This page shows you the latest news items in this category. This is page number 18.

Total 5528 results found since Jan 2013.

Sarcoidosis triggered by immune checkpoint blockade.
Authors: Heppt M, Niesert AC, Flaig M, Berking C PMID: 30264301 [PubMed - in process]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - September 29, 2018 Category: Dermatology Tags: Hautarzt Source Type: research

Advanced pulmonary sarcoidosis: long-term follow-up of 10 years or more.
Conference abstracts
Source: The Aspergillus Website - updates - September 27, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Sarcoidosis: proteomics and new perspectives for improving personalized medicine.
Abstract INTRODUCTION: Through synergistic approaches integrating biomedical data from omics sciences to the clinical practice, precision medicine aims at more accurate identification of risk factors, characterization of endotypes, patient stratification, establishment of individualized therapy, and prediction of outcomes. Areas covered: This review evaluates the potential role of different -omics approaches for the development and application of Precision Medicine to sarcoidosis patients. This systemic and heterogeneous inflammatory disease is of unknown aetiology, affects people of any age and requires genotypic...
Source: Genomics Proteomics ... - September 25, 2018 Category: Genetics & Stem Cells Authors: Landi C, Carleo A, Cillis G, Rottoli P Tags: Expert Rev Proteomics Source Type: research

Cardiac Sarcoidosis Presenting as Complete Atrioventricular Block: Findings on PET/MRI.
Authors: Lee CH, Son JW, Kong EJ PMID: 30238713 [PubMed]
Source: Korean Circulation Journal - September 22, 2018 Category: Cardiology Tags: Korean Circ J Source Type: research

Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Using 19-G Needle for Sarcoidosis
Conclusion: This series reports a higher diagnostic yield than most other published studies and opens platform for direct comparison of each available needle. It also adds to the safety data for this larger needle. In addition, it raises doubt into utility of TBLB for diagnosis of sarcoidosis, which can increase the procedural complications.
Source: Journal of Bronchology and Interventional Pulmonology - September 22, 2018 Category: Respiratory Medicine Tags: Original Investigations Source Type: research

Pretesticular and Testicular Effects of Systemic Sarcoidosis: A Case Report.
Conclusion: This case illustrates the difficulties faced in managing the fertility of men who develop systemic sarcoidosis. It also highlights the diagnostic and therapeutic challenges faced by physicians when presented with a case of systemic sarcoidosis. PMID: 30230796 [PubMed - in process]
Source: Journal of Reproductive Medicine - September 22, 2018 Category: Reproduction Medicine Tags: J Reprod Med Source Type: research

Cardiac sarcoidosis and ventricular arrhythmias. A rare association of a rare disease. A retrospective cohort study from the National Inpatient Sample and current evidence for management.
CONCLUSIONS: The present study showed that sarcoidosis was associated with increased rates of ventricular tachyarrhythmia, which can affect the overall disease morbidity and mortality. PMID: 30234899 [PubMed - as supplied by publisher]
Source: Cardiology Journal - September 20, 2018 Category: Cardiology Authors: Salama A, Abdullah A, Wahab A, Eigbire G, Hoefen R, Alweis R Tags: Cardiol J Source Type: research

Sarcoid-like granulomatosis in cancer patients treated with immune checkpoints inhibitors.
CONCLUSIONS: Knowledge of this toxicity is crucial as the clinical signs and radiological patterns may suggest tumour progression. PMID: 30220489 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Cardiac sarcoidosis: Diagnosis confirmation by bronchoalveolar lavage and lung biopsy
The diagnosis of cardiac sarcoidosis (CS) is difficult to ascertain due to the insensitivity of endomyocardial biopsy. Current diagnostic criteria require a positive endomyocardial biopsy or extra-cardiac biopsy with clinical features suggestive of CS. Common tests for diagnosis of pulmonary sarcoidosis include bronchoalveolar lavage (BAL), lung and mediastinal lymph node (MLN) biopsies. Our objective was to determine the diagnostic utility of these tests in patients with suspected CS and without prior history of pulmonary involvement.
Source: Respiratory Medicine - September 16, 2018 Category: Respiratory Medicine Authors: Bradley J. Petek, David G. Rosenthal, Kristen K. Patton, Sanaz Behnia, Jonathan M. Keller, Bridget F. Collins, Richard K. Cheng, Lawrence A. Ho, Paco E. Bravo, Carmen Mikacenic, Ganesh Raghu Source Type: research

