This page shows you the latest news items in this category. This is page number 7.

Total 5085 results found since Jan 2013.

Outcome of cardiac sarcoidosis after radiofrequency ablation and placement of AICD- A propensity matched analysis.
CONCLUSION: RFA can be an effective modality for the short-term treatment of ventricular dysrhythmias in cardiac sarcoidosis; however, after more than 12 months, the number of appropriate therapies escalates. Accordingly, ICD placement is recommended for all patients who undergo RFA for VT associated with CS, whether it is successful or not. Low LVEF and unsuccessful ablation were strong predictors of future events. PMID: 26237358 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Glucocorticoids and Sarcoidosis: A Longitudinal Study on the Effects on Cortical and Trabecular Bone.
CONCLUSION: Treatment of initial mild sarcoidosis with dose tapered glucocorticoid therapy only mildly affects the final trabecular and cortical bone and hormone levels. Dose tapering is an important part in glucocorticoid therapy, likely contributing to the mild effects on bone observed in this study. PMID: 26237357 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Does physical training reduce fatigue in sarcoidosis?
CONCLUSION: Fatigue reduced after a period of physical training in sarcoidosis patients. Moreover, psychological health and physical functions improved. Future studies are warranted to assess the benefits of physical training in sarcoidosis. PMID: 26237356 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Benefits of physical training in patients with idiopathic or end-stage sarcoidosis-related pulmonary fibrosis: a pilot study.
CONCLUSION: A 12-week physical training program improved or maintained exercise capacity in patients with IPF (despite disease progression) or fibrotic sarcoidosis. The results from this pilot study could be used to design prospective studies aimed at answering lingering questions about exercise training in patients with these progressive, incurable conditions. PMID: 26237355 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 4, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Granuloma genes in sarcoidosis: what is new?
Purpose of review: Nonnecrotizing granulomas in the affected organ are the hallmark of sarcoidosis. This review summarizes most recent genetic findings in sarcoidosis with a focus on genes that might influence granuloma formation or resolution. Specific results in multiple ethnic groups and certain clinical subphenotypes, such as extra-pulmonary organ involvement, are discussed. Recent findings: Associations of genetic variants in antigen-presenting molecules (HLA-DRB1) were shown to confer risk to sarcoidosis and certain disease phenotypes in populations of different ethnic origins. Specific DRB1 alleles, such as *0301 an...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Marjolein Drent and Johan Grunewald Source Type: research

Features of sarcoidosis associated with chronic disease.
CONCLUSION: In our study, the majority of sarcoidosis patients were receiving systemic therapy five years after initial diagnosis. Patients with reduced lung function, neurologic disease, lupus pernio, and cardiac disease were more likely to require prolonged treatment. PMID: 25591138 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Activated CD8+ T cells and natural killer T cells in bronchoalveolar lavage fluid in hypersensitivity pneumonitis and sarcoidosis.
CONCLUSION: This study suggests a role for the bronchoalveolar lavage fluid lymphocyte subsets HLA-DR+ CD8+ T cells and natural killer T cells in the diagnostic work up of sarcoidosis and hypersensitivity pneumonitis. PMID: 25591143 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Renal Sarcoidosis: epidemiological and follow-up data in a cohort of 27 patients.
CONCLUSIONS: We demonstrated that GIN is more often associated with advanced stages of renal insufficiency than any other histological manifestation of RS. Furthermore, prednisone therapy is effective in improving eGFR and in reducing total urinary protein secretion. We suggest that the key prognostic factor for renal survival in RS is the early response to treatment. PMID: 25591142 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidosis, a report from Guilan (an Iranian Northen province) (2001-09).
CONCLUSION: It seems many clinical and radiological aspects of sarcoidosis in our patients are similar to other series. However, presentation with Lofgren's syndrome is a common feature and skin (n=48, 12.3%) and eye (n=19, 4.8%) involvement are less frequent. There is significant difference between west and east of Guilan in relation to referred patients (12.9 % vs 78.5% respectively).Of course this may be due to referral issues of patients and medical teamwork connections  PMID: 25591139 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Adalimumab Induced Subcutaneous Nodular Sarcoidosis; A Rare Side Effect of Tumor Necrosis Factor-α Inhibitor.
