking corticosteroids, show evidence of increased bone fragility. The purpose of this review is to provide an evidence-based rationale on how to treat sarcoidosis patients with bone health issues. Recent findings: Evidence from observational studies show that decreased 25-hydroxy vitamin D is common in sarcoidosis. However, the great majority of sarcoidosis patents have normal or often elevated levels of 1,25-dihydroxy vitamin D (calcitriol), a marker ...
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Cutaneous sarcoidosis
Purpose of review: Cutaneous sarcoidosis occurs in up to 30% of patients with sarcoidosis and skin findings are often the initial presenting symptom. Cutaneous sarcoidosis is a rare skin disease and many aspects of the disease presentation and treatment are not well understood. This review will highlight developments in the epidemiology, clinical presentation, diagnosis and treatment of cutaneous sarcoidosis over the past several years. Recent findings: Epidemiological studies from several different populations reaffirm that cutaneous sarcoidosis is more common in women and is often the presenting symptom of systemic sarc...
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Transcriptome profiles in sarcoidosis and their potential role in disease prediction
Purpose of review: Sarcoidosis is a systemic disease defined by the presence of nonnecrotizing granuloma in the absence of any known cause. Although the heterogeneity of sarcoidosis is well characterized clinically, the transcriptome of sarcoidosis and underlying molecular mechanisms are not. The signal of all transcripts, small and long noncoding RNAs, can be detected using microarrays or RNA-Sequencing. Analyzing the transcriptome of tissues that are directly affected by granulomas is of great importance to understand biology of the disease and may be predictive of disease and treatment outcome. Recent findings: Multipl...
Source: Current Opinion in Pulmonary Medicine - August 3, 2017 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Robert P. Baughman and Marcel Veltkamp Source Type: research

Necrotizing sarcoid granulomatosis: a distinctive form of pulmonary granulomatous disease
Conclusion: NGS is a disease often confounded clinically with malignancy or with sarcoidosis even histologically when all criteria are not strictly applied. This review provides NGS' characteristics and discusses its differential diagnosis form sarcoidosis, Wegener granulomatosis and tuberculosis. This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - July 29, 2017 Category: Respiratory Medicine Authors: Georgia Karpathiou, Anna Batistatou, Panagiotis Boglou, Dimitrios Stefanou, Marios E. Froudarakis Tags: Review Article Source Type: research

Sarcoidosis: Drugs under Investigation
Semin Respir Crit Care Med 2017; 38: 532-537 DOI: 10.1055/s-0037-1603768Etiology of sarcoidosis is still elusive, yet there has been considerable progress in various areas of basic and clinical research. In this review, we focus on ongoing or recently completed clinical–pharmacological studies in patients with sarcoidosis. Positive studies were published in well-characterized and homogenous subcohorts of sarcoid patients. Several drugs have shown a positive effect on sarcoidosis-associated fatigue, cutaneous sarcoidosis, and pulmonary hypertension in sarcoid patients. It seems that the recruitment of clinically precisely...
Source: Seminars in Respiratory and Critical Care Medicine - July 27, 2017 Category: Respiratory Medicine Authors: Schupp, Jonas Christian Frye, Bj örn Christian Zissel, Gernot M üller-Quernheim, Joachim Tags: Review Article Source Type: research

Granulomas within renal epithelial neoplasms in patients with sarcoidosis: A causal association?
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Nasma K. Majeed, Andres M. Acosta, Andre Kajdacsy-Balla, Suman Setty, Nathan A. Aardsma Sarcoidosis is a chronic granulomatous disease that can involve virtually every organ system, but most commonly presents as lung, skin, or lymph node disease. Although kidney involvement is usually clinically silent, granulomatous interstitial nephritis − the hallmark of renal sarcoidosis − can lead to functional impairment and organ failure. Also, recent studies have suggested an association between sarcoidosis and an increased risk...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Glucocorticoid sparing effect of zoledronic acid in sarcoid hypercalcemia
ConclusionZoledronic acid should be studied as a potential first-line agent for sarcoid hypercalcemia. Furthermore, disease-modifying effects of zoledronic acid in sarcoidosis should be investigated.
Source: Archives of Orthopaedic and Trauma Surgery - July 19, 2017 Category: Orthopaedics Source Type: research