Pulmonary Multiloculated 'Lotus Torus-like' Sarcoidosis Mimicking Lung Adenocarcinoma.
Authors: Kanaji N, Nakashima N, Inoue T, Ibuki E, Murota M, Kadowaki N Abstract A 34-year-old Japanese woman exhibited a 35×25-mm solitary multiloculated mass shadow in the left lower lobe mimicking lung adenocarcinoma. On computed tomography, the mass resembled a lotus torus. A transbronchial lung biopsy and mediastinal lymph node biopsy led to the diagnosis of sarcoidosis. This lotus torus-like mass regressed spontaneously. This is the second reported case of pulmonary cavitary sarcoidosis with a 'lotus torus-like' appearance. We propose several findings regarding the lotus torus-like appearance by comparing the...
Source: Internal Medicine - September 15, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Significant elevation of the levels of B-cell activating factor (BAFF) in patients with sarcoidosis
This study demonstrated that the BAFF levels in both the serum and BALF were positively correlated with the disease activity markers and disease severity. BAFF may be useful as an indicator of both the disease activity and severity.
Source: Clinical Rheumatology - September 12, 2018 Category: Rheumatology Source Type: research

Endobronchial Ultrasound Elastography Helps Identify Fibrotic Lymph Nodes in Sarcoidosis.
PMID: 30207738 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 12, 2018 Category: Respiratory Medicine Authors: Livi V, Cancellieri A, Pirina P, Fois A, van der Heijden EHFM, Trisolini R Tags: Am J Respir Crit Care Med Source Type: research

Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis.
Abstract The feature of pulmonary sarcoidosis is characterized by a Th1/Th17/regulatory T cells (Tregs) -driven inflammatory process in lung, resulting in noncaseating granulomas containing CD4+ T cells. Tregs increase in both lung and peripheral blood, with damaged immunoregulatory function. The current study investigated the effects of IL33 or anti-IL23 antibody on restoring the homeostasis and functions of Tregs in mycobacterial superoxide dismutase A (SodA)-induced pulmonary sarcoidosis. IL33 or anti-IL23 antibody was administered to mice with late-stage pulmonary sarcoidosis. The levels of Th1/Th17/Tregs and ...
Source: International Immunopharmacology - September 6, 2018 Category: Allergy & Immunology Authors: Zhang B, Zhao F, Mao H, Ma W, Zhang Y, Zhang X, Ding J, Gao Q, Wen Y Tags: Int Immunopharmacol Source Type: research

A Study Evaluating the Diagnostic Yield and Safety of the ProCore vs Conventional EBUS-TBNA Needle in Subjects With Suspected Sarcoidosis
Condition:   Sarcoidosis Interventions:   Device: Procore biopsy needle;   Device: Conventional biopsy needle Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting
Source: ClinicalTrials.gov - September 3, 2018 Category: Research Source Type: clinical trials

Relationship between CT activity score with lung function and the serum angiotensin converting enzyme in pulmonary sarcoidosis on chest HRCT
To address the reliability of CT activity score (CTAS) and investigate the relationships between CTAS, lung function changes after treatment and the serum angiotensin-converting enzyme (SACE) levels. Fifty-seven sarcoidosis patients underwent chest high-resolution CT (HRCT) and spirometry, as well as SACE examination, were retrospectively analyzed. Follow-up spirometry in each patient was obtained about 6 months after the initial spirometry. The correlations between CTAS and pulmonary function changes were evaluated by Spearman correlation analysis. According to SACE status, patients were divided into normal and high leve...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Answer: Pulmonary tuberculosis in sarcoidosis patients: two cases.
PMID: 30479239 [PubMed - in process]
Source: Tuberkuloz ve Toraks - September 1, 2018 Category: Respiratory Medicine Authors: Üçsular F, Karadeniz G, Polat G, Yalnız E Tags: Tuberk Toraks Source Type: research

Pulmonary tuberculosis developed in sarcoidosis patients.
PMID: 30479238 [PubMed - in process]
Source: Tuberkuloz ve Toraks - September 1, 2018 Category: Respiratory Medicine Authors: Miyazaki K, Yamada H, Tamura T, Shiozawa T, Satoh H Tags: Tuberk Toraks Source Type: research

Causes of mediastinal/hilar granulomatous lymphadenitis.
Conclusions: In this study, we found that the most common cause of granulomatous lymphadenitis was sarcoidosis. Contrary to expectations, the number of patients diagnosed with tuberculosis was very low. PMID: 30479228 [PubMed - in process]
Source: Tuberkuloz ve Toraks - September 1, 2018 Category: Respiratory Medicine Authors: Erbay M, Özsu S, Ayaydın Mürtezaoğlu ES, Türkyılmaz A, Özçelik N, Bülbül Y, Ersöz Ş Tags: Tuberk Toraks Source Type: research

Whole-exome sequencing identifies rare genetic variations in German families with pulmonary sarcoidosis
This study highlights the subsets of functional rare gene variants involved in pulmonary sarcoidosis, such as, regulations of calcium ions, G-protein-coupled receptor, and immune system including retinoic acid binding. The implicated mechanisms in etiopathogenesis of familial sarcoidosis thus in clude Wnt signalling, inflammation mediated by chemokine and cytokine signalling and cadherin signalling pathways.
Source: Human Genetics - September 1, 2018 Category: Genetics & Stem Cells Source Type: research