We describe the first case of adalimumab-induced subcutaneous nodular sarcoidosis in a patient with pulmonary sarcoidosis. PMID: 25363227 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Body composition profiling in a Dutch sarcoidosis population.
Conclusions: Muscle atrophy was present in 25% of sarcoidosis patients and was associated withmore severe pulmonary disease. Prospective studies with longitudinal design are needed to assess the association between muscle atrophy and disease severity in sarcoidosis. PMID: 24351620 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Laryngeal sarcoidosis: a case-control study.
CONCLUSIONS: LS is a rare condition that is often associated to other loco-regional localizations. LS are often difficult to manage. Survival is good but may require a medico-surgical approach. PMID: 25363223 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Granulomatous cutaneous sarcoidosis: diagnosis, relationship to systemic disease, prognosis and treatment.
Authors: Mañá J, Marcoval J, Rubio M, Labori M, Fanlo M, Pujol R Abstract Sarcoidosis is an antigen-mediated disease of unknown aetiology, characterized by the presence of non-caseating epithelioid cell granulomas in multiple organs. Cutaneous involvement in sarcoidosis is classified as specific, when biopsy reveals non-caseating granulomas, and non-specific, typically erythema nodosum. Granulomatous skin lesions occur in 9% to 37% of patients. The skin is the second most commonly involved organ after the lung. A skin biopsy is easy to perform and enables an early diagnosis with a minor invasive procedure. Some t...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Role of Propionibacterium Acnes in Sarcoidosis: A Meta-analysis.
Conclusions: The present data and meta-analysis supports an association between P. acnes and some cases of sarcoidosis. PMID: 24351617 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A randomized controlled study of conventional TBNA versus EBUS-TBNA for diagnosis of suspected stage I and II sarcoidosis.
CONCLUSION: The overall diagnostic yield of EBUS-TBNA for stage I and II sarcoidosis was higher than TBNA. However, Conventional TBNA has very high diagnostic yield,similar to EBUS-TBNA, if the lymph nodes located on the 4th and 7th group or the shortest diameter was greater than 15 mm. PMID: 25363221 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Anti-cyclic citrullinated peptide antibodies in patients with sarcoidosis.
CONCLUSION: The prevalence of anti-CCP antibodies in patients with sarcoidosis was found to be significantly lower than RA patients and similar with the healthy control group. This result shows that anti-CCP antibodies don't have an important role in the pathogenesis of sarcoidosis, but could be important in revealing the overlap syndromes of sarcoidosis-RA. PMID: 25363220 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Om Prakash Sharma, MD, FRCP, FCCP - 4 July 1936 - 19 August 2012. Internationally acclaimed specialist in sarcoidosis.
Authors: Baughman RP, Drent M, Costabel U Abstract Internationally acclaimed specialist in sarcoidosis. PMID: 24284301 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Seasonality of Sarcoidosis: the 'heat' is on…
Authors: Gupta D Abstract Letter to the editor. PMID: 24284300 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Cardiac sarcoidosis and coronary artery disease: a two-hit mechanism to left ventricular dysfunction (Or is It)?
This report describes a case of cardiac sarcoidosis in a 40-year-old man with minimal risk factors for coronary artery disease who was found to have a critical coronary lesion on angiography performed for declining left ventricular function. The case highlights the diagnostic and therapeutic issues surrounding cardiac sarcoidosis and raises the question of a possible link between sarcoidosis and premature coronary artery disease. It also stresses the importance of ruling out ischemia in any patient with declining left ventricular function. PMID: 24284299 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Widespread heavy damage of capillary endothelial cells in the pathogenesis of sarcoidosis - Evidence by monoclonal von Willebrand factor immunohistochemistry in the bronchus and lung of patients with sarcoidosis.