Non-cardiac sarcoid actually affects the heart by reducing coronary flow reserve
Sarcoidosis is a multisystem granulomatous disease of unclear etiology that is characterized by the formation of non-caseating granuloma in various organs, resulting from an immune-mediated reaction to a yet unknown antigen in genetically predisposed individuals1. The prevalence of sarcoidosis is quite variable and contingent upon ethnicity, gender and regions. For example, the prevalence is 10/100,000 for Caucasians in the USA and Europe, while there is an increased prevalence of sarcoid in African-Americans as compared to Caucasians with a ratio 10 –17:1 [1].
Source: Atherosclerosis - July 6, 2017 Category: Cardiology Authors: Carlos G. Santos-Gallego, Allen J. Weiss, Javier Sanz Tags: Editorial Source Type: research

Sudden cardiac death due to sarcoidosis. Case report.
Abstract Sarcoidosis is a systemic granulomatous disease of unknown aetiology, which is characterized by bilateral hilar lymphadenopathy and pulmonary disease. Clinically detected cardiac involvement occurs in 5% of sarcoid patients, although cardiac manifestations are discovered in 25% of the cases at autopsy. Sarcoid heart disease frequently causes atrioventricular block. The authors present the case of a 44-year-old man with bradycardia. On admission, second degree Mobitz II, then third degree atrioventricular block was diagnosed. Coronarography showed normal coronary arteries. 2.5 years following artificial Bi...
Source: Orvosi Hetilap - July 1, 2017 Category: General Medicine Authors: Sejben I, Som Z, Cserni G Tags: Orv Hetil Source Type: research

Chronic pulmonary aspergillosis complicating sarcoidosis
Chronic pulmonary aspergillosis (CPA) complicating sarcoidosis (SA) is associated with high mortality, and there is a lack of clarity regarding the relative contributions of SA or CPA. This was a retrospective single-centre study on CPA-SA. In total, 65 patients (44 men), aged 41.4±13.5 and 48.3±11.9 years at the time of SA and CPA diagnoses, respectively, were included between 1980 and 2015. Of these, 64 had fibrocystic SA, most often advanced, with composite physiological index (CPI) >40 (65% of patients) and pulmonary hypertension (PH) (31%), and 41 patients (63%) were treated for SA (corticosteroi...
Source: European Respiratory Journal - June 15, 2017 Category: Respiratory Medicine Authors: Uzunhan, Y., Nunes, H., Jeny, F., Lacroix, M., Brun, S., Brillet, P.-Y., Martinod, E., Carette, M.-F., Bouvry, D., Charlier, C., Lanternier, F., Planes, C., Tazi, A., Lortholary, O., Baughman, R. P., Valeyre, D. Tags: Interstitial and orphan lung disease, Respiratory infections and tuberculosis Original Articles: Sarcoidosis and aspergillosis Source Type: research

Case of cutaneous sarcoidosis with multiple morphologies and review of the clinical spectrum
We report a case of a 51-year-old white female with sarcoidosis who sequentially exhibited multiple biopsy-proven cutaneous sarcoid morphologies, including subcutaneous nodules, red papules on normal surrounding skin, and papules withi n a preexisting scar.
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research

Quantitative Interpretation of FDG PET for Cardiac Sarcoidosis Reclassifies Visually Interpreted Studies and Potentially Reduces Unnecessary Downstream Interventions
Conclusion: Re-interpretation of FDG PET/CT imaging for cardiac sarcoidosis using quantitative techniques lead to a nearly 1/3 of visually "FDG positive" studies being reclassified as normal (no FDG uptake). In 7/22 patients that were reclassified as normal, initiation or increase of immunosuppression could potentially have been avoided, thus possibly limiting toxicities of these medications. The adverse event rate for arrhythmias and CHF in patients reclassified as normal was low. This suggests quantitative interpretation of FDG PET/CT for CS could reduce unnecessary immunosuppressive treatment in some patients. Research Support: None
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Varghese, M., Miller, E. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

Relative value of cardiac MRI and FDG-PET in treatment follow-up for cardiac sarcoidosis.
Conclusion: Myocardial FDG uptake in suspected CS is presumed to represent active inflammation. When treated with oral steroids this improved or resolved on short term follow up. Despite several of the treated cases showing LGE on the initial CMR this was not altered by treatment and there was no change in LV/RV function or volumes. Untreated patients showed no change on follow-up FDG PET or CMR. Although oral steroids modify myocardial disease activity, it remains to be seen whether treatment will alter long term cardiac outcome. (1) Coulden et al. RSNA 2016:archive.rsna.org/2016/16009768.html. (2) Coulden et al. Eur Radi...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Coulden, R., Crean, A., Sonnex, E., Abele, J. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