Fatal amoebic meningoencephalitis caused by Balamuthia mandrillaris in a sarcoidosis patient.
PMID: 30175737 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - August 31, 2018 Category: Infectious Diseases Authors: Tarai B, Agarwal P, Krishnamoorthi S, Mewara A, Khurana S Tags: Jpn J Infect Dis Source Type: research

Disease in a Nutshell Sarcoidosis.
PMID: 30170027 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - August 28, 2018 Category: Allergy & Immunology Authors: Wang V, Jiang F, Kallepalli A, Basen T, Yusin J, Krishnaswamy G Tags: Ann Allergy Asthma Immunol Source Type: research

Sarcoidosis
is a granulomatous disease of unknown origin that can affect any organ system. It may cause respiratory tract, cardiac, ocular, neurologic, and cutaneous manifestations in isolation or in combination. The cause of sarcoidosis is poorly understood, but because exposure to certain environmental antigens in genetically susceptible individuals can lead to granulomatous inflammation mediated by a predominant T helper-1 (Th1) –mediated response, that mechanism is possible. Several disease clusters have been reported in response to environmental events, such as exposures to industrial chemicals or dust such as observed in the ...
Source: Annals of Allergy, Asthma and Immunology - August 28, 2018 Category: Allergy & Immunology Authors: Vivian Wang, Fonda Jiang, Anita Kallepalli, Tyler Basen, Joseph Yusin, Guha Krishnaswamy Tags: Disease in a Nutshell Source Type: research

Prevalence and incidence of sarcoidosis in Korea: a nationwide population-based study
The prevalence and incidence of sarcoidosis varies worldwide. We estimated the prevalence and incidence of sarcoidosis in Korea using nationwide claims data from the Korean Health Insurance Review and Assessme...
Source: Respiratory Research - August 28, 2018 Category: Respiratory Medicine Authors: Hee-Young Yoon, Hyeong Min Kim, Ye-Jee Kim and Jin Woo Song Tags: Research Source Type: research

Disease in a Nutshell Sarcoidosis
Sarcoidosis is a granulomatous disease of unknown etiology which can affect any organ system. It may cause respiratory tract, cardiac, ocular, neurologic, and cutaneous manifestations in isolation or in combination. The etiology of sarcoidosis is poorly understood but since exposure to certain environmental antigens in genetically susceptible individuals can lead to granulomatous inflammation mediated by a predominant T helper-1 (Th1) mediated response, that mechanism is possible. Several disease clusters have been reported in response to environmental events such as exposures to industrial chemicals or dust such as observ...
Source: Annals of Allergy, Asthma and Immunology - August 28, 2018 Category: Allergy & Immunology Authors: Vivian Wang, Fonda Jiang, Anita Kallepalli, Tyler Basen, Joseph Yusin, Guha Krishnaswamy Tags: Disease in a Nutshell Source Type: research

Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?
Idiopathic Pulmonary Fibrosis (IPF) and Sarcoidosis are distinct clinical entities. Fibrotic disease in pulmonary sarcoidosis is typically upper lobe predominant. In IPF fibrosis is basilar and peripheral predominant [usual interstitial pneumonia (UIP) pattern]. Sarcoidosis and UIP have rarely been observed in the same patient. We sought to characterize patients manifesting both sarcoidosis and IPF and compare clinical features and survival to that of patients with “Lone-IPF” (IPF only) and pulmonary sarcoidosis with fibrosis in a non-UIP pattern.
Source: Respiratory Medicine - August 23, 2018 Category: Respiratory Medicine Authors: Bridget F. Collins, Robyn L. McClelland, Lawrence A. Ho, Carmen R. Mikacenic, Jennifer Hayes, Carolyn Spada, Ganesh Raghu Source Type: research

Hepatic sarcoidosis.
Authors: Watanabe T, Jodo S PMID: 30127039 [PubMed - in process]
Source: Canadian Medical Association Journal - August 23, 2018 Category: General Medicine Tags: CMAJ Source Type: research

IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.
Abstract The mechanisms underlying abnormal granuloma formation in patients with sarcoidosis are complex and remain poorly understood. A novel in vitro human granuloma model was used to determine the molecular mechanisms of granuloma-genesis in patients with sarcoidosis in response to putative disease-causing mycobacterial antigens. Peripheral blood mononuclear cells (PBMCs) from patients with active sarcoidosis and from normal, disease-free controls were incubated for 7 days with purified protein derivative (PPD)-coated polystyrene beads. Molecular responses were analyzed, as reflected by differential expression ...
Source: Am J Respir Cell Mol... - August 22, 2018 Category: Respiratory Medicine Authors: Locke LW, Crouser ED, White P, Julian MW, Guirado Caceres E, Papp AC, Le VT, Sadee W, Schlesinger LS Tags: Am J Respir Cell Mol Biol Source Type: research