Authors: Mochizuki I, Kubo K, Hond T Abstract We have observed that electron microscopically there were many damages of the plasma membrane of the bronchial and lung capillary endothelial cells in sarcoidosis and at the same time, platelets adhesion and eosinophil attached to the capillary vessels. And characteristically, the capillary endothelial cells showed appearance of the lipid droplets including saturated and unsaturated fatty acids in the cytoplasm and capillary lumina in all cases. For elucidation of the functions in the capillary endothelial cells, we performed the histochemical study of monoclonal antibo...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sulfasalazine induced lung toxicity masquerading as sarcoidosis - case report and review of the literature.
We report a case of a 46 year old female being treated with Sulfasalazine for Ulcerative Colitis, who developed shortness of breath and a radiographic pattern of hilar adenopathy. Biopsy showed granulomas that resembled Sarcoidosis. We review different presentations of Sulfasalazine induced lung disease and describe the first known case of Sulfasalazine lung toxicity mimicking Sarcoidosis. PMID: 24284297 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Errata Corrige: Sarcoidosis Vasc Diffuse Lung Dis 2014; 31; Suppl. 1; 3. The clinical and integrated management of COPD.
This article is being simultaneusly published in Multidisciplinary Respiratory Medicine 2014; 9:25(Sarcoidosis Vasc Diffuse Lung Dis 2014; 31 Suppl 1: 3-21). PMID: 25078647 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Unsuspected exposure to beryllium: potential implications for sarcoidosis diagnoses.
Authors: Laczniak AN, Gross NA, Fuortes LJ, Field RW Abstract Exposure to Beryllium (Be) can cause sensitization (BeS) and chronic beryllium disease (CBD) in some individuals.  Even relatively low exposures may be sufficient to generate an asymptomatic, or in some cases a symptomatic, immune response. Since the clinical presentation of CBD is similar to that of sarcoidosis, it is helpful to have information on exposure to beryllium in order to reduce misdiagnosis. The purpose of this pilot study is to explore the occurrence of Be surface deposits at worksites with little or no previous reported use of commercially...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Could HLA-DR B1*11 allele be a clue for predicting extra-pulmonary sarcoidosis?
CONCLUSIONS: We demonstrated a strong positive link between the haplotype HLA DRB1*15 and sarcoidosis in a Turkish Caucasian population and a potential protective effect of HLA DRB1*11 from extra-pulmonary involvement of disease. PMID: 25078644 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Association of sarcoidosis and ulcerative colitis: a review of 20 cases.
We report a case of this association and describe its clinical, radiological and functional characteristics based on a review of the literature. This association must be recognized by the physician and must be clearly distinguished from a systemic site of ulcerative colitis or drug-related pneumonitis. PMID: 24284294 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis.
ConclusionsThe CLEAR regimen is associated with improved absolute FVC, as well as increased functional capacity and quality-of-life in selected chronic pulmonary sarcoidosis patients.  Larger, randomized, controlled trials are needed to confirm these findings and to identify patients most likely to benefit from therapy. ClinicalTrials.gov number NCT01169038. PMID: 24284293 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidosis and Purified Protein Derivative reactivity.
CONCLUSION: These results provide no evidence for the involvement of different mycobacteria in the pathogenesis of sarcoidosis. PMID: 25078642 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Oncostatin m in bronchoalveolar lavage correlates with the severity of sarcoidosis.
Conclusions: Direct correlation was found between clinical parameters including lung function tests (FEV1 and FVC) and OSM secretion from mast cells in patients with sarcoidosis. These findings suggest that mast cells and OSM have a role in sarcoidosis. Further studies to confirm these preliminary results are suggested. PMID: 24284292 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Lack of correlation of BTNL2 polymorphism and cancer risk in sarcoidosis. BTNL2 and cancer risk in sarcoidosis.
CONCLUSIONS: These results confirm the association of BTNL2 rs2076530SNP with the susceptibility to develop sarcoidosis, but not with an increased risk of cancer in these patients. PMID: 25078641 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Socio-demographic profile of patients with sarcoidosis vis-à-vis tuberculosis.
Conclusions: Patients with sarcoidosis are likely to be better educated and more affluent compared to those with tuberculosis and healthy controls and this can be useful in clinical differential diagnosis of the two conditions in populations with high prevalence of TB. PMID: 24284291 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Association between physical functions and quality of life in sarcoidosis.