FDG Uptake Quantification and Right Ventricular Dysfunction in Cardiac Sarcoidosis
Conclusion: These results suggest that several proposed quantitative metrics relating RV or septal FDG uptake correlate with RV function as assessed by TAPSE. RVCMA shows a statistical distinction between normal and abnormal TAPSE patient groups. Interestingly, the second best performing metric, septal cardiac metabolic activity, suggests that increased septal inflammation may be a predictor of poor RV function. Research Support: None
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Bindschadler, M., Petek, B., Elman, S., Cheng, R., Patton, K., Soine, L., Alessio, A. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

Cardiac PET/CT in the Management of Cardiac Sarcoidosis: Association of FDG Uptake with Changes in Symptoms and Medications
Conclusion: While there is an association between worsening symptoms and increased FDG uptake in the myocardium, FDG uptake alone is not a strong predictor of symptom changes (AUC only 0.6). These results may be confounded by numerous factors including many known limitations of myocardial FDG inflammation imaging (e.g., incomplete FDG suppression, spatial resolution, motion) and the unknown impact of the effect of ongoing steroid therapy on baseline FDG trapping. These initial results suggest that patients with similar functional class had reduced FDG uptake if they were on steroids. Further work is needed to assess if ste...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Elman, S., Bindschadler, M., Petek, B., Cheng, R., Patton, K., Soine, L., Alessio, A. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

Prognostic Role of Serial Quantitative Evaluation of 18Fluorodeoxyglucose Uptake by PET/CT in Patients with Cardiac Sarcoidosis Presenting with Ventricular Tachycardia
Conclusion: In patients with CS and VT, temporal reduction of FDG uptake evaluated by a quantitative approach is strongly associated with improvement in systolic function, better arrhythmia free survival, less mortality and less hospitalizations for heart failure
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Castro, S., Muser, D., Santangeli, P., Magnani, S., Werner, T., Garcia, F., Desjardins, B., Marchlinski, F., Alavi, A. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research

Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects.
Authors: Kuroda H, Saijo Y, Fujiuchi S, Takeda H, Ohsaki Y, Hasebe N Abstract Several susceptibility genes for sarcoidosis have been identified, but their relationship to the clinical state and prognosis remains to be elucidated. The aim of this study was to elucidate the relationship between sarcoidosis and five single nucleotide polymorphisms (SNPs) of three cytokines expected to play an important role in the inflammatory response. A case-control study was performed with 208 unrelated patients who met the diagnostic criteria for sarcoidosis used in Japan since 2006, and 328 control subjects. Five SNPs were analyz...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

An analysis of seasonality of sarcoidosis in the United States veteran population: 2000-2007.
CONCLUSION: The lack of seasonality in this study indicates that season is not a dominant factor in complex gene-environment-host interaction that precedes presentation of new sarcoidosis cases in the United States Veteran population. PMID: 23461080 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidosis: vaginal wall and vulvar involvement.
We report the case of a 45-year-old married woman who presented with 2 months history of a vulval mass as large as a soybean, and did not reveal any remarkable pulmonary signs. Biopsy results showed non-caseous granulomatous inflammation consistent with sarcoidosis in the vulvar lesion. To our knowledge, this is the first reported case of this entity in the world. Based on the related literature, we highlight the possibility of gynecologic involvement in sarcoidosis. PMID: 23461079 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Anxiety and depression in sarcoidosis: the influence of age, gender, affected organs, concomitant diseases and dyspnea.
CONCLUSIONS: The analysis of mental distress should take into account comparisons with normative values. Young patients deserve special social support. Dyspnea proved to be an important symptom in the prediction of anxiety and depression. PMID: 23461077 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States.
CONCLUSIONS: The analysis indicates that sarcoidosis tends to improve over time in terms of pulmonary function and medication requirements. The disease was found to be more severe in blacks than whites. Treatment was not necessarily required. These results provide a comprehensive model of the course and treatment of sarcoidosis in the clinical setting. PMID: 23461074 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Bronchial hyperreactivity in sarcoidosis patients: correlation with airflow limitation indices.
CONCLUSION: BHR occurs frequently in sarcoidosis patients and should be considered especially in patients with airflow limitation. PMID: 23461071 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Endpoints for clinical trials of sarcoidosis.
Authors: Baughman RP, Drent M, Culver DA, Grutters JC, Handa T, Humbert M, Judson MA, Lower EE, Mana J, Pereira CA, Prasse A, Sulica R, Valyere D, Vucinic V, Wells AU Abstract Over the past few years an increasing number of prospective controlled sarcoidosis treatment trials have been completed. Unfortunately, these studies utilize different endpoints making comparisons between studies difficult. At the recent World Association of Sarcoidosis and other Granulomatous disease (WASOG) meeting, a session was dedicated to the evaluation of clinical endpoints for various disease manifestations. These included pulmonary, ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