Sarcoid-Like Granulomatosis Induced by Nivolumab Treatment in a Lung Cancer Patient
We describe the case of an 81-year-old male with cT1aN2M1b stage IV pleomorphic carcinoma of the left upper lobe of the lung. After primary treatment with carboplatin and paclitaxel, recurrence was observed in the left supraclavicular lymph node and left adrenal gland. We initiated the administration of nivolumab as a secondary treatment. Reduction was observed in the swelling of the left supraclavicular lymph node and left adrenal gland, but the tumor shadow in the right upper lobe appeared to increase. Bronchoscopy was performed, and the biopsy result showed granulomas; the findings resembled a sarcoid-like granulomatous...
Source: Case Reports in Oncology - August 17, 2018 Category: Cancer & Oncology Source Type: research

Fatal fulminant cryptococcemia complicating sarcoidosis: is it to be expected?
We describe a case of cryptococcemia that rapidly progressed toward fatality without apparent other sites of infection. We discuss on the importance of serum cryptococcal polysaccharide antigen testing for identifying at-risk patients who might benefit from timely diagnosis and treatment of cryptococcosis
Source: Medical Mycology Case Reports - August 17, 2018 Category: Biology Source Type: research

Familial aggregation and heritability of sarcoidosis: a Swedish nested case-control study
Sarcoidosis is believed to be caused by both genetic and environmental risk factors, but the proportion of the susceptibility to sarcoidosis that is mediated by genetics remains unknown. We aimed to estimate the familial aggregation and heritability of sarcoidosis using a case–control–family study design and population-based Swedish registers. We identified 23 880 individuals with visits for sarcoidosis in the Swedish National Patient Register using International Classification of Diseases codes (1964-2013). Information on Löfgren's syndrome was available for a subset diagnosed at Karolinska University ...
Source: European Respiratory Journal - August 16, 2018 Category: Respiratory Medicine Authors: Rossides, M., Grunewald, J., Eklund, A., Kullberg, S., Di Giuseppe, D., Askling, J., Arkema, E. V. Tags: Original Articles: Interstitial lung diseases Source Type: research

Balloon pulmonary angioplasty – efficient therapy of chronic thromboembolic pulmonary hypertension in the patient with advanced sarcoidosis – a case report
We report unusual case of confirmed chronic thromboembolic pulmonary hypertensi...
Source: BMC Pulmonary Medicine - August 16, 2018 Category: Respiratory Medicine Authors: Andrzej Labyk, Dominik Wretowski, Sabina Zybi ńska-Oksiutowicz, Aleksandra Furdyna, Katarzyna Ciesielska, Dorota Piotrowska-Kownacka, Olga Dzikowska –Diduch, Barbara Lichodziejewska, Andrzej Biederman, Piotr Pruszczyk and Marek Roik Tags: Case report Source Type: research

Cardiac sarcoidosis - an expert review for the chest physician.
Authors: Ho JS, Chilvers ER, Thillai M Abstract INTRODUCTION: Sarcoidosis is a multisystem granulomatous disease predominantly affecting the lungs, with increased risk of cardiovascular disease, pulmonary hypertension and cardiac sarcoidosis (CS), the latter due to direct granuloma infiltration. Sarcoidosis is often managed by chest physicians who need to understand the diagnostic pathways and initial management plans for patients with cardiac involvement. Areas covered: The most serious consequence of CS is sudden cardiac death due to ventricular tachyarrhythmias or complete atrioventricular block. Additional comp...
Source: Expert Review of Respiratory Medicine - August 14, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis
ConclusionsCerebrovascular events may be the first manifestation of neurosarcoidosis, and have a prognosis impact in such patients, leading to death and permanent neurological impairment.
Source: Journal of Neurology - August 14, 2018 Category: Neurology Source Type: research

New Insights On Ocular Sarcoidosis: An Optical Coherence Tomography Angiography Study.
CONCLUSION: The depth-resolved nature of OCT-A allowed new insights on OS-induced microvascular and perfusion impairments. PMID: 30081683 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - August 11, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Vitamin D Homeostasis in Sarcoidosis
Conditions:   Sarcoidosis;   Vitamin D Insufficiency Interventions:   Drug: Ergocalciferol;   Drug: Placebo;   Drug: Calcium Citrate with Vitamin D2 Sponsor:   University of Texas Southwestern Medical Center Not yet recruiting
Source: ClinicalTrials.gov - August 8, 2018 Category: Research Source Type: clinical trials