CONCLUSIONS: QOL is reduced in sarcoidosis. Fatigue and exercise capacity showed important stable associations with QOL, especially in the physical health domain. FAS and 6MWT should therefore be included in the management of sarcoidosis. PMID: 25078639 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The value of chest radiograph and computed tomography in pulmonary sarcoidosis.
Authors: Greco FG, Spagnolo P, Muri M, Paladini I, Chizzolini F, Piciucchi S, Colombi D, Sverzellati N Abstract Imaging makes a significant contribution to the diagnosis, prognosis and follow-up in sarcoidosis. Despite its increasing use, the role of computed tomography (CT) scanning in patients with known or suspected pulmonary sarcoidosis is still undefined. This review aims to compare the utility and limitations of chest radiograph and CT in patients with pulmonary sarcoidosis, with regards to the most critical clinical issues such as the diagnostic sensitivity, the differential diagnosis, and the prediction of ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sharma O.P. Gerry James and the sarcoidosis movement. Biography of a Medical Luminary.
Authors: Peros-Golubicic T PMID: 24071891 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Practical eminence and experience-based recommendations for use of TNF-α inhibitors in sarcoidosis.
CONCLUSION: Based on earlier studies and consensus amongst world's leading sarcoidologists, practical recommendations for the use of TNF-α inhibitors in sarcoidosis were established. These recommendations, with emphasis on indications, dosage and discontinuation regimens, have been developed to support the clinician in the management of refractory sarcoidosis patients. PMID: 25078637 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

TLR7 Gln11Leu single nucleotide polymorphism in patients with sarcoidosis.
Authors: Bordignon M, Bargagli E, Agostini Et Al C Abstract Sarcoidosis is a multi-factorial systemic disease with increased activity of the cellular immune components which is responsible of the formation of non-caseating granulomas in involved organs. Recent views on the etiology indicate interactions between inherited susceptibility and environmental or lifestyle factors. Concerning genes that may influence susceptibility to sarcoidosis Toll-like receptors (TLRs) may represent plausible candidates. In this present study, we investigated the X-linked TLR7 rs179008/Gln11Leu polymorphism situated on exon 3. SNP gen...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Treatment of sarcoidosis-associated pulmonary hypertension: A single centre retrospective experience using targeted therapies.
CONCLUSIONS: Our results suggest that targeted therapies are safe in  patients with SAPH. Controlled trials are warranted before therapeutic recommendations can be made. PMID: 25078636 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Massive splenomegaly and pancytopenia reuealing sarcoidosis in a child.
Authors: Viprey M, Donadieu J, Epaud Et Al R Abstract Clinical presentation of sarcoidosis in children is very variable and dependant upon age. Herein, we report the first association of massive splenomegaly and pancytopenia as the revealing mode of sarcoidosis in an 8-year-old girl who, despite bone marrow involvement, had a remarkable good outcome following steroid therapy. PMID: 24071888 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Psychosis: a rare but serious psychiatric anomaly in patients with sarcoidosis.
Authors: Kapoor S Abstract I read with great interest the recent article by Hinz et al. 1 Interestingly, sarcoidosis may rarely be associated with manic or psychotic symptoms.   Psychotic disorders are seen in 6.3% of all patients with sarcoidosis, especially in patients with "neurosarcoidosis". 2 Neurosarcoidosis usually occurs in conjunction with systemic sarcoidosis.  Rarely, neurosarcoidosis may be present as an isolated syndrome with no systemic involvement. Overall psychosis is seen in 16.9% of patients with neurosarcoidosis. 3 The cerebrum and the meninges are the sites most commonly involved. However, the...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

First presentation of sarcoidosis with severe obstructive sleep apnoea and epiglottic invilvement.
We present a patient whose first presentation with sarcoidosis was with dysphonia, upper airways obstruction and severe obstructive sleep apnoea (OSA) . Systemic steroids and hydroxycholoroquine led to improvement in phonation, endoscopic appearance and upper airway obstruction with significant improvement in Apnoea Hypopnoea Index (AHI) on polysomnography. PMID: 24071887 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

An unusual manifestation of Cardiac Sarcoidosis.