TLR7 Gln11Leu single nucleotide polymorphism in patients with sarcoidosis.
Authors: Bordignon M, Bargagli E, Agostini Et Al C Abstract Sarcoidosis is a multi-factorial systemic disease with increased activity of the cellular immune components which is responsible of the formation of non-caseating granulomas in involved organs. Recent views on the etiology indicate interactions between inherited susceptibility and environmental or lifestyle factors. Concerning genes that may influence susceptibility to sarcoidosis Toll-like receptors (TLRs) may represent plausible candidates. In this present study, we investigated the X-linked TLR7 rs179008/Gln11Leu polymorphism situated on exon 3. SNP gen...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Massive splenomegaly and pancytopenia reuealing sarcoidosis in a child.
Authors: Viprey M, Donadieu J, Epaud Et Al R Abstract Clinical presentation of sarcoidosis in children is very variable and dependant upon age. Herein, we report the first association of massive splenomegaly and pancytopenia as the revealing mode of sarcoidosis in an 8-year-old girl who, despite bone marrow involvement, had a remarkable good outcome following steroid therapy. PMID: 24071888 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

First presentation of sarcoidosis with severe obstructive sleep apnoea and epiglottic invilvement.
We present a patient whose first presentation with sarcoidosis was with dysphonia, upper airways obstruction and severe obstructive sleep apnoea (OSA) . Systemic steroids and hydroxycholoroquine led to improvement in phonation, endoscopic appearance and upper airway obstruction with significant improvement in Apnoea Hypopnoea Index (AHI) on polysomnography. PMID: 24071887 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Detection of sarcoidosis associated fasciitis by uptake on a FDG PET scan: a novel finding.
We report a case of a sarcoidosis patient with bilateral calf and thigh stiffness who was noted to ha ve intense linear FDG uptake on a PET scan that localized to the fascia of his calves and theighs. His serum creatine kinase level was normal. Fasciitis has rarely been reported to be detected on FDG PET scans, and, to our knowledge, never in a sarcoidosis patient. FDG PET may have a role in identifying fasciitis or myositis when a patient has muscular complaints and no clinical or laboratory evidence of muscle injury. PMID: 24071886 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Mortality among African American women with sarcoidosis: data from the Black Women's Health Study.
CONCLUSIONS: In the Black Women's Health Study, women with sarcoidosis were more than twice as likely to die as women without the disease, with many of the deaths directly attributable to sarcoidosis.  Sarcoidosis is an important cause of premature death among black women with the disease. PMID: 24071884 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Calcium and vitamin D metabolism in sarcoidosis.
Conclusion: Sarcoidosis associated hypercalcemia, which is often accompanied by renal insufficiency, responds to treatment of sarcoidosis and withdrawal of vitamin D supplementation. Measurement of serum vitamin 1,25(OH)2 vitamin D3 appears to best evaluate vitamin D status in sarcoidosis patients. PMID: 24071882 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Verrucous sarcoidosis of the skin simulating squamous cell carcinoma.
Authors: Pezzetta S, Zarian H, Agostini C, Salmaso R, Alaibac M Abstract Here, we report a case of a 38-year-old woman with a history of systemic sarcoidosis who developed cutaneous verrucous sarcoidosis simulating a squamous cell carcinoma. This modality of presentation is unusual in both caucasic patients and in woman and may represent a diagnostic challenge for dermatologists. PMID: 24003538 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Disseminated nocardiosis mimicking exacerbation of pulmonary sarcoidosis.
We present an unusual case of disseminated nocardiosis in a patient diagnosed before with sarcoidosis and treated with glucocorticoids. Clinical symptoms initially mimicked exacerbation of pulmonary sarcoidosis. The course of disease was severe. PMID: 24003537 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The internal consistency of PRO fatigue instruments in sarcoidosis: superiority of the PFI over the FAS.
CONCLUSION: We found that the PFI had "excellent" consistency in our sarcoidosis clinic. The FAS did not demonstrate the same degree of internal consistency. The Cronbach's estimate of the FAS with items #4 and #10 removed was vastly superior to the FAS. These data support our contention that FAS items #4 and #10 detract from the internal consistency of this PRO. They also suggest that the PFI is superior to the FAS in terms of reliability. PMID: 24003536 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Differentiation of lymphoma versus sarcoidosis in the setting of mediastinal-hilar lymphadenopathy: assessment with diffusion-weighted MR imaging.
CONCLUSIONS: Diffusion-weighted imaging may be useful besides other modalities in differentiating lymphoma from sarcoidosis in mediastinal-hilar lymphadenopathy. PMID: 24003535 [PubMed - indexed for MEDLINE]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research