We describe an atypical presentation of sarcoidosis as non-tropical non hypereosinophilic endomyocardial fibrosis in a middle aged female who presented to us with refractory heart failure. PMID: 24751457 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Expect the unexpected: unusual neurological presentation of bone marrow sarcoidosis.
This report describes a case of a 58-year-old man who presented with a five-month history of bilateral lower limb paresis. His paresis was associated with urinary and fecal incontinence and impotence, but without any loss of sensations. Head, chest, abdominal, and pelvic CT scans and MRI images, and a full-body Gallium 67 scan were all within normal limits. A CT-guided biopsy of the L1-L2 vertebral bodies showed non-caseating granulomatous inflammation. Serum angiotensin-converting enzyme (ACE) level was elevated. A diagnosis of bone marrow sarcoidosis was made after other differential diagnoses were excluded. PMID: 2...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

New brain lesions in a patient with sarcoidosis: is it neurosarcoidosis?
We present this case as a diagnostic challenge. New enhancing brain lesions occurring in a patient with long standing sarcoidosis, while likely to be neurosarcoidosis, may be due to a complication of immunosuppressant therapy. The need for early biopsy, if the lesions do not improve, should be considered. PMID: 24751455 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Efficacy Results of a 52-week Trial of Adalimumab in the Treatment of Refractory Sarcoidosis.
CONCLUSIONS: In this small, open-label study, adalimumab improved refractory pulmonary sarcoidosis and was well tolerated (ClinicalTrials.gov identifier NCT00311246). PMID: 24751453 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Extent of disease activity assessed by 18F-FDG PET/CT in a Dutch sarcoidosis population.
Conclusions The majority of studied patients appeared to have PET positive findings (75%), of which a high proportion (75%) displayed extrathoracic activity. Hence, PET can be especially useful in the assessment of extent, distribution and consistency of inflammatory activity in sarcoidosis to provide an explanation for persistent disabling symptoms and/or to provide a suitable location for biopsy. PMID: 24751452 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.
Conclusion: An instrument was developed by expert opinion that may be useful for the clinician and researcher in establishing criteria for sarcoidosis organ involvement. PMID: 24751450 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

How many organs need to be involved to diagnose sarcoidosis?: An unanswered question that, hopefully, will become irrelevant.
Authors: Judson MA, Baughman RP Abstract Not available. PMID: 24751448 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Scadding revisited: a proposed staging system for sardiac sarcoidosis.
Authors: Berman JS, Govender P, Ruberg FL, Mazzini M, Miller EJ Abstract Not available. PMID: 24751447 [PubMed - as supplied by publisher]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The high frequency of healthcare use in patients one year prior to a sarcoidosis diagnosis.
CONCLUSIONS: Patients with sarcoidosis undergo a large amount of healthcare prior to diagnosis, some of which may not be necessary, compared to controls with respiratory-related disease. These results highlight the need for improved diagnostic algorithms to identify patients with sarcoidosis and avoid potentially excessive delays in diagnosis. PMID: 25363229 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Combined pulmonary involvement in hereditary lysozyme amyloidosis with associated pulmonary sarcoidosis: a case report.
Authors: McCarthy C, Deegan AP, Garvey JF, McDonnell TJ Abstract Sarcoidosis is a multisystem inflammatory disorder of unknown cause which can affect any organ system. Autosomal dominant lysozyme amyloidosis is a very rare form of hereditary amyloidosis. The Arg64 variant is extraordinarily rare with each family showing a particular pattern of organ involvement, however while Sicca syndrome, gastrointestinal involvement and renal failure are common, lymph node involvement is very rare. In this case report we describe the first reported case of sarcoidosis in association with hereditary lysozyme amyloidosis. PM...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Extranodal marginal zone B cell lymphoma of the orbit in a patient with sarcoidosis: a case report.
CONCLUSIONS: It is still unclear if the presence of immunosuppression or an autoimmune disease increases the risk of lymphoproliferative malignancies {6}. Malignancy should always be suspected and investigated. PMID: 25363228 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research